• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4713-4717
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• 2012

Objectives: This systematic review of cohort studies aimed to identify any association between specific dietary patterns and risk of colorectal cancer (CRC). Dietary patterns involve complex interactions of food and nutrients summarizing the total diet or key aspects of the diet for a population under study. Methods and materials: This review involves 6 cohort studies of dietary patterns and their association with colorectal cancer. An exploratory or a posteriori approach and a hypothesis-oriented or a priori approach were employed to identify dietary patterns. Results: The dietary pattern identified to be protective against CRC was healthy, prudent, fruits and vegetables, fat reduced/diet foods, vegetables/fish/poultry, fruit/wholegrain/dairy, healthy eating index 2005, alternate healthy eating index, Mediterranean score and recommended food score. An elevated risk of CRC was associated with Western diet, pork processed meat, potatoes, traditional meat eating, and refined grain pattern. Conclusion: The Western dietary pattern which mainly consists of red and processed meat and refined grains is associated with an elevated risk of development of CRC. Protective factors against CRC include a healthy or prudent diet, consisting of vegetables, fruits, fish and poultry.

• BMB Reports
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• 제51권11호
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• pp.563-571
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• 2018

Colorectal cancer (CRC), the third most common cancer in the world, has no specific biomarkers that facilitate its diagnosis and subsequent treatment. The miRNAs, small single-stranded RNAs that repress the mRNA translation and trigger the mRNA degradation, show aberrant levels in the CRC, by which these molecules have been related with the initiation, progression, and drug-resistance of this cancer type. Numerous studies show the microRNAs influence the cellular mechanisms related to the cell cycle, differentiation, apoptosis, and migration of the cancer cells through the post-transcriptionally regulated gene expression. Specific patterns of the upregulated and down-regulated miRNA have been associated with the CRC diagnosis, prognosis, and therapeutic response. Concretely, the downregulated miRNAs represent attractive candidates, not only for the CRC diagnosis, but for the targeted therapies via the tumor-suppressing microRNA replacement. This review shows a general overview of the potential uses of the miRNAs in the CRC diagnosis, prognosis, and treatment with a special focus on the downregulated ones.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3967-3971
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• 2012

Aims: To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX-2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (${\alpha}$ inclusion= 0.10, ${\alpha}$ elimination = 0.15, R2 = 0.718). Conclusions: Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3425-3428
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• 2015

Objective: To explore the association of serum tumor abnormal protein (TAP) with other serological biomarkers e.g. carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 19-9 (CA19-9) and its clinical application in colorectal cancer (CRC) patients. Methods: Patients (N=98) were enrolled into this study with histologically or cytologically confirmed CRC. Using a test kit, the level of TAP was determined, while chemiluminescence was used to measure the levels of some other common serological biomarkers e.g. CEA, CA125 and CA19-9. Results: The area of TAP condensed particulate matter decreased after chemotherapy compared with before chemotherapy when CT or MRI scans showed disease control. In contrast, it increased with disease progression (P<0.05). Furthermore, a statistically significant difference was confirmed in monitoring of TAP and common serological biomarkers e.g. CEA and CA19-9 (p<0.05). Conclusions: Detecting TAP in CRC patients has high sensitivity and specificity and can be used as a new independent indicator for clinically monitoring CRC patients in the course of chemotherapy.

• Advances in concrete construction
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• 제4권1호
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• pp.49-69
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• 2016

This work investigates the mechanical properties of conventional concrete (CC) and self compacting concrete (SCC) using fine rubber and silpozz were accompanied by a comparative study between conventional rubberized concrete (CRC) and self compacting rubberized concrete (SCRC). Fine rubber (FR) from scrap tires has replaced the fine aggregate (FA) and Silpozz has been used as a replacement of cement at the proportions of 5, 10 and 15%. Silpozz as a partial replacement of cement in addition of superplasticiser (SP) increases the strength of concrete. Fresh concrete properties such as slump test, compaction factor test for CRC, whereas for SCRC slump flow, $T_{500}$, V-funnel, L-box, U-box, J-ring tests were conducted along with the hardened properties tests like compressive, split tensile and flexural strength test at 7, 28 and 90 days of curing. The durability and microstructural behavior for both CRC and SCRC were investigated. FR used in the present study is 4.75 mm passing with fineness modulus 4.74.M30 grade concrete is used with a mix proportion of 1:1.44:2.91 and w/c ratio as 0.43. The results indicate that as FR quantity increases, workability of both CRC and SCRC decreases. The results also show that the replacement of natural fine aggregate (NFA) with FR particles decreases the compressive strength with the increase of flexural strength observed upto 5% replacement of FR. Also replacement of cement with silpozz resulted enhancement of strength in SCRC.

