• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6249-6254
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• 2015

Targeting breast cancer awareness along with comprehensive cancer care is appropriate in low and middle income countries like India, where there are no organized and affordable screening services. It is essential to identify the existing awareness about breast cancer in the community prior to launching an organized effort. This study assessed the existing awareness about breast cancer amongst women and their health seeking practices in an urban community in Mumbai, India. A postal survey was undertaken with low or no cost options for returning the completed questionnaires. The majority of the women were aware about cancer but awareness about symptoms and signs was poor. Women were willing to accept more information about cancer and those with higher awareness scores were more likely to seek medical help. They were also more likely to have undergone breast examination in the past and less likely to use alternative medicines. High income was associated with better awareness but this did not translate into better health seeking behaviour. Organized programmes giving detailed information about breast cancer and its symptoms are needed and women from all income categories need to be encouraged for positive change towards health seeking. Further detailed studies regarding barriers to health seeking in India are necessary.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.861-865
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• 2014

Background: High risk HPV (HR-HPV) testing has been recommended as an effective tool along with cytology screening in identification of cervical intraepithelial lesions (CINs) and prevention of their progress towards invasive cervical cancer. The aim of this study was to assess the HR-HPV DNA status by Hybrid Capture 2 (HC2) assay in healthy asymptomatic women of North-East India. Materials and Methods: This study examined cervical cell samples of forty three (n=43) healthy women by HC2 assay. A High Risk HPV DNA kit (Qiagen) was used which can detect 13 high risk HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68. Results: The mean relative light units (RLU) for samples was in the range of 141-5, 94, 619. HR-HPV DNA was confirmed in 16% (7/43) of participant women samples. Among demographic and clinical parameters, menstrual irregularity (p=0.039) and infection history (p=0.028) has shown statistically significant differences between the HR-HPV-positive and negative groups. In the HR-HPV positive group, two women were confirmed for CINs after colposcopy and histopathologic examination. Conclusions: We suggest that there may be an association between irregular menstruation and infection history of the urogenital tract with HR-HPV DNA prevalence in North-East Indian asymptomatic women. HC2 assay can be a valuable tool for HR-HPV screening.

• 한국융합학회논문지
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• 제12권9호
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• pp.373-385
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• 2021

글로벌 데이터를 사용하여 암 건강정보문해력과 암 조기진단 행위 사이의 관계를 체계적으로 평가하고자 하였다. PRISMA 리뷰 가이드라인에 따라 2021년 1월31일까지 PubMed, CINAHL, Embase, Cochrane Library 4개의 웹 데이터베이스에 발표된 원문을 검색하였으며, 참고문헌 목록을 통해 추가로 검색하였다. 18세 이상의 참여자, 암 건강정보문해력과 암 조기진단 행위를 포함하여 측정하였다. 포함 기준에 충족되는 17건의 원문은 암 건강정보문해력을 측정했고 암 조기진단 행위에는 유방 촬영술, 임상 유방암 검진, Papanicolaou 검사, 대장 내시경 검사, PSA 검진 등이 포함되었다. 그중에 11건의 원문에서 암 건강정보문해력과 암 조기진단 행위 사이는 통계적으로 높은 긍정적인 상관관계를 확인하였다. 이러한 결과를 바탕으로 추후 연구에서는 암 건강 지식에 대한 효과적인 중재프로그램과 가이드라인을 개발하는 것에 초점을 맞추어야 한다. 연구결과를 근거로 암 조기진단율 과 공중 보건 향상을 위해서 암 건강정보문해력과 암 조기진단 행위에 관한 모든 영역으로 연구 범위를 확대하여야 한다.

• Journal of Digestive Cancer Research
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• 제1권1호
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• pp.43-47
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• 2013

췌장암에 대한 근치적 절제술 후에 잔여 췌장에서 발생한 췌장암에 대한 보고는 거의 없는 상태이며, 특히 잔여췌장에 발생한 췌장암에 대하여 반복 췌장절제를 시행한 보고는 더욱 드물다. 저자들은 췌장미부에 발생한 췌장암에 대하여 근치적 절제술을 시행 후 35개월에 잔여 췌장에서 발생한 췌장암으로 췌장십이지장 절제술을 시행한 경우와 췌장두부에 발생한 췌장암에 대하여 췌장십이지장 절제술을 시행 후 20개월 만에 잔여 췌장에 췌장암이 발생하여 췌장미부절제술을 시행한 경우를 경험하였기에 고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5551-5556
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• 2012

