• Journal of Astronomy and Space Sciences
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• 제19권3호
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• pp.187-196
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• 2002

2000년 11월부터 2001년 5월까지 총 16일간 맥동 식쌍성 Y Carn을 소백산천문대의 61cm 망원경에 부착된 단일 V 필터로 CCD 측광을 수행하였다. 새롭게 얻은 V 광도곡선과 Broglia & Marin(1974)의 BV 광도곡선을 Wilson-Devinney 방법의 Mode 2(분리형)와 Mode 5(준분리형)으로 분석하였다. 분석 결과는 다음과 같다. 1) 광도곡선 분석만으로는 분리헝과 준분리형의 Roche 모형 중 어느 것이 Y Cam의 진실한 Roche 모형인가를 가려낼 수가 없다. 2) Y Cam의 B광도곡선에는 삼체의 광도가 약 2%, V광도곡선에는 약 3% 존재한다. 3) Y Cam의 주성에서 발생하는 맥동에 의한 밝기 변화는 광도곡선 해에 거의 영향을 주지 않으나, 맥동을 고려하였을 경우 분리형 모델이 준분리형 모델보다 약간 더 관측치를 잘 맞춘다. 4) 분리형과 준분리형 각각에 대해 Y Cam의 절대물리량을 계산하였다.

• 한국생산제조학회지
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• 제8권3호
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• pp.28-34
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• 1999

The objective of this study is to estimate and to compensate far the volumetric error of a workpiece influenced by the geometric error of a machine tool. In this paper, the volumetric error is defined and the error synthesis model is presented. Then, the volumetric error of workpiece is calculated and compared through the simulation, and a new tool-path is generated to compensate for the error in the post-processor of CAM system using the error synthesis model. By this method, the error is compensated without modification or replacement of a machine tool being in use.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1998년도 추계학술대회 논문집
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• pp.134-139
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• 1998

The objective of this study is to estimate and to compensate for the volumetric error of a machine tool. In this paper, the volumetric error is defined and error synthesis model is presented. Then, the volumetric error of workpiece is compared through the virtual machining and a new tool-path is generated to compensate for the error in the post-processor of CAM system using the error synthesis model. By this method, the error is compensated without modification or replacement of a machine tool being in use.

• 공업화학
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• 제23권4호
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• pp.394-398
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• 2012

아스트라갈린(AS)은 폴리페놀의 일종인 캠페롤(KR)에 글루코스가 하나 결합해있는 배당체로서, 천연에는 미량만이 존재하고 있다. 최근 tea seed extract (TSE)에 포함되어 있는 camelliaside A (CamA) 및 camelliaside B (CamB)로부터 복합효소인 Mash에 의한 부분가수분해에 의해 AS를 합성할 수 있다는 것이 알려졌다. 본 논문에서는, Mash에 의한 TSE의 선택적 가수분해에 의해 AS를 제조하는 공정에서 반응 온도, 효소량 및 반응물의 농도 등의 변수에 따른 반응성을 검토하였다. 반응 온도, 효소량 등이 증가할수록 AS의 생성 반응은 빨랐으나, 일단 생성된 AS가 급격하게 KR로 변환되는 문제점이 나타났다. 결론적으로, 반응 속도 및 AS의 선택성 측면을 고려하면, $50^{\circ}C$에서 TSE 대비 2배의 Mash를 사용하여 15%의 기질 농도에서 반응을 수행하는 것이 최적인 것으로 나타났다.

• ETRI Journal
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• 제28권3호
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• pp.401-404
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• 2006

A new log-domain first-order multifunction filter is proposed in this letter. The proposed filter is systematically derived using the state-space synthesis procedure from a corresponding block diagram. It provides low-pass (LP), high-pass (HP), and all-pass (AP) responses simultaneously for a single input signal. The filter circuit has a very simple structure since it uses only bipolar junction transistors (BJTs) and a grounded capacitor. It can be electronically tuned by changing an external current. The filter has a greater bandwidth due to its inherent current-mode and log-domain operations. PSPICE simulations are given to confirm the theoretical analysis.

• The Korean Journal of Physiology and Pharmacology
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• 제14권5호
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• pp.331-336
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• 2010

In rapidly growing tumors, hypoxia commonly develops due to the imbalance between $O_2$ consumption and supply. Hypoxia Inducible Factor (HIF)-$1{\alpha}$ is a transcription factor responsible for tumor growth and angiogenesis in the hypoxic microenvironment; thus, its inhibition is regarded as a promising strategy for cancer therapy. Given that CamKII or PARP inhibitors are emerging anticancer agents, we investigated if they have the potential to be developed as new HIF-$1{\alpha}$-targeting drugs. When treating various cancer cells with the inhibitors, we found that a CamKII inhibitor, KN-62, effectively suppressed HIF-$1{\alpha}$ specifically in hepatoma cells. To examine the effect of KN-62 on HIF-$1{\alpha}$-driven gene expression, we analyzed the EPO-enhancer reporter activity and mRNA levels of HIF-$1{\alpha}$ downstream genes, such as EPO, LOX and CA9. Both the reporter activity and the mRNA expression were repressed by KN-62. We also found that KN-62 suppressed HIF-$1{\alpha}$ by impairing synthesis of HIF-$1{\alpha}$ protein. Based on these results, we propose that KN-62 is a candidate as a HIF-$1{\alpha}$-targeting anticancer agent.

