• Proceedings of the Korean Nuclear Society Conference
• /
• 2001.05a
• /
• pp.112.1-112
• /
• 2001

• 한국전기화학회:학술대회논문집
• /
• 2003.04a
• /
• pp.56-56
• /
• 2003

• 대한예방의학회:학술대회논문집
• /
• 1998.10b
• /
• pp.196-197
• /
• 1998

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.5
• /
• pp.2031-2037
• /
• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• Journal of the Korean Electrochemical Society
• /
• v.11 no.1
• /
• pp.6-10
• /
• 2008

The amount of methanol crossover was measured with changing the operating condition by using a liquid methanol concentration sensor. Appropriate operating condition was discussed in terms of methanol crossover. Mechanism of methanol crossover was classified into three items which are diffusion, convection and electro-osmosis. Contribution of each mechanism to methanol crossover and the effect of operating condition were analyzed with varying methanol concentration, pressure difference between anode and cathode, current, temperature, and stoichiometry of anode fuel. Among the three mechanisms diffusion affected mostly and electro-osmosis effect was observed only under high methanol concentration.

• Korean Journal of Microbiology
• /
• v.49 no.1
• /
• pp.1-7
• /
• 2013

During meiosis, genetic recombinants are formed by homologous recombination accompanying with the programmed double-strand breaks (DSBs) and strand exchanges between homologous chromosomes. The mechanism is generated by recombination intermediates such as single-end invasions (SEIs) and double-Holliday junctions (dHJs), and followed by crossover (CO) or non-crossover (NCO) products. Our study was focused on the analysis of meiotic recombination intermediates (DSBs, SEIs, and dHJs) and final recombination products (CO and NCO). We identified these meiotic recombination intermediates using DNA physical analysis under HIS4LEU2 "hot spot" system in budding yeast, Saccharomyces cerevisiae. For DNA physical analysis, when the hot spot locus is recognized by restriction enzyme from synchronous meiotic cells, the fragmented DNA that are forming recombination intermediates can be detected and quantified through Southern hybridization analysis. Our study suggests that this system can analyze the structural change of recombination intermediates during DSB-SEI transition, double-Holiday junctions and crossover/non-crossover products in meiosis.

• The Korean Journal of Applied Statistics
• /
• v.26 no.4
• /
• pp.675-686
• /
• 2013

The Korea Food and Drug Administration(KFDA) recommends the use of a $2{\times}2$ crossover design to assess the bioequivalence of generic drugs. However, a standard $2{\times}2$ crossover design for bioequivalence trials is often considered problematic due to ethical and economic issues as highly variable drugs are usually required by large numbers of subjects when designing the trial. To overcome this problem a $2{\times}4$ crossover design has been a recommended option as per US regulations; in addition, a $2{\times}3$ crossover design has also recently drawn special attention as an efficient alternative. The current KFDA regulation requires an ANOVA table for every bioequivalence study; however, ANOVA tables of $2{\times}4$ and $2{\times}3$ crossover designs have never been published in the literature. This study shows the derivation of tables of analysis of variance for a $2{\times}4$ cross-over design and a $2{\times}3$ cross-over design. We also suggest a sample size formulas for $2{\times}2$, $2{\times}4$ and $2{\times}3$ crossover designs to provide information on the selection of efficient designs for highly variable drugs.

• Korean Journal of Social Welfare
• /
• v.60 no.3
• /
• pp.253-274
• /
• 2008

The link between work life and family life is an essential subject matter in understanding the lives of dual-earner couples. Concepts of spillover and crossover explain the link between work and family. The present study examines both the positive and negative aspects in these processes. The data come from the Sloan Working Families Study conducted by the Alfred P. Sloan Center on Parents, Children, and Work and NORC at the University of Chicago. The Experience Sampling Method employed explores directly the daily life experiences of the participants. The data were analysed using t-test. Both spillover and crossover were found in the lives of dual-earner couples in this study. Men and women brought happy emotions at work to home, but the data provide limited support for spillover of negative emotions. Gender differences were more apparent in examining the process of crossover. Men appear responsive to the positive and negative emotional experiences their spouse brought home while women were found not to be responsive to their spouses' positive emotional experiences at work. Furthermore, the analysis revealed an interesting trend concerning the emotions of working couples in that they generally seem to recover to their average level of emotions once home. This suggests that home can be a respite from strong emotions, a comforting place. By looking closely into the emotions experienced by working parents in their daily lives, this study adds contextual understanding concerning the link between work and family life. The findings on the effects of positive experiences at work invite social work practitioners and researchers to further investigate the phenomena of spillover and crossover processed in greater detail, taking into account this contextual aspect of family life as well as the work life of dual-earner couples.

• The KIPS Transactions:PartC
• /
• v.15C no.1
• /
• pp.37-44
• /
• 2008

In order to minimize the signaling delay for a resource reservation on the new routing path after the handover of Mobile Node(MN) is completed, it is important to discover the crossover node where the old and new routing paths meet. With the 크로스오버 노드 being found, the signaling messages only need to be transferred on the changed part of the end-to-end path. The crossover node is generally discovered using the end-to-end Session ID(SID) of the established session between MN and Correspondent Node(CN). However, in the Hierarchical Mobile IPv6(HMIPv6) network, if the Mobile Anchor Point (MAP) reserves the resource by aggregate with the Home Agent(HA), the crossover node discovery cannot be performed in the general way since the aggregate SID that has established between the previous MAP and HA is different from the that of the current MAP and HA after MN's handover. In this paper, we propose a mechanism to discover the crossover node within the tunnel between the MAP and the HA in an HMIPv6 network, assuming that the Next Steps in Signaling(NSIS) is deployed for the resource reservation and the aggregate reservation is applied over the MAP and HA tunnel. The local repair required for the change of path is performed upon the crossover node discovery. The simulation results show that the proposed scheme reduces the signaling delay for the reservation and outperforms the existing scheme with respect to throughput during the handover.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.9
• /
• pp.2835-2838
• /
• 2014