• CDE review
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• v.14 no.1
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• pp.38-40
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• 2008

• Proceedings of the Korea Society of Design Studies Conference
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• 2002.11b
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• pp.148-149
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• 2002

• Computational Structural Engineering
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• v.2 no.1
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• pp.11-13
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• 1989

• Electronics and Telecommunications Trends
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• v.7 no.1
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• pp.3-15
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• 1992

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2659-2664
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• 2015

Background: To examine the expression of cysteine-rich 61 (Cyr61/CCN1) protein in laryngeal squamouscell carcinoma (LSCC) tissues, and its relationship with the tumor epithelial-mesenchymal transition (EMT), invasion, metastasis, and prognosis. Materials and Methods: Immunohistochemistry was used to detect the expressions of Cyr61, Vimentin (Vim), and E-cadherin (E-cad) in 88 cases of LSCC tissues and 30 cases of tumor-adjacent normal tissues. Vim and E-cad were used as mesenchymal and epithelial markers, respectively, to determine the relationship between Cyr61 expression and the EMT of LSCC cells. In addition, clinical and histopathological data were combined to analyze the relationship between the positive-expression rates of Cyr61, Vim and E-cad and LSCC invasion, metastasis and prognosis. Results: In LSCC tissues, Vim expression rate was significantly higher than that of the tumor-adjacent tissues, whereas E-cad expression rate was significantly lower than that of the tumor-adjacent tissues. The Vim expression rate was significantly higher in stages T3 and T4 than in stages T1 and T2 LSCC tissues, whereas E-cad expression rate was significantly lower in stages T3 and T4 than in stages T1 and T2 LSCC tissues. Compared to the group without lymph node metastasis, the Vim expression rate was significantly higher and the E-cad expression rate was significantly lower in the group with lymph node metastasis. The expression rate of Cyr61 was significantly higher in LSCC tissues than in the tumor-adjacent normal tissues. In addition, the Cyr61 expression rate was higher in stages T3 and T4 than in stages T1 and T2 LSCC, and higher in the group with lymph node metastasis than in the group without lymph node metastasis. The Vim expression rate was significantly higher in the Cyr61 positive group than in the Cyr61 negative group, whereas the E-cad expression rate was significantly higher in the Cyr61 negative group than in the Cyr61 positive group. Survival analysis indicated that survival rates of Cyr61 positive, Vim positive and E-cad negative groups were significantly lower than that of Cyr61 negative, Vim negative and E-cad positive groups, respectively. Conclusions: Cyr61 expression is closely associated with LSCC invasion and lymph node metastasis. Overexpression of Cyr61 may induce EMT and therefore leads to LSCC invasion and metastasis and poor prognosis. Cyr61 may become a new maker for clinical prediction of LSCC invasion and metastasis and a new target for LSCC treatment.

• Journal of Institute of Convergence Technology
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• v.1 no.1
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• pp.9-12
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• 2011

Structural analysis of a tire is done using a commercial software, ANSYS Workbench. The properties of rubber of the tire is represented using a Mooney-Rivlin model. The bead in the tire is made of structural steel. 3D CAD model of the tire is obtained from a commercial CAD-specialized software, CATIA. Using an imported 3D CAD geometric model, a mesh system with fifty thousand nodes is constructed using ANSYS. A time-variant point force is applied to the rim of the tire, and the deformation of the tire is computed. It is found that both bending and twisting of the tire are observed where the point force is applied. The deformation of the tire is asymmetric, which results in the help of ripping the tire using the helper. It is also found that the deformation undergoes linearly with the applied force. When the force is larger than 1500N, then the deformation becomes larger than the half of the thickness of the tire. In the future, a more realistic rubber model will be applied and validated with the measured data.

• Korean Journal of Veterinary Research
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• v.57 no.4
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• pp.209-214
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• 2017

Wild raccoon dogs (Nyctereutes procyonoides koreensis) may play a role transmitting several pathogens to humans and pet animals. Information concerning the incidence of rabies, canine distemper virus (CDV), canine parvovirus (CPV), canine adenovirus type 2 (CAdV-2), canine parainfluenza virus type 5 (CPIV-5), and canine herpesvirus (CHV) is needed in wild raccoon dogs. In total, 62 brain samples of raccoon dogs were examined for rabies virus (RABV) and CDV, and 49 lung samples were screened for CDV, CAdV-2, CPIV-5, and CHV. No RABV, CAdV-2, CPIV-5, or CHV was identified, but nine CDV antigens (8.1%, 9/111) were detected. Moreover, 174 serum samples from wild raccoon dogs were screened for antibodies against the five major viral pathogens. The overall sero-surveillance against CDV, CPV, CAdV-2, CPIV-5, and CHV in wild raccoon dogs was 60.3%, 52.9%, 59.8%, 23.6%, and 10.3%, respectively. Comparisons of the sero-surveillance of the five pathogens showed that raccoon dogs of Gyeonggi province have slightly higher sero-positive rates against CDV, CPV, and CHV than those of Gangwon province. These results indicate high incidences of CDV, CPV, and CAdV-2 in wild raccoon dogs of two Korean provinces and a latent risk of pathogen transmission to companion and domestic animals.

