• CELLMED
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• v.2 no.2
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• Journal of Korean Academy of Nursing
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• v.34 no.2
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• pp.290-296
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• 2004

Purpose: The purpose of this study was to develop a home care nursing network system for operating home care effectively and efficiently by utilizing a wire-wireless network and mobile computing in order to record and send patients' data in real time, and by combining the headquarter office and the local offices with home care nurses over the Internet. It complements the preceding research from 1999 by adding home care nursing standard guidelines and upgrading the PDA program. Method: Method/l and Prototyping were adopted to develop the main network system. Result: The detailed research process is as follows: 1 )home care nursing standard guidelines for Diabetes, cancer and peritoneal-dialysis were added in 12 domains of nursing problem fields with nursing assessment/intervention algorithms. 2) complementing the PDA program was done by omitting and integrating the home care nursing algorhythm path which is unnecessary and duplicated. Also, upgrading the PDA system was done by utilizing the machinery and tools where the PDA and the data transmission modem are integrated, CDMX-1X base construction, in order to reduce a transmission error or transmission failure.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.12
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• pp.111-122
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• 2014

As radiotherapy has become one of the widely used techniques in cancer treatment, accurate tracking of patient's respiratory motion is considered to be more important in treatment planning and dose calculations. Inaccurate motion tracking can cause severe issues such as errors in target/normal tissue delineation and increasing the volume of healthy tissues exposed to high doses. Different methods have been introduced to estimate the respiratory motion, but most of them require some electronic devices or expensive materials. As an inexpensive and easy to use alternative to the previous methods, we propose a new 3D respiratory motion tracking method by using stereo vision techniques of detecting and decoding visual coded markers.

• Journal of the Korean Data and Information Science Society
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• v.23 no.1
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• pp.1-11
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• 2012

When the microarray experiment developed, main interest was limited to detect differentially expressed genes associated with a phenotype of interest. However, as human diseases are thought to occur through the interactions of multiple genes within a same functional category, the unit of analysis of the microarray experiment expanded to the set of genes. For the phenotype of censored survival time, Gene Set Enrichment Analysis(GSEA), Global test and Wald type test are widely used. In this paper, we modified the Wald type test by adopting normal score transformation of gene expression values and developed a parametric test which requires much less computation than others. The proposed method is compared with other methods using a real data set of ovarian cancer and a simulation data set.

• Journal of the Korea Society of Computer and Information
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• v.21 no.11
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• pp.17-21
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• 2016

Heterogeneity assessment of tumor in oncology is important for diagnosis of cancer and therapy. The aim of this study was performed assess heterogeneity tumor region in PET image using texture analysis. For assessment of heterogeneity tumor in PET image, we inserted sphere phantom in torso phantom. Cu-64 labeled radioisotope was administrated by 156.84 MBq in torso phantom. PET/CT image was acquired by PET/CT scanner (Discovery 710, GE Healthcare, Milwaukee, WI). The texture analysis of PET images was calculated using occurrence probability of gray level co-occurrence matrix. Energy and entropy is one of results of texture analysis. We performed the texture analysis in tumor, liver, and background. Assessment textural features of region-of-interest (ROI) in torso phantom used in-house software. We calculated the textural features of torso phantom in PET image using texture analysis. Calculated entropy in tumor, liver, and background were 5.322, 7.639, and 7.818. The further study will perform assessment of heterogeneity using clinical tumor PET image.

• Nuclear Engineering and Technology
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• v.52 no.10
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• pp.2339-2345
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• 2020

Radiation imaging systems consisting of a large number of channels greatly benefit from multiplexing methods to reduce the number of channels with minimizing the system complexity and development cost. In conventional pixelated radiation detector modules, such as anger logic, is used to reduce a large number of channels that transmit signals to a data acquisition system. However, these methods have limitations of electrical noise and distortion at the detector edge. To solve these problems, a multiplexing concept using a digital signal encoding technique based on a time delay method for signals from detectors was developed in this study. The digital encoding multiplexing (DEM) method was developed based on the time-over-threshold (ToT) method to provide more information including the activation time, position, and energy in one-bit line. This is the major advantage of the DEM method as compared with the traditional ToT method providing only energy information. The energy was measured and calibrated by the ToT method. The energy resolution and coincidence time resolution were observed as 16% and 2.4 ns, respectively, with DEM. The position was successfully distributed on each channel. This study demonstrated the feasibility that DEM was useful to reduce the number of detector channels.

