• Journal of the Semiconductor & Display Technology
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• v.21 no.1
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• pp.85-90
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• 2022

In this paper, an asynchronous nonvolatile memory module using a self-diagnosis function was designed. For the system to work, a lot of data must be input/output, and memory that can be stored is required. The volatile memory is fast, but data is erased without power, and the nonvolatile memory is slow, but data can be stored semi-permanently without power. The non-volatile static random-access memory is designed to solve these memory problems. However, the non-volatile static random-access memory is weak external noise or electrical shock, data can be some error. To solve these data errors, self-diagnosis algorithms were applied to non-volatile static random-access memory using error correction code, cyclic redundancy check 32 and data check sum to increase the reliability and accuracy of data retention. In addition, the possibility of application to an asynchronous non-volatile storage system requiring reliability was suggested.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1819-1823
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• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.40 no.5
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• pp.369-378
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• 2003

This paper presents design and VLSI implementations of a reassembly processor for ATM/AAL. The assembly processor is responsible for processing ATM cells from the receive physical interface. It controls the transfer of the AAL payload to host memory and performs all necessary SAR and CPCS checks. We propose the improved structure of cell identification algorithm and smart scatter method for host memory management. The proposed cell identification algorithm quickly locates the appropriate reassembly VC table based on the received VPI./VCI channel value in the ATM header. The cell identification algorithm also allow complete freedom in assignment of VCI/VPI values. The reassembly processor uses a smart scatter method to write cell payload data to host memory. It maintains the scatter operation and controls the incoming DMA block during scatter DMA to host memory. The proposed reassembly processor can perform reassembly checks on AAL. OAM cell. For an AAL5 connection, only CPCS checks, including the CRC32, are performed. In this paper, we proposed a practical reassembly architecture. The design of reassembly processor has become feasible using 0.6${\mu}{\textrm}{m}$ CMOS gate array technology.

• Journal of Microbiology and Biotechnology
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• v.32 no.7
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• pp.938-948
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• 2022

Gastric cancers (GC) are generally malignant tumors, occurring with high incidence and threatening public health around the world. Circular RNAs (circRNAs) play crucial roles in modulating various cancers, including GC. However, the functions of circRNAs and their regulatory mechanism in colorectal cancer (CRC) remain largely unknown. This study focuses on both the role of circCOL1A2 in CRC progression as well as its downstream molecular mechanism. Quantitative polymerase chain reaction (qPCR) and western blot were adopted for gene expression analysis. Functional experiments were performed to study the biological functions. Fluorescence in situ hybridization (FISH) and subcellular fraction assays were employed to detect the subcellular distribution. Luciferase reporter, RNA-binding protein immunoprecipitation (RIP), co-immunoprecipitation (Co-IP), RNA pull-down, and immunofluorescence (IF) and immunoprecipitation (IP) assays were used to explore the underlying mechanisms. Our results found circCOL1A2 to be not only upregulated in GC cells, but that it also propels the migration and invasion of GC cells. CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2. In sum, CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. Our study offers a potential novel target for the early diagnosis and treatment of GC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1845-1849
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• 2014

Background: There is no standard treatment for patients with colorectal cancer (CRC) progressing after irinotecan and oxaliplatin treatment. Here we aimed to retrospectively evaluate the efficacy and tolerability of raltitrexed in combination with oral 5-fluoropyrimidine (uracil tegafur-UFT) or mitomycin C as salvage therapy in mCRC patients. Materials and Methods: A total of 62 patients who had received raltitrexed combined with UFT or mitomycin C were identified between December 2008 and June 2013. They were given raltitrexed 2.6 $mg/m^2$ (max 5 mg) i.v. on day 1 in combination with either oral UFT 500 mg/day on days 1-14 every 3 weeks (group A) or mitomycin C 6 $mg/m^2$ i.v. on day every 3 weeks (group B). Results: Forty-two patients (67.7%) were in group A and 20 (32.2%) in group B. In 15 patients (24%) grade 3/4 toxicity was observed, resulting in dose reduction, and in 13 patients (20.9%) dose delay was necessary. The median progression free survival (PFS) was 3 months (95%CI 2.65-3.34) and median overall survival (OS) was 6 months (95%CI 2.09-9.90) in the whole group. Median PFS was 3 months (95%CI 2.60-3.39) in group A vs 3 months (95%CI 1.64-4.35) in group B (p=0.90). Median OS was 6 months (95%CI 2.47-9.53) in group A vs 12 months (95%CI 2.83-21.1) in group B (p=0.46). Conclusions: The combination of raltitrexed with UFT or mitomycin C seem to be a salvage therapy option due to safety profile and moderate clinical activity in heavily-pretreated mCRC patients.

