Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer |
Ahmed, Hanaa H
(Hormones Department, National Research Centre)
Aglan, Hadeer A (Hormones Department, National Research Centre) Zaazaa, Asmaa M (Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University) Shalby, Aziza B (Hormones Department, National Research Centre) Toumy, Sayed A El (Chemistry of Tannins Department, National Research Centre) |
1 | Balaji C, Muthukumaran J, Nalini N (2014). Chemopreventive effect of sinapic acid on 1,2-dimethylhydrazineinduced experimental rat colon carcinogenesis. Hum Exp Toxicol, 33, 1253-68. DOI |
2 | Banchroft JD, Stevens A, Turner DR (1996). Theory and practice of histological techniques. 4thEd. Churchill Livingstone, Philadelphia, USA pp 25-90. |
3 | Bancroft JD, Gamble M (2008). Theory and practice of histological techniques. 6th Ed. Churchill Livingstone, Philadelphia, USA pp 433-69. |
4 | Agullo G, Gamet L, Besson C, Demigne C, Remesy C (1994). Quercetin exerts a preferential cytotoxic effect on active dividing colon carcinoma HT29 and CaCO2 cells. Cancer Lett, 87, 55-63. DOI |
5 | Ahmed H, Banerjee PP, Vasta GR (2007). Differential expression of galectins in normal, benign and malignant prostate epithelial cells: silencing of galectin-3 expression in prostate cancer by its promoter methylation. Biochem Biophys Res Commun, 358, 241-6. DOI |
6 | Barker N, Clevers H (2006). Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov, 5, 997-1014. DOI |
7 | Bulzomi P, Galluzzo P, Bolli A, et al (2012). The pro-apoptotic effect of quercetin in cancer cell lines requires -dependent signals. J Cell Physiol, 227, 1891-8. DOI |
8 | Cappell MS (2007). From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy. Minerva Gastroenterol Dietol, 53, 351-73. |
9 | Chao DT, Korsmeyer SJ (1998). BCL-2 family: regulators of cell death. Annu Rev Immunol, 16, 395-419. DOI |
10 | Chen W, Lin M, Zhang B, et al (2007). Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. World J Gastroenterol, 13, 699-708. DOI |
11 | Raftery L, Goldberg RM (2010). Optimal delivery of cytotoxic chemotherapy for colon cancer. Cancer J, 16, 214-9. DOI |
12 | Kikuchi A (1999). Roles of Axin in the Wnt signalling pathway. Cell Signal, 11, 777-88. DOI |
13 | Kim HP, Son KH, Chang HW, Kang SS (2004). Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacol Sci, 96, 229-45. DOI |
14 | Park C, Chang JY, Hahm ER, et al (2005). Quercetin, a potent inhibitor against -catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun, 328, 227-34. DOI |
15 | Paul S, Kundu R (2013). Antiproliferative activity of methanolic extracts from two green algae, Enteromorpha intestinalis and Rizoclonium riparium on HeLa cells. DARU, 21, 1-12. DOI |
16 | Chien AJ, Moon RT (2007). WNTs and WNT receptors as therapeutic tools and targets in human disease processes. Front Biosci, 12, 448-57. DOI |
17 | Clements WM, Lowy AM, Groden J (2003). Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer, 3, 113-20. DOI |
18 | Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC (2000). An LDL-receptor-related protein mediates Wnt signalling in mice. Nature, 407, 535-8. DOI |
19 | Plaumann B, Fritsche M, Rimpler H, Brandner G, Hess RD (1996). Flavonoids activate wild type p53. Oncogene, 13, 1605-14. |
20 | Puglisi F, Minisini AM, Barbone F, et al (2004). Galectin-3 expression in non-small cell lung carcinoma. Cancer Lett, 212, 233-9. DOI |
21 | Rajamanickam S, Agarwal R (2008). Natural products and colon cancer: current status and future prospects. Drug Dev Res, 69, 460-71. DOI |
22 | Ousingsawat J, Spitzner M, Puntheeranurak S, et al (2007). Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res, 13, 824-31. DOI |
23 | Ramos S (2008). Cancer chemoprevention and chemotherapy, dietary polyphenols and signalling pathways. Mol Nutr Food Res, 52, 507-52. DOI |
24 | Rampone B, Schiavone B, Martino A, Confuorto G (2010). Current role of hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from colorectal cancer. World J Gastroenterol, 16, 1299-1302. DOI |
25 | Reya T, Clevers H (2005). Wnt signalling in stem cells and cancer. Nature, 434, 843-50. DOI |
