• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.295-300
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• 2012

Breast self-examination (BSE) is important for early diagnosis of breast cancer (BC). However, the majority of Turkish women do not perform regular BSE. We aimed to evaluate the effects of education level on the attitudes and behaviors of women towards BSE. A descriptive cross-sectional study was conducted on 413 women (20-59 years), divided into university graduates (Group I, n = 224) and high school or lower graduates (Group II, n = 189). They completed a 22-item scale assessing the knowledge level, attitudes and behaviors regarding BSE, and the Turkish version of the Champion's Revised Health Belief Model. A significantly higher number of women in Group II did not believe in early diagnosis of BC. A significantly higher number of Group I had conducted BSE at least once, and their BSE frequency was also significantly high. Moreover, a significantly lower number of Group I women considered themselves to not be at risk for BC and the scores for "perceived susceptibility" and "perceived barriers" were significantly higher. Logistic regression analysis identified the university graduate group to have a higher likelihood of performing BSE, by 1.8 times. Higher educational levels were positively associated with BSE performance. Overall, the results suggest that Turkish women, regardless of their education level, need better education on BSE. Consideration of the education level in women will help clinicians develop more effective educational programs, resulting in more regular practice and better use of BSE.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3851-3854
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• 2013

Objective: To explore changes in the serum tumor makers, hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) and vascular endothelial growth factor (VEGF) level and their relations in patients with non-small cell lung cancer (NSCLC) before and after intervention. Materials and Methods: Forty patients with NSCLC and 40 healthy individuals undergoing physical examination in our hospital provided the observation and control groups. HIF-$1{\alpha}$ and VEGF levels in serum were detected by enzyme-linked immuno-sorbent assay (ELISA) in the observation group before and after intervention and in control group on the day of physical examination, along with serum carcino-embryonic antigen (CEA), neuron-speci ic enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group with a fully automatic biochemical analyzer. Clinical effects and improvement of life quality in the observation group were also evaluated. Results: The total effective rate and improvement of life quality after treatment in observation group were 30.0% and 32.5%, respectively. Serum HIF-$1{\alpha}$ and VEGF levels in the control group were lower than that in observation group (p<0.01), but remarkably elevatedafter intervention (p<0.01). In addition, serum CEA, NSE and SCC levels were apparently lowered by treatment (p<0.01). Serum HIF-$1{\alpha}$ demonstrated a positive relation with VEGF level (p<0.01) and was inversely related with CEA, NSE and SCC levels (p<0.01). Conclusions: Significant correlations exist between marked increase of serum HIF-$1{\alpha}$ and VEGF levels and decrease of indexes related to hematological tumor markers in NSCLC patients after intervention.

• 대한방사선기술학회지:방사선기술과학
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• 제26권2호
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• pp.43-47
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• 2003

비특이적인 위장관 징후나 증상이 있는 환자를 우선적으로 초음파검사를 시행 해보면 결직장에 국한성 종괴나 분절성 벽비후 등을 묘출해 낼 수 있다. 저자들은 다양한 증례를 통하여 대장암의 초음파검사상 특징적인 소견과 유용성이 있는지를 살펴보았다. 대장조영촬영술을 실시하기 전 복부 초음파검사로 대장암 소견을 보여 수술로 확진된 11명과 타 병원에서 대장암으로 진단 받고 치료를 받고자 내원한 환자 40명을 중심으로 총 51명의 초음파검사 결과를 분석하였다. 대장암 발생부위는 결장 및 직장에서 27예(53%)로 가장 많았고, $40{\sim}50$대(60%)에서 암 발생율이 높았으며, 남녀 비율은 비슷했다. 초음파검사의 비교적 특징적인 소견은 부분적인 대장벽 비후 42예, 종괴형태 9예로 나타났다. 복부동통, 종괴, 배변습관의 변화 등 비특이적인 증상이 있는 환자에서 초음파검사로 대장암의 가능성이 있는 불규칙한 종괴나 분절성 벽비후를 쉽게 찾아 낼 수 있었다. 초음파검사는 고통이 없고 비침습적인 검사로서 내부장기의 검사를 하는데 유용하며, 복부검사 시 위장관을 포함하여 검사한다면 위장관 질환 등을 보다 조기에 발견할 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8541-8551
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• 2016