• Korean Journal of Child Studies
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• v.32 no.2
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• pp.53-70
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• 2011

Child Friendly Cities (CFC) is a framework for action with the aim of implementing the UN CRC led by local government in an urban context. A number of surveys with 755 children and adolescents were conducted in order to assess the community's child-friendliness level of Seoul. The results of this study were as follows : 1) Comprehensive assessment of the city's child-friendliness was overall seen to be negative. 2) In regards to the city's child-friendliness, the assessments of Children were more positive than those of the adolescents. 3) Boys assessed the city's child-friendliness more positively than girls. 4) The children and adolescents living in more wealthy communities assessed the city's child-friendliness more positively than those living in poorer areas. This study suggested that a local action plan for the Child Friendly Cities must be implemented to fulfill the CFC standards.

• Annual Conference of KIPS
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• 2001.10b
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• pp.1379-1382
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• 2001

본 논문에서는 ATM 망에서의 통합 네트워크 구현을 위한 IP data packet를 처리하기 위한 AAL type5 프로토콜 프로세서를 설계 및 구현하였다. AAL 계층의 중요 기능들은 ITU-T Recommendation 1.363과 1.363.5 에 근거하여 설계하였다. AAL 계층의 주요한 역할은 데이터의 Segmentation 및 셀의 Reassembly를 하는 것으로, Segmentation 과정에서는 상위 계층의 연속적인 데이터를 Segmentation하여 53-byte 크기의 ATM 셀을 구성하는 기능이다. Reassembly 과정에서는 들어오는 셀들을 연속적인 데이터로 만들어 AAL 계층 보다 상위 계층으로 전달하는 것이다. 이 과정에서 셀의 Header 를 확인한 후 crc-32를 통한 오류 검정을 거치게 되며, 데이터에 오류가 있을 경우에는 해당 셀을 버리고 오류가 없을 시에만 상위 계층으로 전달한다. 본 논문에서 구현한 AAL Type 5 프로세서는 향후 모든 Type의 data를 수용하는 칩 개발에 유용할 것으로 사료된다. 본 논문에서 원할한 테스트를 위해 데이터의 loop back 신호 DLB를 사용했다 VHDL 해석기로는 Synopsys 사의 VHDL Analyzer를 사용하였고, Design Compiler로 회로를 합성하였다.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.205.2-206
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• 2003

This experiment was designed to evaluate the immune responses after treatment of diabetes by using water extract of traditional herbal drugs on the splenocytes and peritoneal macrophages in vivo. We found two herbal materials of the hypoglycemic agents based on inhibitory activity of ${\alpha}$-glucosidase. These potential herbal drugs which remarkably inhibited ${\alpha}$-glucosidase in STZ-induced diabetic mices (STZ 150 mg/kg, i.p.) were Mori radicis Cortex(MRC, 2.32 mg/mouse) and Cudraniae radicis Cortex (CRC, 2.24mg/mouse). (omitted)

• Proceedings of the KIEE Conference
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• 2004.07d
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• pp.2562-2564
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• 2004

This paper addresses a simulation for the Ethernet based data transmission between the CIC(Centralized Traffic Control System) and the SCADA(Supervisory Control and Data Acquisition) system. Fame error rate and throughput are calculated and compared for the two cases that the CTC/SCADA has an extra error control scheme besides the internal CRC32 of the Ethernet and that no extra error control has been done. Simulation program is constructed with the Matlab and the Matlab GUI and then converted into a stand-alone $c^{++}$ program to be used on any non-Matlab environments.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.1
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• pp.185-191
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• 2015

This paper suggest the safety class communication board in order to design the safety network of the nuclear safety class controller. The reactor protection system use the digitized networks because from analog system to digital system. The communication board shall be provided to pass the required performance and test of the safety class in the digital network used in the nuclear safety class. Communication protocol is composed of physical layer(PHY), data link layer(MAC: Medium Access Control), the application layer in the OSI 7 layer only. The data link layer data package for the cyber security has changed. CRC32 were used for data quality and the using one way communication, not requests and not responses for receiving data, does not affect the nuclear safety system. It has been designed in accordance with requirements, design, verification and procedure for the approving the nuclear safety class. For hardware verification such as electromagnetic test, aging test, inspection, burn-in test, seismic test and environmental test in was performed. FPGA firmware to verify compliance with the life-cycle of IEEE 1074 was performed by the component testing and integration testing.