• 제목/요약/키워드: Calcium profile

검색결과 112건 처리시간 0.018초

난소절제와 칼슘 섭취수준이 흰쥐의 지질패턴과 항산화능에 미치는 영향 (Effects of Ovariectomy and Calcium Intake on Lipid Profile and Antioxidant Capacities in Rats)

  • 최미경;강명화;김미현
    • Journal of Nutrition and Health
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    • 제41권4호
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    • pp.299-306
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    • 2008
  • The purpose of this research was to investigate the effect of the calcium intake on lipid profile and antioxidant capacities in ovariectomized (OVX) rats. Rats were divided into 3 groups and fed diet with different levels of calcium (low 0.1%, adequate 0.5%, high 1.5%) for 4 weeks. The half of rats in each group was ovariectomized and the others were sham-operated. And rats were fed same diets for 8 weeks after operation. Feed intake and weight gain were significantly higher in OVX group than those in sham-operated. Serum HDL-cholesterol was the highest in high-calcium group of OVX. Hepatic triglyceride of low-calcium group in sham-operated was the highest, while that of highcalcium group in OVX was the highest. Hepatic activities of glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px), and catalase were significantly decreased by increasement of calcium intake. Hepatic TBARS level was the lowest in high-calcium group of OVX. And hepatic level of TBARS induced by AAPH was significantly decreased by increasement of calcium intake. These results may indicate that the high calcium intake have the potential role to improve lipid profiles and antioxidant capacities in OVX rats.

FINITE ELEMENT MODEL TO STUDY TWO DIMENSIONAL UNSTEADY STATE CYTOSOLIC CALCIUM DIFFUSION

  • Tewari, Shivendra Gajraj;Pardasani, Kamal Raj
    • Journal of applied mathematics & informatics
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    • 제29권1_2호
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    • pp.427-442
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    • 2011
  • Calcium is a vital second messenger for signal transduction in neurons. Calcium plays an important role in almost every part of the human body but in neuronal cytosol, it is of utmost importance. In order to understand the calcium signaling mechanism in a better way a finite element model has been developed to study the flow of calcium in two dimensions with time. This model assumes EBA (Excess Buffering Approximation), incorporating all the important parameters like time, association rate, influx, buffer concentration, diffusion constant etc. Finite element method is used to obtain calcium concentration in two dimensions and numerical integration is used to compute effect of time over 2-D Calcium profile. Comparative study of calcium signaling in two dimensions with time is done with other important physiological parameters. A MATLAB program has been developed for the entire problem and simulated on an x64 machine to compute the numerical results.

칼슘 존재하에서 인산과 구연산업이 분리대두단백질의 유화 안정성에 미치는 영향 (Effect of Phosphate and Citrate Salts on the Emulsion Stability of Soy Protein Isolate in the Presence of Calcium)

  • 김영숙;염동민;황재관
    • 한국식품영양학회지
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    • 제7권3호
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    • pp.177-182
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    • 1994
  • The effect of phosphate salt (NafHP04) and sodium citrate on the emulsion stability of soy protein isolate (SPI) in the presence of calcium was investigated in terms of salt concentration and addition order. Both phosphate and citrate salts decreased the solubility of SPI despite their pH enhancing effects. Addition of calcium chloride (CaCl2) significantly decreased ES, which showed nearly negligible at more than 3 mM CaCl2 concentration. When Na2HP04 were added in the presence of 5 mM Cac12, 55 greatly increased up to 20mM concentration, above which however ES decreased. It was found that the addition order of Na2HPO4 and CaCl2 affected ES. The addition of phosphate and subsequent CaCl2 exhibited the higher 55 than the reverse order. In both cases, the overall ES profile was found to be nearly similar to the solubility profile of SPI, indicating the positive relationship between solubility and emulsion stability of SPI in the presence of calcium. Similar trend to the phosphate effect on ES was also observed for sodium citrate in the presence of calcium.

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칼슘과 제니스테인 섭취가 고지방식이로 유도된 비만 모델 마우스의 체지방과 지질대사에 미치는 영향 (Effects of Calcium and Genistein on Body Fat and Lipid Metabolism in High Fat-induced Obese Mice)

