• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 하계종합학술대회 논문집(2)
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• pp.261-264
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• 2001

In this paper, we design IP of ATM AAL layer for B-ISDN. The designed ATM AAL module supports the function for AAL type 0, AAL type 3/4, AAL type 5. The designed IP provides for automatic CRC-32 and CRC-10 for AAL type and AAL type 3/4. Also our IP inserts and extracts the header and trailer for each type automatically. After HDL description, it is verified by the simulation. The designed U is implemented in Xilinx FPGA. Rx AAL module operates at 35MHz and Rx AAL module operates at 50MHz. The designed IP can be applicable in high-speed ATM SAR(Segmentation and Reassembly) chip.

• 한국철도학회논문집
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• 제7권4호
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• pp.296-301
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• 2004

This paper addresses an analysis for a railway data transmission protocol-Ethernet based data transmission between the CTC(Centralized Traffic Control System) and the SCADA(Supervisory Control and Data Acquisition) system. Fame error rates of the data transmissions are calculated and compared for the two cases that the CTC/SCADA has an extra data transmission error control(CRCI6) besides the inherent error control of the Ethernet(CRC32), and that the CTC/SCADA has no extra data transmission error control. With simulation results it has been verified that the extra data transmission error control(CRC16) contributes to lowering the frame error rate.

• Biomolecules & Therapeutics
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• 제32권1호
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• pp.104-114
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• 2024

Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. However, the therapeutic potential of LCC in treating colorectal cancer (CRC) and its underlying molecular mechanisms remain unclear. Chemotherapy for CRC is challenging because of the development of drug resistance. In this study, we examined the antiproliferative activity of LCC in human colorectal carcinoma HCT116 cells, oxaliplatin (Ox) sensitive and Ox-resistant HCT116 cells (HCT116-OxR). LCC significantly and selectively inhibited the growth of HCT116 and HCT116-OxR cells. An in vitro kinase assay showed that LCC inhibited the kinase activities of EGFR and AKT. Molecular docking simulations using AutoDock Vina indicated that LCC could be in ATP-binding pockets. Decreased phosphorylation of EGFR and AKT was observed in the LCC-treated cells. In addition, LCC induced cell cycle arrest by modulating the expression of cell cycle regulators p21, p27, cyclin B1, and cdc2. LCC treatment induced ROS generation in CRC cells, and the ROS induction was accompanied by the phosphorylation of JNK and p38 kinases. Moreover, LCC dysregulated mitochondrial membrane potential (MMP), and the disruption of MMP resulted in the release of cytochrome c into the cytoplasm and activation of caspases to execute apoptosis. Overall, LCC showed anticancer activity against both Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, inducing ROS generation and disrupting MMP. Thus, LCC may be potential therapeutic agents for the treatment of Ox-resistant CRC cells.

• 한국통신학회논문지
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• 제32권6A호
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• pp.519-536
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• 2007

본 논문에서는 최근 많은 연구가 진행되고 있는 공간 다중화 기법인 Iterative BLAST를 기반으로 채널 값의 Sum을 이용하여 양호한 통신 링크를 적응적으로 선택하는 송/수신 안테나 선택 기법과 선택된 안테나를 사용하여 시스템의 신뢰성을 향상시키기 위한 안테나 스케줄링 기반 Hybrid-Automatic Repeat reQuest (UARO) 스위칭 기법을 결합한다. 본 논문에서 제안된 HARQ 스위칭 알고리즘은 각 안테나에 삽입된 CRC (Cyclic Redundancy Check) 코드를 사용하여 안테나별로 ACK (Acknowledgement) 와 NAK (Non Acknowledgement)를 확인한 후, 재전송 요구 시, 송신 안테나를 스케줄링하여 ACK 안테나에서는 CC (Chase Combining) 기법을, NAK 안테나에서는 IR (Incremental Redundancy) 기법을 적용하여 재전송이 이루어지게 한다. 본 논문에서 제안한 알고리즘의 적용시, SNR 이득과 공간 다이버시티 이득이 발생하여 기존 HARQ 시스템에 비하여 링크 성능이 향상됨을 SCM-E 채널 환경에서 모의 실험을 통하여 검증한다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.771-772
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• 2008

