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http://dx.doi.org/10.7314/APJCP.2012.13.8.3967

Multivariate Analysis of Molecular Indicators for Postoperative Liver Metastasis in Colorectal Cancer Cases  

Qian, Li-Yuan (Department of General Surgery, Xiangya Third Hospital, Central South University)
Li, Ping (Department of Burn and Plastics Surgery, Xiangya Third Hospital, Central South University)
Li, Xiao-Rong (Department of General Surgery, Xiangya Third Hospital, Central South University)
Chen, Dao-Jin (Department of General Surgery, Xiangya Third Hospital, Central South University)
Zhu, Shai-Hong (Department of General Surgery, Xiangya Third Hospital, Central South University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.8, 2012 , pp. 3967-3971 More about this Journal
Abstract
Aims: To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX-2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (${\alpha}$ inclusion= 0.10, ${\alpha}$ elimination = 0.15, R2 = 0.718). Conclusions: Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers.
Keywords
Colorectal cancer; post-operative liver metastasis; molecular indicators; multivariate analysis;
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