• 제목/요약/키워드: Cannabinoid

검색결과 50건 처리시간 0.02초

SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor

  • M.H. Rhee;Kim, S.K.
    • Proceedings of the Korean Society of Embryo Transfer Conference
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    • 한국수정란이식학회 2002년도 국제심포지엄
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    • pp.96-96
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    • 2002

  • We examined the role of SR 144528 (N-[-(1S-endo-1,3,,3-trimethyl-bicycle[2, 2, 1 ] heptan-2-y1]-5-(-4-chloro-3-mothyl-phenyl)-(4-methylbenzyl)-pyrazole-3- carboxamide) in the modulation of certain AC isoforms in transiently transfected COS-7 cells. We found that CB2 in COS cells has a constitutive activity, and thus leading to inhibition of AC-V activity even in the absence of agonist. In addition, this constitutive modulation of AC is reversed by SR144528. It is now well established that several G protein-coupled receptors can signal without agonist stimulation(constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive G protein-coupled receptor signaling. Agonist activation of the G$\_$i/o/-coupled peripheral cannabinoid receptor CB2 normally inhibits adenylyl cyclase type V and stimulates adenylyl cyclase type II. Using transfected COS cells, we show here that application of SR144528, an inverse agonist of CB2, leads to a reverse action (stimulation of adenylyl cyclase V and inhibition of adenylyl cyclase II). This inverse agonism of SR144528 is dependent on the temperature, as well as on the concentration of the cDNA of CB2 transfected. Pertussis toxin blocked the regulation of adenylyl cyclase activity by SR 144528.

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Effects of Cannabis sativa Extract on Skin Physiology and Activity (대마추출물의 피부생리 및 활성에 미치는 영향)

  • Mu Jun Kim;Jung Un Shin;Hyun Kee Kim;Dong Wook Shin
    • Journal of the Society of Cosmetic Scientists of Korea
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    • 제50권2호
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    • pp.95-102
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    • 2024

  • With the recent trend towards the legalization and relaxation of regulations surrounding medical cannabis, the diverse benefits of cannabis extracts are being scientifically validated, positioning them as promising next-generation ingredients across various fields. Compounds extracted from cannabis, such as cannabinoid (CB), cannabidiol (CBD), phytocannabinoid (pCB), and hemp seed hexane extracts (HSHE), have been shown to reduce skin inflammation, improve moisture retention exhibit strong antioxidant effects, and improve various skin conditions. In this paper, we review the effects of hemp extracts on the skin and explore their potential role as cosmetic ingredients.

  • https://doi.org/10.15230/SCSK.2024.50.2.95 인용 PDF