• Journal of Haehwa Medicine
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• v.21 no.1
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• pp.11-21
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• 2012

New onset diabetes is a major complication after kidney transplantation. However, the natural course of posttransplantation diabetes mellitus (PTDM) remains unclear. The aim of this study was to demonstrate the detailed natural courses of PTDM according to the onset and persistency of hyperglycemia, and to investigate risk factors for development of different courses of PTDM in renal allograft recipients. The purpose of this study is to develop novel immune suppressants for PTDM using of action mechanism of them. The use of immunosuppressive drugs in transplanted patients is associated with the development of diabetes, possibly due to ${\beta}$-cell toxicity. To better understand the mechanisms leading to post-transplant diabetes, we investigated the actions of prolonged exposure of ${\beta}$-cells to therapeutical levels of tacrolimus (FK506) or cyclosporin A(CsA). The immunosuppressive drug cyclosporine(CsA) is a potent agent widely used after organ transplantations and various autoimmune disorders. After using CsA, some patients suffer severe complications including renal and vascular toxicity. The renal or vascular toxicity is influenced by the degree of the endothelial damage. FK506(tacrolimus) is a widely used immunosuppressive agent in the treatment of various medical conditions, including autoimmune disease, bone marrow and organ transplantations. We found some interesting clusters and confirmed the feasibility of cDNA microarray in the study of Immunosuppressant. In this study, we investigated gene expression patterns induced by Immunosuppressant in RIN-m5F of rat insulinoma cell line. Gene expressions evaluated using cDNA microarry in two clusters were increased or decreased. this study provides comprehensive comparison of the patterns of gene expression changes induced by CsA and FK506 in ${\beta}$-cells. This study could establish that the mode of action mechanism by which currently used insulin inhibitors inducing PTDM could be elucidated at least in part, which raises the possibility that novel immune suppressive PTDM can be developed. The molecular biological study on PTDM will also contribute the progress in diabetes research field as well as in that of PTDM.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.2
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• pp.23-30
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• 2010

The research presents moisture content measuring and calibration method of road pavement, especially asphalt concrete pavement for performance evaluation or remaining life prediction using Time Domain Reflectometry(TDR) sensor, CS616 made by campbell INC. Before calibration test of CS616, accomplished a sensor verification tests. Verification test items were covering depth and interference effect of two CS616 sensors, temperature effects between $5^{\circ}C\sim25^{\circ}C$ and compaction ratio effects. Covering depth and interference effects between two CS616 sensors were just small and the effects of temperature and compaction ratio effected a Volumetric Moisture Contents at $\pm6%$ under disregard appeared with the fact that was possible. Also, obtained the calibration equation of the subgrade and subbase course, $R^2$ showed above of all 0.9.

• Journal of Convergence for Information Technology
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• v.11 no.1
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• pp.167-174
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• 2021

The purpose of this study is to examine the effect of computational thinking course on learning flow and collaborative self-efficacy of university students and to explore the effectiveness of computational thinking course as liberal arts education. For this study, 177 freshmen at a university in Chungnam Province were surveyed learning flow and collaborative self-efficiency. The collected data were analyzed with Stata IC 14 for ��2 test and t-test. The results of this study are as follows. First, the learning flow of students who took computational thinking course were significantly higher(t=3.837 p<.001) compared to those who did not. Second, the collective self-efficiency of students who took computational thinking course were significantly higher(t=2.277 p<.01) compared to those who did not. Therefore the results show that computational course has positive effects on learning flow and collaborative self-efficiency of university students. Based on these findings, discussions and implications were presented on the importance and effectiveness of computational thinking course.

