• 한국항공우주학회지
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• 제30권1호
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• pp.49-55
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• 2002

광섬유 브래그 격자/외부 패브리-페로 간섭 (FBG/EFPI) 센서를 이용하여 비대칭 적층판의 성형시 및 성형후 변형률과 온도를 동시에 모니터링 하였따. 본 논문에서는 광섬유 센서의 출력에 대한 변형률 및 온도의 관계를 수치적으로 유도하였으며 이를 통해 센서의 특성 행렬을 구하였다. 따라서 각각의 센서에 대해 특성 행렬을 구하기 위해 센서의 보정실험을 수행할 필요가 없다. 광원으로는 파장 이동 광섬유 레이저를 사용하였다. 두 개의 FBG/EFPI 센서를 Gr/Ep 비대칭 직교적층 복합적층판에 방향과 위치를 달리하여 삽입하고 오토클레이브 내에서 성형하는 동안 두 지점에서의 성형변형률과 온도를 실시간으로 모니터링 하였다. 또한 열챔버 내에서 제작된 적층판의 열변형률과 온도를 측정하였다. 이러한 실험들을 통해 복합재료의 효울적인 스마트 프로세싱에 대한 기초를 마련할 수 있으며 비대칭 직교적층 복합적층판의 열적 거동에 대해 알 수 있을 것이다.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3444-3450
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• 2013

Three phase hollow fiber-liquid phase microextraction (HF-LPME), which is faster, simpler and uses a more environmentally friendly sample-preparation technique, was developed for the analysis of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in human urine. For the effective simultaneous extraction/concentration of NSAIDs by three phase HF-LPME, parameters (such as extraction organic solvent, pH of donor/acceptor phase, stirring speed, salting-out effect, sample temperature, and extraction time) which influence the extraction efficiency were optimized. NSAIDs were extracted and concentrated from 4 mL of aqueous solution at pH 3 (donor phase) into dihexyl ether immobilized in the wall pores of a porous hollow fiber, and then extracted into the acceptor phase at pH 13 located in the lumen of the hollow fiber. After the extraction, 5 ${\mu}L$ of the acceptor phase was directly injected into the HPLC/UV system. Simultaneous chromatographic separation of seven NSAIDs was achieved on an Eclipse XDB-C18 (4.6 mm i.d. ${\times}$ 150 mm length, 5 ${\mu}m$ particle size) column using isocratic elution with 0.1% formic acid and methanol (30:70) at a HPLC-UV/Vis system. Under optimized conditions (extraction solvent, dihexyl ether; $pH_{donor}$, 3; $pH_{acceptor}$, 13; stirring speed, 1500 rpm; NaCl salt, 10%; sample temperature, $60^{\circ}C$; and extraction time, 45 min), enrichment factors (EF) were between 59 and 260. The limit of detection (LOD) and limit of quantitation (LOQ) in the spiked urine matrix were in the concentration range of 5-15 ng/mL and 15-45 ng/mL, respectively. The relative recovery and precision obtained were between 58 and 136% and below 15.7% RSD, respectively. The calibration curve was linear within the range of 0.015-0.96 ng/mL with the square of the correlation coefficient being more than 0.997. The established method can be used to analyse of NSAIDs of low concentration (ng/mL) in urine.

• Environmental Engineering Research
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• 제22권2호
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• pp.186-192
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• 2017

The carbon paste electrode (CPE) was modified with the pristine bentonite and hybrid material (HDTMA-modified bentonite). The modified-CPEs are then employed as working electrode in an electrochemical detection of As(V) from aqueous solutions using the cyclic voltammetric measurements. Cyclic voltammograms revealed that As(V) showed reversible behavior onto the working electrode. The hybrid material-modified carbon paste electrode showed significantly enhanced electrochemical signal which was then utilized in the low level detection of As(V). Moreover, the studies were conducted at neutral pH conditions. The electrochemical studies were conducted with scan rates (20 to 200 mV/s) to deduce the mechanism of redox processes involved at the electrode surface. The anodic current was linearly increased, increasing the concentration of As(V) from 5.0 to $35.0{\mu}g/g$ using the hybrid material-modified electrode. This provided fairly a good calibration line for As(V) detection. The presence of varied concentrations of As(III) in the determination of total arsenic was studied. The influence of several cations and anions viz., Cu(II), Mn(II), Zn(II), Pb(II), Cd(II), Fe(III), $Cl^-$, $NO_3{^-}$, $PO_4{^{3-}}$, EDTA and glycine in the detection of As(V) from aqueous solution was also studied. Further, in an attempt to simulate the real matrix analysis, the tap water sample was spiked with As(V) and subjected for As(V) detection using the modified-CPE.

