Immune Responses to Plant-Derived Recombinant Colorectal Cancer Glycoprotein EpCAM-FcK Fusion Protein in Mice |
Lim, Chae-Yeon
(Department of Medicine, College of Medicine, Chung-Ang University)
Kim, Deuk-Su (Department of Medicine, College of Medicine, Chung-Ang University) Kang, Yangjoo (Department of Medicine, College of Medicine, Chung-Ang University) Lee, Ye-Rin (Vegetable Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration) Kim, Kibum (Department of Medicine, College of Medicine, Chung-Ang University) Kim, Do Sun (Vegetable Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration) Kim, Moon-Soo (Department of Chemistry, Ogden College of Science and Engineering, Western Kentucky University) Ko, Kisung (Department of Medicine, College of Medicine, Chung-Ang University) |
1 | Park, S. R., Shin, Y. K., Lee, K. J., Lee, J. H., Hedin, D., Mulvania, T., Lee, S. H. and Ko, K. (2014) Expression, glycosylation and function of recombinant anti-colorectal cancer mAb CO17-1A in SfSWT4 insect cells. Entomol. Res. 44, 39-46. DOI |
2 | Song, I., Kang, Y. J., Choi, S. L., Han, D., Kim, D. S., Lee, H. K., Lee, J. C., Park, J., Kim, D. S. and Ko, K. (2019) Purification of plant-derived anti-virus mAb through optimized pH conditions for coupling between protein A and epoxy-activated beads. PeerJ 7, e6828. DOI |
3 | Tangye, S. G., Ma, C. S., Brink, R. and Deenick, E. K. (2013) The good, the bad and the ugly-TFH cells in human health and disease. Nat. Rev. Immunol. 13, 412-426. DOI |
4 | Haynes, N. M., Allen, C. D., Lesley, R., Ansel, K. M., Killeen, N. and Cyster, J. G. (2007) Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene1high germinal center-associated subpopulation. J. Immunol. 179, 5099-5108. DOI |
5 | Jang, E. and Youn, J. (2013) The niche of follicular helper T cells in systemic autoimmune diseases. Hanyang Med. Rev. 33, 1-9. DOI |
6 | Hamel, K. M., Liarski, V. M. and Clark, M. R. (2012) Germinal center B-cells. Autoimmunity 45, 333-347. DOI |
7 | Barnett, L. G., Simkins, H. M., Barnett, B. E., Korn, L. L., Johnson, A. L., Wherry, E. J., Wu, G. F. and Laufer, T. M. (2014) B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J. Immunol. 192, 3607-3617. DOI |
8 | Choi, S.-C. and Morel, L. (2020) Immune metabolism regulation of the germinal center response. Exp. Mol. Med. 52, 348-355. DOI |
9 | Guthmiller, J. J., Graham, A. C., Zander, R. A., Pope, R. L. and Butler, N. S. (2017) Cutting edge: IL-10 is essential for the generation of germinal center B cell responses and anti-plasmodium humoral immunity. J. Immunol. 198, 617-622. |
10 | Khurana, P., Boeckx, L., Lauriks, W., Leclaire, P., Dazel, O. and Allard, J. F. (2009) A description of transversely isotropic sound absorbing porous materials by transfer matrices. J. Acoust. Soc. Am. 125, 915-921. DOI |
11 | Kim, D. S., Kang ,Y. J., Lee, K. J., Qiao, L., Ko, K., Kim, D. H., Myeung, S. C. and Ko, K. (2020) A plant-derived antigen-antibody complex induces anti-cancer immune responses by forming a large quaternary structure. Int. J. Mol. Sci. 21, 5603. DOI |
12 | Laidlaw, B. J. and Cyster, J. G. (2021) Transcriptional regulation of memory B cell differentiation. Nat. Rev. Immunol. 21, 209-220. DOI |
13 | Park, S. R., Lee, J.-H., Kim, K., Kim, T. M., Lee, S. H., Choo, Y.-K., Kim, K. S. and Ko, K. (2020) Expression and in vitro function of antibreast cancer llama-based single domain antibody VHH expressed in tobacco plants. Int. J. Mol. Sci. 21, 1354. DOI |
14 | Laidlaw, B. J., Lu, Y., Amezquita, R. A., Weinstein, J. S., Vander Heiden, J. A., Gupta, N.,T., Kleinstein, S. H., Kaech, S. M. and Craft, J. (2017) Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci. Immunol. 2, eaan4767. DOI |
15 | Lee, J. H. and Ko, K. (2017) Production of recombinant anti-cancer vaccines in plants. Biomol. Ther. (Seoul) 25, 345-353. DOI |
16 | Naito, Y., Takematsu, H., Koyama, S., Miyake, S., Yamamoto, H., Fujinawa, R., Sugai, M., Okuno, Y., Tsujimoto, G., Yamaji, T., Hashimoto, Y., Itohara, S., Kawasaki, T., Suzuki, A. and Kozutsumi, Y. (2007) Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol. Cell. Biol. 27, 3008-3022. DOI |
