• International Journal of Oral Biology
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• v.40 no.1
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• pp.19-25
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• 2015

Osteocytes may function as mechanotransducers by regulating local osteoclastogenesis. Reduced availability of oxygen, i.e. hypoxia, could occur during disuse, bone development, and fracture. Receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) is an osteoblast/stromal cell derived essential factor for osteoclastogenesis. The hypoxia induced osteoclastogenesis via increased RANKL expression in osteoblasts was demonstrated. Hypoxic regulation of gene expression generally involves activation of the hypoxia-inducible factor (HIF) transcription pathway. In the present study, we investigated whether hypoxia regulates RANKL expression in murine osteocytes and HIF-$1{\alpha}$ mediates hypoxia-induced RANKL expression by transactivating RANKL promoter, to elucidate the role of osteocyte in osteoclastogenesis in the context of hypoxic condition. The expression levels of RANKL mRNA and protein, as well as hypoxia inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) protein, were significantly increased in hypoxic condition in MLO-Y4s. Constitutively active HIF-$1{\alpha}$ alone significantly increased the levels of RANKL expression in MLO-Y4s under normoxic conditions, whereas dominant negative HIF-$1{\alpha}$ blocked hypoxia-induced RANKL expression. To further explore to find if HIF-$1{\alpha}$ directly regulates RANKL transcription, a luciferase reporter assay was conducted. Hypoxia significantly increased RANKL promoter activity, whereas mutations of putative HIF-$1{\alpha}$ binding elements in RANKL promoter prevented this hypoxia-induced RANKL promoter activity in MLO-Y4s. These results suggest that HIF-$1{\alpha}$ mediates hypoxia-induced up-regulation of RANKL expression, and that in osteocytes of mechanically unloaded bone, hypoxia enhances osteoclastogenesis, at least in part, via an increased RANKL expression in osteocytes.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.2
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• pp.73-78
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• 2010

Wave energy is dissipated mainly by friction on the seabed until the waves reach the surf zone. Many researchers have investigated the mechanism of wave friction and the bottom shear stress induced by wave motion at a certain point is now well estimated by introducing the wave friction factor related to the near bed velocity given by linear wave theory. The variation of wave energy or wave height over a long distance can be, however, estimated by an iteration process when the propagation of waves is strongly influenced by bed friction. In the present study simple semi-theoretical equation has been developed to compute the variation of wave height for the condition of wave propagation on a constant beach slope. The ratio of wave height is determined by the product of shoalng factor and wave height friction factor (frictional wave energy dissipation factor). The wave height estimated by the new equation is compared with the wave height estimated by the solution of numerical integration for the condition that the waves propagate on a constant slope.

• Proceedings of the KIEE Conference
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• 2006.05a
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• pp.71-73
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• 2006

Our company(KOWACO) has periodically performed off-line diagnostic test for 14 hydro generators (rated 11 kV over) for 15 years. In this paper, we summarized results of dissipation factor tip-up test and partial discharge test about these generators. Among these, we chose two generators and performed insulation reinforcement (cleaning and varnish Painting). We compared change of insulation condition for the stator winding based upon off-line diagnostic test result before and after repair. Test result shows that insulation condition was improved after insulation reinforcement. This insulation reinforcement has a function to reduce cause of deterioration, so we can know that it extends lifetime of generator and it is a very important factor for stable operation of facilities.

• Proceedings of the KIEE Conference
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• 2005.11a
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• pp.157-159
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• 2005

In this study, in order to develop Pb-free piezoelectric ceramics, $[Li_{0.04}(Na_{0.44}K_{0.52)-(Nb_{0.86}Ta_{0.10}Sb_{0.04})]O_3$ ceramics were fabricated by conventional mixed oxide method and their piezoelectric characteristics were investigated according to the poling condition. The transition temperature from orthorhombic phase to tetragonal phase observed at $93[^{\circ}C]$ and Curie temperature was $346[^{\circ}C]$. At $50[^{\circ}C]$ poling temperature, dielectric constant, electromecha nical coupling factor kp, piezoelectric $d_{33}$ const ant, coercive field Ec, remanant polarization Pr and mechanical quality factor Qm showed the optimum value of 737, 0.45, 209[pC/N], 1l.34[kV/cm], $7.14[{\mu}C/cm^2]$ and 205, respectively.