  • 김미현;김설희;박현우;김완기;이연숙
    • Journal of Nutrition and Health
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    • 제39권8호
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    • pp.733-741
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    • 2006
  • The study was conducted to investigate the effects of dietary calcium and soy isoflavone on body fat and lipid metabolism in high fat-induced obesity. Four week old female C57/BL6J mice, known as a good model of diet-induced obesity, were fed low Ca and high fat diet for 6 weeks. After induced obesity, mice were divided into six groups according to diets varying calcium contents (0.1 or 1.5%) and genistein contents (0 or 500 or 1,000 ppm). Body weight, fat pad (perirenal fat and parameterial fat), adipocyte size, serum total lipid and total cholesterol were significantly decreased by both high Ca intake and genistein supplementation. However, the effect of genistein supplementation showed in low Ca-fed groups. Serum LDL-cholesterol and TG were significantly decreased by high Ca intake and genistein supplementation, respectively. In liver, lipogenic enzymes (fatty acid synthase and malic enzyme) activity and TG were significantly decreased by both high Ca intake and genistein supplementation. This inhibitory effect of genistein on lipogenic enzymes showed in low Ca-fed groups. But liver total cholesterol and total lipid were significantly decreased by high Ca intake and genistein supplementation, respectively. Fecal excretion of total lipid, total cholesterol and TG were significantly increased by high Ca intake, not by genistein supplementation. In conclusion, high calcium intake and genistein supplement may be beneficial for suppression of obesity through direct anti-adipogenesis by decreasing fat weight and size and indirect anti-lipo-genesis by inhibiting lipogenic enzymes activity and improving lipid profile.

Differential Vasorelaxant Effects of KR-30075, a New Cyclic AMP-phosphodiesterase Inhibitor, on Guinea-pig Pulmonary, Bovine Coronary and Renal Arteries

  • Jung, Yee-Suk;Kwon, Kwang-Il;Zee, Ok-Pyo
    • Archives of Pharmacal Research
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    • 제13권2호
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    • pp.136-141
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    • 1990
  • The vasorelaxant effects of KR-30075 in guinea-pig pulmonary, bovine coronary and renal arterial strips contracted by either$K^+$depolarization, phenylephrine, or prostaglandin $F_{2a}$($PGF_{2a}$) were evaluated. KR-30075 was more potent than imazodan as a vasorelaxant against $PGF_{2a}$-induced contractions in bovine coronary and renal arteries, whereas against$K^+$induced contractions KR-30075 was less potent than imazodan in guieapig pulmonary arteries and more potent in bovine coronary arteries. KR-30075 was more potent against contractions induced by phenylephrine or $PGF_{2a}$ than the contractions induced by $K^+$ This profile of activity for KR-30075 was similar to that of imazodan and dissimilar from the calcium entry blocking agent nifedipine. There was no vascular selectivity of KR-30075 between bovine coronary and renal arterial strip preparations. In conclusion, this study shows that KR-30075 represents the vasorelaxant effects on guinea-pig pulmonary, bovine coronary and renal arteries without specific vascular selectivity. The vasorelaxant profile of KR-30075, with different sources of vascular smooth muscle, is unlike that of calcium entry blocking agent and more similar to the profile of the agent that inhibit cyclic nucleotide phosphodiesterase.

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칼슘 첨가 마늘 페이스트로 제조한 양갱의 품질특성 및 항산화성 (Quality Characteristics and Antioxidant Activity of Calcium-added Garlic Yanggaeng)

  • 전미라;김민희;손찬욱;김미리
    • 한국식품영양과학회지
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    • 제38권2호
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    • pp.195-200
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    • 2009
  • 마늘과 칼슘을 이용한 기능성과 고가치의 양갱을 제조하기 위하여 칼슘의 종류를 각각 달리하고, 마늘을 무취화 시킨 칼슘첨가 마늘페이스트를 제조한 후 양갱을 만들어 품질 특성 및 항산화성, 관능적 특성을 평가하였다. 칼슘첨가 마늘 양갱은 산도가 무첨가군보다 증가하였으며, 당도가 다소감소하였으나 유의적 차이를 보이지는 않았다. 양갱의 색도 측정 결과는 칼슘 및 마늘의 첨가에 따라 L값이 감소하였으며, a값과 b값은 유의적으로 증가하였으나, 대조군의 L값과 유사한 군은 젖산칼슘, 탄산칼슘, 칼슘파우더이었다. 마늘양갱의 기계적 경도는 탄산칼슘, 젖산칼슘, 칼슘파우더 첨가군에서 증가하였으며, 탄력성은 칼슘파우더를 첨가한 경우에 증가하였다. DPPH 라디칼 소거능 및 hydroxyl 라디칼 소거능에 대한 항산화 활성 역시 무첨가군에 비해 마늘양갱과 칼슘첨가 마늘양갱에서 높아지는 경향을 보였는데 특히, 탄산칼슘, 젖산칼슘, 칼슘믹스에서였다. 관능검사 결과 마늘 냄새, 마늘 맛에서 유의적 차이를 보이지 않았으며, 전체적인 수용도에 있어서 탄산칼슘, 젖산칼슘, 구연산칼슘 첨가군이 높은 점수를 받았다. 이상의 결과를 볼 때 칼슘첨가 마늘 페이스트는 새로운 기능성 양갱을 제조하는데 있어서 좋은 소재로서의 가능성을 가지고 있다고 사료된다.

