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Enhancing Alzheimer's Disease Classification using 3D Convolutional Neural Network and Multilayer Perceptron Model with Attention Network

  • Enoch A. Frimpong;Zhiguang Qin;Regina E. Turkson;Bernard M. Cobbinah;Edward Y. Baagyere;Edwin K. Tenagyei
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.11
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    • pp.2924-2944
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    • 2023
  • Alzheimer's disease (AD) is a neurological condition that is recognized as one of the primary causes of memory loss. AD currently has no cure. Therefore, the need to develop an efficient model with high precision for timely detection of the disease is very essential. When AD is detected early, treatment would be most likely successful. The most often utilized indicators for AD identification are the Mini-mental state examination (MMSE), and the clinical dementia. However, the use of these indicators as ground truth marking could be imprecise for AD detection. Researchers have proposed several computer-aided frameworks and lately, the supervised model is mostly used. In this study, we propose a novel 3D Convolutional Neural Network Multilayer Perceptron (3D CNN-MLP) based model for AD classification. The model uses Attention Mechanism to automatically extract relevant features from Magnetic Resonance Images (MRI) to generate probability maps which serves as input for the MLP classifier. Three MRI scan categories were considered, thus AD dementia patients, Mild Cognitive Impairment patients (MCI), and Normal Control (NC) or healthy patients. The performance of the model is assessed by comparing basic CNN, VGG16, DenseNet models, and other state of the art works. The models were adjusted to fit the 3D images before the comparison was done. Our model exhibited excellent classification performance, with an accuracy of 91.27% for AD and NC, 80.85% for MCI and NC, and 87.34% for AD and MCI.

Development of Digital Fashion Design Utilizing the Characteristics of Women's Traditional Costumes in the Tang Dynasty of China (중국 당(唐)나라 여성 전통 복식 특성을 활용한 디지털 패션디자인)

  • Ziheng Zhou;Youn-Hee Lee
    • Journal of the Korea Fashion and Costume Design Association
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    • v.26 no.1
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    • pp.17-31
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    • 2024
  • The purpose of this study is to propose a modern use of traditional culture by developing creative fashion designs that combine modern and traditional styles based on an analysis of traditional costumes of women in the Tang Dynasty of China. The characteristics of the Tang Dynasty women's costume are as follows. The Tang Dynasty women's costume consists of a short coat (衫, Shan), skirt (裙, Qun), half-arm shawl (半臂, Banbi), and short embroidered cape (帔, Pei). The colors are succinct and elegant, commonly red, yellow, green and navy blue in its entirety. It may be classified by pattern that blend plant patterns, animal patterns, geometric patterns, and two or more mixed patterns. On the basis of the characteristics for traditional women's costume during the Tang Dynasty, the CLO 3D program is employed to develop digital fashion design for four pairs of 3D digital clothing and the production of two pairs of work product. The results are as follows. First, the development of fashion design reflecting the design characteristics of traditional women's clothing in the Tang Dynasty of China could be expressed as fashion design reflecting unique values while connecting tradition and modernity. Second, the 3D virtual clothing program displays an extremely important effect in design deployment and pattern arrangement by having efficiency and convenience in clothing production. The CLO 3D program is closely combined with the 2D design and 3D effect and heightened efficiency while being appropriate to realize sustainability while saving processing time and energy for the sample products. Third, the production of an actual product by facilitating the 3D virtual clothing design may lead to time savings and an effective economy and may allow for the comparison of digital fashion design and actual products as well as confirming the effects of digital fashion design.

Co-administration of alcohol and combination antiretroviral therapy (cART) in male Sprague Dawley rats: a study on testicular morphology, oxidative and cytokines perturbations

  • Elna Owembabazi;Pilani Nkomozepi;Tanya Calvey;Ejikeme Felix Mbajiorgu
    • Anatomy and Cell Biology
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    • v.56 no.2
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    • pp.236-251
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    • 2023
  • Alcohol consumption alongside combination antiretroviral therapy (cART) has attracted research interest, especially because of increasing male infertility. This study investigated the combined effects of alcohol and cART on testicular morphology, biomarkers of oxidative stress, inflammation, and apoptosis. Rats, weighing 330-370 g, were divided into four groups of six animals each; control, alcohol treated (A), cART, and alcohol plus cART treated (A+cART). Following 90 days treatment period, animals were euthanized, testis extracted, and routinely processed for histology and immunohistochemical analysis. Significantly decreased epithelial area fraction, increased luminal and connective tissue area fractions, and reduction of epithelial height and spermatocyte number, were recorded in the treated groups compared to control. Extensive seminiferous epithelial lesions including widened intercellular space, karyolysis, and sloughing of germinal epithelium were recorded in all the treated groups. Furthermore, upregulation of inducible nitric oxide synthase and 8-hydroxydeoxyguanosine, interleukin-6, and caspase 3 recorded in treated animals, was more significant in A+cART group. Also, the levels of interleukin-1β and tumor necrosis factor-α were more elevated in A and cART treated groups than in A+cART, while MDA was significantly elevated in cART and A+cART treated groups compared to control group. Altogether, the results indicate testicular toxicity of the treatments. It is concluded that consuming alcohol or cART induces oxidative stress, inflammation, and apoptosis in testis of rats, which lead to testicular structural and functional derangements, which are exacerbated when alcohol and cART are consumed concurrently. The result will invaluably assist clinicians in management of reproductive dysfunctions in male HIV/AIDS-alcoholic patients on cART.