Cytological examination is widely used as a diagnostic tool because of the ease of collecting cells from the involved area. However, the diagnostic yield of cytological examination is unsatisfactory; the reasons include sampling error, poorly prepared samples, small numbers of malignant cells, and low grades of cellular atypia. In this study, we focused on the high infectivity of adenovirus towards epithelial cells and applied the luciferase-expressing adenoviral vector to a new cancer cell detection tool. In addition, adenoviral infectivity was enhanced by modifying viral fiber proteins. The sensitivity of the diagnostic tool was tested using the NCI-H1299 lung cancer cell line, and validated in body fluid samples from cancer patients with a variety of etiology. Results showed that the adenovirus efficiently transfected NCI-H1299 with high sensitivity. Only 10 cancer cells were sufficient for detection of luciferase signals. In body fluid samples, the adenovirus confirmed the diagnosis for malignant and benign cancer, but not in non-epithelial cell derived samples. This study provides proof-of-concept for a more reliable and sensitive diagnostic tool for epithelium-derived cancer.

• 융합정보논문지
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• 제9권5호
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• pp.65-76
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• 2019

본 연구는 국민건강영양조사 제7기 2차년도(2017) 자료를 이용하여 우리나라 20세 이상 성인 여성의 폐경 여부가 유방암에 미치는 영향을 파악하기 위해 시도되었다. 연구 대상자는 3,414명이었고, 자료는 SPSS / Win 25.0 프로그램을 이용하여 복합표본 빈도분석, 복합표본 교차분석(Rao-Scott ${\chi}^2$ test), 복합표본 로지스틱 회귀분석을 실시하였다. 주요 결과는 대상자의 연령에 따라 50~59세에서 40~49세 보다 유방암이 1.7% 더 많았고, 음주 빈도가 전혀 없는 경우가 거의 매일 있는 경우 보다 1.7%가 유의하게 더 많았다. 폐경 연령은 44세 이하가 50세 이상 보다 유방암이 2.1% 유의하게 더 높았다. 폐경 여부에 따라 폐경 후가 폐경 전 보다 유방암이 1.7% 더 많았다. 연령과 음주 빈도를 동시에 보정하였을 때 대상자는 폐경 후에 비해 전에서 유방암이 0.03배 유의하게 낮았다. 이상의 결과로 44세 이하의 폐경한 젊은 여성의 유방암 관리에 많은 관심을 가져야 할 것이며, 지속적으로 증가하고 있는 유방암 유병률을 감소시키기 위한 다학제간의 노력이 필요하다.

• 한국식생활문화학회지
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• 제35권4호
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• pp.363-370
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• 2020

This study analyzed the health characteristics and comorbidity of adult men aged 40 years by dividing them into a control group of those without any disease related to fine dust and a patient group with one or more diseases related to fine dust in areas with high levels of fine dust pollution using the sixth and seventh Korea National Health and Nutrition Examination Survey (2013-2017). Among the general characteristics, the mean age of the patient group was significantly older than that of the control group (p<0.001), and in terms of the health-related characteristics, the frequency of breakfast consumption in the patient group was higher than in the control group (p<0.043). The body measurements were similar in the patient and control groups. Regarding the prevalence of comorbidity, the patient group showed a higher prevalence of hypertension, dyslipidemia, stroke, myocardial infarction, heart failure, and diabetes than the control group, but the differences were not statistically significant. On the other hand, the prevalence of other cancers (except stomach cancer, liver cancer, colorectal cancer, breast cancer, and cervical cancer) in the patient group was higher than in the control group (p<0.05). In terms of the clinical characteristics, the glycated hemoglobin levels in the patient group were significantly higher than in the control group (p<0.048). Information on nutrition and health in areas with frequent occurrences of fine dust was obtained through the study results, which can be used as basic data for measures of health and diet management against diseases that will increase in relation to fine dust.

