• Journal of Radiation Protection and Research
• /
• v.48 no.2
• /
• pp.100-106
• /
• 2023

Background: As breast tissue expanders consist of metallic materials in the needle guard and ferromagnetic injection port, irradiation can produce radioactivation. Materials and Methods: A CPX4 (Mentor Worldwide LLD) breast tissue expander was exposed using the Versa HD (Elekta) linear accelerator. Two photon energies of 6 and 10 MV-flattening filter free (FFF) beams with 5,000 monitor units (MU) were irradiated to identify the types of radiation. Furthermore, 300 MU with 10 MV-FFF beam was exposed to the CPX4 breast tissue expander by varying the machine dose rates (MDRs) 600, 1,200, and 2,200 MU/min. To assess the instantaneous dose rates (IDRs) solely from the CPX4, a tissue expander was placed outside the treatment room after beam irradiation, and a portable radioisotope identification device was used to identify the types of radiation and measure IDR. Results and Discussion: After 5,000 MU delivery to the CPX4 breast tissue expander, the energy spectrum whose peak energy of 511 keV was found with 10 MV-FFF, while there was no resultant one with 6 MV-FFF. The time of each measurement was 1 minute, and the mean IDRs from the 10 MV-FFF were 0.407, 0.231, and 0.180 μSv/hr for the three successive measurements. Following 10 MV-FFF beam irradiation with 300 MU indicated around the background level from the first measurement regardless of MDRs. Conclusion: As each institute room entry time protocol varies according to the working hours and occupational doses, we suggest an addition of 1 minute from the institutes' own room entry time protocol in patients with CPX4 tissue expander and the case of radiotherapy vaults equipped with a maximum energy of 10 MV photon beams.

• The Journal of Internal Korean Medicine
• /
• v.23 no.1
• /
• pp.123-131
• /
• 2002

Objective : It is well known that modern chemotherapy against cancer has side effects to a living body, especially hemopoietic and immunologial disfunctions. However, there are no effective ways to reduce them. Recently, traditional Korean herb medicine has been reported to have some biological modifying responses. Therefore, we hypothesized that additional application of herb medicine during chemotherapy is more effective to reduce its side effects. While we were studying the effects, we have observed the inhibitory effect of Soamgudamikgitang on formation of side effects derived from Cyclophosphamide, it has been used in clinical practice at Kyung Hee Medical Center. Methods : We injected 200mg/kg of Cyclophosphamide, one time, to an experimental group, consisting of ten mice. We divided them into eight groups: normal, CPX, SAKT 2mg, SAKT 10mg, SAKT 50mg, SAKT 2mg, CPX, SAKT 10mg+CPX, SAKT 50mg+CPX. We injected Soamgudamikgitang seven days, five days, three days, and one day before we injected CPX. One day, three days, and five days after CPX injection, we injected Soamgudamikgitang again and then killed all the mice. The parameters determined in this experiment were daily body weight liver and spleen weight, RBC, WBC, and platelet for hemopoietic dysfunction and AST, ALT for hepatotoxicity, BUN, creatine for renal toxcity, lymphocyte proliferation activity and lymphocyte subsets for immunological toxcity. Results : We have found that Soamgudamikgitang has inhibitory effects on the formation of Cyclophosphamide's side effects. Significant differences between the group, which contained Cyclophosphamide, and the other group, which contains Cyclophosphamide and 2, 10, 50mg of Soamgudamikgitang respectively were observed. Platelets(2mg of Soamgudamikgitang, p<0.05 ;10mg, p<0.01 ;50mg, p<0.001), liver weight(50mg, p<0.01), spleen weight(10mg, p<0.05), AST(all groups, p<0.01), ALT(2mg, p<0.01 ;10mg, p<0.05 ;50mg, p<0.01), BUN(2mg, p<0.01 ;50mg, p<0.05). Although immunological in both lymphocyte proliferation and its subsets were not observed, which shows that Soamgudamikgitang has a strong effect on T cell activities. Conclusions : From the above results, we can expect that the combined therapy of Soamgudamikgitang and Cyclophosphamide is more effective for treating cancer patients.