Evaluation of Environmental and Economic Impacts of Advanced Wastewater Treatment Plants with Life Cycle Assessment (고도 하수처리장의 전과정평가에 따른 환경성 및 경제성 평가)

  • Pyo, SeHee;Kim, MinJeong;Lee, SeungChul;Yoo, ChangKyoo
    • Korean Chemical Engineering Research
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    • v.52 no.4
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    • pp.503-515
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    • 2014
  • A lot of existing wastewater treatment plants (WWTPs) are rebuilt or retrofitted for advanced wastewater treatment processes to cope with reinforced effluent criteria of nitrogen and phosphorous. Moreover, how to treat the wasted sludge from WWTPs has been also issued since the discharge of the wasted sludge into ocean is impossible from 2011 due to the London Convention 97 protocol. These trend changes of WWTPs get a motivation to assess environmental and economic impacts from the construction stage to the waste stage in WWTPs. Therefore, this study focuses on evaluation of environmental and economic impacts of the advanced wastewater treatment processes and waste sludge treatment process by using life cycle assessment. Four advanced wastewater treatment processes of Anaerobic/Anoxic/Oxic ($A_2O$), 5 stages-Bamard Denitrification Phosphate (Bardenpho), Virginia Initiative Plant (VIP), and Modified University of Cape Town (MUCT) are chosen to compare the conventional activated sludge (CAS) and three waste sludge treatment methods of land fill, incineration, and composting are used. To evaluate environmental and economic impacts of each advanced wastewater treatment processes, life cycle assessment (LCA) and life cycle cost (LCC) are conducted based on International organization for standardization (ISO) guidelines. The results clearly represent that the $A_2O$ process with composting shows 52% reduction in the environmental impact than the CAS process with landfill. On the other hand, the MUCT process with composting is able to save 62% of the life cycle cost comparing with the CAS process with landfill. This result suggested the qualitative and quantitative criteria for evaluating eco-environmental and economic technologies of advanced treatment processes and also sludge treatment method, where their main influence factors on environmental and economic impacts are analyzed, respectively. The proposed method could be useful for selecting the most efficient and eco-friendly wastewater treatment process and sludge treatment method when retrofitting the existing WWTPs to advanced treatments.

Estimate and Environmental Assessment of Greenhouse Gas(GHG) Emissions and Sludge Emissions in Wastewater Treatment Processes for Climate Change (기후변화를 고려한 하수처리공법별 온실가스 및 슬러지 배출량 산정 및 환경성 평가)

  • Oh, Tae-Seok;Kim, Min-Jeong;Lim, Jung-Jin;Kim, Yong-Su;Yoo, Chang-Kyoo
    • Korean Chemical Engineering Research
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    • v.49 no.2
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    • pp.187-194
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    • 2011
  • In compliance with an international law about the ocean dumping of the sludge, the proper sewage treatment process which occurs from the wastewater treatment process has been becoming problem. Generally the sewage and the sludge are controlled from anaerobic condition when the sewage is treated and land filled, where the methane$(CH_{4})$ and the nitrous oxide $(N_{2}O)$ from this process are discharged. Because these gases have been known as one of the responsible gases for global warming, the wastewater treatment process is become known as emission sources of green house gases(GHG). This study is to suggest a new approach of estimate and environmental assessment of greenhouse gas emissions and sludge emissions from wastewater treatment processes. It was carried out by calculating the total amounts of GHG emitted from biological wastewater treatment process and the amount of the sludgegenerated from the processes. Four major biological wastewater treatment processes which are Anaerobic/Anoxic/Oxidation$(A_{2}O)$, Bardenpho, Virginia Initiative Plant(VIP), University of Cape Town(UCT)are used and GPS-X software is used to model four processes. Based on the modeling result of four processes, the amounts of GHG emissions and the sludge produced from each process are calculated by Intergovernmental Panel on Climate Change(IPCC) 2006 guideline report. GHG emissions for water as well as sludge treatment processes are calculated for environmental assessment has been done on the scenario of various sludge treatments, such as composting, incineration and reclamation and each scenario is compared by using a unified index of the economic and environmental assessment. It was found that Bardenpho process among these processes shows a best process that can emit minimum amount of GHG with lowest impact on environment and composting emits the minimum amount of GHG for sludge treatment.

