• 대한수의학회지
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• 제27권2호
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• pp.269-275
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• 1987

Radiation-induced life shortening, carcinogenesis and other pathological changes were investigated in NIH(GP) mice after $^{60}Co-{\gamma}$ ray irradiation(100~700rads). The results were summarized as follows: 1. There were little difference in body weights, hematological examination and other clinical findings between normal and irradiated groups. 2. Mean survival time of the mice after irradiation were decreased dose-dependently. 3. Main gross findings of the mice irradiated were appeared as enlargement of spleen, thymus and lymph nodes, tumorous nodules of lung and cyst of ovary. Especially, enlargement of thymus was promineort in high dose group. 4. Microscopically, there were various findings including myeloid leukemia, thymic lymphoma, lung adenoma, adenosquamous cell carcinoma of pancreas, pneumonia and other pathological changes. Especially thymic lymphoma was highly frequent in the 700 rads group.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4815-4822
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• 2012

Invasion and metastasis are the major causes of cancer-related death. Pharmacological or therapeutic interventions such as chemoprevention of the progression stages of neoplastic development could result in substantial reduction in the incidence of cancer mortality. (-)-Epigallocatechin-3-gallate (EGCG), a promising chemopreventive agent, has attracted extensive interest for cancer therapy utilizing its antioxidant, anti-proliferative and inhibitory effects on angiogenesis and tumor cell invasion. In this study, we assessed the influence of EGCG on the proliferative potential of HeLa cells by cell viability assay and authenticated the results by nuclear morphological examination, DNA laddering assay and cell cycle analysis. Further we analyzed the anti-invasive properties of EGCG by wound migration assay and gene expression of MMP-9 and TIMP-1 in HeLa cells. Our results indicated that EGCG induced growth inhibition of HeLa cells in a dose- and time-dependent manner. It was observed that cell death mediated by EGCG was through apoptosis. Interestingly, EGCG effectively inhibited invasion and migration of HeLa cells and modulated the expression of related genes (MMP-9 and TIMP-1). These results indicate that EGCG may effectively suppress promotion and progression stages of cervical cancer development.

• Journal of Yeungnam Medical Science
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• 제33권2호
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• pp.142-145
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• 2016

Gastric cancer is the most common cancer in Korean males and can easily spread to distant organs such as the liver, lungs, brain, or bones. However, skin metastasis, particularly of the eye, is rare. Metastatic eyelid cancer is extremely rare; metastases from internal organs have not been reported so far. We recently experienced a patient with metastatic eyelid cancer from adenocarcinoma of the stomach. A 62-year-old female was admitted with a right upper eyelid mass and foreign body sensation. She had a history of stomach cancer of 3 years. She was treated by chemotherapy and radiotherapy for pathologic fracture. After receiving supportive care for 2 years, the mass appeared on her right pupil. Punch-biopsy of the mass was performed and histological examination revealed adenocarcinoma, the same as the initial histological result. We report this case with a review of related literature.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4991-4998
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• 2016

Objective: This research was conducted to explore mechanisms behind the potency of quercetin in inhibiting colon cancer induced in an experimental model. Materials and Methods: Forty adult male rats of Wistar strain were distributed into 4 groups; a negative control group, a colon cancer bearing group, a quercetin-treated group and a 5-fluorouracil (5-FU)-treated group. Serum TAG72 and GAL3 levels were quantified by ELISA. Colonic Wnt5a and Axin-1 gene expression was estimated by PCR. In addition, colonic tissues were subjected to immunohistochemical examination of Bax expression and histological investigation of histopathological alterations. Results: Quercetin elicited significant reduction in serum TAG72 and GAL3 levels, in addition to significant suppression of colonic Wnt5a gene expression and amplification of colonic Axin-1 gene expression. Also, it caused moderate positive reaction for Bax in mucosal epithelium. Conclusion: The present research provides experimental evidence about the activity of quercetin in the colon cancer of rats. Inhibitory effects on cancer development might be ascribable to regulatory action on Wnt signaling and induction of apoptosis.

• Journal of Gastric Cancer
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• 제1권1호
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• pp.64-67
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• 2001

An exceedingly rare case of perforated early gastric cancer is reported. A 68-year-old man developed peritonitis due to perforation of early gastric cancer. An emergency radical operation was performed and was followed by an uneventful recovery. Histologic examination of the surgical specimen showed type III early gastric cancer composed of a signet ring cell carcinoma. Five years after surgery, the patients was alive with no evidence of tumor recurrence. The rarity of this complication in early gastric cancer is discussed, and a review of the literature is presented.

• Journal of Gastric Cancer
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• 제14권4호
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• pp.271-274
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• 2014

Prostate cancer is the second most common cause of cancer death in men in the United States. The most common sites of metastasis include the bone, lymph nodes, lung, liver, pleura, and adrenal glands, whereas metastatic prostate cancer involving the gastrointestinal tract has been rarely reported. A 64-year-old African-American man with a history of prostate cancer presented with anemia. He reported the passing of dark colored stools but denied hematemesis or hematochezia. Colonoscopy revealed circumferential nodularity, and histology demonstrated metastatic carcinoma of the prostate. Esophagogastroduodenoscopy showed hypertrophic folds in the gastric fundus, and microscopic examination revealed tumor cells positive for prostate-specific antigen. Bone scanning and computed tomography of the abdomen and pelvis did not show metastasis. It is crucial to distinguish primary gastrointestinal cancer from metastatic lesions, especially in patients with a history of cancer at another site, for appropriate management.

