• Journal of Gastric Cancer
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• v.6 no.4
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• pp.221-226
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• 2006

Purpose: Controversy still exists over in the prognostic significance of microscopic tumor cell dissemination in patients with cancer. This study evaluated the prognostic implication of isolated tumor cells in the bone marrow of patients with gastric cancer. Materials and Methods: Four hundred nineteen (419) patients who underwent surgery for gastric cancer between June 1998 and July 2000 were enrolled in the study. Bone marrow aspirate was obtained from the iliac crest before removal of the primary tumor. Mononuclear cells were isolated and stained with AE-1/AE-3 PAN-CYTOKERATIN. Results: Cytokeratin-positive cells were found in the bone marrow of 219 patients (52.3%). The incidence varied significantly with the depth of invasion (P=0.021) and the stage (P=0.026). The five-year survival rate of patients with cytokeratin-positive cells was 74.1% and that of patients without cytokeratin-positive cells was 81.1%(P=0.2481). There were no significant differences in the recurrence rate and the site of recurrence according to whether or not cytokeratin-positive cells were present in the bone marrow. Conclusion: The presence of cytokeratin-positive cells in the bone marrow of patients with gastric cancer did not predict outcome and recurrence. Therefore, it cannot be used as a prognostic factor.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.7
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• pp.920-926
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• 2019

In this study, we analyzed the erosion variation of beach area at Haeundae Beach after coastal improvement project using video monitoring system operated by the Coastal Erosion Monitoring (Ministry of Oceans and Fisheries). Haeundae Beach was well maintained and stabilized following large scale nourishment through coastal improvement project despite of seasonal fluctuations. However, multiple typhoons over the last two years caused beach stabilization patterns and seasonal fluctuations to lost equilibrium, resulting in rapid erosion. In particular, the sandy beach was eroded by typhoon Solic and Kongray in 2018 and failed to recover beach area in winter by seasonal fluctuations. And due to multiple typhoons in 2019, the beach area was reduced 9.5 % (12,607 ㎡) year-on-year. According to analyze the observed wave and beach area data in Haeundae, the tendency of erosion and sedimentation was influenced by seasonal incident wave direction for each section(west, center and east part). Therefore, to identify the causes of decreasing seasonal fluctuation characteristics and continuous erosion, hereafter, more precise monitoring of different factors are needed, such as the crest heights of submerged breakwater and its loss of function, and sand leakage to the outside around submerged breakwater.

• The Journal of Korean Academy of Prosthodontics
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• v.32 no.4
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• pp.484-514
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• 1994

Cantilever bridge is widely used by mny clinicians, but its worst mechanical character, so called Class I lever system, makes dentists hesitate to restore the missing tooth with it. Therefore it is important to study stress of the cantilever bridge. In this study, two models of cantilever bridges that restores the missing mandibular second molar with two abutment teeth were constructed. One model was a type of cantilever bridge supported by a normal alveolar bone, the other one was supported by an alveolar bone resorbed to its 1/3 of root length. Maximum bite force(550N) and funtional maximum bite force(300N) were vertically applied to the distal end of the pontic, distal 1/3, and distal half of the pontic. And each force was also applied to centric occlusal contacts as a distributed force. Total 16 loading cases were compared and analyzed with 3-dimensional finite element method. The results were as follows: 1. The stress was concentrated on the joint of the pontic and the retainer, grooves, and distal cervical margin of the posterior retainer. 2. In case of maximum bite force(550N) at the end of the pontic, the risk of fracture at the joint of the pontic and the retainer was high. 3. In case of distributed force in centric occlusion and functional maximum bite force(300N), the stresses were less than the yield strength of the type VI gold for any loading cases. 4. In case of alveolar bone resorption, the occlusal force to the cantilever pontic caused more stress on the root apex and less stress on the alveolar crest region of the distal surface of the posterior abutment. 5. In case of alveolar bone resorption, the displacement was larger than that of normal alveolar bone in all loading cases.