• Journal of Pharmacopuncture
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• v.23 no.2
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• pp.54-61
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• 2020

Inflammation is an immune response of the human body but excessive inflammation is taken as a major factor in the development of many diseases including autoimmune disorders, cancer and nerve disorders etc. In this regards the need is to suppress the inflammatory response. Suppression of extra or imperfect inflammatory response is not a big deal provided there is an exact knowledge of particular target in the body. Recent advancements in Pharmacological aspect made the therapy with improved outcomes in number of patients. Anticytokine therapy might be one of the important and novel approaches for inflammation and Arthritis. This can be achieved only when we go through the pathophysiology of expression and identification of mediators. Let's take an example of cytokine like interleukins (IL), chemokines, interferons (INF), tumor necrosis factors (TNF-α), growth factors, and colony stimulating factors) release pathway which is a major signalling protein in inflammatory response. In the present study we have reviewed the recent pharmacological therapeutic advancement, inflammatory mediators, receptors, and major signalling pathways. Such information will not only provide the idea about the mechanism of action of Pharmaceuticals and molecular targets but also it provides a new aspect for drug designing and new corrective approaches in existing clinical medicines. This study will be a source of good information for the researchers working in the area of drug designing and molecular Pharmacology especially in anti-inflammatory and anti arthritic medicines for target based therapy.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07b
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• pp.715-717
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• 2005

Support vector machine(SVM)은 최근 각광받는 기계학습 방법 중 하나로서, kernel function 이라는 사상(mapping)을 이용하여 입력 공간의 벡터를 classification이 용이한 특징 (feature) 공간의 벡터로 변환하는 것을 근간으로 한다. SVM은 이러한 특징 공간에서 두 클래스를 구분 짓는 hyperplane을 일련의 최적화 방법론을 사용하여 찾아내며, 주어진 문제가 convex problem 인 경우 항상 global optimal solution 을 보장하는 등의 장점을 지닌다. 한편 bioinformatics 연구에서 주로 사용되는 데이터는 측정 오류 등 일련의 오류를 포함하고 있으며, 이러한 오류는 기계학습 방법론이 어떤 decision boundary를 찾아내는가에 영향을 끼치게 된다. 특히 SVM의 경우 이러한 오류는 특징 공간 벡터간의 관계를 나타내는 Gram matrix를 변화로 나타나게 된다. 본 연구에서는 입력 공간에 오류가 발생할 때 그것이 SVM 의 decision boundary를 어떻게 변화시키는가를 대표적인 두 가지 kernel function, 즉 linear kernel과 Gaussian kernel에 대해 분석하였다. Wisconsin대학의 유방암(breast cancer) 데이터에 대해 실험한 결과, 데이터의 오류에 따른 SVM 의 classification 성능 변화 양상을 관찰하여 커널의 종류에 따라 SVM이 어떠한 특성을 보이는가를 밝혀낼 수 있었다. 또 흥미롭게도 어떤 조건 하에서는 오류가 크더라도 오히려 SVM 의 성능이 향상되는 것을 발견했는데, 이것은 바꾸어 생각하면 Gram matrix 의 일부를 변경하여 SVM 의 성능 향상을 꾀할 수 있음을 나타낸다.

• Journal of Korean Institute of Industrial Engineers
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• v.42 no.2
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• pp.129-137
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• 2016

A colonoscopy is important because it detects the presence of polyps in the colon that can lead to colon cancer. How often one needs to repeat a colonoscopy may depend on various factors. The main purpose of this study is to determine personalized surveillance interval of colonoscopy based on characteristics of patients including their clinical information. The clustering analysis using a partitioning around medoids algorithm was conducted on 625 patients who had a medical examination at Korea University Anam Hospital and found several subgroups of patients. For each cluster, we then performed survival analysis that provides the probability of having polyps according to the number of days until next visit. The results of survival analysis indicated that different survival distributions exist among different patients' groups. We believe that the procedure proposed in this study can provide the patients with personalized medical information about how often they need to repeat a colonoscopy.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.1
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• pp.32-41
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• 2012

Objectives: Information of chemical in electronics industry has not been known enough, although workers' health hazards by chemicals in this industry have been regarded serious. The who always contribute to reveal and control the health hazards and risks in electronics industry have not been the industry but the occupational or environmental victims and grassroot organizations. The similar phenomena can be observed in Korea. Methods: The experiences of individual workers on the occuapational safety and health in semiconductor factory were heard separately and integrated with related literatures. Results:: The first part of this article is largely based on the memories and experiences of individual workers of semiconductor factories, mainly from S semiconductor. Common features of those experiences can be a good resource for detail understanding of the workplace, especially under the situation without any transparent disclosure of information by the governments or the companies. The second part of this article deals with several factors to be considered for control of exposure in workplace; characteristics of workplace and workforce, types of chemicals used, and the way of using the chemicals. Then the current social issues on work-relatedness of cancers of S semiconductor workers are presented briefly. Conclusions: As a conclusion, current OSH situations and issues in Korean electronics industry raise the need of changes in OSH culture. General adaptation of precautionary principle, internalization of costs, and extended responsibility of producers are needed urgently. The OSH professionals both in public and private sectors should support these agendas under their social obligation to protect workers' health.