• IMMUNE NETWORK
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• v.13 no.5
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• pp.194-198
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• 2013

Recent papers have shown that the initial event in the pathogenesis of autoimmune type 1 diabetes (T1D) comprises sensing of molecular patterns released from apoptotic ${\beta}$-cells by innate immune receptors such as toll-like receptor (TLR). We have reported that apoptotic ${\beta}$-cells undergoing secondary necrosis called 'late apoptotic' ${\beta}$-cells stimulate dendritic cells (DCs) and induce diabetogenic T cell priming through TLR2. The role of other innate immune receptors such as TLR7 or TLR9 in the initiation of T1D has also been suggested. We hypothesized that TLR2 blockade could inhibit T1D at the initial step of T1D. Indeed, when a TLR2 agonist, $Pam3CSK_4$ was administered chronically, the development of T1D in nonobese diabetic (NOD) mice was inhibited. Diabetogenic T cell priming by DCs was attenuated by chronic treatment with $Pam3CSK_4$, indicating DC tolerance. For the treatment of established T1D, immune tolerance alone is not enough because ${\beta}$-cell mass is critically reduced. We employed TLR2 tolerance in conjunction with islet transplantation, which led to reversal of newly established T1D. Dipeptidyl peptidase 4 (DPP4) inhibitors are a new class of anti-diabetic agents that have beneficial effects on ${\beta}$-cells. We investigated whether a combination of DPP4 inhibition and TLR2 tolerization could reverse newly established T1D without islet transplantation. We could achieve normoglycemia by TLR2 tolerization in combination with DPP4 inhibition but not by TLR2 tolerization or DPP4 inhibition alone. ${\beta}$-cell mass was significantly increased by combined treatment with TLR2 tolerization and DPP4 inhibition. These results suggest the possibility that a novel strategy of TLR tolerization will be available for the inhibition or treatment of established T1D when combined with measures increasing critically reduced ${\beta}$-cell mass of T1D patients such as DPP4 inhibition or stem cell technology.

• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.5
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• pp.565-570
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• 2015

Spread spectrum communications have increased interest due to their immunity to channel fading and low probability of intercept. One of the limitations of the traditional digital spread spectrum systems is the need for spreading code synchronization. Chaotic communication is the analogue alternative of digital spread spectrum systems beside some extra features like simple transceiver structures. In this paper, This paper was used instead of the digital modulation and demodulation carriers for use in the chaotic signal in a digital communication system among the chaotic modulation schemes, the Differential Chaos Shift Keying(DCSK) is the most efficient one because its demodulator detects the data without the need to chaotic signal phase recovery. Also Implementation of Differential Chaos Shift Keying Communication System Using Matlab/Simulink and the receiver con decode the binary information sent by the transmitter, performance curves of DCSK are given in terms of bit-error probability versus signal to noise ratio with spreading factor as a parameter and we compare it to BPSK modulation.

• 한국해양학회지
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• v.9 no.2
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• pp.10-18
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• 1974

The cold water mass around the southeast coast of the Korean Peninsula is analyzed by using CSK data from 1966 through 1970. It is shown that this water mass flows down from the region offshore of Jukbyun to the area of Youngil Bay along the 100meter contour line of bottom topography. In ordinary summer conditions when the current velocity in the Korea Strait is usually above about 50cm/sec and the wind direction is southwest, the cold water ascends to the surface and makes the surface temperature gradient large, unless disturbed by a tropical cyclon. The bottom water of the Korea Strait is formed by the stratification after the Tsushima intermediate water and the Japan Sea intermediate water have been mixed. In winter the Tsushima intermediate water with high salinity sinks rapidly around the inlet of the Japan Sea and prevents the Japan Sea intemediate water from entering the Korea Strait.

• 한국해양학회지
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• v.8 no.1
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• pp.4-8
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• 1973

Recent dynamic computations of zonal flow and analysis of oceanographic data of CSK in winter indicate year-to year variations in the location and dynmic structure of the Subtropic Countercurrent in the western North Pacific. In January 1966, the Subtropical Countercurrent migrated southward to 21$^{\circ}$- 22$^{\circ}$N Lat in association with the subsurface Subtropical Convergence. At the area of 25$^{\circ}$- 26$^{\circ}$N Lat, another surface thermal front was formed along which a stronger eastward flow of approximately 0.4kt is seen. On the section of 142$^{\circ}$E Long in January 1967, eastward flow appears at every interval of 2$^{\circ}$latitude in the northern waters of 20$^{\circ}$N Lat.