Future Prospects of the Development of Calcium Antagonists

  • Schwartz, Arnold
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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    • pp.53-53
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    • 1993
  • In considering the mechanism of action of the calcium antagonists, it is important to realize that there are three distinct receptor types and that the new classification divides these three drugs as members of the dihydropyridine, phenylalkylamines and benzothiazipines, respectively. The World Health Organization as well as the International Union of Pharmacology and Cardiology have adopted this classification. Unlike every other class of drugs, such as the alpha and beta adrenergic blocking agents, diuretics, etc., the calcium antagonists need to be thought of as three distinct drug classes. The reason they share some, but not all of the pharmacological profile is that they all act at specific receptor domains present in one large protein of 165 daltons present in all excitable tissue. This protein along with several other subunits make up what is known as the voltage-dependent calcium channel (the so-called "L"type, L-VDCC). The mechanism of action of the three drugs involve first a specfic binding and then an inhibition of the movement of calcium into the cell Some of these drugs, such as diltiazem, may have other interesting intracellular effects perhaps associated with protection of the mitochondria during ischemic insults. The nature of the receptor is being explored by molecular genetic techniques, and we have recently cloned two of the major subunits; some of the data will be presented.

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용매침착법을 이용한 페닐부타존의 용출속도에 관한 연구 (Studies on the Dissolution Rate of Phenylbutazone Deposited on Excipients by Solvent Deposition Method)

  • 용재익;손영옥
    • 약학회지
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    • 제29권3호
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    • pp.124-129
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    • 1985
  • A dissolution characteristics of phenylbutazone deposited on Avicel and dibasic calcium phosphate by solvent deposition method were studied. The solvent deposition was confirmed by scanning electron microscopy. Avicel was superior to dibasic calcium phosphate as excipient in dissolution rate. Total amount of phenylbutazone dissolved from Avicel deposition system at 30minutes were enhanced 1.2-1.6 times compared with physical mixtures of them. The dissolution rate of 10% solvent deposition system was highest and that of 75% solvent deposition system was lowest in Avicel system and dibasic calcium phosphate system. Dissolution profile of commercial products was dependent on manufacturing conditions and dissolution rate of 10% Avicel system was greater than that of commercial products.

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추출시간에 따른 돼지 족의 지방산과 칼슘, 마그테슘 함량 변화에 관한연구 (Studies on the Content of fatty Acid Calcium and Magnesium of Pig s Shank According to Extraction Time by Water)

  • 이미경;노기환
    • 한국식품영양과학회지
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    • 제19권1호
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    • pp.61-64
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    • 1990
  • The influence of extraction time on the fatty acid profile and the contents of calcium and magnesium in pig's shank were examined. The 9 kinds of fatty acid were identified in water extracts from pig's shank by GLC. The profiles of fatty acids from different extraction were similer to each other,. The content of linolenic acid was increased after two-hours extraction however the amounts of MUFA, PUFA and p/s ratio were decreased by the longer extraction time. The amount of calcium was 124.7mg% in raw materials but water extracts and bone powder samples showed higher values. in case of magnesium it was 138.4mg% in raw materials, but the extracts showed lower amount and bone powder exhibited higher values.

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LC-MS/MS-based Proteomic Analysis to Identify Protein Phosphorylation in Emiliania huxleyi

  • Duong, Van-An;Nam, Onyou;Jin, EonSeon;Seo, Jae-Min;Park, Jong-Moon;Lee, Hookeun
    • Mass Spectrometry Letters
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    • 제12권4호
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    • pp.163-171
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    • 2021
  • Emiliania huxleyi is a marine phytoplankton that plays a critical role in global carbon and sulfur cycling. The genome of E. huxleyi has been sequenced, and an in-depth proteomic profile of this organism has been reported. This study analyzed the phosphoproteome of E. huxleyi and identified its changes under calcium-limited conditions. A TiO2 microcolumn was used for phosphopeptide enrichment, followed by liquid chromatography-tandem mass spectrometry analysis. Overall, we identified 7,010 phosphorylated sites on 3,355 phosphopeptides associated with 2,929 phosphoproteins in E. huxleyi. Quantitative analysis revealed changes in the phosphoproteome in E. huxleyi when ambient conditions changed to calcium-limited conditions, notably the phosphorylation of some transporters was altered. This study provides an overview of protein phosphorylation in E. huxleyi and paves the way for further investigations of its biological functions.