• Journal of Veterinary Clinics
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• v.38 no.3
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• pp.127-134
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• 2021

Canine atopic dermatitis (CAD) is a genetically predisposed inflammatory and pruritic skin disease presenting characteristic clinical features in dogs. Despite oclacitinib and lokivetmab being commonly used, no study has compared their efficacies in CAD. This study aimed to compare the efficacy, safety, and control of CAD-associated pruritus and skin lesions between oclacitinib and lokivetmab. It also investigated whether switching to lokivetmab from oclacitinib or prednisolone had any benefits. Twenty-five client-owned dogs, newly diagnosed with CAD, were allocated to the oclacitinib (n = 20) and lokivetmab (n = 5) groups and administered oclacitinib (0.4-0.6 mg/kg orally, twice daily for 14 days, then once daily) and lokivetmab (2 mg/kg subcutaneously, every month) for 8 weeks, respectively. The switching group included five dogs previously administered with oclacitinib (n = 4) or prednisolone (n = 1) who were switched to lokivetmab directly at the start of the study. The pruritus visual analog scale (PVAS) and Canine Atopic Dermatitis Extent and Severity Index (CADESI-04) values were surveyed at weeks 0, 4, and 8. Oclacitinib and lokivetmab significantly reduced the PVAS and CADESI-04 scores. Switching from oclacitinib or prednisolone to lokivetmab maintained the severity of pruritus (4 weeks: p = 0.068; 8 weeks: p = 0.068) and dermatitis (4 weeks: p = 0.144; 8 weeks: p = 0.068) at the levels measured at baseline. Thus, both oclacitinib and lokivetmab reduced CAD-associated pruritus by a similar degree. Switching to lokivetmab maintained the severity of pruritus and dermatitis at the same level as the previous treatment.

• The Journal of Korean Academy of Prosthodontics
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• v.42 no.2
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• pp.142-153
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• 2004

Statement of problem: Increasing demand of esthetic restorations made lots of kinds of ceramic materials. Among them, zirconia has been being focused by many dentists. But, mechanical properties of zirconia were still unclear. Purpose : The purposes of this study were to analyze the flexural strength of various zirconia ceramics which had been currently used for clinic i.e., In-Ceram Zirconia(Vita Zahnfabrik, Bad $S\"{a}ckingen$, Germany), Celay Zirconia(Vita Zahnfabrik, Bad $S\"{a}ckingen$, Germany) and CAD/CAM Zirconia (Adens Zi-Ceram. Seoul , Korea). Material and methods: The four point bending test(ASTM Cl161) was used to measure the flexural strength of a specimen before and after circular heat treatment and fatigue loading. Results : 1. The average value of flexural strengths of CAD/CAM Zirconia, Celay Zirconia, In-Ceram Zirconia in dry condition were 806.5 MPa, 669.9 MPa, 605.6 MPa, respectively. There was a statistically significant difference in strength among the types (P<0.05). 2. After thermocycling, the average flexural strengths of CAD/CAM Zirconia, Celay Zirconia, In-Ceram Zirconia were 791.2 MPa, 604.2 MPa, 605.4 MPa, respectively. CAD/CAM Zirconia showed statistically significant higher strength(P<0.05). The others showed no significant difference after thermocycling(P>0.05). 3. After fatigue loading in wet condition. the average flexural strengths of CAD/CAM Zirconia, Celay Zirconia, In-Ceram Zirconia were 806.0 MPa, 674.9 MPa, 601.7 MPa, respectively. There was a significant difference in strength among the types(P<0.05). 4. There was no statistically significant difference in strength of the specimens according to experimental methods except for before and after thermocycling in Celay Zirconia(P>0.05). Conclusion: Besides high esthetic quality, zirconia had sufficiently high mechanical strength.

• Journal of Korea Multimedia Society
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• v.3 no.1
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• pp.63-76
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• 2000

Most work done in CSCW (Computer Supported Collaborative Work) system has been targeted toward supporting the exchange of documents or messages among group members, and yet support for cognitive aspects such as group organization, division and merge of work, and work flow control. The objective of the study is to provide CSCW environment for the engineering design process such as CAD (Computer Aided Design) and CASE (Computer Aided Software Engineering). The proposed DCWA (Distributed Collaborative Writing Aid) system suggests a mechanism that unifies the group organization, work division, and work flow control in the CAO, CASE, and software simulation tool. In particular, CAD relates the group and work partition by providing expressing the relation of drawing object (e.g., binding, attachment, and proportional scaling) which is owned by different members of group, and CASE combining with the simulation tool supports the flexibility of the work flow control. Simulating the prototype before manu-facturing a product can reduce time and cost in development.