• Clinical and Experimental Pediatrics
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• v.52 no.6
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• pp.667-673
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• 2009

Purpose : Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections. The purpose of this study was to analyze TLR2 surface expressions and TLR2-mediated tumor necrosis factor-alpha ($TNF-{\alpha}$) and interleukin-6 (IL-6) production in patients with BCG vaccine-associated suppurative lymphadenitis. Methods : Peripheral monocytes were separated from 16 patients with BCG vaccine-associated suppurative lymphadenitis and 10 healthy controls using a magnet cell isolation kit. Monocytes ($1{\times}10^6$ cells/well) were incubated with a constant amount of $Pam_3CSK_4$ ($100{\mu}g/mL$) for 24 hours. TLR2 surface expression on monocytes was analyzed by FACS analysis and TLR-2 mRNA expression was determined by RT-PCR. TLR2-mediated $TNF-{\alpha}$ and IL-6 production were measured by ELISA. Results : In patients with BCG vaccine-associated suppurative lymphadenitis, low TLR2 expression on monocytes ($3.39{\pm}$1.2% versus $4.64{\pm}2.6%$) together with significantly lower TLR2 mRNA expression than in the healthy controls was seen after $Pam_3CSK_4$ stimulation. TLR2-mediated $TNF-{\alpha}$ and IL-6 production in patients with BCG vaccine-associated suppurative lymphadenitis ($TNF-{\alpha}$, $775.5{\pm}60.8pg/mL$; IL-6, $4,645.8{\pm}583.9pg/mL$) were also lesser than that in healthy controls ($TNF-{\alpha}$, $1,098.5{\pm}94.3pg/mL$; IL-6, $6,696.3{\pm}544.3pg/mL$). Conclusion : These findings suggest that low TLR2 expression on monocytes might be associated with increased susceptibility to BCG vaccine-associated suppurative lymphadenitis.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.4
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• pp.365-372
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• 2015

Aripiprazole (ARI) is a commonly prescribed medication used to treat schizophrenia and bipolar disorder. To date, there have been no studies regarding the molecular pathological and immunotoxicological profiling of aripiprazole. Thus, in the present study, we prepared two different formulas of aripiprazole [Free base crystal of aripiprazole (ARPGCB) and cocrystal of aripiprazole (GCB3004)], and explored their effects on the patterns of survival and apoptosis-regulatory proteins under acute toxicity and cytotoxicity test conditions. Furthermore, we also evaluated the modulatory activity of the different formulations on the immunological responses in macrophages primed by various stimulators such as lipopolysaccharide (LPS), pam3CSK, and poly(I:C) via toll-like receptor 4 (TLR4), TLR2, and TLR3 pathways, respectively. In liver, both ARPGCB and GCB3004 produced similar toxicity profiles. In particular, these two formulas exhibited similar phospho-protein profiling of p65/nuclear factor $(NF)-{\kappa}B$, c-Jun/activator protein (AP)-1, ERK, JNK, p38, caspase 3, and bcl-2 in brain. In contrast, the patterns of these phospho-proteins were variable in other tissues. Moreover, these two formulas did not exhibit any cytotoxicity in C6 glioma cells. Finally, the two formulations at available in vivo concentrations did not block nitric oxide (NO) production from activated macrophage-like RAW264.7 cells stimulated with LPS, pam3CSK, or poly(I:C), nor did they alter the morphological changes of the activated macrophages. Taken together, our present work, as a comparative study of two different formulas of aripiprazole, suggests that these two formulas can be used to achieve similar functional activation of brain proteins related to cell survival and apoptosis and immunotoxicological activities of macrophages.