• Applied Microscopy
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• v.28 no.2
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• pp.139-158
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• 1998

The development of the superior cervical ganglion was studied by electron microscopic method in human fetuses ranging from 40 mm to 260 mm of crown-rump length (10 to 30 weeks of gestational age). At 40 mm fetus, the superior cervical ganglion was composed of clusters of undifferentiated cell, primitive neuroblast, primitive supporting cell, and unmyelinated fibers. At 70mm fetus, the neuroblasts and their processes were ensheated by the bodies or processes of satellite cells. The cytoplasm of the neuroblast contained rough endoplasmic reticulum, mitochondria, Golgi complex, Nissl bodies and dense-cored vesicles. As the neuroblasts grew and differentiated dense-cored vesicles moved away from perikaryal cytoplasm into developing processes. Synaptic contacts between the cholinergic axon and dendrites of postganglionic neuron and a few axosomatic synapses were first observed at 70 mm fetus. At 90 mm fetus the superior cervical ganglion consisted of neuroblasts, satellite cells, granule-containing cells, and unmyelinated nerve fibers. The ganglion cells increased somewhat in numbers and size by 150 mm fetus. Further differentiation resulted in the formation of young ganglion cells, whose cytoplasm was densely filled with cell organelles. During next prenatal stage up to 260 mm fetus, the cytoplasm of the ganglion cells contained except for large pigment granules, all intracytoplasmic structures which were also found in mature superior cervical ganglion. A great number of synaptic contact zones between the cholinergic preganglionic axon and the dendrites of the postganglionic neuron were observed and a few axosomatic synapses were also observed. Two morphological types of the granule-containing cells in the superior cervical ganglion were first identified at 90 mm fetus. Type I granule-containing cell occurred in solitary, whereas type II tended to appeared in clusters near the blood capillaries. Synaptic contacts were first found on the solitary granule-containing cell at 150 mm fetus. Synaptic contacts between the soma of type I granule-containing cells and preganglionic axon termials were observed. In addition, synaptic junctions between the processes of the granule- containing cells and dendrites of postganglionic neuron were also observed from 150 mm fetus onward. In conclusion, superior cervical ganglion cells and granule-containing cells arise from a common undifferentiated cell precursor of neural crest . The granule-containg cells exhibit a local modulatory feedback system in the superior cervical ganglion and nay serve as interneurons between the preganglionic and postganglionic cells.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.1
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• pp.81-96
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• 2007

Nonlinear shoaling characteristics over surf zone are numerically investigated based on spatially averaged NavierStokes equation. We also test the validity of gradient model for turbulent stresses due to wave breaking using the data acquainted during SUPERTANK LABORATORY DATA COLLECTION PROJECT(Krauss et al., 1992). It turns out that the characteristics length scale of breaking induced current is not negligible, which firmly stands against ever popular gradient model, ${\kappa}-{\varepsilon}$ model, but favors Large Eddy Simulation with finer grid. Based on these observations, we model the residual stress of spatially averaged NavierStokes equation after Lagrangian Dynamic Smagorinsky(Meneveau et al., 1996). We numerically integrate newly proposed wave equations using SPH with Gaussian kernel function. Severely deformed water surface profile, free falling water particle, queuing splash after landing of water particle on the free surface and wave finger due to structured vortex on rear side of wave crest(Narayanaswamy and Dalrymple, 2002) are successfully duplicated in the numerical simulation of wave propagation over uniform slope beach, which so far have been regarded very difficult features to mimic in the computational fluid mechanics.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.1
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• pp.55-68
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• 2020