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.257-264
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• 2022

Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can seriously reduce therapeutic efficacy of 5-FU. Recent data show that FoxM1 is associated with 5-FU resistance in CRC. FoxM1 plays a critical role in the carcinogenesis and drug resistance of several malignancies. It has been reported that urushiol V isolated from the cortex of Rhus verniciflua Stokes is cytotoxic to several types of cancer cells. However, the underlying molecular mechanisms for its antitumor activity and its potential to attenuate the chemotherapeutic resistance in CRC cells remain unknown. Here, we found that urushiol V could inhibit the cell proliferation and induced S-phase arrest of SW480 colon cancer cells. It inhibited protein expression level of FoxM1 through activation of AMPK. We also investigated the combined effect of urushiol V and 5-FU. The combination treatment reduced FoxM1 expression and consequently reduced cell growth and colony formation in 5-FU resistant colon cancer cells (SW480/5-FUR). Taken together, these result suggest that urushiol V from Rhus verniciflua Stokes can suppress cell proliferation by inhibiting FoxM1 and enhance the antitumor capacity of 5-FU. Therefore, urushiol V may be a potential bioactive compound for CRC therapy.

• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.65-73
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• 2022

A breakthrough in immunotherapy has changed the outlook for metastatic colorectal cancer (mCRC) treatment as the immune surveillance evasion mechanism of tumor cells has been continuously elucidated. Immune checkpoint inhibitors (ICI), such as pembrolizumab, nivolumab, and ipilimumab, which block immune checkpoint receptors or ligands have been approved for the treatment of mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) mCRC based on numerous clinical studies. However, 50% of dMMR/MSI-H mCRC and most mismatch repair proficient/microsatellite stable mCRC remained unresponsive to current immunotherapy. Clinical trials on combination therapy that adds various treatments, such as target agents, chemotherapy, or radiation therapy to ICI, have been actively conducted to overcome this immunotherapy limitation. Further studies on safety and efficacy are needed although several trials presented promising data. Additionally, dMMR/MSI-H, tumor mutation burden, and programmed cell death ligand-1 expression have been studied as biomarkers for predicting the treatment response to immunotherapy, but the discovery and validation of more sensitively predictable biomarkers remained necessary. Thus, this study aimed to review recent studies on immunotherapy in mCRC, summarize the efficacy and limitation of immunotherapy, and describe the biomarkers that predict treatment response.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.789-792
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• 2005

In this paper, we propose a method that applies pipeline architecture to parallel CRC circuits. We developed a logic partitioning algorithm for applying pipeline architecture. Our algorithm can be used for the polynomial and the input data width, both of arbitrary length and minimize the logic level. Design experiments show the superiority of our approach in reducing the delay in comparison with previous works.

• 한국산학기술학회:학술대회논문집
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• 한국산학기술학회 2003년도 춘계학술발표논문집
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• pp.226-228
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• 2003

본 논문에서는 현재 산업현장에서 사용되고 있는 유선 콘트롤러와 무선 콘트롤러의 문제점을 보완하기 위해 컨벌루션 부호와 CRC부호를 적용한 무선 콘트롤러를 구현하였다. 콘트롤러의 제어를 위해 마이크로프로세서를 이용하였으며, 무선 콘트롤러의 신뢰도 향상을 위해 적용한 컨벌루션 부호는 구속장 k=3, 부호율 ½인 부호를 사용하였고, CRC 부호는 POLYNOMIAL함수를 X/sup 15/ ＋ X² ＋ 1로 사용하여 총 CRC비트 16비트(2바이트)가 되게 하였다. 또한 구현된 무선 콘트롤러를 무선환경에서 테스트하여 송수신시 정확하게 데이터의 송수신이 이루어짐을 확인하였다.

• 물과 미래
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• 제26권1호
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• pp.103-114
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• 1993

수로의 형상과 하상조건에 따른 이행특성을 일정반경곡선(CRC), 정현곡선(SGC) 및 미소지폭파 이론(SWT)의 방법에 의해 연구하였다. 수로의 형상이 사행이고, 하상조건이 거친 하상입자인 사행하천의 경우에는 CRC 및 SGC의 방법을 적용하여 횡방향 하상경사, 수심 및 유속분포의 예측치를 구하고, 이를 실측치와 비교하였다. 또한 가는 입자의 준사행하천(Sinuous Channels)에 대해서는 SWT의 방법을 이용하여 횡방향과 흐름방향의 사행이행량을 각각 구하였다. 그 결과 횡방향 질량이송계수는 사행이행의 크기 및 방향을 결정하는데 중요한 계수임이 확인되었다.