• Journal of Satellite, Information and Communications
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• v.10 no.1
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• pp.62-66
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• 2015

This paper introduces various applications and contents of digital signage, and analyzes conventional communication techniques to increase communication range. To realize digital signage in long distance, this paper proposes a hybrid modulation scheme and analyzes its performance. To verify its performance in real channel environment, we mapped symbols and experimented data transmission and reception with a visible light communication module with USRP. As a result, we confirmed a data receiving range and power of transmission and reception of the hybrid modulation mode. Also, we showed that the proposed modulation scheme has better performance of communication range and power efficiency than that of the conventional QAM technique.

• Journal of the korean society of oceanography
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• v.35 no.4
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• pp.161-169
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• 2000

A seasonal circulation in the East China Sea and the Yellow Sea and its possible cause have been studied with CSK data during 1965-1989. Water mass distributions are clear in winter, but not in summer because the upper layer waters are quite influenced by atmosphere. To solve the problem, a water mass analysis by mixing ratio is used for the lower layer waters. The results show that the distribution of Tsushima Warm Current Water expands to the Yellow Sea in winter and retreats to the East China Sea in summer. It means that there is a very slow seasonal circulation between the East China Sea and the Yellow Sea: Tsushima Warm Current Water flows into the Yellow Sea in winter and coastal water flows out of the Yellow Sea in summer. By the circulation, the front between Tsushima Warm Current Water and coastal water moves toward the shelf break in summer so that the flow is faster in the deeper region. The process eventually makes the transport in the Korea Strait increase. The Kuroshio does not seem to influence the process. A possible mechanism of the process is the seasonal change of sea surface slope due to different local effects of surface heating and diluting between the East China Sea and the Yellow Sea.

• Korean Journal of Remote Sensing
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• v.37 no.1
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• pp.57-67
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• 2021

An earthquake occurred on 17 November 2017 in Pohang, South Korea with a strength of 5.4 Mw. This is the second strongest earthquake recorded by local authorities since the equipment was first installed. In order to improve understanding of earthquakes and surface deformation, many studies have been conducted according to these phenomena. In this research, we will estimate the surface deformation using the Okada model equation. The SAR images of three satellites with different wavelengths (ALOS-2, Cosmo SkyMed and Sentinel-1) were used to produce the interferogram pairs. The interferogram is used as a reference for surface deformation changes by using Okada to determine the source of surface deformation that occurs during an earthquake. The Non-linear optimization (Levemberg-Marquadrt algorithm) and Monte Carlo restart was applied to optimize the fault parameter on modeling process. Based on the modeling results of each satellite data, the fault geometry is ~6 km length, ~2 km width and ~5 km depth. The root mean square error values in the surface deformation model results for Sentinel, CSK and ALOS are 0.37 cm, 0.79 cm and 1.47 cm, respectively. Furthermore, the results of this modeling can be used as learning material in understanding about seismic activity to minimize the impacts that arise in the future.

• Journal of Microbiology and Biotechnology
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• v.20 no.12
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• pp.1724-1734
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• 2010

A phosphate-solubilizing bacterial strain isolated from Hippophae rhamnoides rhizosphere was identified as Rahnella sp. based on its phenotypic features and 16S rRNA gene sequence. The bacterial strain showed the growth characteristics of a cold-adapted psychrotroph, with the multiple plant growth-promoting traits of inorganic and organic phosphate solubilization, 1-aminocyclopropane-1-carboxylate-deaminase activity, ammonia generation, and siderophore production. The strain also produced indole-3-acetic acid, indole-3-acetaldehyde, indole-3-acetamide, indole-3-acetonitrile, indole-3-lactic acid, and indole-3-pyruvic acid in tryptophan-supplemented nutrient broth. Gluconic, citric and isocitric acids were the major organic acids detected during tricalcium phosphate solubilization. A rifampicin-resistant mutant of the strain exhibited high rhizosphere competence without disturbance to the resident microbial populations in pea rhizosphere. Seed bacterization with a charcoal-based inoculum significantly increased growth in barley, chickpea, pea, and maize under the controlled environment. Microplot testing of the inoculum at two different locations in pea also showed significant increase in growth and yield. The attributes of cold-tolerance, high rhizosphere competence, and broad-spectrum plant growth-promoting activity exhibited the potential of Rahnella sp. BIHB 783 for increasing agriculture productivity.