A study on performance comparison of jacket cooling fresh water system for marine diesel engine (선박용 디젤기관의 재킷 냉각청수시스템 성능 비교에 관한 연구)

  • Kim, Duk-Kyung;Lee, Jae-Hyun;Cho, Kwon-Hae
    • Journal of Advanced Marine Engineering and Technology
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    • v.41 no.1
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    • pp.8-14
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    • 2017
  • Due to the financial crisis in 2008, the world economy collapsed leading to an increase in oil prices and a decrease in freight by shipping. To overcome this crisis, major shipping companies ordered larger ships, changed their trading route and improved operating of ships to overcome deficits. In particular, low-speed navigation was much favored by many companies so that it can reduce fuel consumption. However, the long-term operation of high-speed optimized engines in low-speeds has affected the jacket cooling fresh water (J.C.F.W.) system as they fail to maintain the normal operational temperature. The temperature of J.C.F.W. system dropped leading to low temperature corrosion. As a result, when the engine is operating at minimal load the functioning of existing J.C.F.W cooler is decreased and the use of fresh water generator is substantially limited. Therefore, an improvement in the functioning of J.C.F.W. system is necessary. In this paper, in order to review the improvements required for the operation of J.C.F.W. of low-speed operating marine diesel, an experiment was conducted by comparing and analyzing the results of the main engine J.C.F.W. system of a Panamax class bulk carrier 82k and a Cape class bulk carrier 180k by installing and uninstalling the J.C.F.W. Cooler. Thus, this paper proposed an improved design of the J.C.F.W. system that is suitable for the present low-speed operation.

Studies on Manufacturing of Gouda Type Cheese by using of Crystalline Mucor Rennin (Crystalline Mucor Rennin을 이용한 치즈제조에 관한 연구)

  • Yu, Ju-Hyun;Kim, Yu-Sam;Hong, Yun-Myung
    • Korean Journal of Food Science and Technology
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    • v.3 no.1
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    • pp.6-14
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    • 1971
  • Crystalline Mucor rennin and Mucor rennet from Mucor pusillus var. Lindt was compared with Hansen's calf rennet in its properties as a milk clotting enzyme. The method of Gouda type cheese from domestic milk was established by using of Crystalline Mucor rennin and Mucor rennet. The cheese produced by using of Mucor rennet as a milk clotting enzyme sometimes had bitter taste, it can be reduced with using Crystalline Mucor rennin, instead of Mucor rennet. It was also found out that these cheeses could be colored by the pigment from Cape Jasmine which is wildly ubiquitous in Korea.

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Characteristics of Precipitation over the East Coast of Korea Based on the Special Observation during the Winter Season of 2012 (2012년 특별관측 자료를 이용한 동해안 겨울철 강수 특성 분석)

  • Jung, Sueng-Pil;Lim, Yun-Kyu;Kim, Ki-Hoon;Han, Sang-Ok;Kwon, Tae-Yong
    • Journal of the Korean earth science society
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    • v.35 no.1
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    • pp.41-53
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    • 2014
  • The special observation using Radiosonde was performed to investigate precipitation events over the east coast of Korea during the winter season from 5 January to 29 February 2012. This analysis focused on the various indices to describe the characteristics of the atmospheric instability. Equivalent Potential Temperature (EPT) from surface (1000 hPa) to middle level (near 750 hPa) was increased when the precipitation occurred and these levels (1000~750 hPa) had moisture enough to cause the instability of atmosphere. The temporal evolution of Convective Available Potential Energy (CAPE) appeared to be enhanced when the precipitation fell. Similar behavior was also observed for the temporal evolution of Storm Relative Helicity (SRH), indicating that it had a higher value during the precipitation events. To understand a detailed structure of atmospheric condition for the formation of precipitation, the surface remote sensing data and Automatic Weather System (AWS) data were analyzed. We calculated the Total Precipitable Water FLUX (TPWFLUX) using TPW and wind vector. TPWFLUX and precipitation amount showed a statistically significant relationship in the north easterly winds. The result suggested that understanding of the dynamical processes such as wind direction be important to comprehend precipitation phenomenon in the east coast of Korea.

