• Journal of Animal Science and Technology
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• v.56 no.8
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• pp.27.1-27.6
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• 2014

The fat mass and obesity associated (FTO) gene plays an important role in the regulation of energy homeostasis, fat deposition and obesity. For this reason, the FTO gene is a physiological and functional candidate gene for carcass and meat quality traits in beef cattle. The objectives of this study were to identify SNPs in the exonic regions of FTO gene and to evaluate the association of these SNPs with carcass traits in Hanwoo (Korean cattle). In this study, we newly identified two exonic SNPs in Hanwoo population. The g.125550A > T SNP was located in exon 3 and the g.175675C > T SNP was located in exon 6. Genotyping of the two SNP markers was carried out using PCR-RFLP analysis in Hanwoo steers to evaluate their association with carcass traits. As a result, g.125550A > T SNP genotype was significantly associated with effects on marbling score. Animals with the AA and TT homozygous genotypes had a significantly higher marbling score (p < 0.001) than those with AT heterozygous genotype, and this was significant after Bonferroni correction of the significance threshold (p = 0.003). Dominance effect was also observed for the marbling score (P < 0.05) with higher marbling score of homozygous animals. However, no significant associations with meat quality traits were observed for the g.175675C > T SNP. Our results suggest that the exonic SNP g.125550A > T in the FTO gene may be used as a DNA marker for the selection of Hanwoo with higher marbling.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.38 no.6
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• pp.557-563
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• 2010

This paper addresses the issue of adaptive global optimization using Kriging metamodel known as EGO(Efficient Global Optimization). The algorithm adaptively chooses where to generate subsequent samples based on an explicit trade-off between reduction of global uncertainty and exploration of the region of the interest. A strategy that saves the computational cost by using expectations derived from probabilistic nature of approximate model is proposed. At every iteration, a candidate test point that seems to be feasible/inactive or has little possibility to improve for minimum is identified and excluded from updating approximate models. By doing that the computational cost is saved without loss of accuracy.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.12
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• pp.61-67
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• 2000

In switched reluctance motor(SRM) drive, it is necessary to synchronize the stator phase excitation with the rotor position. Therefore the rotor position information is an essential. Usually optical encoders or resolvers are used to provide the rotor position information. These sensors are expensive and are not suitable for high speed operation. In general, the accuracy of the switching angle is dependent upon the resolution of the encoder and the sampling period of the microprocessor. But the region of high speed, switching angles are fluctuated back and forth from the preset values, which are cause by the sampling period of the microprocessor. Therefore, the low cost linear encoder suitable for the practical and stable SRM drive is proposed and the control algorithm to provide the switching signals using the simple digital logic circuit is also presented in this paper. It is verified from the experiments that the proposed encoder and logic controller can be a powerful candidate for the practical low cost SRM drive.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1277_1278
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• 2009

Amorphous oxide semiconductor $InGaZnO_4$(IGZO) is a very promising candidate of channel layer in transparent thin film trasisitor(TTFT) because of its high mobility and high transparency in visible light region. Amorphous IGZO films were deposited at room temperature on a fused silica substrate using pulsed laser deposition method. In-situ post annealing was carried out at 150-450C right after film deposition. The $O_2$ partial pressures during the deposition and the post annealing was fixed to 10mTorr. The electron transport properties of the amorphous IGZO films were improved by thermal annealing. The temperature range in which the improvement of the electrical properties, was 150C~300C.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.2
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• pp.161-168
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• 2016

Abnormal localization of tumor suppressor proteins is a common feature of renal cancer. Nuclear export of these tumor suppressor proteins is mediated by chromosome region maintenance-1 (CRM1). Here, we investigated the antitumor effects of a novel reversible inhibitor of CRM1 on renal cancer cells. We found that S109 inhibits the CRM1-mediated nuclear export of RanBP1 and reduces protein levels of CRM1. Furthermore, the inhibitory effects of S109 on CRM1 is reversible. Our data demonstrated that S109 significantly inhibits proliferation and colony formation of renal cancer cells. Cell cycle assay showed that S109 induced G1-phase arrest, followed by the reduction of Cyclin D1 and increased expression of p53 and p21. We also found that S109 induces nuclear accumulation of tumor suppressor proteins, Foxo1 and p27. Most importantly, mutation of CRM1 at Cys528 position abolished the effects of S109. Taken together, our results indicate that CRM1 is a therapeutic target in renal cancer and the novel reversible CRM1 inhibitor S109 can act as a promising candidate for renal cancer therapy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.4
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• pp.918-923
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• 2008