• 보건의료산업학회지
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• 제8권4호
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• pp.221-229
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• 2014

Breast cancer is increasing at a remarkable rate in Korea. We investigated the association between oral contraceptive use and breast cancer in Korean women. Using the 5th Korea National Health and Nutrition Examination Survey data, 8,495 women aged over 30 years are analyzed. Furthermore, the data used in this study is obtained using a complex sampling method in order that it is generalized. The previous studies in Korea, were not statistically significant due to the relatively short duration during which oral contraceptives had been available. However, the longer duration of oral contraceptive use exhibits tendency to increase the risk of breast cancer. Women using oral contraceptives, particularly for more than two years have an increased occurrence of breast cancer compared with women who do not use oral contraceptives. This result reflects the late introduction of oral contraceptives in Korea compared with developed countries. The recent increase in interest about the use of oral contraceptives has been increasing for a variety of reasons. Therefore, it is necessary for continuous and specific clinical studies to examine the connections between the first use of oral contraceptives, oral contraceptives use duration, adverse effects of oral contraceptives and breast cancer in order to develop strategies for preventing breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.191-194
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• 2015

Purpose: To estimate the incidence of breast cancer in Yemeni female patients presenting with a breast mass. Materials and Methods: This retrospective study was carried out with 595 female patients with palpable breast lumps, attending to Alkuwait university hospital, Sana'a, Yemen. Triple assessment, including breast examination, mammography and biopsy (FNAC, core needle, or excision), for all patients were performed. Results: The incidences of benign and malignant lesions was calculated. Some 160 (26.9%) of 595 patients had malignancies; 213 (35.8%) were fibroadenomas; 12 (2.0%) were fibrocystic change; 143 (24.03%) were inflammatory lesions (including mastitis and ductectasia); 62 (10.4%) were simple cysts, while 5 (0.8%) were phyllodes tumors. The mean age of patients with malignant lumps was 44.3 years. Conclusions: Among Yemeni female patients with palpable breast lumps, the rate of breast cancer is high, with occurrence at an earlier age than in Western countries. Improving breast cancer awareness programs and increasing breast cancer screening centers inb different areas of Yemen are needed to establish early diagnosis and offer early and optimal treatment.

• 대한방사선기술학회지:방사선기술과학
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• 제29권1호
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• pp.29-37
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• 2006

유방암은 여성의 암발생에서 가장 많이 차지하고 있으며 생활양식의 변화에 따라 점점 증가하고 있다. 전 인구의 50%을 차지하고 있는 여성에서 유방 검사는 유방X-선촬영이 스크리닝 검사로 가장 많이 사용되고 있어 정도관리가 매우 중요하다. 따라서 본 조사는 경상북도를 4개 구역으로 나누어 유방촬영장비에 대한 조사야와 광조사야의 일치도, 광학농도, 압박율, 팬톰을 이용한 전체모조 병소 수 및 일반적인 정도관리의 실태를 조사 하였다. 조사야의 일치도에서는 조사대상 11개 병원비 장비 중 7곳이 기준치에 적합했으며, 광학농도는 6곳, 압박율은 7곳이 합격한 것으로 조사되었다. 전체모조병소 속의 섬유소, 석희화그룹, 종괴들의 수는 모두 10개 이상으로 나와 기준치 내에 포함 되었으나 전용현상기와 판독대를 보유하고 있는 의료기관은 3곳이였다. 이와 같은 결과는 유방영상의 화질관리가 제대로 되고 있지 않음을 반영한다. 또한 압박장치, 조사야 일치도, 팬텀 영상 평가의 3개 항목을 모두 충족시키는 경우는 27.2%로 나타나 정확한 유방암의 진단을 위해 정도관리에 대한 관심이 더욱 필요하다고 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6783-6790
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• 2013

Background: Breast cancer is the commonest type of cancer among women, and in Malaysia 50-60% of the new cases are being detected at late stages. Do age, education level, income, ethnicity, relationship with breast cancer patients and knowledge of breast cancer risk factors influence breast screening practices? This study revealed interesting but significant differences. Objectives: To assess the knowledge of breast cancer risk factors and early detection measures among women in a high risk group. Materials and Methods: A cross sectional survey of one hundred and thirty one women relatives of breast cancer patients was carried out. Participants were selected through purposive sampling, during hospital visits. A self-administered questionnaire was used for data collection. Results: The majority of the respondents (71%) had poor knowledge of the risk factors for breast cancer. Income, relationship with a patient and practise of breast cancer screening predicted performance of mammography, $R^2$=0.467, F=12.568, p<0.0001. Conclusions: The finding shows inadequate knowledge of breast cancer risk factors and poor cancer screening practise among women with family history of breast cancer. Poor knowledge and practise of breast screening are likely to lead to late stage presentation of breast cancer disease. Some important predictors of breast cancer screening behaviour among women with positive family history of breast cancer were identified. An understanding of the strengths and significance of the association between these factors and breast screening behaviour is vital for developing more targeted breast health promotion.