• Geotechnical Engineering
• /
• v.14 no.3
• /
• pp.95-108
• /
• 1998

Downhole testing and seismic CPT (SCPT) have been widely used to evaluate stiffness profiles of the subgrade. Advantages of downhole testing and SCPT such as low cost, easy operation and a simple seismic source have got these testings more frequently adopted in site investigation. For the automated analysis of downhole testing and SCPT, the concept of interval measurements has been practiced. In this paper. a new inversion procedure to deal tilth the interval measurements for the automated downhole testing and SCPT (including a newlydeveloped continuous SCPT) is proposed. The forward modeling in the new inversion procedure incorporates ray path theory based on Snell's law. The formulation for the inversion analysis is derived from the maximum likelihood approach, which estimates the maximum likelihood of obtaining a particular travel time from a source to a receiver. Verification of the new inversion procedure was performed with numerical simulations of SCPT using synthesized profiles. The results of the inversion analyses performed for the synthetic data show that the new inversion analysis is a valid procedure which enhances Va profiles determined by downhole testing and SCPT.

• BMB Reports
• /
• v.36 no.3
• /
• pp.312-318
• /
• 2003

The purpose of this study was to investigate the effects of altering relative intakes of fat and carbohydrates on serum lipid profiles, hepatic acyl-CoA synthetase (ACS), carnitine palmitoyltransferase-I (CPT-I), and the acetyl-CoA carboxlyase (ACC) mRNA level in Sprague-Dawley rats. For four weeks the rats were fed either an AIN-76 diet or one of its modified diets that were supplemented with 20% beef tallow (high-fat diet, HF) and 66.3% sucrose (highsucrose diet, HS). The HS group had significantly higher serum triglyceride and total cholesterol concentrations when compared with the other groups. Serum LDL-cholesterol concentrations in the HS and HF groups were significantly higher when compared to the normal diet (ND) group. Serum HDL-cholesterol levels of the ND and HS groups were significantly higher than those of the HF group. The hepatic total lipid level of the HF group was significantly higher than those of other groups; triglyceride levels of the HS and HF groups were significantly higher than those of the ND group. Hepatic ACS mRNA levels of the HF group were significantly higher than those of the ND group. Hepatic CPT-I mRNA levels were higher in the HF group than other groups. Also, ACC mRNA levels in the liver increased in the HF group. In conclusion, changes in the composition of dietary fat and carbohydrates could affect the hepatic ACS, CPT-I, and ACC mRNA levels. These results facilitate our understanding of the coordinated regulation of the ACS, CPT-I, and ACC mRNA levels and will serve to enhance our understanding of the molecular mechanisms that underlie the regulation of fatty acid metabolism.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.11
• /
• pp.4875-4883
• /
• 2016

Background and objective: Breast cancer-related lymphoedema (BCRL) is a disabling complication with long term impact on quality on life after breast cancer treatment. Its management remains a major challenge for patients and health care professionals; the goal of this overview was to summarize effects of different treatment strategies for patients with BCRL. Methods: A thorough search was undertaken to allow a systematic review or meta-analysis of treatments for BCRL. Two investigators independently selected studies and abstracted the data. Results: Combined physical therapy (CPT) with different combinations of surgery, oral pharmaceuticals, low-level laser therapy, weight reduction, mesenchymal stem cell therapy, kinesio tex taping, and acupuncture might be effective in reducing lymphoedema, but exercise demonstrated no obvious benefit. The results of direct comparisons showed CPT might be more effective than standard physiotherapy (ST). Manual lymphatic drainage (MLD) may not offer additional benefits to ST for swelling reduction, but could facilitate compression bandaging. MLD seemed to have similar effects with self-administered simple lymphatic drainage (SLD) or using an intermittent pneumatic compression pump (IPC). IPC might also not be associated with additional effectiveness for CPT. Efficacy of stem cell therapy vs. compression sleeve or CPT, as well as the effects of daflon and coumarin could not be established. Conclusion: Although many treatments for BCRL might reduce lymphoedema volume, their effects were not well established. The quality of many of the original studies in the included reviews was not optimal, so that in future randomized control trials are a high priority.

• Journal of Oriental Neuropsychiatry
• /
• v.26 no.2
• /
• pp.131-142
• /
• 2015

Objectives: The purpose of this study is to evaluate the personality traits and cognitive characteristics of the Sasang constitution by comparing the Eysenck Personality Questionnaire (EPQ), Temperament and Character Inventory (TCI), Continuous Performance Test (CPT) and Stroop Test. Methods: One hundred and six healthy subjects (age 20 to 40) were analyzed; 45 Taeeumin, 30 Soyangin and 31 Soeumin. The Sasang constitution was diagnosed by a sasang constitutional medicine specialist based on the results of a Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD), the external appearance, temperament and symptoms. The results of the EPQ, TCI, CPT and Stroop Test were compared between Sasang constitutions. Results: Among the seven dimensions of EPQ, Taeeumin and Soyangin scored significantly higher than Soeumin in Extraversion. Soyangin scored significantly higher than Soeumin in Impulsiveness. Among the four temperament dimensions of TCI, Taeeumin and Soyangin scored significantly higher than Soeumin in novelty seeking, reward dependence and persistence. Soeumin scored significantly higher than Taeeumin and Soyangin in harm avoidance. Among the three character dimensions of TCI, Soyangin scored significantly higher than Taeeumin in self transcendence. The results for CPT showed no significant differences between sasang constitutions. Taeeumin had a significantly higher color score in the stroop test than Soeumin. Conclusions: The personality tests showed significant differences between Sasang constitutions, but the neuropsychological test did not show any differences. Further studies should be performed to identify neuropsychological differences between Sasang constitutions.

