• Biomolecules & Therapeutics
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• v.30 no.6
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• pp.546-552
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• 2022

Epidermal cell adhesion molecule (EpCAM) is a tumor-associated antigen (TAA), which has been considered as a cancer vaccine candidate. The EpCAM protein fused to the fragment crystallizable region of immunoglobulin G (IgG) tagged with KDEL endoplasmic reticulum (ER) retention signal (EpCAM-FcK) has been successfully expressed in transgenic tobacco (Nicotiana tabacum cv. Xanthi) and purified from the plant leaf. In this study, we investigated the ability of the plant-derived EpCAM-FcK (EpCAM-FcK^P) to elicit an immune response in vivo. The animal group injected with the EpCAM-FcK^P showed a higher differentiated germinal center (GC) B cell population (~9%) compared with the animal group injected with the recombinant rhEpCAM-Fc chimera (EpCAM-Fc^M). The animal group injected with EpCAM-FcK^P (~42%) had more differentiated T follicular helper cells (Tfh) than the animal group injected with EpCAM-Fc^M (~7%). This study demonstrated that the plant-derived EpCAM-FcK fusion antigenic protein induced a humoral immune response in mice.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.19 no.5
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• pp.684-690
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• 2010

A drum cam with rotational follower has a cam mechanism and it is mainly used in its application such as index table and ATC of machine tool. Also its use can reduce the backlash in its kinematic movement. To machine the drum cam with rotational follower, 5-axis CNC machine tool is generally used and its kinematic principle is included in it's design. Until now, the commercialized CAM software can't cover the application of the drum cam machining. Even if, some special software was developed for machining a drum cam, the post processing method for finish machining was not developed yet. And to overcome the problem, the form tool is still used on the tool path of rough machining. This study includes the induction of the post processing technique for the finish machining of drum cam on three 5-axis CNC machine tools, type AC, AB and BC. To prove the finishing geometric profile, the result was clearly verified through inspection and geometric measurement after direct machining of the drum cam in AC type 5-axis machine tool in this study.

• Journal of Haehwa Medicine
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• v.19 no.1
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• pp.75-86
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• 2010

These days, traditional and complementary/alternative medicine (TM/CAM) becomes more upsurging topics of increasing importance and the use and popularity of TM/CAM is rapidly expanding, Since the tradition and situation on TM/CAM of each country is quite different, the concept and system of TM/CAM expressed by different countries shows the variety of range. Some countries recognize TM/CAM as one part of two branches of medical science and have integrated into national health care system. In these countries, education systems for TM/CAM are also well organized formal education systems, such as the Republic of Korea, DPR Korea, China (including Hong Kong and Macao), and Viet Nam. However, other countries in Asia and the Pacific. still do not have formal and/or informal education system and do not recognize TM/CAM as a kind of health care systems. This paper reviews the current situation of education and training on TM/CAM in the Asia and the Pacific. As a result, fifteen countries (31.3%) of 48 member countries in Asia and the Pacific have formal education systems for TM/CAM, twelve countries (25.0%) do not have formal education system and twenty one countries (43.7%) do not have available information. At least six countries are allocating the curriculum of medical school to the education of both allopathic and traditional medicine. For the proper use and development of TM/CAM, the development of formal education system as well as the integration into the national health care system are needed.

• Journal of the Korean Society for Precision Engineering
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• v.10 no.1
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• pp.52-61
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• 1993

Developed in this research is a CAM system for 5-axis NC Machining of sculptured surfaces. We identify problems in generating 5-axis NC data and propose methods of overcoming them. Issues discussed in this paper are: kinematic modelling of NC machines; determination of cutter position (location and orientation); check of machine work-range; linear trajectory plann- ing ; calculation of feedrate number. The proposed system has been implemented in FORTRAN77 on the Personal IRIS EWS, and it also constitutes a module of the CAD/CAM system 'CASSET' developed in KIST CAD/CAM lab.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.6
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• pp.1056-1063
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• 1994

In this paper a content addressable memory (CAM) is designed by adopting best-match method. It has a single processing element(PE) architecture with high computational efficiency and throughput. It is composed of three main functional blocks(input MUX, best-match CAM, control part). It support fully parallel processing. Logic simulation is completed by using QUICKSIM, Circuit simulation is performanced by using HSPICE. Its layout is based on the ETRI 3 m n-well process design rules. Its maximum operating frequency is 20 MHz.