• Proceedings of the KIEE Conference
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• 2006.07e
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• pp.51-52
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• 2006

Our company(KOWACO) has periodically performed off-line diagnostic test for 14 hydro generators (rated 11 kV over) for 15 years. In this paper, we summarized results of dissipation factor tip-up test and partial discharge test about these generators. Among these, we chose two generators and performed insulation reinforcement (cleaning and varnish painting). We compared change of insulation condition for the stator winding based upon off-line diagnostic test result before and after repair. Test result shows that insulation condition was improved after insulation reinforcement. This insulation reinforcement has a function to reduce cause of deterioration, so we can know that it extends lifetime of generator and it is a very important factor for stable operation of facilities.

• Journal of the Korean Society for Heat Treatment
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• v.26 no.4
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• pp.178-184
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• 2013

The effects of thickness and surface grinding condition on the fracture strength of Si wafer with a thickness under $100{\mu}m$ were investigated. Fracture strength was measured by ball breaker test for about 330 dies (size: $4mm{\times}4mm$) per each wafer. For statistical analysis of the fracture strength, scale factor was determined from Weibull plot. Ball breaker fracture strength was observed to increase with decreasing thickness of silicon die. For the silicon dies of different surface conditions, ball breaker fracture strength was high in the order of polished, ground (#4800), and ground (#320 grit) specimen. Probabilistic fracture strength (i.e., scale factor) increased with decreasing surface roughness of silicon die.

• Bulletin of the Society of Naval Architects of Korea
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• v.25 no.1
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• pp.21-32
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• 1988

An experimental study was carried out to identify the fatigue fracture behavior of steel for merchant ships. The bending and shear loads were applied simultaneously on the specimens to simulate of real load condition for a ship. The effects of the stress intensity factor under mode I with mode II loading condition on the initiation and the propagation of a crack were investigated, with particular emphasis on mode II. When the $K_{II}$ stress intensity factor in mode II was applied under mode I loading condition, the propagation behavior of a crack is to be affected mainly by the anisotropic characteristic of materials.

• Korean Journal of Hydrosciences
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• v.7
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• pp.107-124
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• 1996

Pipe design normally requires pump power, discharge or pipe diameter for each condition given. Due to several investigators the pipe friction factor con now be estimated by explicit way for a wide range of flow condition. In various problems of pipe design, however, the flow condition cannot be pre-determined even for a uniformly rough pipe. In these cases a lot of iterations are often required to have an accurate solution with ordinary approach. This paper presents the direct computation method of discharge and pipe diameter without any iteration process. Introducing the power law of friction factor, various non-dimensional physical numbers are derived such as power-diameter number, power-discharge number, diameter-slope number and discharge-slope number. One of the physical numbers concerned with discharge or pipe diameter can be related to a combination of the other in an explicit way.

• Journal of radiological science and technology
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• v.23 no.1
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• pp.13-19
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• 2000

We have presented with the "A study on overexposure rate according to over-density in chest X-ray radiography(I)" last year. In this report, We could calculate the entrance skin dose from chest X-ray film density the formula $I_0=Ix/e^{-{\mu}x}{\times}mG$, (mG is Bucky factor) was used to deliver the skin dose. At that time, There was two problems that the Bucky factor from maker was not equal to field experience and the field size influenced on the Attenuation Rate. The experiment of Bucky factor was done from film method and retried the Attenuation Rate of Acryle phantom according to Good & Poor geometry. As the results, The Bucky factor from maker higher than in this experiments $30{\sim}40%$. The Attenuation Rate in good geometric condition brings about a little alteration compare with poor geometric condition. In the field experiment, we could get the chest image with very low entrance skin radiation dose $29.3{\mu}Sv$, especially with air gap methode, the entrance skin dose was detected $10{\mu}Sv$.

• Culinary science and hospitality research
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• v.14 no.1
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• pp.73-83
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• 2008

The purpose of this study was to investigate purchasing variables in the organic food consumption level in Busan. To achieve this purpose, 240 residential women who are organic food consumers were chosen. Among them, 149 women took part in the study. The questionnaire was composed of three parts: 8 demographic characteristics, 9 organic food purchasing conditions, and 22 purchasing variables. The research was continued from August 20th until September 10th, 2007. To derive the results, descriptive analysis, factor analysis, and ANOVA were used by spss 14.0. To sum up the results, three organic food consumption groups were classified into high, middle, and low consumption levels depending on buying condition for organic material. For the factor analysis, 5 factors were named as confidence, quality, safety, appearance, and economy. On the high consumption level, economy factor was highly important than other groups. In general, price would be a more sensitive factor, so they answered the adjusted price range; 52 participants said under 10%, 22 between 11% and 20%, and 17 over 40%.