• Proceedings of the Korean Society of Life Science Conference
• /
• 2007.10a
• /
• pp.47.1-47.1
• /
• 2007

See Full Text

• Journal of the korean veterinary medical association
• /
• v.33 no.8
• /
• pp.494-501
• /
• 1997

• Journal of The Korea Institute of Healthcare Architecture
• /
• v.27 no.4
• /
• pp.7-14
• /
• 2021

Purpose: This study summarized architectural planning data for clinical practice spaces for CPX/OSCE and Simulation spaces, through analysis of domestic and foreign literature and a survey of domestic colleges of medicine. Methods: This study analyzed the architectural planning elements of the clinical practice spaces of the college of medicine, through a literature review on the clinical practice space and the survey of four recently established colleges of medicine. Results: ① It is desirable to plan the floor plan type for Simulation and CPX/OSCE spaces as a corridor-separated type that separates the circulations between students and staff (faculty). ② The simulation area arranges their practice rooms around the control space where the circulation of the staff is made. Conversely, it is desirable to arrange the CPX/OSCE rooms around the test waiting room where students enter. ③ It is desirable to separate access to the staff and students to allow student control, and to install various support spaces facing the staff corridor to secure the movement of equipment and the flow of evaluators. ④ In the simulation area, the equipment stored in the storage must be set in each room before the practice according to the setting of delivery or surgery like, and the equipment that has been removed must be back, so the circulation is short and does not intersect with the student circulations. ⑤ Debriefing rooms, seminar rooms, etc. are arranged in the staff area for review and discussion of clinical situations where practice and evaluation have been completed. Implications: It is important to configure an appropriate movement system and spatial zoning for each space for simulation and CPX/OSCE.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.16 no.11 s.116
• /
• pp.1124-1131
• /
• 2006

This paper presents a novel method to determine sound power level(PWL) emitted by a travelling vehicle for road traffic noise simulation. The PWL is evaluated by the equivalent sound pressure level (SPL) measured by close proximity method and the sound power correction factor derived from the maximum SPL measured by pass-by method and the propagation attenuation of vehicle noise during the pass-by measurement. Using the method, we derive the empirical formula for PWL estimation in 1/1-octave and overall frequency bands for 8 vehicles (automobile, SUV, small truck, large bus, trailer, 3 dump trucks) tested at two road surfaces (dense graded asphalt, 30mm transverse tinning concrete) of Korean highway test road. The suggested approach, if securing sufficient data to represent the acoustic characteristics of all vehicle types, has il strong merit to be able to evaluate sound power levels for any combination of vehicle categories and traffic volumes.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2006.05a
• /
• pp.421-427
• /
• 2006

This paper presents a novel method to determine sound power level(PWL) emitted by a travelling vehicle for road traffic noise simulation. The PWL is evaluated by the equivalent sound pressure level(SPL) measured by close proximity method and the sound power correction factor derived from the maximum SPL measured by pass-by method and the propagation attenuation of vehicle noise during the pass-by measurement. Using the method, we derive the empirical formula for PWL estimation in 1/1-octave and overall frequency bands for 8 vehicles(automobile, SUV, small truck, large bus, trailer, 3 dump trucks) tested at two road surfaces(dense graded asphalt, 30mm transverse tinning concrete) of Korean highway test road. The suggested approach, if securing sufficient data to represent the acoustic characteristics of au vehicle types, has a strong merit to be able to evaluate sound power levels for any combination of vehicle categories and traffic volumes.

