• Proceedings of the Korean Ceranic Society Conference
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• 2002.10a
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• pp.52.2-52
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• 2002

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.652-662
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• 2010

The purpose of this experiment was to study the effects of demineralized bone matrix (DBM), calcium sulfate (CS), and calcium metaphosphate (CMP) on osteogenesis of unicortical 5-mm-diameter defects in canine femurs. Seventy-two femoral unicortical defects of nine adult beagles (eighteen femurs, four unicortical femoral defects were made in each femur) were made. Three bone graft substitutive materials such as CS, DBM, and CMP and the empty controls were compared each other. The postimplanted specimens were harvested at week 4, 8, and 24 for radiographic, biochemical and histomorphologic evaluation. In radiograph, CS group appeared to be absorbed rapidly and made new cortical bone. Defects of cortical bone was gradually filled with new bone around bone graft materials in DBM group. Bone graft substitutes weren't absorbed rapidly but, remained performing structural roles in cortical bone after 24 weeks in CMP group. Radiographic intensity of control group showed significantly (p < 0.05) lower compared to that of experimental group. Defects treated with either CS, DBM or CMP had more bone formation than the untreated defects (p < 0.05). The results of analysis in the cortical bone region were deduced the conclusions as follows. Three bone graft materials seemed to accelerate the formation of new bone compared with controls for 24 weeks. CMP group having more or less large particle space was more adequate than DBM group, as well as more compact CS group was more pertinent than CMP group as the glues for bones.

• The Journal of Advanced Prosthodontics
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• v.5 no.2
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• pp.172-178
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• 2013

PURPOSE. The purpose of this study was to assess the difference in efficacy between calcium metaphosphate (CMP)-coated implant fixtures and conventional resorbable blasted media (RBM) processed implant fixtures. MATERIALS AND METHODS. This study targeted 50 implants from 44 patients who visited Dankook University Dental Hospital. Implantations were done separately for RBM treated and CMP-coated implants, although their design was the same. Calcium metaphosphate has a quicker biodegradation process through hydrolysis compared to other phosphate calcium groups. For the first year of the implantation, the resorption volume of marginal bone analyzed via radiography and perio-test value were measured, under the check plan. Their analyses were composed of a non-inferiority trials test. A 95% level of reliability was used. RESULTS. In the comparative analysis of the resorption volume of marginal bone and the perio-test value, no statistically significant difference was found between the CMP-coated implants and RBM implants. CONCLUSION. One year after the implant placement, CMP-coated implants were found not to be inferior to the conventional RBM implants.

• Proceedings of the Korean Ceranic Society Conference
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• 2002.10a
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• pp.202.1-202
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• 2002

• Journal of Periodontal and Implant Science
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• v.28 no.4
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• pp.559-568
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• 1998

direct bone apposition during bone remodelling. To address these problem, we developed a new ceramic, calcium metaphosphate(CMP), and report herein the biologic response to CMP in subcutaneous tissue, muscle and bone. Porous CMP blocks were prepared by condensation of anhydrous $Ca(H_2PO_4)_2$ to form non-crystalline $Ca(PO_3)_2$. Macroporous scaffolds were made using a polyurethane sponge method. CMP block possesses a macroporous structure with approximate pore size range of 0.3-1mm. CMP blocks were implanted in 8mm sized calvarial defect, subcutaneous tissue and muscle of 6 Newzealand White rabbits and histologic observation were performed at 4 and 6 weeks later. CMP blocks in subcutaneous tissue and muscle were well adapted without any adverse tissue reaction and resorbed slowly and spontaneously. Histologic observation of calvarial defect at 4 and 6 weeks revealed that CMP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CMP blocks didn't show any adverse tissue reaction and resorbed spontaneously also in calvarial defect. This result revealed that CMP had a high affinity for bone and was very biocompatible. From this preliminary result, it was suggested that CMP was a promising ceramic as a bone substitute and tissue engineering scaffold for bone formation.

• Journal of the Korean Ceramic Society
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• v.44 no.5 s.300
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• pp.144-147
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• 2007

Calcium metaphosphate (CMP) nanofibers with a diameter of ${\sim}600nm$ were prepared using electrospun CMP/polyvinylpyrrolidone (PVP) fibers through a process of drying for 5 h in air followed by annealing for 1 h at $650^{\circ}C$ in a vacuum. The viscosity of the CMP/PVP precursor containing 0.15 g/ml of PVP was 76 cP. Thermal analysis results revealed that the fibers were crystallized at $569^{\circ}C$. The crystal phase of the as-annealed fiber was determined to be ${\delta}-CMP\;({\delta}-Ca(PO_3)_2)$. However, the morphology of the fibers changed from smooth and uniform (as-spun fibers) to linked-particle characteristics with a tubular form most likely due to the decomposition of the inner PVP matrix. It is expected that this large amount of available surface area has the potential to provide unusually high bioactivity and fast responses in clinical hard tissue applications.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.449-454
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• 1998

It is well known that new tissue or blood vessel is grown into a porous calcium phosphate ceramics used as a bone graft substitute due to their excellent biocompatibility. In this study, the most chemically stable porous $\beta$-crystalline form in various forms of calcium metaphosphate, Ca(PO$_3$)$_2$is prepared by the controlled thermolysis of monocalcium phosphate, Ca(H$_2$PO$_4$)$_2$.The diameter of cylindrical pores formed during cooling was controlled by a holding time at the melting point of a monocalcium phosphate and by the change of a crystallization temperature, to obtain the most appropriate size (about 200$\mu$m) of pores for the application of bone substitutes and matricuts. It was observed that the increasing holding time at the melting point of monocalcium phosphate results in the decreases of cylindrical pore sizes.

• Journal of Korean Dental Science
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• v.2 no.1
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• pp.28-30
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• 2009

Purpose : The purpose of this pilot experiment was to evaluate early bone response in two types of coated implants using the rabbit tibia model. Materials and Methods : Screw type titanium implants manufactured with a calcium metaphosphate (CMP) coating and hydroxyapatite (HA) coating were placed in the tibiae of 3 New Zealand White rabbits. The bone responses at 2 weeks after insertion were evaluated and compared by histomorphometry. Results : There was no significant difference in bone-to-implant contact between the groups (P>.05). However, some qualitative differences on histologic views were found. Conclusions : CMP-coating is suggested to be the preferred candidate for fast osseointegration over HAcoating.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.6
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• pp.511-520
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• 2010

Purpose: This study was conducted in order to compare the efficacy of osseointegration of three different calcium metaphosphate (CMP) coated implants in the rabbit's femur. Materials and Methods: Twenty four rabbits and three different type of CMP coated implants and RBM implants were used in this study. The animals were divided into 4 groups on the basis of implant surface characteristics. Two implants were installed into the condyle of femur of each rabbits. The animals were sacrificed at 2 and 4 weeks after installation. The undecalcified specimens were prepared for histological, radiological examination and histomorphometric analysis of implant-bone contact ratios (BIC) and bone area ratio (BA). Results: Two implants were failed to osseointegrate and implant success rate was 95.2%. There were not any significant inflammatory response in all groups. Fluorescent image at 4 weeks shows that remodeling is slower in RBM group than CMP group. CMP III showed more active remodeling than CMP I, II. In histomorphologic analysis, BIC ratio at 2 weeks was lower than 4 weeks. Conclusion: The results suggest that the ratios of CMP coated implants were higher than that of RBM control group but there is no significantly difference between RBM group and CMP group. In conclusion, CMP coated implant had more clinical availability than RBM implants.

• 대한치주과학회:학술대회논문집
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• 2002.11a
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• pp.115-115
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• 2002