• 한국해양학회지
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• v.4 no.2
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• pp.83-86
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• 1969

해양관측의 세계적인 공통성으로 해서 염분검정법이 이미 오래 전부터 통일화 되었지만 근래에 와서는 용존산소량 정량법도 국제적인 Intercalibration을 하는 등규격화에의 기운이 나고 있다. 다시 Kuroshio 합동조사에서는 영양염의 정량에 있어 공통된 표준용액을 사용하므로써 조작상의 편리와 측정치의 신뢰성을 더욱 향상시키자는 의도에서 일본이 국제적인 영양염 표준용액의 조제 및 배포에 관한 안을 내어 1965년 Manila 회의를 거쳐 일본 상모중앙화학연구소의 관원씨가 이를 맡아 1966년부터 시작하여 1967년까지에 요오드산칼리움, 아질산염, 인산염, 규산염의 표준용액을 만들어 1968년 봄부터 시험적으로 일본국내와 동남아 수개국에 나누어 사용해 왔던 것이다. 다시 1968년 9월의 SCOR 의 영양염에 관한 Working Group 회의에서 CSK Std. Solution을 사용하여 세계각국에서 현재 사용하고 있는 영양염 분석방법의 Intercalibration을 하자는 회의가 있었고, 이것을 권고사항으로 SCOR에 보고하여 1968년 11월에 ICES가 승인하므로써 Intercalibration에 관한 원칙이 정해졌다. 동시에 Finland의 Koroleff씨와 Palmork씨가 organizer로 정해졌던 것이다. 이 보다 약간 앞서 본인이 상모중연에 가 있을 때 Std. Solution으로서 아질산염용액 만으로 각종무기질소화합물의 표준용액으로 대용한다는 것은 비합리적이므로 질산염과 암모늄염의 표준용액이 있어야 한다고 주장하여 우선 질산염용액을 추가로 만들기로 하여 1968년 11월부터 표준물질의 정제부터 시작 되었다. 1969년 1월에 Intercalibration 에 관한 구체적인 회의를 위해 Scripps 해양연구소에 관원, Wooster Rakestraw, Cieskes씨등이 모여 우선 일본상모중연에서 만들고 있는 인산염, 질산염, 아질산염, 규산염의 CSK 표준용액을 표준시료로하여 SCOR 과 ICES의 해양화학분과에서 선정한 세계 100개처에 나누어 현재 각자가 사용하고 있는 방법의 정밀도와 정확도를 check하는 소위 International intercalibration을 1969년 9월부터 시작하기로 확정을 보았고, 동시에 구체적인 지시가 있었던 것이다. 이시료를 받는 사람에게는 다만 그것의 농도범위만 알려주고 정확한 농도는 Koreleff와 관원씨만이 알고 있기로 하여 측정에 분석자의 주관이 개입되지 못하도록 했고, 분석치는 SCOR가 모아 해석하되 번호제로 하여 어떤 나라의 누구가 했다는 것은 밝히지 않기로 되어 있다. 이같은 내력으로 CSK Std. Solution이 국제적인 Intercalibration용의 표준시료로서 시험적으로 사용되기 까지는 되었으나, CSK Std. Solution 그자체에 관해서는 아직도 해결해야 할 점, 개량을 요하는 점이 많다. 이하에서는 주로 개량을 요하는 점에 관해 몇가지 언급하고자 한다.

• Korean Journal of Medicinal Crop Science
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• v.27 no.6
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• pp.365-375
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• 2019

Background: Oxidative stress plays an important role in neuro-degenerative disorders such as Alzheimer's disease. Oxidative stress is mediated by reactive oxygen species (ROS), which are implicated in the pathogenesis of numerous diseases, and account for the toxicity of a wide range of compounds. Methods and Results: In order to study the neuro-protective effect of the complex extracts of Aster scaber Thunberg (AS) and Chaenoleles sinensis Koehne (CSK) against hydrogen peroxide in PC12 cells, cell viability was evaluated by the MTT assay using tetrazole, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and the intracellular ROS levels were determined the by 2',7'-dichlorofluorescein diacetate (DCF-DA) assay. In order to examine the anti-amnesic effects of the complex extracts of AS and CSK, behavioral tests were performed on male ICR mice. The ameliorating effect of the complex extracts against Aβ_1-42-induced learning and memory impairment was analyzed by y-maze and passive avoidance tests. The AS and CSK extracts showed neuro-protective activity both in vitro and in vivo, and the neuro-protective effect of their 60 : 40 (AS : CSK) mixture was better than that of the other mixtures. Moreover, the complex extracts synergistically inhibited acetylcholinesterase activity and rapid peroxidation. Conclusions: A mixture of the AS and CSK extracts could be used to develop functional foods and serve as raw materials for the development of therapeutics against Alzheimer's disease.

