• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4301-4305
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• 2014

Tanshinone IIA is a pharmacologically active ingredient extracted from Danshen, a Chinese traditional medicine. Its molecular mechanisms are still unclear. The present study utilized computational approaches to uncover the potential targets of this compound. In this research, PharmMapper server was used as the inverse docking tool andnd the results were verified by Autodock vina in PyRx 0.8, and by DRAR-CPI, a server for drug repositioning via the chemical-protein interactome. Results showed that the retinoic acid receptor alpha ($RAR{\alpha}$), a target protein in acute promyelocytic leukemia (APL), was in the top rank, with a pharmacophore model matching well the molecular features of Tanshinone IIA. Moreover, molecular docking and drug repurposing results showed that the complex was also matched in terms of structure and chemical-protein interactions. These results indicated that $RAR{\alpha}$ may be a potential target of Tanshinone IIA for APL. The study can provide useful information for further biological and biochemical research on natural compounds.

• 가정과삶의질연구
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• 제20권4호
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• pp.103-111
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• 2002

This study is to examine the relationship of HOME and personality with Preschool children's school readiness. The subjects were 138 children(4 to 6 year-old) and their mothers in Seoul, Gyunggi-do, and Chungnam. The instruments for this study were Cooperative Preschool Inventory(CPI), The Home Observation for Measurement of the Environment(HOME), and Children's Personality Test. The data were analyfed by Pearson's r, stepwise regression, ANOVA, Scheffe test for the post hoc test, and Cronbach a for the reliability in SPSS PC program. The major findings with the preschool children's school readiness were as follows. 1) That was significant correlations with HOME(language environment and encouragement of independence) and personality(sociability and familiarity). 2) That was explained significantly by sociability, encouragement of independence, language environment, and stimuli for development. 3) That was no sex-difference and was an increase by age. 4) There were significant differences in preschool children's school readiness, HOME, and personality by familial demographic variables.

• 한국안전학회지
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• 제29권2호
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• pp.82-88
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• 2014

Recently, the concepts of community adaptation and ability to restore have been emphasized in order to evaluate disaster vulnerability and risk exposure level. In particular, the concept of disaster management that voluntarily takes measures prior to disaster situations has been introduced based on participatory disaster management that the community should take responsibility for one's own safety. This study diagnosed the community response capability on four model areas such as Goseong-gun and Gimhae-si, Gyeongsangnam-do and Gimcheon-si and Bonghwa-gun, Gyeongsangbuk-do and represented the Community Preparedness Indicator(CPI) for each region as a result.

• 진공이야기
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• 제1권2호
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• pp.24-29
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• 2014

Display is a key component in electronic devices. OLED is growing very fast recently due to the explosion of the smart phone market although still LCD is the dominating display technology in the display market at the moment. Also needs for the large area and high resolution TVs and flexible displays are increasing these days. Especially flexible display is expected to be one of the key technologies in mobile devices requiring small device size and large display size. Contrary to the conventional displays, flexible display requires organic materials for the substrate, the active driving element and also for the display element. Plastic film as a substrate, organic semiconductor as an active component of the transistor and organic light emitting materials or electronic paper as a display element are studied actively. In this article, mainly backplane technologies such as substrates and the transistor materials for flexible display will be introduced.

• 음성과학
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• 제9권4호
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• pp.3-14
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• 2002

VPI occurs when the velum and lateral and posterior pharyngeal wall fail to separate the nasal cavity from the oral cavity during deglutition and speech. There are a number of congenital and acquired conditions which result in VPI. Congenital conditions include cleft palate, submucous cleft palate and congenital palatal insufficiency (CPI). Acquired conditions include carcinoma of the palate or pharynx and neurologic disorders. The speech characteristics of VPI is characterized by hypernasality, nasal air emission, decreased intraoral air pressure, increased nasal air flow, decreased intelligibility. VPI can be treated with various methods that include speech therapy, surgical procedures to reduce the velopharyngeal gap, speech aid prosthesis, and combination of surgery and prosthesis. This article describes four cases of VPI treated by speech aid prosthesis and speech therapy with satisfactory result.