In order to investigate the hydraulic characteristics of a boundary layer streaming over the beach cusps appeared in swells prevailing mild seas, we numerically simulated the shoaling process of Edge waves over the beach cusp. Synchronous Edge waves known to sustain the beach cusps could successfully be duplicated by generating two obliquely colliding Edge waves in front of beach cusps. The amplitude A_B and length L_B of Beach Cusp were elected to be 1.25 m and 18 m, respectively based on the measured data along the Mang-Bang beach. Numerical results show that boundary layer streaming was formed at every phase of shoaling process without exception, and the maximum boundary layer streaming was observed to occur at the crest of sand bar. In RUN 1 where the shortest waves were deployed, the maximum boundary layer streaming was observed to be around 0.32 m/s, which far exceeds the amplitude of free stream by two times. It is also noted that the maximum boundary layer streaming mentioned above greatly differs from the analytical solution by Longuet-Higgins (1957) based on wave Reynolds stress. In doing so, we also identify the recovery procedure of natural beaches in swells prevailing mild seas, which can be summarized such as: as the infra-gravity waves formed in swells by the resonance wave-wave interaction arrives near the breaking line, the sediments ascending near the free surface by the Phase II waves orbital motion were carried toward the pinnacle of foreshore by the shoreward flow commenced at the steep front of breaking waves, and were deposited near the pinnacle of foreshore due to the infiltration.

• Archives of Plastic Surgery
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• v.36 no.5
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• pp.531-537
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• 2009

Purpose: Alveolar bone grafting has become an essential process in the treatmemt of alveolar cleft patient for stabilization of the maxillary arch, elimination of oronasal fistula, the reconstruction of the soft tissue nasal base support, and creation of bony support for tooth eruption for implant. The use of Autologous iliac cancellous bone is preferable because of the adequate quantity and high osteoinductive potential. However, even with iliac bone, insufficient osteoregeneration and absorption occur due to several factors such as the patient's age, cleft width, functional stress, and others. In order to increase osteoregeneration where the iliac bone is placed, the present study is associated with bone marrow aspirate (BMA). The experimental study evaluated the efficacy of osteoregeneration in normal cleft rabbits when alveolar bone grafting was performed with autologous iliac corticocancellous bone. Methods: Twenty - four New Zealand White rabbits were divided randomly into 2 groups (BMA, control). All animals underwent harvesting of corticocancellous bone graft from the right posterior iliac crest via standard surgical technique. $1m{\ell}$ of BMA were obtained by scraping the needle and aspirate with $10m{\ell}$ syringe from the contralateral iliac bone wall. The muco - periosteal flap on the palate was elevated. A mixture of Equal bone's volumes with BMA and saline as its control was inserted into the cleft. Animals were sacrificed at 2, 4, and 8 weeks and maxilla was harvested for dental peri - apical X-ray, bone matrix density (BMD),and histologic analysis. Result: BMD of regenerated bone to the cleft in the rabbits was higher than that of the control rabbits. X-ray, histologic analysis showed that increased osteoregeneration and low absorption rate were observed in the BMA group. Conclusion: Our experimental study showed BMA enhanced the osteoregeneration and survival rate of alveolar bone grafting. BMA is easy to extract & cost - time effective. So it can be an effective enhancers for bone grafting mixtures.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.32.1-32.4
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• 2020