• 한국전산구조공학회논문집
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• 제31권4호
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• pp.207-213
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• 2018

본 연구에서는 건물 실내 공간 정보 획득을 위해 Microsoft사의 $Kinect^{(R)}$ v2를 활용한 point cloud 기법을 도입하였다. 카메라로 취득한 2차원의 투영 공간 이미지 픽셀 좌표를 각 카메라의 보정을 거쳐 3차원 이미지 변환하며 이를 토대로 공간 정보를 구현하였다. 기준점을 중심으로 $360^{\circ}$ 회전하여 취득한 3차원 이미지를 통해 거리 측정이 불가한 기존의 2차원 이미지의 한계를 개선하였으며, 이 과정을 통해 얻은 point cloud를 통해 3차원 map을 형성하였다. 형성된 3차원 map은 기존의 공간정보 융 복합을 위한 센서와 비슷한 수준의 측정 효율을 가지면서 동시에 렌즈 왜곡 현상에 대한 후처리 과정을 통해 공간 정보를 정확하게 측정할 수 있도록 하였다. 측정한 결과를 2D 도면과 실제 공간 및 구조부재의 길이 및 위치 등과 비교하여 검증하였다.

• Archives of Pharmacal Research
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• 제29권6호
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• pp.514-519
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• 2006

A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) In dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. The mobile phase was methanol - diethylamine solution (0.05 M) (20:80, v/v, pH adjusted to 3.0 with $H_3PO_4$) with a detection wavelength of 240 nm. The limit of quantitation (LOQ) of LDP in a biological matrix was determined to be 25.25 ng/mL. The calibration curve was linear across the concentration range of 25.25 to 2020 ng/mL. The intra-day and inter-day precision values (CV%) were within 7% and accuracy (R.E. %) was within 6% of the nominal values for medium (252.5 ng/mL) and high (2020 ng/mL) LDP concentrations. For the LDP concentration at the LOQ, the intra-day and inter-day precision and accuracy were within 20% and 10%, respectively. The average absolute recovery for LDP was 70.28%. This method was successfully used to analyze plasma samples in a steady-state bioavailability study of a newly developed sustained-release LDP tablets (SR) using immediate-release tablets (IR) as the reference. The relative bioavailability of the SR was determined to be $106.3\;{\pm}\;12.8%$ (n=6). The $C_{max}$ of the SR was significantly lower (p<0.05), and the $t_{max}$ was significantly longer than that of the IR (p<0.05). The results of ANOVA and two one-sided tests indicated that the SR exhibited acceptable sustained release properties and was bioequivalent to the IR.

• 분석과학
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• 제18권6호
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• pp.475-482
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• 2005

화학분석 분야에는 ISO 17025에 따른 체계적 품질 관리/보증의 요구가 커지면서, 측정 불확도의 표기가 크게 요구되고 있다. 측정품질의 정량화를 위하여, 화학분석의 QA/QC 문헌들로부터 화학분석 품질에 영향을 미치는 중요한 불확도 요소를 선정하였고, 이것을 측정결과 평가 요소의 기본인 7개의 품질요소로서 반복성, 직선성, 소급성, 변동성, 매질효과, 균질성, 안정성으로 구분하였다. 화학분석의 QA/QC를 위한 이 7대 품질 요소의 측정 모델화, 표준불확도의 계산 및 합성방법을 각각 예로서 제시하였다.

• 분석과학
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• 제28권4호
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• pp.299-307
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• 2015

In May 2012, a safety hazard issue arose because some kiwifruit growers in New Zealand had sprayed streptomycin to prevent kiwifruit canker. Therefore, for food safety management, analytical methods to determine streptomycin residues in kiwifruits are required. We developed an analytical method to determine streptomycin residues in kiwifruit samples using liquid chromatograph tandem mass spectrometer (LC-ESI-MS/MS). Streptomycin residues in samples were extracted using 1% formic acid in methanol, centrifugation for 10 min, and subsequent supernatant filtration. Purified samples were subjected to LC-ESI-MS/MS to confirm presence of and quantify streptomycin residues. Average streptomycin recoveries (6 replicates each sample) were in the range of 94.8%-110.6% with relative standard deviations of <10%. The linearity of the concentration range of 0.01-5.0 mg/kg using a matrix-matched calibration gave R² = 0.9995. The limit of quantification (LOQ) was 0.01 mg/kg. Results showed that our analytical method is rapid, simple, and sensitive, with easy sample preparation.