• 한국건설관리학회논문집
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• 제10권3호
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• pp.130-138
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• 2009

Bromilow's time-cost (BTC) relationship was examined for building projects in Vietnam using actual construction time and total construction cost. Data set was collected from 77 historical building construction projects completed between 1999 and 2005 which were adjusted by consumer price index (CPI) to 2000 price. Time-cost equations were specified respected to two sectors, public and private, in Vietnamese construction industry and all cases. It is shown that a public funded building project has the longer construction duration than a similar budget private funded project. The resulting models are statistically significant. The adjusted R-square coefficients of all cases, public and private projects models are respectively 0.403, 0.436 and 0.377 mean that the BTC regression lines moderately fit the data set.

• Asia pacific journal of information systems
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• 제4권1호
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• pp.3-31
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• 1994

Potential employers considering locations for production or service facilities typically equire detailed advance knowledge of the wages they will be expected to offer for workers in various occupational categories. The State of Missouri s Department of Labor and Industrial Relations is often contacted by organizations requesting such information. The current wage rate survey approach, initiated in 1988, allows the Department to predict an appropriate wage rate for a given occupation in certain counties, adjusted for changes in the Consumer Price Index (CPI). However, both Department employees and firms have indicated that improved prediction responsiveness and accuracy are desirable. A major deficiency of the current approach is its inability to predict wages for unsurveyed counties. This paper describes a knowledge-based system (KBS), currently in the prototype testing stage, that is expected to supplement the wage rate survey in the near future.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2000년도 추계학술발표대회 논문집
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• pp.58-62
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• 2000

The fabrication process and analysis of thermal properties of 50~76vo1% SiCp/Al metal matrix composites(MMCs) for heatsink materials in electronic packaging were investigated. The 50~76vo1% SiCp/Al MMCs fabricated by pressure infiltration casting process showed that thermal conductivities were 85~170W/mK and coefficient of thermal expansion(CTE) were ranged 10~6ppm1k. Specially, the thermal conductivity and CTE of 71vo1%SiCp/Al MMCs were ranged 115~156W/mK and 6~7ppm/K. respectively, which showed a improved thermal properties than the conventional electronic packaging materials such as ceramics and metals.

• 한국건축시공학회지
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• 제2권4호
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• pp.105-112
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• 2002

The EVMS(Earned Value Management System) comes from C/SCSC which was first released by the United States Department of Defense in December 1967, and preyed very powerful and efficient project management tool from a lot of practices. Although it is an excellent tool, we can not be succeed appling foreign system due to the differences of construction culture and law between the Korean and US construction industries. EAC(Estimate at Completion) is one of the most important functions in the EVMS. The purpose of this study is to propose the improved EAC method according to the performance indices better than old that and to prove from examples. In advance, the improved EAC method is to estimate more exactly costs and to promote efficiency in construction projects.

• 정보기술과데이타베이스저널
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• 제5권1호
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• pp.51-67
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• 1998

There exist a number of information systems planning(ISP) methodologies. As the level of market competition gets intensified, firms are more likely to engage in organizational transformations such as BPR and CPI(continuous process improvement). Because this new requirement should be incorporated into ISP methodology, the number of ISP methodologies available will be continually increasing. However, we could not find a framework for understanding and classifying these divergent methodologies. So, we here present a framework for classifying ISP methodology classes. With this framework, we categorize different classes of ISP methodologies and identify their limitations in terms of missing elements and links. And we move on to present new technical innovations and other methodological advances that, if properly integrated with ISP methodologies, would help us derive an IT infrastructure plan more effectively. Furthermore, in search of software tools or aids supporting the application of ISP methodologies, we identify requirements of ISP-supporting software tools and evaluate functions of existing software tools, then suggesting a future direction to that end.