26 | Duthie GG, Duthie SJ, Kyle JA (2000). Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants. Nutr Res Rev, 13, 79-106. DOI |
27 | Clevers H (2006). Wnt/beta-catenin signaling in development and disease. Cell, 127, 469-80. DOI |
28 | Csokay B, Pradja N, Weber G, Olah E (1997). Molecular mechanisms in the antiproliferative action of quercetin. Life Sci, 60, 2157-63. DOI |
29 | Damdinsuren B, Nagano H, Wada H, et al (2007). Interferon alpha receptors are important for antiproliferative effect of interferon-alpha against human hepatocellular carcinoma cells. Hepatol Res, 37, 77- 83. DOI |
30 | Eguchi H, Nagano H, Yamamoto H, et al (2000). Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells. Clin Cancer Res, 6, 2881-90. |
31 | Cheong T, Shin J, Chun K (2010). Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents. Cancer Sci, 101, 94-102. DOI |
32 | Endo H, Hosono K, Fujisawa T, et al (2009). Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions. Gut, 58, 1637-43. DOI |
33 | Endo K, Kohnoe S, Tsujita E, et al (2005). Galectin-3 expression is a potent prognostic marker in colorectal cancer. Anticancer Res, 25, 3117-21. |
34 | Greco C, Vona R, Cosimelli M, et al (2004). Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions. Glycobiology, 14, 783-92. DOI |
35 | Nagano H, Miyamoto A, Wada H, et al (2007). Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer, 110, 2493-501. DOI |
36 | Nakahara S, Raz A (2007). Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway. Cancer Metastasis Rev, 26, 605-10. DOI |
37 | Nakamura M, Nagano H, Sakon M, et al (2007). Role of the Fas/FasL pathway in combination therapy with interferon-alpha and fluorouracil against hepatocellular carcinoma in vitro. J Hepatol, 46, 77-88. DOI |
38 | Galluzzo P, Martini C, Bulzomi P, et al (2009). Quercetin induced apoptotic cascade in cancer cells: Antioxidant versus estrogen receptor a dependent mechanisms. Mol Nutr Food Res, 53, 699-708. DOI |
39 | Gellad ZF, Provenzale D (2010). Colorectal cancer: national and international perspective on the burden of disease and public health impact. Gastroenterology, 138, 2177-90. DOI |
40 | Guadagni F, Roselli M, Cosimelli M, et al (1996). TAG-72 expression and its role in the biological evaluation of human colorectal cancer. Anticancer Res, 16, 2141-8. |
41 | Harborne JB (1984). Phytochemical methods. 2nd Ed, Chapman and Hall, London pp 1-36. |
42 | He XT, Fan XM, Zha XL (2011). Ghrelin inhibits 5-fluorouracil- induced apoptosis in colonic cancer cells. J Gastroenterol Hepatol, 26, 1169-73. DOI |
43 | Hughes RC (2001). Galectins as modulators of cell adhesion. Biochimie, 83, 667-76. DOI |
44 | Iurisci I, Tinari N, Natoli C, et al (2000). Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res, 6, 1389-93. |
45 | Katoh M (2003). Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells. Int J Oncol, 22, 209-12. |
46 | Kondo M, Nagano H, Wada H, et al (2005). Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells. Clin Cancer Res, 11, 1277-86. |
47 | Kim JY, Kim EH, Park SS, et al (2008). Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. J Cell Biochem, 105, 1386-98. DOI |
48 | Kiss R, Dubois J (2011). Quercetin inhibits a large panel of kinases implicated in cancer cell biology. Int J Oncol, 38, 833-42. |
49 | Klaus A, Birchmeier W (2008). Wnt signalling and its impact on development and cancer. Nat Rev Cancer, 8, 387-98. DOI |
50 | Kuo PC, Liu HF, Chao JI (2004). Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. J Biol Chem, 279, 55875-985. DOI |
51 | Noda T, Nagano H, Takemasa L, et al (2009). Activation of Wnt/b-catenin signalling pathway induces chemoresistance to interferon-a/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer, 100, 1647-58. DOI |
52 | Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW (1999). p53/p21 WAF1/CIP1 expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett, 136, 215-21. DOI |
53 | Narisawa T, Fukaura Y (2003). Prevention by intrarectal 5-aminosalicylic acid of N-methylnitrosourea-induced colon cancer in F344 rats. Dis Colon Rectum, 46, 900-3. DOI |