Background: The coverage of breast and cervical cancer screening has only slightly increased in the past decade in Thailand, and these cancers remain leading causes of death among women. This study identified socioeconomic and contextual factors contributing to the variation in screening uptake and coverage. Materials and Methods: Secondary data from two nationally representative household surveys, the Health and Welfare Survey (HWS) 2007 and the Reproductive Health Survey (RHS) 2009 conducted by the National Statistical Office were used. The study samples comprised 26,951 women aged 30-59 in the 2009 RHS, and 14,619 women aged 35 years and older in the 2007 HWS were analyzed. Households of women were grouped into wealth quintiles, by asset index derived from Principal components analysis. Descriptive and logistic regression analyses were performed. Results: Screening rates for cervical and breast cancers increased between 2007 and 2009. Education and health insurance coverage including wealth were factors contributing to screening uptake. Lower or non-educated and poor women had lower uptake of screenings, as were young, unmarried, and non-Buddhist women. Coverage of the Civil Servant Medical Benefit Scheme increased the propensity of having both screenings, while the universal coverage scheme increased the probability of cervical screening among the poor. Lack of awareness and knowledge contributed to non-use of both screenings. Women were put off from screening, especially Muslim women on cervical screening, because of embarrassment, fear of pain and other reasons. Conclusions: Although cervical screening is covered by the benefit package of three main public health insurance schemes, free of charge to all eligible women, the low coverage of cervical screening should be addressed by increasing awareness and strengthening the supply side. As mammography was not cost effective and not covered by any scheme, awareness and practice of breast self examination and effective clinical breast examination are recommended. Removal of cultural barriers is essential.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7061-7064
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• 2014

Background: To assess the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of intraoperative gross examination (IGE) of uterine specimens in determining deep myometrial invasion and cervical invasion compared to final histology. Materials and Methods: The clinical, surgical and histological data of all FIGO stage I-II endometrial cancer (EC) patients who had primary surgery were reviewed. Results of the IGE for myometrial invasion and cervical invasion were compared to the final histology. The sensitivity, specificity, PPV, NPV, and accuracy of the IGE in determining deep myometrial invasion and cervical invasion were calculated. Association between clinico-pathological factors and discrepancy between IGE and final histology in the determination of myometrial invasion was also assessed. A p-value of <0.05 was considered significant. Results: From January 2007 to December 2012, 179 patients diagnosed with clinical stage I-II endometrial cancer underwent surgical staging. The sensitivity and specificity of IGE in detecting deep myometrial invasion were 42.4% and 90.0%, respectively, and the PPV and NPV were 67.6% and 76.1%. The overall accuracy of IGE was 74.3%. The sensitivity and specificity of IGE in identifying cervical invasion were 28.6% and 97.5%, respectively, while the PPV and NPV were 60.0% and 91.1%. The overall accuracy of IGE was 89.4%. Conclusions: The sensitivity of IGE for detecting deep myometrial invasion and cervical invasion in early-stage EC is too low to be used alone. Alternative methods including intraoperative frozen section analysis, preoperative three dimensional ultrasound, and preoperative magnetic resonance imaging should be strongly considered.

• Tuberculosis and Respiratory Diseases
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• 제64권4호
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• pp.314-317
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• 2008

47세 남자가 내원 3주 전부터 발생한 호흡곤란 및 흉막성 흉통으로 입원하였다. 단순흉부촬영 및 흉부 CT 상 흉수 소견을 보여 시행한 흉강천자 결과, 림프구 우세 삼출액 소견을 보였으나, adenosine deaminase (ADA) 16.4 U/L로 감소하였고 세포진 검사 음성 소견을 보였다. 흉강경 검사 관찰되는 흉막의 다발성 결절에서 조직 생검 결과 전이성 유두모양 (papillary) 암으로 진단하였고, 원발 병소로 갑상샘 우엽의 미세결절 발견하여 갑상샘절제술을 시행했다. 갑상샘암은 내분비계의 악성 종양 중 가장 흔하며, 유두모양 갑상샘암이 가장 흔하다. 특징적으로 진행이 더디며 예후도 좋은 편으로, 원격 전이는 흔하지 않다. 전이성 악성 흉수는 드물게 보고되며, 대부분 원발 갑상샘암의 수술적 절제 등의 치료 후 경과 중에 재발하는 것으로 알려져 있다. 저자들은 특히 기존에 진단되지 않은 갑상샘암이, 흉수 형태로 처음 발현되는 경우를 경험하여 진단 및 치료하였기에 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5869-5873
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• 2015