• International Journal of Oral Biology
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• v.41 no.1
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• pp.17-23
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• 2016

Chronic/cyclic neutropenia, leukocyte adhesion deficiency syndrome, Papillon-$Lef{\grave{e}}vre$ syndrome, and $Ch{\grave{e}}diak$-Higashi syndrome are associated with severe periodontitis, suggesting the importance of neutrophils in the maintenance of periodontal health. Various Toll-like receptor (TLR) ligands are known to stimulate neutrophil function, including FcR-mediated phagocytosis. In the present study, the effect of TLR2 activation on the non-opsonic phagocytosis of oral bacteria and concomitant production of reactive oxygen species (ROS) by human neutrophils was evaluated. Neutrophils isolated from peripheral blood were incubated with Streptococcus sanguinis or Porphyromonas gingivalis in the presence of various concentrations of $Pam_3CSK_4$, a synthetic TLR2 ligand, and analyzed for phagocytosis and ROS production by flow cytometry and chemiluminescence, respectively. $Pam_3CSK_4$ significantly increased the phagocytosis of both bacterial species in a dose-dependent manner. However, the enhancing effect was greater for S. sanguinis than for P. gingivalis. $Pam_3CSK_4$ alone induced ROS production in neutrophils and also increased concomitant ROS production induced by bacteria. Interestingly, incubation with P. gingivalis and $Pam_3CSK_4$ decreased the amounts of ROS, as compared to $Pam_3CSK_4$ alone, indicating the possibility that P. gingivalis survives within neutrophils. However, neutrophils efficiently killed phagocytosed bacteria of both species despite the absence of $Pam_3CSK_4$. Although P. gingivalis is poorly phagocytosed even by the TLR2-activated neutrophils, TLR2 activation of neutrophils may help to reduce the colonization of P. gingivalis by efficiently eliminating S. sanguinis, an early colonizer, in subgingival biofilm.

• Journal of Nutrition and Health
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• v.49 no.4
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• pp.241-246
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• 2016

Purpose: Aloe-emodin (AE), an ingredient of aloe, is known to exhibit anti-inflammatory activities. However, little is known about the underlying molecular mechanisms of its inflammatory modulatory activity in vitro. In the present study, we investigated the anti-inflammatory potential of AE using $Pam_3CSK_4$-stimulated macrophages. Methods: RAW 264.7 macrophages were treated with AE (0~20 mM) for 1 h, followed by treatment with $Pam_3CSK_4$ for 1 h. After incubation, mRNA expression levels of cytokines were measured. The effect of AE on TLR2-related molecules was also investigated in $Pam_3CSK_4$-stimulated RAW 264.7 macrophages. Results: AE attenuated $Pam_3CSK_4$-stimulated expression of proinflammatory cytokines, including tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6), and interleukin-$1{\beta}$ ($IL-1{\beta}$) in RAW 264.7 macrophages. Two concentrations of AE ($10{\mu}M$ and $20{\mu}M$) effectively reduced mRNA expression of TLR2 by 41.18% and 54.43%, respectively, compared to that in control cells (p < 0.05). AE also decreased nuclear factor-kappa B ($NF-{\kappa}B$) activation and mitogen-activated protein kinase (MAPK) phosphorylation. Phosphorylation levels of ERK1/2, p38, and JNK were markedly reduced by $20{\mu}M$ AE. In particular, AE decreased phosphorylation of ERK in a dose-dependent manner in $Pam_3CSK_4$-stimulated RAW 264.7 macrophages. Conclusion: Our data indicate that AE exerts its anti-inflammatory effect by suppressing TLR2-mediated activation of $NF-{\kappa}B$ and MAPK signaling pathways in macrophages.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2003.10a
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• pp.66-66
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• 2003

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.12
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• pp.1797-1805
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• 1993

An algorithm for the threshold decision from the maximum mismatching correlation value in a direct-sequence spread-spectrum system is presented. This algorithm is named the TDMMC(Threshold Decision from the Maximum Mismatching Correlation value). The purpose of the algorithm is to set the decision threshold in the system which will provide large probability of signal detection. Using this algorithm, the proper setting of the threshold for various SNRs is possible. An additional block called the Threshold Block is used to improve the system performance. The result from the computer simmulation has shown that appling the TDMMC to the noncoherent DS/SS-CSK system can achieve performance improvement.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.40 no.3
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• pp.595-601
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• 2015