• 대한원격탐사학회지
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• 제20권6호
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• pp.369-382
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• 2004

본 연구는 Terra ASTER 영상과 LANDSAT 7 ETM+ 분광 영상정보와 같은 상이한 방사 및 공간 해상도를 갖는 위성 센서의 영상을 지질학적으로 활용하기 위한 선형분광혼합분석(LSMA: Linear Spectral Mixture Analysis)기법의 적용성을 목적으로 한다 실제 적용사례로서 몽골지역을 대상으로 ASTER 영상과 LANDSAT 7 ETM+ 분광 영상정보를 이용하여 지질학적 주제도 자성과정을 수행하였다. 두 영상 정보에 대하여 기하 보정 및 방사 휘도 조정 등의 전처리 작업을 수행한 후 사전 지질조사 정보와 두 영상정보의 밴드 별 상관도를 분석하여 7개의 지질단위의 분광 클래스를 선택하였고 20개 밴드완 위성 영상자료를 LSMA 기법에 적용하였다. 처리 결과로 주제도 작성의 대상으로 한 7개의 지질단위에 대한 각각의 주제도를 얻게 되었다. 결론적으로 LSMA 기법은 지질 주제도 작성을 위한 효과적인 접근 방법 중의 하나로 판단된다.

• 분석과학
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• 제32권5호
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• pp.163-172
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• 2019

Methamphetamine (MA) is currently the most abused illicit drug in Korea and its major metabolite is amphetamine (AP). As MA exist as two enantiomers with the different pharmacological properties, it is necessary to determine their respective amounts in a sample. Thus a chiral stationary phase liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for identification and quantification of d-MA, l-MA, d-AP, and l-AP in human urine. Urine sample ($200{\mu}L$) was diluted with pure water and purified using solid-phase extraction (SPE) cartridge. A $5-{\mu}L$ aliquot of SPE treated sample solution was injected into LC-MS/MS system. Chiral separation was carried out on the Astec Chirobiotic V2 column with an isocratic elution for each enantiomer. Identification and quantification of enantiomeric MA and AP was performed using multiple reaction monitoring (MRM) detection mode. Linear regression with a $1/x^2$ as the weighting factor was applied to generate a calibration curve. The linear ranges were 25-1000 ng/mL for all compounds. The intra- and inter-day precisions were within 3.6 %, while the intra- and inter-day accuracies ranged from -5.4 % to 11.8 %. The limits of detection were 2.5 ng/mL (d-MA), 3.5 ng/mL (l-MA), 7.5 ng/mL (d-AP), and 7.5 ng/mL (l-AP). Method validation parameters such as selectivity, matrix effect, and stability were evaluated and met acceptance criteria. The applicability of the method was tested by the analysis of genuine forensic urine samples from drug abusers. d-MA is the most common compound found in urine and mainly used by abusers.

• 한국환경농학회지
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• 제40권2호
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• pp.99-107
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• 2021

BACKGROUND: Pesticide uptake by a rotational crop after being used for the primary crop is a potential cause of violation against the pesticide law if the pesticide is not registered in the secondary crop. This study was conducted to investigate the plant back interval (PBI) of fluopyram for the rotational cultivation of radish. METHODS AND RESULTS: Two experimental approaches were performed the evaluation of residues in radish cultivated successively in soil 16 days after treated with fluopyram onto pepper plant (T1) and in radish cultivated in bare soil treated with fluopyram at PBI 30 and PBI 60 days (T2). A modified QuEChERS method coupled with LC/MS/MS analysis showed good linearity of matrix-matched standard calibration of fluopyram with the coefficient values of determination greater than 0.995. Recovery values at levels of 0.01, 0.05, 0.1 and 0.25 mg/kg ranged from average 84.9 to 117.6% with RSD less than 10%. Fluopyram residues in radish harvested from T1 and T2 were found as levels less than maximum residue limit. CONCLUSION: This study suggests 20~30 days as the PBI of fluopyram for the rotational cultivation of radish in the greenhouse soil treated with fluopyram used for pepper as the primary crop.