• Transactions of the Korean Society of Automotive Engineers
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• v.3 no.5
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• pp.90-99
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• 1995

A numerical method is proposed to synthesize automotive cam profiles. An arbitrary acceleration profile for the cam follower motion is divided into several segments, each of them is described by a Hermite curve. A cam profile is defined by control point locations and control variables assigned to each segment. Closed form equations are derived for velocity and displacement constraints which should be satisfied for the curve to be a cam profile. Because the method is flexible and provide arbitrary local controllability, any types of cam acceleration profile can be reproduced by the method. The method is expecially useful for the design of roller type OHC valve trains which need precise local control in the cam profile design to avoid under-cutting problems.

• Journal of Advanced Marine Engineering and Technology
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• v.30 no.1
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• pp.58-64
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• 2006

This work focuses on reducing the noise and vibration levels of an LPi fuel pump, which are generated from the dynamic motions of pump elements and non-uniform flow of fuel. The noise and vibration levels increase as the revolution speed of the cam goes up. The fuel pump consists of five cavity cells, plungers and diaphragms, which are driven by the cam. The optimal design of the cam profile is performed to decrease the accelerations of moving Parts and to obtain a smooth hydraulic force through a dynamic analysis of a cam-plunger mechanism. The cam-Plunger with a cavity is modeled as a 2 degrees of freedom system having non-linear contacts, the cam profile being represented in terms of Fourier series in order to determine the optimal shape of the cam. From the optimized cam Profile, the acceleration of the diaphragm is reduced in $78\%$, the hydraulic force becoming smoother in case that the hydraulic force is rapidly dropped.

• Journal of Korea Multimedia Society
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• v.12 no.8
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• pp.1055-1065
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• 2009

High-dynamic-range (HDR) rendering technology changes the range from the broad dynamic range (up to 9 log units) of a luminance, in a real-world scene, to the 8-bit dynamic range which is the common output of a display's dynamic range. One of the techniques, iCAM06 has a superior capacity for making HDR images. iCAM06 is capable of making color appearance predictions of HDR images based on CIECAM02 and incorporating spatial process models in the human visual system (HVS) for contrast enhancement. However there are several problems in the iCAM06, including obscure user controllable factors to be decided. These factors have a serious effect on the output image but users get into difficulty in that they can't find an adequate solution on how to adjust. So a suggested model gives a quantitative formulation for user controllable factors of iCAM06 to find suitable values which corresponds with different viewing conditions, and improves subjective visuality of displayed images for varying illuminations.

• Korean Journal of Computational Design and Engineering
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• v.8 no.1
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• pp.35-40
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• 2003

In this paper, we present the methods to develop a Web-based CAM system that is capable to simulate machining processes in solid model form through internet. The methods include the dynamic representation on Web of machining operation, workpiece definition on the request of users, interpretation technique of NC par programs through CORBA, and algorithm for efficient machining simulation. Based on the methods, a Web-based CAM system it implemented at http://virtual.ulsan.ac.kr. Using the Web-based CAM system, public users tan simulate machining processes by own NC part programs.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1353-1357
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• 2005

A CAM program for forming design Automated of CAM for Spring using car was developed in this study. This program was written in AUTO-LISP on the AUTO-CAD system with a personal. An approach to the system is based on the kinemateic of the object function. We make a determination of an cam programming. A cam spline is continuous in displacement, velocity and acceleration. The best cam curve is obtained by changing the kinemateic of the object function. The result has improved all characteristics such as velocity, acceleration and displacement compared with that of the modified cycloid curve.