Background: Breast and cervical cancers are among the most frequent and most fatal cancers in women. Life span of patients may be increased and quality of life improved through early diagnosis and treatment. This investigation was performed in order to determine knowledge and practices of female health personnel working at a university hospital regarding breast and cervical cancers. Materials and Methods: This descriptive investigation was performed in Erciyes University Hospitals in 2014. A total of 524 female health personnel were included in the study. Data were collected through a questionnaire of 36 questions prepared by the researchers. The Chi square test and logistic regression were used for statistical analyses. Results: The mean age of the study group was $32.8{\pm}6.9$ years, 18.3% being doctors and 81.7% nurses. Of the study group, 60.5% stated that they performed self breast-examination, 4.4% underwent HPV testing, 26.3% thought about taking an HPV test, 34.7% of those who are 40 years and over had mammography regularly and 19.5% of those who were married had a Pap smear conducted regularly. Most important causes of not performing the methods for early diagnosis of breast and cervical cancers are "forget and neglect". Conclusions: It was concluded that female doctors and nurses do not pay sufficient attention to screening programs for breast and cervical cancers. The importance of early diagnosis and treatment should be emphasized during the undergraduate education and in-service training programs. Health condition of personnel and their utilization of preventive health care should be followed by occupational physicians.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1181-1184
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• 2015

Background: Accurate measurement of breast mass size is fundamental for treatment planning. We evaluated performance of BreastLight apparatus in detection breast of masses with this in mind. Materials and Methods: From July 2011 to September 2013, a total of 500 women referred to mammography unit in Yazd, Iran for screening were recruited to this study. Performance of BreastLight in detection breast masses regard their sizeing, measured with clinical breast examination (CBE), mammography and sonography, was assessed. Sonographic and mammography examinations were performed according to breast density among women in two groups of women younger (n=105) and older (n=395) than 30 years. Size correlations were performed using Spearman rho analysis. Differences between mass size as assessed with the different methods (mammography, sonography, and clinical examination) and the BreastLight detection were analyzed using $X^2$-trend test. Results: Performance of the BreastLight in detection of lesions smaller than or equal to 1 cm assessed by CBE, mammography and sonography was 4.4%,7.7% and 12.5% and for masses larger than 4 cm was 65%, 100% and 57.1%, respectively. The performance of BreastLight in detection was significantly increased with larger masses (p<0.001). Conclusions: We conclude that clinical measurement of breast cancer size is as accurate as that from mammography or ultrasound. Accuracy can be improved by the use of a simple formula of both clinical and mammographic measurements.

• 지역사회간호학회지
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• 제14권3호
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• pp.496-506
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• 2003

The purpose of this study is to analyze the affecting factors on breast self-examination of middle-aged women in Korea. The subjects were 141 women on Jeju Island, and materials were collected through an organized questionnaire from March to August 2002. The data were analyzed by using descriptive statistics, $x^2$-test. A-nova and Discriminant analysis by the SAS program. The major results are as follows: 1. 53% of the subjects performed the breast self-examination. The practice of breast self-examination was correlated with the education level, income, low salt diet, more than 30 minutes of regular exercise. 2. Attitudes towards breast self-examination were not a significant practice regarding breast self-examination. However, the cognition about difficulty of breast self-examination partly showed an important barrier factor to the positive attitude. 3. The average self-efficacy concerning breast self-examination was 3.03. The stages of change related to the subjects showed that a contemplation stage was high. 4. With a stepwise multiple regression, the most significant factor on self-efficacy related with breast self-examination was the contemplation stage, 30-40 aged women. high income, regular exercise, low salt diet, family cancer history, etc. 5. With the discriminant analysis, the most important factors related with the practice of the breast self-examination were income and self-efficacy. The power of discriminant was 59%. The results of this study suggests that programs should be developed to promote practice and the self-efficacy related with breast self-examination.

• 대한수의학회지
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• 제27권2호
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• pp.269-275
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• 1987

Radiation-induced life shortening, carcinogenesis and other pathological changes were investigated in NIH(GP) mice after $^{60}Co-{\gamma}$ ray irradiation(100~700rads). The results were summarized as follows: 1. There were little difference in body weights, hematological examination and other clinical findings between normal and irradiated groups. 2. Mean survival time of the mice after irradiation were decreased dose-dependently. 3. Main gross findings of the mice irradiated were appeared as enlargement of spleen, thymus and lymph nodes, tumorous nodules of lung and cyst of ovary. Especially, enlargement of thymus was promineort in high dose group. 4. Microscopically, there were various findings including myeloid leukemia, thymic lymphoma, lung adenoma, adenosquamous cell carcinoma of pancreas, pneumonia and other pathological changes. Especially thymic lymphoma was highly frequent in the 700 rads group.