• 오토저널
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• 제5권3호
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• pp.45-55
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• 1983

This paper discussed about Application Technique of Numerical Methods for large structure. The dynamic behaviours of a vehicle were investigated through finite element modelling. After dividing a vehicle body into three substructures, Basic Mass System was composed of 60 flexual modes which was obtained from the dynamic characteristics of each substructure using Modal Synthesis Method. Engine, transmission and rear axle, etc. were added to Basic Mass Model, consequently Full Mass System was constructed by 72 degree of freedoms. Full Mass System was analyzed over the frequency range 0.5-50.0 Hz under the loading conditions which were Stationary Gaussian Random Process. Results and discussions provided the guidelines to eliminate resonances among the parts and to improve the Ride Quality. The Absorbed Power was used as a standard to determine the Ride Quality. The RMS value of driver's vertical acceleration was obtained 0.423g from the basic model and 0.415g from the modified model.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 1994년도 춘계학술대회 논문집
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• pp.7-34
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• 1994

;Recently the sheet forming simulation technology revealed great progress in the sense of practical application in the automotive, electric/electronics and aviation/space industries. The goal of sheet forming simulation is to embedded in the design engineering system which is consisted by the analysis and synthesis modules. This design simulation system predicts the slackness of sheet and estimate the formability, and search the optimum material/forming/structure conditions. This OVER-ALL OPTIMUM DESIGN can be classified as follow; 1. ANALYZING PROCEDURE: Numerical simulation based on nonlinear theories -geometry, material and friction nonlinearities- 2. OPTIMIZATION PROCEDURE: Optimum design based on mathematical programing and AI technologies, those are implemented in CAD/CAM/CAE System - Concurrent Engineering System-. In this paper, four subjects will be discussed; (1) State of arts of computer simulation technologies in Japan. (2)History of sheet forming simulation. (3) Benchmark problems. (4) Future technology in the sheet forming simulation.ation.

• 대한화장품학회지
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• 제47권4호
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• pp.341-352
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• 2021

아세로라는 천연 비타민 C 함량이 높아 우수한 원료이지만 안정화하기가 어려워 화장품 소재로서의 연구가 거의 이루어지지 못하고 있다. 따라서 본 연구는 아세로라 추출물을 안정화 시키는 혼합 리포좀 제형을 제조하여, 안전성 시험으로 BCOP assay 및 HET-CAM assay를 통한 안점막자극시험, 인체피부 일차자극시험을 통한 피부자극시험을 평가하였다. Tyrosinase 활성저해, melanin 생성저해를 통한 미백 효과 및 procollagen type-I C-peptide 생성을 통한 주름 효과를 평가하여 기능성 화장품 소재로서의 가능성을 확인하고자 하였다. 또한, 아세로라 추출물 혼합 리포좀이 함유된 크림을 제조하여 시험대상자를 대상으로 피부주름, 피부미백에 대한 인체효능평가를 진행하였다. 아세로라 추출물 혼합 리포좀의 BCOP assay, HET-CAM assay 및 인체피부 일차자극 시험결과에서 모두 자극을 보이지 않아 피부 및 안자극에서 안전함을 확인하였다. Tyrosinase 활성저해능을 확인한 결과, 아세로라 추출물 혼합 리포좀은 1,000 ㎍/mL 농도에서 75.8%의 tyrosinase 활성 저해능을 확인하였으며, melanin 생성 저해시험에서 B16F10 세포주의 생존율에 영향을 미치지 않는 아세로라 추출물 혼합 리포좀 1,000 ㎍/mL 농도에서 46.2%의 멜라닌 생성 저해능을 확인하였다. Procollagen type-I C-peptide에서 아세로라 추출물 혼합 리포좀은 HS68 세포주의 생존율에 영향을 미치지 않는 1,000 ㎍/mL 농도에서 152.1%의 collagen 합성능을 확인하였으나, MMP-1 활성억제는 확인할 수 없었다. 아세로라 추출물 혼합 리포좀이 함유된 크림에 대한 피부주름 및 피부멜라닌 인체효력평가에서 피부주름 지표와 피부멜라닌 지표에서 통계학적으로 유의하게 개선됨을 확인하였다. 이상의 연구 결과를 바탕으로 아세로라 추출물 혼합 리포좀이 안자극과 피부자극을 나타내지 않는 안전한 천연 소재임을 확인하였으며, 피부 주름 개선 및 미백 화장품 소재로써 활용 가능성이 높을 것으로 사료된다.

• Journal of Plant Biotechnology
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• 제43권3호
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• pp.302-310
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• 2016

A study aimed at identifying putative drought responsive genes that confer tolerance to water stress deficit in tea plants was conducted in a 'rain-out shelter' using potted plants. Eighteen months old drought tolerant and susceptible tea cultivars were each separately exposed to water stress or control conditions of 18 or 34% soil moisture content, respectively, for three months. After the treatment period, leaves were harvested from each treatment for isolation of RNA and cDNA synthesis. The cDNA libraries were sequenced on Roche 454 high-throughput pyrosequencing platform to produce 232,853 reads. After quality control, the reads were assembled into 460 long transcripts (contigs). The annotated contigs showed similarity with proteins in the Arabidopsis thaliana proteome. Heat shock proteins (HSP70), superoxide dismutase (SOD), catalase (cat), peroxidase (PoX), calmodulinelike protein (Cam7) and galactinol synthase (Gols4) droughtrelated genes were shown to be regulated differently in tea plants exposed to water stress. HSP70 and SOD were highly expressed in the drought tolerant cultivar relative to the susceptible cultivar under drought conditions. The genes and pathways identified suggest efficient regulation leading to active adaptation as a basal defense response against water stress deficit by tea. The knowledge generated can be further utilized to better understand molecular mechanisms underlying stress tolerance in tea.