17 | Palm, A.-K. E. and Henry, C. (2019) Remembrance of things past: long-term B cell memory after infection and vaccination. Front. Immunol. 10, 1787. DOI |
18 | Park, S.-R., Lim, C.-Y., Kim, D.-S. and Ko, K. (2015a) Optimization of ammonium sulfate concentration for purification of colorectal cancer vaccine candidate recombinant protein GA733-FcK isolated from plants. Front. Plant Sci. 6, 1040. |
19 | Perreau, M., Savoye, A.-L., De Crignis, E., Corpataux, J.-M., Cubas, R., Haddad, E. K., De Leval, L., Graziosi, C. and Pantaleo, G. (2013) Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J. Exp. Med. 210, 143-156. DOI |
20 | Rich, R. R. and Chaplin, D. D. (2019) The human immune response. In Clinical Immunology, pp. 3-17.e1. Elsevier. |
21 | Yardeni, T., Eckhaus, M., Morris, H. D., Huizing, M. and HoogstratenMiller, S. (2011) Retro-orbital injections in mice. Lab. Anim. 40, 155-160. DOI |
22 | Song, I., Lee, Y. K., Kim, J. W., Lee, S.-W., Park, S. R., Lee, H. K, Oh, S., Ko, K., Kim, M. K., Park, S. J., Kim, D. H., Kim, M.-S., Kim, D. S. and Ko, K. (2021) Effect of an endoplasmic reticulum retention signal tagged to human anti-rabies mAb SO57 on its expression in Arabidopsis and plant growth. Mol. Cells 44, 770-779. DOI |
23 | Stebegg, M., Kumar, S. D., Silva-Cayetano, A., Fonseca, V. R., Linterman, M. A. and Graca, L. (2018) Regulation of the germinal center response. Front. Immunol. 9, 2469. DOI |
24 | Verch, T., Hooper, D. C., Kiyatkin, A., Steplewski, Z. and Koprowski, H. (2004) Immunization with a plant-produced colorectal cancer antigen. Cancer Immunol. Immunother. 53, 92-99. DOI |
25 | Lu, Z., Lee, K.-J., Shao, Y., Lee, J.-H., So, Y., Choo, Y.-K., Oh, D.-B., Hwang, K.-A., Oh, S. H., Han, Y. S. and Ko, K. (2012) Expression of GA733-Fc fusion protein as a vaccine candidate for colorectal cancer in transgenic plants. J. Biomed. Biotechnol. 2012, 364240. |
26 | Crotty, S. (2011) Follicular helper CD4 T cells (Tfh). Annu. Rev. Immunol. 29, 621-663. DOI |
27 | Hao, Z., Duncan, G. S., Seagal, J., Su, Y.-W., Hong, C., Haight, J., Chen, N.-J., Elia, A., Wakeham, A. and Li, W. Y. (2008) Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 29, 615-627. DOI |
28 | Kerfoot, S. M., Yaari, G., Patel, J. R., Johnson, K. L., Gonzalez, D. G., Kleinstein, S. H. and Haberman, A. M. (2011) Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34, 947-960. DOI |
29 | King, C. (2011) A fine romance: T follicular helper cells and B cells. Immunity 34, 827-829. DOI |
30 | Lim, C.-Y., Lee, K. J., Oh, D.-B. and Ko, K. (2015) Effect of the developmental stage and tissue position on the expression and glycosylation of recombinant glycoprotein GA733-FcK in transgenic plants. Front. Plant Sci. 5, 778. |
31 | Ma, C. S., Deenick, E. K., Batten, M. and Tangye, S. G. (2012) The origins, function, and regulation of T follicular helper cells. J. Exp. Med. 209, 1241-1253. DOI |
32 | Mesin, L., Ersching, J. and Victora, G. D. (2016) Germinal center B cell dynamics. Immunity 45, 471-482. DOI |
33 | Mintz, M. A. and Cyster, J. G. (2020) T follicular helper cells in germinal center B cell selection and lymphomagenesis. Immunol. Rev. 296, 48-61. DOI |
34 | Nahshol, O., Bronner, V., Notcovich, A., Rubrecht, L., Laune, D. and Bravman, T. (2008) Parallel kinetic analysis and affinity determination of hundreds of monoclonal antibodies using the ProteOn XPR36. Anal. Biochem. 383, 52-60. DOI |
35 | Nicholson, L. B. (2016) The immune system. Essays Biochem. 60, 275-301. DOI |
36 | Park, H.-J., Kim, D.-H. and Choi, J.-M. (2013) Germinal center formation controlled by balancing between follicular helper T cells and follicular regulatory T cells. Hanyang Med. Rev. 33, 10-16. DOI |
37 | Nojima, T., Haniuda, K., Moutai, T., Matsudaira, M., Mizokawa, S., Shiratori, I., Azuma, T. and Kitamura, D. (2011) In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo. Nat. Commun. 2, 465. DOI |
![]() |