Background: Le Fort I osteotomy is a highly effective treatment for skeletal jaw deformities and is commonly performed. High Le Fort I osteotomy is a modified surgical procedure performed for improving the depression of the cheeks by setting the osteotomy higher than the conventional Le Fort I osteotomy. Developments in three-dimensional (3D) technology have popularized the use of 3D printers in various institutions, especially in orthognathic surgeries. In this study, we report a safe and inexpensive method of performing a high Le Fort I osteotomy using a novel 3D device and piezosurgery, which prevent tooth root injury without disturbing the operation field for patients with a short midface and long tooth roots. Results: A 17-year-old woman presented with facial asymmetry, mandibular protrusion, a short midface, and long tooth roots. We planned high Le Fort I osteotomy and bilateral sagittal split ramus osteotomy. Prevention of damage to the roots of the teeth and the infraorbital nerve and accurate determination of the posterior osteotomy line were crucial for clinical success. Le Fort I osteotomy using 3D devices has been reported previously but were particularly large in size for this case. Additionally, setting the fixing screw of the device was difficult, because of the risk of damage to the roots of the teeth. Therefore, a different surgical technique, other than the conventional Le Fort I osteotomy and 3D device, was required. The left and right parts of the 3D device were fabricated separately, to prevent any interference in the surgical field. Further, the 3D device was designed to accurately cover the bone surface from the piriform aperture to the infra-zygomatic crest with two fixation points (the anterior nasal spine and the piriform aperture), which ensured stabilization of the 3D device. The device is thin and does not interfere with the surgical field. Safe and accurate surgical performance is possible using this device and piezosurgery. The roots of the teeth and the infraorbital nerve were unharmed during the surgery. Conclusions: This device is considerably smaller than conventional devices and is a simple, low-cost, and efficient method for performing accurate high Le Fort I osteotomy.

• Journal of Periodontal and Implant Science
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• v.49 no.3
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• pp.171-184
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• 2019

Purpose: To evaluate the effects of intra-alveolar socket grafting, subepithelial connective tissue grafts, and individualized abutments on peri-implant hard and soft tissue outcomes following immediate implant placement. Methods: This randomized experimental study employed 5 mongrel dogs, with 4 sites per dog (total of 20 sites). The mesial roots of P3 and P4 were extracted in each hemimandible and immediate dental implants were placed. Each site was randomly assigned to 1 of 4 different treatment groups: standardized healing abutment (control group), alloplastic bone substitute material (BSS) + standardized healing abutment (SA group), BSS + individualized healing abutment (IA group), and BSS + individualized healing abutment + a subepithelial connective tissue graft (IAG group). Clinical, histological, and profilometric analyses were performed. The intergroup differences were calculated using the Bonferroni test, setting statistical significance at P<0.05. Results: Clinically, the control and SA groups demonstrated a coronal shift in the buccal height of the mucosa ($0.88{\pm}0.48mm$ and $0.37{\pm}1.1mm$, respectively). The IA and IAG groups exhibited an apical shift of the mucosa ($-0.7{\pm}1.15mm$ and $-1.1{\pm}0.96mm$, respectively). Histologically, the SA and control groups demonstrated marginal mucosa heights of $4.1{\pm}0.28mm$ and $4.0{\pm}0.53mm$ relative to the implant shoulder, respectively. The IA and IAG groups, in contrast, only showed a height of 2.6mm. In addition, the height of the mucosa in relation to the most coronal buccal bone crest or bone substitute particles was not significantly different among the groups. Volumetrically, the IA group ($-0.73{\pm}0.46mm$) lost less volume on the buccal side than the control ($-0.93{\pm}0.44mm$), SA ($-0.97{\pm}0.73mm$), and IAG ($-0.88{\pm}0.45mm$) groups. Conclusions: The control group demonstrated the most favorable change of height of the margo mucosae and the largest dimensions of the peri-implant soft tissues. However, the addition of a bone substitute material and an individualized healing abutment resulted in slightly better preservation of the peri-implant soft tissue contour.

• The Journal of Korean Academy of Prosthodontics
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• v.57 no.3
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• pp.304-311
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• 2019

After the teeth were extracted, maxillary and mandibular alveolar ridges show the opposite resorption pattern and as a result, the mandibular arch is enlarged than maxillary arch relatively. In this situation, we should evaluate both alveolar ridge relationship and arrange the artificial teeth properly for stability of removable prosthesis. This case is a 77 years old male patient who wishes to make removable prosthesis and has atrophic alveolar ridge. By use of model scanner and CAD software, the angle between interalveolar crest line and occlusal plane was easily measured. Depending on the measurement, the artificial teeth are arranged in unilateral cross bite and after completion, patient was satisfied with the denture which showed proper stability, retention, support.