• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.305-307
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• 2021

본 논문에서는 ICT(Information Communication Technology) 기술을 이용하여 스마트팩토리 기반 CPPS(Cyber Pysical Production System)를 활용한 Digital-Twin 플랫폼 개발과 관련된 연구를 제안한다. 본 연구를 통해 개발된 플랫폼은 선행 제조 공정 계획 단계부터 BOP(Bill of Process) 관리 기능을 포함하여 P3R(Product, Process, Plant, Resource)을 연계한 3D Model 시뮬레이션 기능을 수행한다. 또한 생산 공정, 설비, 레이아웃, 생산량 예측이 가능한 Digital Twin 플랫폼을 제안한다. 본 논문을 통해 제안된 플랫폼은 초기 계획 설계 단계에서부터 제조, 생산, 운영 및 유지보수 단계까지의 전체 스마트팩토리 제조 공정을 관리할 수 있는 특징을 제안하였다.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2002년도 추계국제학술대회
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• pp.125-134
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• 2002

Crop Protection Products (CPPs) are a useful weapon in our fight against the pests, diseases and weeds that harm or destroy our food. To be effective CPPs need to exhibit some persistence. The consequence of this is that residues of the original material or its metabolites may remain on food and thus there is a potential for the intake of such residues. The issue of CPP residues in food is an emotional subject and is rarely debated rationally or supported by scientific facts. Media headlines like “Poison in our food” or “These days enough Pesticides (CPPs) are sprayed onto vegetables to turn you into one” are testimony to the high level of emotion that surrounds the subject of CPP residues in food. Recent surveys of consumers have indicated that more than 80 percent view CPP residues in food as a “serious hazard”. This significantly exceeds concerns over drugs, hormones in meat, nitrates in food, irradiated foods, food additives, or artificial colours.

• IMMUNE NETWORK
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• 제16권1호
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• pp.33-43
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• 2016

Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4⁺ and CD8⁺ T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination.

• 대한한방내과학회지
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• 제29권3호
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• pp.800-809
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• 2008

Objective : Although chronic prostatitis/chronic pelvic pain syndrcme(CP/CPPS) is a common disease, there is no consensus on the etiology or pathology and treatment. This was a double-blinded, placebo-controlled, randomized clinical trial, investigating the therapeutic effects of the traditional Korean medicine, Bosingunyang-tang(BSGYT). Method : Participants who met US National Institutes of Health (NIH) consensus criteria for CP/CPPS were entered after applying inclusion/exclusion criteria. They were randomized to the BSGYT or placebo group. and treated three times a day for 6 weeks. NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was used to estimate the clinical symptoms of CP/CPPS. Prostaglandin E2 and ${\beta}$-endorphin in prostatic fluid, collected by 2-glass pre-massage and post-massage test, were analyzed as factors associated with pain and inflammation. Result : The mean decrease in NIH-CPSI total score of the BSGYT group was 11.0 points, which is 5.7 points more than the placebo group. (Mann Whitney test P=0.038) Also the BSGYT group showed three times higher response rate than the placebo group in NIH-CPSI pain subscale score. (Fisher's exact test P=0.027) In those responders, prostaglandin E2 decreased significantly. (Wilcoxon's signed-ranks test P=0.037). No specific side effects were observed. Conclusion : After a 6-week treatment period, BSGYT improved clinical symptoms of CP/CPPS patients by decreasing PGE2 level in prostatic fluid.

• Molecules and Cells
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• 제28권4호
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• pp.341-345
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• 2009

MiRNAs are non-coding RNAs that play a role in the regulation of major processes. The inhibition of miRNAs using antisense oligonucleotides (ASOs) is a unique and effective technique for the characterization and subsequent therapeutic targeting of miRNA function. Recent advances in ASO chemistry have been used to increase both the resistance to nucleases and the target affinity and specificity of these ASOs. Peptide nucleic acids (PNAs) are artificial oligonucleotides constructed on a peptide-like backbone. PNAs have a stronger affinity and greater specificity to DNA or RNA than natural nucleic acids and are resistant to nucleases, which is an essential characteristic for a miRNA inhibitor that will be exposed to serum and cellular nucleases. For increasing cell penetration, PNAs were conjugated with cell penetrating peptides (CPPs) at N-terminal. Among the tested CPPs, Tat-modified peptide-conjugated PNAs have most effective function for miRNA inhibition. PNA-based ASO was more effective miRNA inhibitor than other DNA-based ASOs and did not show cytotoxicity at concentration up to 1,000 nM. The effects of PNA-based ASOs were shown to persist for 9 days. Also, PNA-based ASOs showed considerable stability at storage temperature. These results suggest that PNA-based ASOs are more effective ASOs of miRNA than DNA-based ASOs and PNA-based ASO technology, compared with other technologies used to inhibit miRNA activity can be an effective tool for investigating miRNA functions.

• 말소리와 음성과학
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• 제4권2호
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• pp.89-94
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• 2012

The aim of this study is to investigate the usefulness of the parameter CPP (cepstral peak prominence) and LTAS (long term average spectrum) band energy for an analysis of breathy voice with vocal fold paralysis. Thirty-four female subjects who have vocal paralysis after thyroidectomy participated in this study. According to the perceptual judgements by three speech pathologists and one phonetic scholar, subjects were divided into two groups: breathy voice group (n = 21) and non-breathy voice group (n = 13). Maximum sustained phonation task was measured for acoustic analysis. CPP-related (i.e. mean F0, mean CPP, and mean CPPs) and LTAS-related (i.e. minimum, maximum, and mean) parameters were used. Independent samples t-test was conducted. Regarding CPP, there are significant differences in mean CPP and mean CPPs between groups. The values of mean CPP and CPPs in the non-breathy voice group are higher than those in the breathy voice group. The CPP could be regarded as the useful parameter for breathy voice analysis in the clinic. When it comes to LTAS, energy from 0 to 2 kHz are significantly different between groups. The minimum value of non-breathy group is lower than that of breathy group, whereas the maximum value of non-breathy group is higher. The frequency band below 2 kHz seems to be related to breathy voice.