• Journal of Convergence for Information Technology
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• v.7 no.6
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• pp.19-24
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• 2017

The purpose of this study is to investigate the relationship among the Clinical learning environment, clinical practice course satisfaction and the major satisfaction of nursing students. The subjects of this study were included 118 nursing students in one area. Data collection was conducted in September 20 17, and data analysis was descriptive statistics and Pearson's correlation. The results of the study showed that the average of the Clinical learning environment was $3.32{\pm}0.41$, the average clinical practice course satisfaction was $3.88{\pm}0.55$ and the average level of satisfaction was $3.99{\pm}2.30$. Clinical Practice Environment and Clinical Practice Course Satisfaction was (r=.586, p=.000), and the Clinical Practice Course Satisfaction with Major satisfaction was (r=.560, p=.000), Clinical Learning Environment and Major Satisfaction significant positive correlation (r=.530, p=.000). In order to increase resilience, it is necessary to improve the clinical practice environment and the major satisfaction through a detailed study.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.335-344
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• 2021

The purpose of this paper is the development of course data models and learning achievement computation algorithms for enabling the course-embedded assessment(CEA), which is essential of competency-based education in higher education. The previous works related CEA have weakness in the development of the systematic solution for CEA computation. In this paper, we propose data models and algorithms to implement competency-based assessment system. Our data models are composed of a layered architecture of learning outcomes, learning modules and activities, and an associative matrix of learning outcomes and activities. The proposed methods can be applied to the development of the course-embedded assessment system as core modules. We evaluated the effectiveness of our proposed models through applying the models to a practical course, Java Programing. From the result of the experiments we found that our models can be used in the assessment system as a core module.

• Tuberculosis and Respiratory Diseases
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• v.59 no.4
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• pp.397-405
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• 2005

Background : Laminin-1 is known to have regular functions in the development and course of differentiation of the lungs. The morphogenesis and distribution of laminin-1 still remains as a mystery and its distribution and changes in the molecular structure of laminin-1 in the pathogenesis of the lung still is a subject of great controversy. In this study, experiments were done to delineate the distribution and changes in the amount of laminin-1 after inducing inflammation of the lungs by exposing experimental animals to CS gas and especially, to find compositions of laminin-1 within type II pneumocytes. Materials and Methods : The experimental subjects of study were newborn rats and the extracted tissue from the experimental rats were viewed under light microscope and electron microscope after the sections were treated with immunohistochemical methods and immunogold reaction methods using bounded gold particles. Results : 1) Lymphocytes and mononuclear phagocytes invaded the alveolar septa in the 2 day group rats after CS gas exposure and intense interstitial inflammation was seen in the 3 day group. 2) Laminin immunoreactions decreased to a moderate degree in the 2 and 3 day group rats after CS gas exposure and strong laminin immunoreactions were seen again in the 5 and 7 day group rats. 3) Gold particles in basal lamina of the lung blood-air barrier decreased and in the type I pneumocytes decreased in the 2 and 3 day group rats after CS gas exposure. 4) Gold particles were seen only on the surface of the cell membranes of type II pneumocytes of the 1 and 2 day group rats after CS gas exposure. 5) Few gold particles around the lamellar bodies and cytoplasm of type II pneumocytes in the control rat group and at 12 hours after CS gas exposure. Gold particles are seen only on the surface of type II pneumocytes of the 1 and 2 day group rats after CS gas exposure and are evenly distributed in small amounts in the cells of the 3 day group after CS gas exposure. Conclusion : CS gas exposure in the rats caused inflammation of lung alveolar septa and also induced a decrease in laminin-1 in basal lamina and loss of laminin-1 in the cytoplasm of type II pneumonocytes. As the inflammatory cells disappeared, an increase in the distribution of laminin-1 occurred. This reflects tissue regeneration functions of laminin-1 in the pneumocytes of rats and the distribution of laminin-1 in type II pneumocytes can be seen through the electron microscope using immunogold methods.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6451-6455
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• 2015