• Journal of the Korean Geotechnical Society
• /
• v.36 no.10
• /
• pp.57-71
• /
• 2020

Liquefaction-induced sand boils were observed during the Pohang earthquake (Moment magnitude, 5.4) on November 15, 2017, specifically in the region of agricultural fields and park areas near the epicenter. This was recorded as the first observed liquefaction phenomenon in Korea. This paper analyzes liquefaction potentials at the key sites at Pohang area. The simplified methods and current design standard were used to evaluate the occurrence of liquefaction. The seismic demand was estimated based on the NGA-WEST2 ground motion prediction equations (GMPEs). The liquefaction resistance of the ground was determined using the in-situ tests: standard penetration test (SPT) and cone penetration test (CPT). The liquefaction potentials were quantified by liquefaction potential index (LPI), which were compared with those from the previous studies.

• Land and Housing Review
• /
• v.3 no.3
• /
• pp.279-286
• /
• 2012

The limit states design method is replacing the allowable stress design method worldwide, e.g. the design code of ISO and various construction codes of Korea are adopting the reliability based limit state method. This paper proposed LRFD design value which is one of limit states design method for the PHC bored pile used as building foundation. This paper analysed 81 load test results and the bearing design(Meyerhof method & SPT-CPT conversion method), and proposed LRFD value for each design reliability Index 2.33 and 3.0 for PHC bored pile. LRFD value of PHC bored pile represents 0.36~0.44 for Meyerhof method and 0.24~0.31 for SPT-CPT conversion method according to the deign reliability index.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.33 no.2
• /
• pp.631-642
• /
• 2013

The standard CPT(Cone Penetration Test), which can be easily performed to investigate in-situ soil engineering properties, has been widely used. CPT are also widely being utilized in centrifuge model tests. In this study, a miniature cone with 10mm diameter was developed and its applicability in the centrifuge was evaluated. The developed miniature cone was equipped with a four degree-of-freedom in-flight robot. A series of cone penetration tests was performed under four centrifuge acceleration levels. As results, the cone resistances measured at the same confining stress within shallow penetration depth were affected by the centrifugal accelerations. The critical depth was proportional to the cone diameter and relative density. Cone resistances results below the critical depth and soil parameters obtained from the laboratory tests were compared with those by previously proposed empirical relations.

• YAKHAK HOEJI
• /
• v.53 no.4
• /
• pp.222-227
• /
• 2009

Human topoisomerase I (Topo I) plays a pivotal role in cell replication, transcription and repair and, therefore, is an important anti-cancer target. 20S-camptothecin (CPT) is a representative Topo I inhibitor. Compounds belonging to CPT family inhibit the religation step of Topo I-DNA by binding to the DNA cleavage site. Computational docking studies with Surflex-Dock were carried out to investigate the binding modes between Topo I-DNA binary complex structure and the ligand such as 20S-CPT and 9,10-substituted 20S-CPT analogues. The docking results demonstrated that most of the compounds with $IC_{50}$ value under $0.5{\mu}M$ intercalated exactly between the -1 and +1 DNA bases, deeply toward the cleavage site. The complex was stabilized by hydrogen-bonding and hydrophobic interactions with both the enzyme and the DNA. The compounds with $IC_{50}$ value above $0.5{\mu}M$ were poorly docked and did not intercalate. In addition, the docking results confirmed the overall correlation between the $IC_{50}$ values and docking scores, indicating the possible use of the modeling for the prediction of biological activity and design of potential inhibitors.

• Korean Journal of Psychosomatic Medicine
• /
• v.30 no.2
• /
• pp.80-98
• /
• 2022

Posttraumatic stress disorder (PTSD) is well known to have a limited response to drug treatment. Many recently published clinical care guidelines recommend trauma-focused psychotherapies such as cognitive processing therapy (CPT) and prolonged exposure therapy (PE) as first-line treatment and medication such as serotonin reuptake inhibitors and venlafaxine as second-line treatment. Current review introduces the session composition and contents of CPT and presents various CPT studies that show therapeutic effect for civilian and veterans/military with PTSD. In order for clinicians to help effectively patients with PTSD, it is necessary to learn and actively use evidence-based trauma-focused psychotherapies including CPT and PE.

• Journal of the Korean Geotechnical Society
• /
• v.25 no.2
• /
• pp.67-77
• /
• 2009

In this study, the relations of cone tip resistances (qc) and DMT indices of cemented sand are analyzed from a series of calibration chamber tests. The experimental results show that, with increasing the cementation level, three DMT indices also increase. The CPT and DMT do not appear to properly reflect the cementation effect of sand, since the penetration induces the damage of cementation. Nevertheless, the DMT is more sensitive to deformation characteristics of cemented sand than CPT. It is also observed that the $E_D/q_c$ ratio of cemented sand is larger than that of uncemented sand. However, the $K_D-q_c/{\sigma}_v'$ relation is independant of cementation, unlike the result of previous study. In addition, this study evaluates the constrained modulus and cohesion intercept of cemented sand using the relation between cone resistance and dilatometer constrained modulus ($M_D$).