In this paper, we analyze the characterization of Mibench, an embedded system benchmark program, using simplescalar simulator. The experimental results show Mibench generally is formed by lots of integer and memory access instructions. Especially, IPC of rijndael decoding is effected by cache size largely, but IPC of CRC32 is few effected by cache size or branch predicting algorithm.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 II
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• pp.799-802
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• 2003

In this paper a FPGA implementation of WEP protocol is described. IEEE 802.11 specifies a wired LAN equivalent data confidentiality algorithm. WEP(Wired Equivalent Privacy) is defined as protecting authorized users of a wireless LAN from casual eavesdropping. WEP use RC4 algorithm for data encryption and decryption, also it use CRC-32 algorithm for error detection. The WEP protocol is implemented using Xilinx VirtexE XCV1000E-6HQ240C FPGA chip with PCI bus interface.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2002년도 추계종합학술대회
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• pp.265-269
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• 2002

본 논문에서는 무선랜 시스템에서 보안상의 취약점을 해소하기 위해 적용되고 있는 보안 기법들에 관해 분석하였다. WLAN에서 적용되고 있는 보안규정 WEP는 RC4 스트림 키퍼의 특징에서 오는 IV Reuse 문제 및 ICV를 생성하는 CRC-32의 선형특성에 따른 문제를 분석하고 현재 사용되는 보안기법인 액세스컨트롤의 강화와 WEP 키관리 및 VPN에서의 사용자 인증알고리즘 및 데이터 암호화기술을 분석하고, 802.11a에서 보안모델의 나아갈 방향을 제시하였다.

• 항공우주기술
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• 제7권1호
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• pp.83-90
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• 2008

차세대 저궤도 위성의 탑재소프트웨어 저장메모리는 부트 코드와 모니터 소프트웨어를 내장한 부트 롬과 비행소프트웨어 이미지를 저장한 듀얼 NVMEM 형태로 개발되고 있다. 부트 롬에 내재된 부트 로더는 프로세서 초기화 이후 GPIO의 입력에 따라 비행소프트웨어 모드 혹은 모니터 모드로 천이하게 된다. 비행소프트웨어 모드에서는 듀얼 NVMEM중 선택된 NVMEM에 대한 CRC를 체크하여 정상적일 경우 NVMEM에 저장되어 있는 탑재소프트웨어를 코드가 수행 될 RAM으로 적재 한 후 VxWorks RTO5를 구동하여 테스크를 생성하여 탑재소프트를 수행하게 된다. 모니터 모드에서는 지상에서 NVMEM reprogramming을 가장 메인으로 수행하며 기본적인 보드 레벨 테스트를 수행할 수 있다. 본 논문에서는 차세대 저궤도 위성의 부트 롬 소프트웨어 설계 및 시뮬레이터 기반의 검증 방법에 대하여 기술한다.

• Journal of Ginseng Research
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• 제39권3호
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• pp.230-237
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• 2015

Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West. Methods: A genetically engineered $Apc^{Min/+}$ mouse model was used in this study. We analyzed the saponin composition of American ginseng used in this project, and evaluated its effects on the progression of high-fat-diet-enhanced CRC carcinogenesis. Results: After oral ginseng administration (10-20 mg/kg/d for up to 32 wk), experimental data showed that, compared with the untreated mice, ginseng very significantly reduced tumor initiation and progression in both the small intestine (including the proximal end, middle end, and distal end) and the colon (all p < 0.01). This tumor number reduction was more obvious in those mice treated with a low dose of ginseng. The tumor multiplicity data were supported by body weight changes and gut tissue histology examinations. In addition, quantitative real-time polymerase chain reaction analysis showed that compared with the untreated group, ginseng very significantly reduced the gene expression of inflammatory cytokines, including interleukin-$1{\alpha}$ (IL-$1{\alpha}$), IL-$1{\beta}$, IL-6, tumor necrosis factor-${\alpha}$, granulocyte-colony stimulating factor, and granulocyte-macrophage colony-stimulating factor in both the small intestine and the colon (all p < 0.01). Conclusion: Further studies are needed to link our observed effects to the actions of the gut microbiome in converting the parent ginsenosides to bioactive ginseng metabolites. Our data suggest that American ginseng may have potential value in CRC chemoprevention.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.627-633
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• 2015

Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.