Background: Primary bone neoplasms are rare, contributing only 0.2% of the global burden of all human malignancies. Osteosarcoma (OS) and chondrosarcoma (CS) are the most common malignancies of bone. The giant cell tumor of bone (GCTb) is a benign tumor with behavior characterized by osteolytic bone destruction. The OS, CS and GCTb affect both sexes, all races and generally have incidence peaks regarding the age of the patient which vary according to the tumor type. We analyzed the incidences of OS, CS and GCTb and their relations with gender and age in patients treated in the National Rehabilitation Institute (INR, for its acronym in Spanish) over a period of nine years. Materials and Methods: In the study period, clinic pathological data for 384 patients were obtained with clinical, radiological and histopathological diagnosis for OS, GCTb and CS. Data analysis was performed using the chi-square and Fisher's exact tests. Results: From 2006 to 2014 were recorded 384 cases of bone malignancies in the database of INR. The GCTb had the highest incidence (53.1%), followed by OS (31.3%) and finally the CS (15.6%). The overall average age was $33.6{\pm}15.8$ years and the overall frequency of gender had a ratio of 1/1.03 male/female. The states with the highest incidence were Distrito Federal and Estado de Mexico with 29.2% and 25.3% respectively. Malignant neoplasms of bone assessed in the course of nine years show three significant increases in 2008, 2011 and 2014 (p=0.14). We found association between sex and tumor type (p=0.03), GCTb and CS predominated in females (54.9% and 56.6% respectively), while for the OS males were most affected (59.1%). Age was different in relation with tumor type (p=0.0001), average age was $24.3{\pm}11.2$ years for OS, $34.5{\pm}13$ years for GCTb and $49.2{\pm}18.5$ years for CS. Furthermore, associations of tumor type with topographic location of the primary tumor (P=0.0001) were found. Conclusions: In this study we can see that incidence of musculoskeletal tumor in our population is continuously increasing and in nine years an approximately 200% increase of musculoskeletal tumor cases was observed.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.281-285
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• 2018

The purpose of this research is to make a Flipped-MOOC model which can be applied and practiced in the college course after analyzing the characteristics and cases of MOOC and Flipped learning. For this, this study implemented the following tasks. First, this study analyzed the management and class types of MOOC and flipped learning through literature research. Secondly, flipped learning was applied in the course for a semester and the strong point and weak point of the course was analyzed and the alternative was suggested. Thirdly, the core ideas and strategies of Flipped-MOOC model was deducted for enhancing the participation and interaction of the students in the course which uses the MOOC content and applies flipped learning, and the instructional strategies and direction for the effective management in the real educational field was suggested. As a result, Flipped-MOOC model is expected to contribute for the educational revolution, change and quality improvement, and it is expected that Flipped-MOOC model might contribute to the lifelong education and educational competitiveness.

• Journal of Life Science
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• v.9 no.1
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• pp.9-13
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• 1999

Reduced thiols were important compounds for the maintenance of leukemia and lymphoma cell survival (and growth). In the course of examining the microenvirn-mental effects on lymphoma and leukemia cell growth, we found that cysteine suppressed apoptosis in these cells. In a present study, in order to investigate the role of cystein on the suppression of apoptotic cell death, we used CS21, P388, and L1210 cell lines. The addition of BSO, an inhibitor of glutathione synthase, induced apoptosis of these cells by blocking the cellular uptake of cysteine in CS21 cells. Although L1210 cells underwent apoptosis without thiol compounds, the addition of these compounds suppressed the apoptosis and promoted the growth or L1210 cells. When specific inhibitors of caspase3-like proteases, but not caspase1-like proteases, were activated during the L1210 cell apoptosis but the addition of thiol compounds suppressed the activation of caspase3-like proteases. These results suggest that reduced thiols including cysteine play an important role in the suppression of cell apoptosis by inhibiting the activation of caspase3-like proteases.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.1
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• pp.41-47
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• 2018

Radioactive substances, especially $^{137}Cs$ discharged in the course of Nuclear Power Plant Accident or maintenance of power plants, cause contamination of the soil. For habitation of residents and reuse of industrial land, it is inevitably necessary to decontaminate the soil. This study examines a soil washing process that has actually been used for washing of radioactive-contaminated soil. The soil washing process uses a washing agent to weaken surface tension of the soil and cesium, separating cesium from the soil. In this study, in order to raise the efficiency of the process, a flocculating agent was added to the washing water to remove fine soil and cesium. The cesium concentrations before and after applying the flocculating agent to cesium solution were measured through ICP-OES. When using 0.1 g of J-AF flocculating agent in the experiment, the maximum Cs removal performance was approximately 88%; the minimum value was 67%. Species combinations between cesium and soil were predicted using Visual MINTEQ Code; the ability to reuse the washing water or not, and the removal rate of the fine soil, determined via measurement of the turbidity after applying the flocculating agent, were determined.