TRANSPORT AND DIFFUSION OF POLLUTANTS IN THE COASTAL WATERS OF ONSAN INDUSTRIAL COMPLEX (온산공단 부근의 해양오염물질 이동)

  • CHANG Sun-duck;LEE Jong-Sub;HAN Kyeong-Hwa
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.13 no.4
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    • pp.151-162
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    • 1980
  • To clarify the dispersion of pollutants introduced in the coastal region, a series of current measurements, the drogue and drift bottle experiments as well as the dye diffusion experiments were carried out in Onsan Bay and in the coastal waters of Ubong-ri near Ulsan. In the southeastern coastal region of Korean peninsula, that is, in the outside of Onsan Bay, the flood tidal current flows south-south-westward, and the ebb current flows north-north-eastward at a maximum speed of 1.0-1.1 knots at spring tide. In an inlet south of Cape Ubong, an anticyclonic eddy of 1 km in diameter is usually formed during both flood and ebb flows. The tidal current predominates in Onsan Bay at around spring tide. The maximum speed around spring tide was observed to be approximately 0.14 knot, while it was slower than 0.1 knot and variable at neap tide when the wind drift current played an important role. The flood tidal current flows westward while the ebb flow flows eastward in the northern region of the bay. The flood tidal current in the southern region of the bay flows west-north-westward, while the ebb current east-north-eastward. Wind drift currents in the coastal region of southern Korea are generally deduced to be southward in winter, the monthly mean speed being approximately 0.1 knot. Dye solution released at the northwestern corner in Onsan Bay was transported by eastward ebb tidal current toward the mouth of the bay dispersing by the wind. The apparent diffusion coefficient at 150 minutes after release in the bay was calculated to be $4.4\times10^4\;cm^2.sec^{-1}$, whereas that in the anticyclonic eddy was more or less smaller.

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Aggressive behavior of dementia patients in a facility (일 개 요양소에서의 치매환자의 공격행동에 대한 연구)

  • Oh Jin Joo
    • Journal of Korean Public Health Nursing
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    • v.12 no.2
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    • pp.172-184
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    • 1998
  • This study was to examine the characteristics of aggressive behaviour of dementia patients. It was based on the observation of the patients in a facility for dementia patients. Observation continued for two days from 9a.m. to 5p.m .. aggressive behavior was recorded using the instrument of Ryden. The result of this study is as follows. 1. appearance rate of aggressive behaviour During two days $74\%$ of the patients did aggressive behaviour(first day-$41.8\%$. second day-$62.8\%$). The average aggressive behaviour per person was 1.65. 2. types of aggressive behaviour Aggressive behaviour was the most frequent in verbal domain(157 case; $52.5\%$). Physical domain was the second$(136case;\;45.5\%)$, and sexual domain was the last$(6 case;\;2.0\%)$. More concretely, abusive/vulgar language$(74case;\;24.7\%)$ was more than anything else. Aggressive language$(65case;\;21.7\%)$, pushing$(39case;\;13.0\%)$, intimidating posture$(21case;\;7.0\%)$. slapping $(18case;\; 6.0\%)$ followed it. 3. correlation to other factors such as sex. age etc. The average aggressive behaviour of female(2.07) was higher than that of male(1.23) (p=.05). Age also had meaningful correlation to the frequency of aggressive behaviour(p=.04). All the other factors-the period of living in facility, the seriousness of dementia. movements in daily life. CAPE, emotional state. the extent of trouble in cognition- have nothing to do with the frequency of aggressive behaviour. 4. the time, place and the target of aggressive behavior Aggressive behaviour appeared more frequently in the afternoon $(138case;\;46.4\%)$ than in the morning or at lunch time. The patient's room ranked the first in the list of places where aggressive behaviour took place $(162case;\; 54.5\%)$. Nursing personnel topped in the target of aggressive behaviour$(119case;\; 39.8\%)$. 5. the preceding causes of the aggressive behavior the most frequent preceding causes of the behavior was the stimulus of another residents $(133case, 44.4\%)$ and that of nsg personnel was few relatively$(65 cases,\; 21.7\%)$. 6. Nursing personnel used verbal reaction most frequently$(40 cases,\; 51\%)$ and in a behavioral reaction they used physical restraint $(12 cases,\; 17.1\%)$ most frequently. In the reactions of nsg personnel. the rate of undesired reaction was high$(41cases,\; 44.28\%)$. and in that of the attacked residents, the usual reaction was most frequent $(80cases,\; 65.0\%)$. In the future it is needed to investigate the characteristics of aggressive behavior of dementia patients, and based on this the method of intervention must be developed. Today the number of dementia patient increases so nurses must strive to encounter aggressive behavior more desirably.

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