• International Journal of Oral Biology
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• 제40권1호
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• pp.19-25
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• 2015

Osteocytes may function as mechanotransducers by regulating local osteoclastogenesis. Reduced availability of oxygen, i.e. hypoxia, could occur during disuse, bone development, and fracture. Receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) is an osteoblast/stromal cell derived essential factor for osteoclastogenesis. The hypoxia induced osteoclastogenesis via increased RANKL expression in osteoblasts was demonstrated. Hypoxic regulation of gene expression generally involves activation of the hypoxia-inducible factor (HIF) transcription pathway. In the present study, we investigated whether hypoxia regulates RANKL expression in murine osteocytes and HIF-$1{\alpha}$ mediates hypoxia-induced RANKL expression by transactivating RANKL promoter, to elucidate the role of osteocyte in osteoclastogenesis in the context of hypoxic condition. The expression levels of RANKL mRNA and protein, as well as hypoxia inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) protein, were significantly increased in hypoxic condition in MLO-Y4s. Constitutively active HIF-$1{\alpha}$ alone significantly increased the levels of RANKL expression in MLO-Y4s under normoxic conditions, whereas dominant negative HIF-$1{\alpha}$ blocked hypoxia-induced RANKL expression. To further explore to find if HIF-$1{\alpha}$ directly regulates RANKL transcription, a luciferase reporter assay was conducted. Hypoxia significantly increased RANKL promoter activity, whereas mutations of putative HIF-$1{\alpha}$ binding elements in RANKL promoter prevented this hypoxia-induced RANKL promoter activity in MLO-Y4s. These results suggest that HIF-$1{\alpha}$ mediates hypoxia-induced up-regulation of RANKL expression, and that in osteocytes of mechanically unloaded bone, hypoxia enhances osteoclastogenesis, at least in part, via an increased RANKL expression in osteocytes.

• 한국해안·해양공학회논문집
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• 제22권2호
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• pp.73-78
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• 2010

파에너지는 쇄파되기 이전까지 주로 해저면과의 마찰력에 의하여 감소한다. 파마찰력을 산정하기 위한 연구는 여러 연구자들에 의해 진행되어 왔으며 어느 특정지점에서의 파마찰력 또는 파마찰손실률은 선형파이론으로 주어지는 해저면 입자유속과 연관된 파마찰계수의 도입으로 상당히 정확하게 간단하게 산정할 수 있다. 그러나 장구간에 걸쳐 파마찰력에 의하여 점차적으로 감소되는 파고변이는 상당한 반복 과정을 거쳐야 산정할 수 있었다. 본 연구에서는 기존 경험식을 이용해 전난류, 완난류 경우에 대해 일정경사면에서 천수효과와 마찰손실에 의한 파고 변화를 비교적 간단한 방법으로 추정하는 방법을 제시하였다. 해빈경사가 일정할 때 파고 변이률은 천수계수와 파고 마찰손실계수의 곱으로 간단히 구할 수 있다. 실제 해안과 비슷한 조건의 경우에 대하여 반복시산 과정으로 구한 수치와 간편 산정식으로 간단히 계산한 결과를 비교하여 제시하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 춘계학술대회 논문집 전기설비전문위원
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• pp.71-73
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• 2006

Our company(KOWACO) has periodically performed off-line diagnostic test for 14 hydro generators (rated 11 kV over) for 15 years. In this paper, we summarized results of dissipation factor tip-up test and partial discharge test about these generators. Among these, we chose two generators and performed insulation reinforcement (cleaning and varnish Painting). We compared change of insulation condition for the stator winding based upon off-line diagnostic test result before and after repair. Test result shows that insulation condition was improved after insulation reinforcement. This insulation reinforcement has a function to reduce cause of deterioration, so we can know that it extends lifetime of generator and it is a very important factor for stable operation of facilities.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 추계학술대회 논문집 전기물성,응용부문
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• pp.157-159
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• 2005

In this study, in order to develop Pb-free piezoelectric ceramics, $[Li_{0.04}(Na_{0.44}K_{0.52)-(Nb_{0.86}Ta_{0.10}Sb_{0.04})]O_3$ ceramics were fabricated by conventional mixed oxide method and their piezoelectric characteristics were investigated according to the poling condition. The transition temperature from orthorhombic phase to tetragonal phase observed at $93[^{\circ}C]$ and Curie temperature was $346[^{\circ}C]$. At $50[^{\circ}C]$ poling temperature, dielectric constant, electromecha nical coupling factor kp, piezoelectric $d_{33}$ const ant, coercive field Ec, remanant polarization Pr and mechanical quality factor Qm showed the optimum value of 737, 0.45, 209[pC/N], 1l.34[kV/cm], $7.14[{\mu}C/cm^2]$ and 205, respectively.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 전기설비
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• pp.51-52
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• 2006