• Journal of Advanced Marine Engineering and Technology
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• 제29권2호
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• pp.236-242
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• 2005

Dynamic Positioning(DP) system maintains ship's position (fixed location or predetermined track) exclusively by means of CPPs and thrusters. To generate the control input adequate to various situation an integrated controller for CPPs and thrusters is required. The integrated controller is composed of a thrust calculation algorithm and a thrust allocation algorithm. The thrust calculation algorithm generates thrusts in the surge direction and the sway direction from the desired forward and lateral speed and generates a moment about the yaw axis from desired heading angle. The thrust allocation algorithm allocates the generated thrusts and moment to each CPP and thruster. Computer simulations are executed to confirm the effectiveness of the suggested controller.

• 산업경영시스템학회지
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• 제43권1호
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• pp.143-150
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• 2020

To enhance the effectiveness of the FMS (flexible manufacturing system), it is necessary for the manufacturing control system to be upgraded by integrating the cyber and the physical manufacturing systems. Using the CPPS (Cyber-Physical Production System) concept, this study proposes a 4-stage vertical integration and control framework for an aircraft parts manufacturing plant. In the proposed framework, the process controller prepares the operations schedule for processing work orders generated from the APS (advanced planning & scheduling) system. The scheduled operations and the related control commands are assigned to equipments by the dispatcher of the line controller. The line monitor is responsible for monitoring the overall status of the FMS including work orders and equipments. Finally the process monitor uses the simulation model to check the performance of the production plan using real time plant status data. The W-FMCS (Wing rib-Flexible Manufacturing Control & Simulation) are developed to implement the proposed 4-stage CPPS based FMS control architecture. The effectiveness of the proposed control architecture is examined by the real plant's operational data such as utilization and throughput. The performance improvement examined shows the usefulness of the framework in managing the smart factory's operation by providing a practical approach to integrate cyber and physical production systems.

• 대한공간정보학회지
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• 제20권2호
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• pp.63-71
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• 2012

최근 포털 사이트들을 중심으로 거리 기반의 파노라마 영상 서비스(Street-Level Imagery, SLI)가 제공되고 있다. SLI는 거리상에서 실세계를 바라보는 것과 동일한 영상으로 매우 직관적이고 상세한 정보 제공이 가능하다. 이러한 특성을 가지는 SLI는 타 공간정보와 합성을 통하여 활용성이 더욱 증대될 수 있다. 하지만, 서로 다른 공간정보 데이터셋을 합성할 경우 실세계의 동일 객체가 서로 다른 위치에 표현되는 위치 편차 문제는 합성의 품질을 저하시키는 요인이 된다. 따라서 본 연구는 SLI를 현재 가장 널리 활용되고 있는 2D 지도와 합성하기 위한 상호간의 위치 편차 제거를 목표로 한다. 위치 편차 제거는 (1) 컨트롤 포인트 쌍 탐색을 위한 SLI 촬영 궤적과 2D 지도의 도로 레이어간 교차로 매칭, (2) 경향성 분석을 통한 부정확한 컨트롤 포인트 쌍 제거, (3) 정확한 컨트롤 포인트 쌍을 이용한 국지적 조정 등의 세부 프로세스를 포함한다. 또한, SLI를 포함하는 합성 결과에 적합한 정확도 평가 방법을 제시하고, 이를 통하여 위치 편차 제거의 효과를 검증한다.

• 임상이비인후과
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• 제29권2호
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• pp.212-222
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• 2018

Background and Objectives : The purpose of this study was to compare the measured values of acoustic and auditory perceptual assessments between normal and functional dysphonia (FD) groups. Materials and Methods : 102 subjects with FD and 59 normal voice groups were participated in this study. Mid-vowel portion of the sustained vowel /a/ and two sentences of 'Sanchaek' were edited, concatenated, and analyzed by Praat script. And then auditory-perceptual (AP) rating was completed by three listeners. Results : The FD group showed higher acoustic voice quality index version 2.02 and version 3.01 (AVQIv2 and AVQIv3), slope, Hammarberg index (HAM), grade (G) and overall severity (OS), values than normal group. Additionally, smoothed cepstral peak prominence in Praat (PraatCPPS), tilt, low-to high spectral band energies (L/H ratio), long-term average spectrum (LTAS) in FD group were lower than normal voice group. And the correlation among measured values ranged from -0.250 to 0.960. In ROC curve analysis, cutoff values of AVQIv2, AVQIv3, PraatCPPS, slope, tilt, L/H ratio, HAM, and LTAS were 3.270, 2.013, 13.838, -22.286, -9.754, 369.043, 27.912, and 34.523, respectively, and the AUC of each analysis was over .890 in AVQIv2, AVQIv3, and PraatCPPS, over 0.731 in HAM, tilt, and slope, over 0.605 in LTAS and L/H ratio. Conclusions : In conclusion, AVQI and CPPS showed the highest predictive power for distinguishing between normal and FD groups. Acoustic analyses and AP rating as noninvasive examination can reinforce the screening capability of FD and help to establish efficient diagnosis and treatment process plan for FD.