54 | Nguyen TT, Tran E, Nguyen TH, et al (2004). The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis, 25, 647-59. |
55 | Mense SM, Hei TK, Ganju RK, Bhat HK (2008). Phytoestrogens and breast cancer prevention: Possible mechanisms of action. Environ Health Perspect, 116, 426-33. DOI |
56 | Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW (1997). Serine phosphorylation-regulated biquitination and degradation of beta-catenin. J Biol Chem, 272, 24735-8. DOI |
57 | Mabry TJ, Markham KR, Thomas MB (1970). The Systematic identification of flavonoids, Springer, Verlag and New York pp 35-109. |
58 | Lee JS, Ishimoto A, Yanagawa S (1999). Characterization of mouse disheveled (Dvl) proteins in Wnt/Wingless signaling pathway. J Biol Chem, 274, 21464-70. DOI |
59 | Logan CY, Nusse R (2004). The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol, 20, 781-810. DOI |
60 | Lu H, Peng T, Hu X, et al (2015). Quercetin potentiates the effect of T cells via modulating the expressions of Granzyme B, perforin and IFN- and also regulates the Wnt/-catenin signalling pathway in human colon cancer cells. Bangladesh J Pharmacol, 10, 251-9. DOI |
61 | Markham KR (1982). Techniques of flavonoid identification, Academic Press, London pp 1-113. |
62 | Uddin S, Choudhry MA (1995). Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochem Mol Biol Int, 36, 545-50. |
63 | Sadik NA, Shaker OG (2013). Inhibitory effect of a standardized pomegranate fruit extract onwnt signalling in 1,2-dimethylhydrazine induced rat colon carcinogenesis. Dig Dis Sci, 58, 2507-17. DOI |
64 | Song L, Tang JW, Owusu L, et al (2014). Galectin-3 in cancer. Clin Chim Acta, 431, 185-91. DOI |
65 | Steinberg P (2010). The role of inflammation in colon cancer induced by food contaminants. Toxicology Lett, 196, 5-6. |
66 | Stevenson DE, Hurst RD (2007). Polyphenolic phytochemicals-just antioxidants or much more?. Cell Mol Life Sci, 64, 2900-16. DOI |
67 | Stoner GD (2009). Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res, 2, 187-94. DOI |
68 | van Duijnhoven FJ, Bueno-De-Mesquita HB, Ferrari P, et al (2009). Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr, 89, 1441-52. DOI |
69 | Vijayababu MR, Arunkumar A, Kanagaraj P, et al (2006). Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem, 287, 109-16. DOI |
70 | Wada H, Nagano H, Yamamoto H, et al (2007). Combination therapy of interferon alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins. Oncol Rep, 18, 801-9. |
71 | Scambia G, Panici PB, Ranelletti FO, et al (1994). Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells. Int J Cancer, 57, 211-5. DOI |
72 | Yamamoto T, Nagano H, Sakon M, et al (2004). Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferonalpha/5-fluorouracil against Hepatocellular Carcinoma. Clin Cancer Res, 10, 7884-95. DOI |
73 | Zamin LL, Filippi-Chiela EC, Vargas J, et al (2014). Quercetin promotes glioma growth in a rat model. Food Chem Toxicol, 63, 205-11. DOI |
74 | Zhang N, Ding YQ, Liang L (2006). Association of galectin-3 expression with biological behaviors of human colorectal carcinoma. Nanfang Yikedaxue Xuebao, 26, 1685-9. |
75 | Zheng Z, Cheng K, Chao J, Wu J, Wang M (2008). Tyrosinase inhibitors from Paper Mulberry (Broussonetia Papyrifera). Food Chem, 106, 529-35. DOI |
76 | Zou J, Glinsky VV, Landon LA, Matthews L, Deutscher SL (2005). Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis, 26, 309-18. |
77 | Seeram NP (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem, 55, 630-5. |
78 | Bafico A, Liu G, Goldin L, Harris V, Aaronson SA (2004). An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell, 6, 497-506. DOI |
79 | Ahmed HH, Shousha WGh, El-Mezayen HA, El-Toumy SA, Ramadan AR (2015): Updates on the biochemical and molecular mechanisms of N-nitrosodiethylamine-induced hepatocellular carcinoma: promising therapeutic role of Punica granatum peel extract. Int J Pharm Sci Rev Res, 32, 121-44. |
80 | Asao T, Takayuki A, Shibata HR, Batist G, Brodt P (1992). Eradication of hepatic metastases of carcinoma H-59 combination chemoimmunotherapy with liposomal muramyl tripeptide, 5-fluorouracil, and leucovorin. Cancer Res, 52, 6254-7. |