• Journal of Society of Preventive Korean Medicine
• /
• v.26 no.3
• /
• pp.73-86
• /
• 2022

Objectives : The purpose of this study was to investigate the satisfaction of students who participated in a role play using the syndrome differentiation CPX (Clinical Performance Examination) scenario in Korean Medicine Classics class, and to find out whether the results were correlated with self-assessment of treatment skills and subject achievement. Methods : In the Korean Medicine Classics class in the first semester of 2022, 44 first-year students in the Department of Korean Medicine completed theoretical education and formative evaluation on the subject of internal damage fever, and then role-played using CPX scenarios. Among them, 41 students consented to the study. Students who agreed to the study answered the satisfaction questionnaire consisting of 13 questions in 2 areas on learning methods and effects, and self-evaluation was conducted according to the evaluation items of medical technology consisting of 23 questions. Satisfaction and self-assessment results were analyzed for correlation, and additionally, correlation with Korean Medicine Classics subject achievement was also analyzed. Results : The result of student satisfaction with the role play was 4.87±0.06 while the result of student self-assessment of clinical skill was 4.73±0.16. The student satisfaction with the role play showed statisticallysignificant correlations with the self-assessment of clinical skill and quiz score of Korean Medical Classics while it did not show correlations with the total score of Korean Medical Classics and paper test. Also, the self-assessment of clinical skill did not show correlations with the total score of Korean Medical Classics, paper test, and quiz. Conclusions : Even though the students who performed the role play using the syndrome differentiation based CPX scenario highly assessed their clinical skill and showed high satisfaction, it did not show significant correlation with the achievement of Korean Medical Classics.

• Food Science of Animal Resources
• /
• v.37 no.1
• /
• pp.134-138
• /
• 2017

Salmonella enterica infects a broad range of host animals, and zoonostic infection threatens both public health and the livestock and meat processing industries. Many antimicrobials have been developed to target Salmonella envelope that performs essential bacterial functions; however, there are very few analytical methods that can be used to validate the efficacy of these antimicrobials. In this study, to develop a potential biosensor for Salmonella envelope stress, we examined the transcription of the S. enterica serovar typhimurium spy gene, the ortholog of which in Escherichia coli encodes Spy (${\underline{s}}pheroplast$ ${\underline{p}}rotein$ ${\underline{y}}$). Spy is a chaperone protein expressed and localized in the periplasm of E. coli during spheroplast formation, or by exposure to protein denaturing conditions. spy expression in S. typhimurium was examined by constructing a spy-gfp transcriptional fusion. S. typhimurium spy transcription was strongly induced during spheroplast formation, and also when exposed to membrane-disrupting agents, including ethanol and the antimicrobial peptide polymyxin B. Moreover, spy induction required the activity of regulator proteins BaeR and CpxR, which are part of the major envelope stress response systems BaeS/BaeR and CpxA/CpxR, respectively. Results suggest that monitoring spy transcription may be useful to determine whether a molecule particularly cause envelope stress in Salmonella.

• Journal of Yeungnam Medical Science
• /
• v.38 no.2
• /
• pp.118-126
• /
• 2021

Background: This study is an analysis of evaluator factors affecting physician-patient interaction (PPI) scores in clinical performance examination (CPX). The purpose of this study was to investigate possible ways to increase the reliability of the CPX evaluation. Methods: The six-item Yeungnam University Scale (YUS), four-item analytic global rating scale (AGRS), and one-item holistic rating scale (HRS) were used to evaluate student performance in PPI. A total of 72 fourth-year students from Yeungnam University College of Medicine in Korea participated in the evaluation with 32 faculty and 16 standardized patient (SP) raters. The study then examined the differences in scores between types of scale, raters (SP vs. faculty), faculty specialty, evaluation experience, and level of fatigue as time passes. Results: There were significant differences between faculty and SP scores in all three scales and a significant correlation among raters' scores. Scores given by raters on items related to their specialty were lower than those given by raters on items out of their specialty. On the YUS and AGRS, there were significant differences based on the faculty's evaluation experience; scores by raters who had three to ten previous evaluation experiences were lower than others' scores. There were also significant differences among SP raters on all scales. The correlation between the YUS and AGRS/HRS declined significantly according to the length of evaluation time. Conclusion: In CPX, PPI score reliability was found to be significantly affected by the evaluator factors as well as the type of scale.