We proposed an embedded capacitor with the unique electrode structure, which electrodes are located on the same plane and dielectric gap was formed by electrodes. We named it 'Gap type EC', and it was analyzed by the FEM(Finite element Method) program tool. The resonant frequency of Cap type EC was obtained at more higher frequency region. Also, resonant frequency was changed with the magnitude and thickness of electrodes. The Gap type EC with the dielectric gap of $50{\mu}m$ showed capacitance density of $55pF/cm^2$. This value is the higher than that of conventional EC. So, we concluded that the Gap type EC can be a good candidate for high frequency decoupling.

• Journal of the Korea Computer Industry Society
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• v.9 no.4
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• pp.149-156
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• 2008

There is the temporal correlation of a animation sequence between the motion vector of current block and the motion vector of previous block. In this paper, we propose the scene change detection algorithm for block matching using the temporal correlation of the animation sequence and the center-biased property of motion vectors. The proposed algorithm determines the location of a better starting point for the search of an exact motion vector using the point of the smallest SAD(sum of absolute difference) value by the predicted motion vector from the same block of the previous frame and the predictor candidate point on each search region. Simulation results show that the proposed algorithm has better detection performance, such as recall rate, then the existing method. The algorithm has the advantage of speed, simplicity and accuracy. In addition, it requires less amount of storage.

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.1
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• pp.50-57
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• 2005

We present a simple and effective method of face and facial feature detection under pose variation of user face in complex background for the human-robot interaction. Our approach is a flexible method that can be performed in both color and gray facial image and is also feasible for detecting facial features in quasi real-time. Based on the characteristics of the intensity of neighborhood area of facial features, new directional template for facial feature is defined. From applying this template to input facial image, novel edge-like blob map (EBM) with multiple intensity strengths is constructed. Regardless of color information of input image, using this map and conditions for facial characteristics, we show that the locations of face and its features - i.e., two eyes and a mouth-can be successfully estimated. Without the information of facial area boundary, final candidate face region is determined by both obtained locations of facial features and weighted correlation values with standard facial templates. Experimental results from many color images and well-known gray level face database images authorize the usefulness of proposed algorithm.

• Journal of Magnetics
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• v.11 no.4
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• pp.182-188
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• 2006

The search for high-density recording materials has been one of most active and vigorous field in the field of magnetism. $FePt-L1_{0}$ nanoparticle has emerged as a potential candidate because of its high anisotropy. In this paper, we provide an overview of recent work at Argonne National Laboratory that contributes to the ongoing dialogue concerning the relation between structure and properties of the FePt nanoparticle system. In particular we discuss the ability to control structure and properties via dosing with Cr. Cr-dosed FePt films were grown via molecular beam epitaxy and annealed at $550^{\circ}C$ in an ultrahigh vacuum chamber, and were studied with the surface magneto-optic Kerr effect (SMOKE), scanning electron microscopy (SEM) and x-ray magnetic circular dichroism (XMCD). We found that small dosage of Cr helps to generate $L1_{0}$ phase FePt magnetic nanoparticles with small size, defined shape and regular spatial distribution on MgO (001) substrate. The nanostructures are ferromagnetic with high magnetic coercivity (${\sim}0.9T$) and magnetic easy axis in the desired out-of-plane orientation. We also show that controlling the lateral region where nanostructures exist is possible via artificial patterning with Cr.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.41 no.5
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• pp.125-134
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• 2004

This paper proposes a method for recognition of traffic signs using wavelet transform and shape information from the segmented traffic sign regions. It first segments traffic sign candidate regions by connected component algorithm from binary images, obtained by utilizing the RGB color ratio of each pixel in the image, and then extracts actual traffic sign regions based on their symmetries on X- and Y-axes. In the recognition stage, it utilizes shape information including moment edge correlogram and the number of crossings which concentric circular patterns from region center intersects with frequency information extracted by wavelet transform It finally performs recognition by measuring similarity with the templates in the database. The experimental results show the validity of the proposed method from geometric transformations and environmental factors.