• 한국체육학회지인문사회과학편
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• 제57권5호
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• pp.269-279
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• 2018

본 연구의 목적은 한국 암환자들의 근력운동 빈도, 근력, 그리고 건강관련 삶의 질과의 관계를 조사하는 것이다. 이를 위해 2014~2016년 국민건강영양조사 자료를 통합하여, 총 647명의 암환자들의 주당 근력운동 빈도, 악력, 건강관련 삶의 질의 관계를 복합표본 일반선형모형과 로지스틱 회귀분석 방법을 이용하여 분석하였다. 분석결과, 근력운동빈도가 주당 0~1일인 암환자들은 5일 이상인 암환자들에 비해(0.852±0.016 vs. 0.890±0.020 ; p=0.006), 상대 악력이 낮은 암환자들은 높은 그룹에 비해 (0.850±0.018 vs. 0.911±0.016; p<0.001) 건강관련 삶의 질 지수 (EQ-5D index) 가 유의하게 낮게 나타났다. 또한, 주당 근력운동 빈도가 0~1일인 암환자들은 5일 이상인 암환자들에 비해 운동능력에 문제가 생길 확률이 4.07배 (95% CI=1.31-12.63), 상대 악력이 낮은 그룹은 높은 그룹에 비해 운동능력에 문제가 생길 확률이 4.94배 (95% CI=2.14-11.41), 일상생활에서는 5.18배 (95% CI=1.56-17.14), 통증/불편에서는 2.46배 (95% CI=1.33-4.55) 증가했다. 본 연구결과를 통해 암환자들의 근력운동 빈도와 근력이 건강관련 삶의 질과 유의한 관계에 있는 것으로 나타났으며, 꾸준한 근력운동으로 인한 근력향상은 암환자들의 삶의 질 관리에 큰 도움이 될 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1953-1958
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• 2015

Background: In India, cancer accounts for 7.3% of DALY's, 14.3% of mortality with an age-standardized incident rate of 92.4/100,000 in men and 97.4/100,000 in women and yet there are no nationwide screening programs. Materials and Methods: We calculated age-standardized and age-truncated (30-69 years) detection rates for men and women who attended the Indian Cancer Society detection centre, New Delhi from 2011-12. All participants were registered with socio-demographic, medical, family and risk factors history questionnaires, administered clinical examinations to screen for breast, oral, gynecological and other cancers through a comprehensive physical examination and complete blood count. Patients with an abnormal clinical exam or blood result were referred to collaborating institutes for further investigations and follow-up. Results: A total of n=3503 were screened during 2011-12 (47.8% men, 51.6% women and 0.6% children <15 years) with a mean age of 47.8 yrs (${\pm}15.1yrs$); 80.5% were aged 30-69 years and 77.1% had at least a secondary education. Tobacco use was reported by 15.8%, alcohol consumption by 11.9% and family history of cancer by 9.9% of participants. Follow-up of suspicious cases yielded 45 incident cancers (51.1% in men, 48.9% in women), consisting of 55.5% head and neck (72.0% oral), 28.9% breast, 6.7% gynecological and 8.9% other cancer sites. The age-standardized detection rate for all cancer sites was 340.8/100,000 men and 329.8/100,000 women. Conclusions: Cancer screening centres are an effective means of attracting high-risk persons in low-resource settings. Opportunistic screening is one feasible pathway to address the rising cancer burden in urban India through early detection.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3271-3274
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• 2012

Purpose : This study was performed to assess whether the weight status is associated with screening rates of breast and cervical cancer in Korean women. Methods: Study participants included women aged between 30 and 80 years from the 4th Korea National Health and Nutrition Examination Survey from 2007 to 2009. Body mass index was classified into ${\sim}18.4kg/m^2$ (underweight), $18.5{\sim}22.9kg/m^2$ (normal), $23{\sim}24.9kg/m^2$ (overweight), $25.0{\sim}29.9kg/m^2$ (moderate obesity) and $30.0kg/m^2$~ (severe obesity) according to the Asia Pacific Standards of WHO recommended definition of obesity. Screening rates of breast and cervical cancer were estimated by the recommendation of the National Cancer Screening Program of the National Cancer Center, Korea. Results : The overall screening rates for breast and cervical cancer were 51.3% and 50.1%, respectively. After covariate adjustment, the screening rates for breast cancer (adjusted odds ratio, 0.70; 95% confidence interval, 0.51 to 0.97) and cervical cancer (adjusted odds ratio, 0.71; 95% confidence interval, 0.53 to 0.94) were significantly lower in the women with severe obesity. Conclusion: Obesity is associated with lower compliance with breast and cervical cancer screening guidelines in Korean women.