These days, research related to Intelligent Transportation System (ITS) technology is being widely considered. ITS is inevitable for future transportation systems to reduce accidents, congestion, and offer a smooth flow of traffic. The use of Visible Light Communication (VLC) in ITS systems has been considered widely because of its EMC/EMI free and LED infrastructure reusable properties. Among the VLC schemes, this study analyzed the performance of the Color Shift Keying (CSK) scheme under a Vehicle-to-Infrastructure (V2I) downlink scenario to verify the capability of CSK as a communication tool for ITS. By modeling daylight noise using the modified Blackbody radiation model, this study examined the performance of V2I VLC under daytime conditions. The relationship between BER, the communication distance, and the amount of ambient-light noises under the pre-described V2I scenario were determined by simulations.

• KIPS Transactions on Computer and Communication Systems
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• v.11 no.1
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• pp.35-42
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• 2022

Visible light communication (VLC) is a method of transmitting data through LED blinking and is vulnerable to eavesdropping because the illumination affects the wide range of area. IEEE standard 802.15.7 defines On-Off Keying (OOK), Variable Pulse Position Modulation (VPPM), and Color Shift Keying (CSK) as modulation. In this paper, we propose an encryption method in VPPM for secure communication. The VPPM uses an encoding method called 4B6B where 16 different outputs are represented with 6-bit. This paper extends the number of outputs to 20, to add complexity while not violating the 4B6B generation conditions. Then each entry in the extended 4B6B table is scrambled using vigenère cipher. The probability of decrypting each 6-bit data is $\frac{1}{20}$. Eavesdropper should perform $\sum\limits_{k=1}^{n}20^k$ number of different trials to decrypt the message if the number of keys is n. The proposed method can be applied to OOK of PHY II and CSK of PHY III. We further discuss the secure encoding that can be used in OOK and CSK without performance degradation.

• The Korean Journal of Community Living Science
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• v.26 no.4
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• pp.761-774
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• 2015

This study examines the dietary life, weight control, perceived body image, self-esteem, and eating disorder of female college students residing in Korea and China. With approval by the IRB of Pusan National University, a survey was conducted in Korea and China. A total of 574 subjects participated in the survey, and they were divided into three groups: 153 Korean female college students residing in Korea (KSK), 180 Chinese female college students residing in Korea (CSK), and 241 Chinese female college students residing in China (CSC). The group of underweight subjects far exceeded the overweight and obese groups, but there was no significant difference (p<0.05). The CSC group showed the highest food intake frequency and eating habit scores, and the KSK group, the lowest (p<0.05). However, the KSK group showed the highest daily life habit score, followed by the CSK and CSC groups, in that order. All groups showed high weight control experience rates mainly for losing weight. In particular, the KSK group showed a much higher rate than the CSC and CSK groups. All groups wanted much thinner body shapes than their actual shapes, resulting in high percentages of body image dissatisfaction. The KSK group showed a higher self-esteem score than the CSC group. The average EAT-26 score was similar across the three groups, but the percentage of eating disorders was much higher in the KSK group than in the CSC and CSK groups.

• Journal of The Korean Association For Science Education
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• v.33 no.3
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• pp.597-625
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• 2013

This study explored how teachers and students in different countries discursively interact to build 'Classroom Science Knowledge' (CSK) - the knowledge generated situatedly in the context of the science classroom. Data came from publicly released $8^{th}$ grade science classroom videos of five nations who participated in the Third TIMSS (Trend in International Mathematics and Science Study) video study. A total of ten video-recorded science lessons and their verbatim transcripts were selected and analyzed using a framework developed by the researchers of the study. It was revealed that a range of discourse modes were utilized and these modes were often sequentially connected to build CSK in the science classrooms. Although dominant discourse modes and their sequences varied among different lessons or different countries, the study identified three salient patterns of science classroom discourse: teacher-guided negotiation and the sequences of exploring - building on the shared and retrieving - elaborating. These patterns were found to be different from the discursive features commonly witnessed in the community of professional scientists and interpreted as implying the existence of unique epistemic cultures shared in science classrooms of different countries. Further studies are suggested to reveal detailed characteristics of these epistemic cultures of science classrooms, as well as to confirm whether any cultural traits inherently shape the differences in science classroom discourse among different nations.