• Molecules and Cells
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• v.41 no.8
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• pp.717-723
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• 2018

Chimeric antigen receptor (CAR) T-cell therapy, an emerging immunotherapy, has demonstrated promising clinical results in hematological malignancies including B-cell malignancies. However, accessibility to this transformative medicine is highly limited due to the complex process of manufacturing, limited options for target antigens, and insufficient anti-tumor responses against solid tumors. Advances in gene-editing technologies, such as the development of Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9), have provided novel engineering strategies to address these limitations. Development of next-generation CAR-T cells using gene-editing technologies would enhance the therapeutic potential of CAR-T cell treatment for both hematologic and solid tumors. Here we summarize the unmet medical needs of current CAR-T cell therapies and gene-editing strategies to resolve these challenges as well as safety concerns of gene-edited CAR-T therapies.

• Journal of KSNVE
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• v.9 no.5
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• pp.991-997
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• 1999

It is getting higher the demand on a good sound in a car. Like some other sensory qualities, achieving a good sound is still treated as a black-box followed by the individual taste of tuning engineers. This study aims to define the attributes of a good car audio sound and the assessment factors affecting the sound quality. With a variety of surveys on professional listening groups and car audio installers, 26 most frequently used vocabularies are selected as typical presentations of car audio sound quality. After repetitions of listening tests with deliberately selected test CD, pre-recorded 15 different digital car-recordings, headphones replay system, and three different listening groups, it is proved that there are at least 5 different assessment factors which significantly affect the car audio sound quality. They are high fidelity, spectral balance, tonal accuracy, sound stage and acoustic fault.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.1642-1645
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• 2008

It is said that the effect in wheels of freight car varies with the type of freight, the condition of operation, the braking device, and the type of bogie. The hardness of open wagon, gondola car, propylene car, covered freight car, container car and hopper car has been measured according to the mileage through this research. As a result, the wheel with more mileages after shaving off the wheel tread has a higher hardness than the others in the case of same type of car.

• MALSORI
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• no.48
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• pp.141-153
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• 2003

Researches into robust recognition in noise environments, especially in car environments, are being carried out actively in speech community. In this paper we will report on three types of corpora that SiTEC (Speech Information TEchnology & industry promotion Center) has created for research into speech recognition in car noise environments. The first is the recordings of 900 Korean native speakers, distributed according to gender, age, and region, who uttered application words in car environments. The second is the collections of mixed noise in 3 car types by model while setting up various noise patterns which can be obtained with the car engine on or off, at different driving speed, and in different road conditions with windows open or closed. The third is the recordings of simulated speech by HATS (Head and Torso Simulator) in car environments with the internal and external noise factors added. These three types of recordings were all made through synchronized 8 channel microphones that are fixed in a car. The creation and applications of these corpora will be reported on in detail.

• Journal of the Korean Society of Clothing and Textiles
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• v.41 no.3
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• pp.446-457
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• 2017

This study surveys the usage and satisfaction of car seat covers, analyzes the satisfaction and luxuriousness of materials used and provides basic data on optimum car seat covers that improve consumer satisfaction, stability, and comfort, while driving. The survey was conducted on 150 people in their 20s to 60s with a car. Consequently, achromatic colored car seat covers were used most and the satisfaction with black was very high. Interior & exterior harmony and the pursued car image were considered important, this consumer psychology impacted the color selection for car seat covers. The satisfaction reasons were different according to materials. Genuine leather was highly regarded in interior & exterior harmony (20.8%), excellent seat sensation (17.7%), excellent tactile sensation (11.5%), and luxuriousness (8.5%). For artificial leather, interior & exterior harmony (16.5%) and easiness of stain removal (13.6%) was rated high and fabric had excellent seat sensation (12.3%) and economics (10.8%). The material, heated and ventilated device affected car seat cover satisfaction. The luxurious image of car seat covers was pursed and was perceived mainly with a sense of sight. Luxury car seat covers were mainly created with materials. Genuine leather and black car seat covers increased luxuriousness. For car seat covers, those with flexibility, excellent compressive elasticity, and thickness were perceived as luxurious.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.11
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• pp.4100-4107
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• 2010

The wrecker truck of lift type is used to move damaged car in accident spot or to move illegal vehicle in towaway zone toward pound.. This special vehicle drives by lifting front or rear side of car with the driving type of towed car. Each car is modelled with CATIA and is simulated with FEM analysis program ANSYS. This study analyzes how dangerous is the triple collision among the wrecker-towed car-driving car as comparing with the usual collision accident with cars. It is studied how responsible is the towed car in case of crashing its back side by driving car. The influence on the driving angle of towed car by lifting wrecker is also considered.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1718-1721
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• 1997

An image processing algorithm is developed in order to recognize the type of cars, the position of a number plate and the characters on the plate. to recognize the type of cars, comparison of two images is used. One has a car image, the other is just a background image without car. After that recognition, a vertical line filter is used to find the location of the plate. Finally the simularity mehod is used to recognize the numbers on plates.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1995.10b
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• pp.159-164
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• 1995

Driving maneuver in car following are affected by not only the factors related to road structure and traffic condition, but also the factors related to driver's cognition to them. So the aim of this research this to model the relation of driver's cognition for car-following distance considering driver's fuzziness for imformation cognition, As a result, driver's cognition of car-following distance model with fuzzy number is proposed. The 'width', which characterizes the fuzzy number can introduce car-following informtion into the model.

• Journal of the Korean Society of Industry Convergence
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• v.11 no.2
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• pp.71-82
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• 2008

In this study, 3 dimensional non-linear race car vehicle model including Chassis, steering and suspension systems were modeled by using Multi-Body Dynamics Simulation Program, DADS 9.5(Dynamic Analysis and Design System),which was used in kinematic and dynamic analysis. A full race car vehicle dynamics model using DADS program was presented and analysis was carried out to estimate the handling characteristics that may be very useful to design a race car in early design stage. The simulation of vehicle handling behavior for step steering input was simulated and compared with different design parameters: torsional stiffness of the front and rear anti roll bars, the motion ratio of the front and rear suspension system, the location of the tie rod joint, in multibody dynamic model. Therefore this simulation model before race car construction in early design step will be helpful for race car designer to save time and limited budget.

• Transactions of the Korean Society of Automotive Engineers
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• v.11 no.5
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• pp.134-139
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• 2003

The car crash accidents in low speed occurs most frequently. Damage on a conventional bumper after the car accident causes the bumper to get fixed most of time. This study shows how a gas tube bumper reduces a damageability and increase repairability after the car accidents. The 15 km/h 40% offset front and rear crash test recommended by RCAR (Research council for automobile repairs) standard was performed and evaluated damages on the gas tube bumper by the pendulum impact tester. In this study, the gas tube bumper reduces damageability and increases repairability after car crash accidents. In addition, car frame design to apply the gas tube bumper may consider to be changed.