Our company(KOWACO) has periodically performed off-line diagnostic test for 14 hydro generators (rated 11 kV over) for 15 years. In this paper, we summarized results of dissipation factor tip-up test and partial discharge test about these generators. Among these, we chose two generators and performed insulation reinforcement (cleaning and varnish painting). We compared change of insulation condition for the stator winding based upon off-line diagnostic test result before and after repair. Test result shows that insulation condition was improved after insulation reinforcement. This insulation reinforcement has a function to reduce cause of deterioration, so we can know that it extends lifetime of generator and it is a very important factor for stable operation of facilities.

• 열처리공학회지
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• 제26권4호
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• pp.178-184
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• 2013

The effects of thickness and surface grinding condition on the fracture strength of Si wafer with a thickness under $100{\mu}m$ were investigated. Fracture strength was measured by ball breaker test for about 330 dies (size: $4mm{\times}4mm$) per each wafer. For statistical analysis of the fracture strength, scale factor was determined from Weibull plot. Ball breaker fracture strength was observed to increase with decreasing thickness of silicon die. For the silicon dies of different surface conditions, ball breaker fracture strength was high in the order of polished, ground (#4800), and ground (#320 grit) specimen. Probabilistic fracture strength (i.e., scale factor) increased with decreasing surface roughness of silicon die.

• 대한조선학회지
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• 제25권1호
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• pp.21-32
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• 1988

An experimental study was carried out to identify the fatigue fracture behavior of steel for merchant ships. The bending and shear loads were applied simultaneously on the specimens to simulate of real load condition for a ship. The effects of the stress intensity factor under mode I with mode II loading condition on the initiation and the propagation of a crack were investigated, with particular emphasis on mode II. When the $K_{II}$ stress intensity factor in mode II was applied under mode I loading condition, the propagation behavior of a crack is to be affected mainly by the anisotropic characteristic of materials.

• Korean Journal of Hydrosciences
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• 제7권
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• pp.107-124
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• 1996

Pipe design normally requires pump power, discharge or pipe diameter for each condition given. Due to several investigators the pipe friction factor con now be estimated by explicit way for a wide range of flow condition. In various problems of pipe design, however, the flow condition cannot be pre-determined even for a uniformly rough pipe. In these cases a lot of iterations are often required to have an accurate solution with ordinary approach. This paper presents the direct computation method of discharge and pipe diameter without any iteration process. Introducing the power law of friction factor, various non-dimensional physical numbers are derived such as power-diameter number, power-discharge number, diameter-slope number and discharge-slope number. One of the physical numbers concerned with discharge or pipe diameter can be related to a combination of the other in an explicit way.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2000년도 전력전자학술대회 논문집
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• pp.163-167
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• 2000

This paper presents the digital control of single-phase power factor correction(PFC) converter which has the variable gain according to the condition of inner control loop error. Generally the gain of inner current control loop in single-stage PFC converter has a constant magnitude. This has a bad influence on the power factor because current loop doesn't operate smoothly in the condition that input voltage is low In particular a digital controller has more time delay than an analog controller and degrades This drops the phase margin of the total digital PFC system,. It causes the problem that the gain of current control loop isn't increased enough. In addition the oscillation happens in the peak value of the input voltage open loop PFC system gain changes according to ac input voltage. These aspects make the design of the digital PFC controller difficult The digital PFC controller presented in this paper has a variable gain of current control loop according to input voltage. The 1kW converter was used to verify the efficiency of the digital PFC controller.

• 대한방사선기술학회지:방사선기술과학
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• 제23권1호
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• pp.13-19
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• 2000

We have presented with the "A study on overexposure rate according to over-density in chest X-ray radiography(I)" last year. In this report, We could calculate the entrance skin dose from chest X-ray film density the formula $I_0=Ix/e^{-{\mu}x}{\times}mG$, (mG is Bucky factor) was used to deliver the skin dose. At that time, There was two problems that the Bucky factor from maker was not equal to field experience and the field size influenced on the Attenuation Rate. The experiment of Bucky factor was done from film method and retried the Attenuation Rate of Acryle phantom according to Good & Poor geometry. As the results, The Bucky factor from maker higher than in this experiments $30{\sim}40%$. The Attenuation Rate in good geometric condition brings about a little alteration compare with poor geometric condition. In the field experiment, we could get the chest image with very low entrance skin radiation dose $29.3{\mu}Sv$, especially with air gap methode, the entrance skin dose was detected $10{\mu}Sv$.