• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7541-7546
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• 2015

Aim: To report the histologic findings on Whipple resection specimens and thus determine the extent and spread of carcinomas of ampullary region and head of pancreas in our population. Setting: Section of Histopathology, Department of Pathology, Aga Khan University Hospital (AKUH), Karachi, Pakistan. Materials and Methods: A case series of 311 consecutive Whipple resection specimens received between January 1,2003 and December 31, 2014. Specimens processed for histologic sections and representative sections submitted and histologically examined as per established and standard protocols. All relevant tumor parameters including histologic type, histologic grade, pathologic T and N stage and tumor size were assessed. Epidemiologic data were also recorded. All findings were analysed using SPSS 19.0 software. Results: Ampullary (periampullary) carcinomas were much more common than carcinomas of the head of the pancreas, especially in males, with an average age of 53 years. Mean tumor size was 2.5 cms, over 54% were well differentiated. A large majority were pT2 or pT3 and N0. Carcinomas of pancreatic head were also more common in males, mean age was 55 years, mean tumor size was 3.5cms, and over 65% were moderately differentiated. The majority were T2 or T3 and pN1. Prognostically, significant statistical correlation was seen with tumor grade and pathologic T and N stage (p values statistically significant). However, tumor size was not statistically significant. Conclusions: Ampullary carcinomas are more common compared to pancreatic carcinomas. Majority of ampullary carcinomas were well differentiated while majority of pancreatic carcinomas were moderately differentiated. Large majority of both types of cases were pT2 or T3. Histologic tumor grade and pathologic T and N stage are significantly related to prognosis in Pakistani patients with ampullary and pancreatic cancers.

• Horticultural Science & Technology
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• v.29 no.1
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• pp.53-60
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• 2011

Cytoplasmic male sterility (CMS) induced by mutant mitochondria genome, has been used for commercial seed production of $F_1$ hybrid cultivars in diverse crops. In pepper (Capsicum annuum L.), two sterile cytoplasm specific gene organization, atp6-2 and coxII were identified. An open reading frame, orf456 nearby coxII gene has been speculated to induce male sterility (MS) by mutagenic analysis. Moreover, molecular markers for atp6-2 and coxII of mitochondrial genotype (mitotype) were developed. However, the Cytoplasmic MS specific markers, atp6SCAR and coxIISCAR markers appeared in both N and S cytoplasms when polymerase chain reaction (PCR) cycles prolonged more than 40 cycles. Since the reported molecular markers were dominant markers, the presence of the faint sterile-specific band in normal cytoplasm may lead to the mis-classification of pepper breeding lines. To solve this problem, one common forward primer and two different reverse primers specific to normal coxII and sterile orf456 genes were designed after analyzing their gene organizations. By using these three primers, N and S coxII specific bands were co-amplified in male-sterile lines, but only normal coxII specific band was amplified in maintainer lines. Since the reverse primer for sterile coxII was specifically designed 275 bp downstream of orf456, relatively stable PCR amplification patterns were observed regardless of the number of PCR cycles. These primer sets easily identified different mitotypes among the divergent breeding lines, commercial cultivars and diverse germplasms.

• The Journal of Korean society of community based occupational therapy
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• v.4 no.1
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• pp.23-31
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• 2014

Objective : The objectives of this study were to compare the variables from Fitmeter accelerometer with them from CMS-70P(Zebris Medizintechnik Gmbh, Germany) and to suggest the availability the accelerometer in the field of occupational therapy. Methods : Twenty participants performed calling, drinking water, washing face and spooning and we measured Sum of Single Vector Magnitude(SSVM) and range of motion(ROM) on the wrist and elbow joints. Results :With respect to the wrist and elbow joints, SSVM and ROM differed significantly according to the task(calling, drinking water, washing face and spooning)(p<.001; p<.001; p<.001; p<.001). As for the wrist joint, SSVM and ROM did not show the significant correlation(p>.05) but as for the elbow joint, SSVM and ROM did show the significant correlation according to the task(p<.01; p<.001; p<.01; p<.05). With regard to the SVM-difference of wrist and elbow joints, calling and washing showed the significant difference (p<.001; p<.05) but drinking and spooning did not show the significant difference(p>.05; p>.05). Conclusion : We suggest that Fitmeter accelerometer would be use to record the kinematic variables during performance of ADL and it can compensate the function of CMS-70P as for the elbow joint than the wrist joint.

• Molecules and Cells
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• v.47 no.3
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• pp.100033.1-100033.13
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• 2024

Considering the recent increase in the number of colorectal cancer (CRC) cases in South Korea, we aimed to clarify the molecular characteristics of CRC unique to the Korean population. To gain insights into the complexities of CRC and promote the exchange of critical data, RNA-sequencing analysis was performed to reveal the molecular mechanisms that drive the development and progression of CRC; this analysis is critical for developing effective treatment strategies. We performed RNA-sequencing analysis of CRC and adjacent normal tissue samples from 214 Korean participants (comprising a total of 381 including 169 normal and 212 tumor samples) to investigate differential gene expression between the groups. We identified 19,575 genes expressed in CRC and normal tissues, with 3,830 differentially expressed genes (DEGs) between the groups. Functional annotation analysis revealed that the upregulated DEGs were significantly enriched in pathways related to the cell cycle, DNA replication, and IL-17, whereas the downregulated DEGs were enriched in metabolic pathways. We also analyzed the relationship between clinical information and subtypes using the Consensus Molecular Subtype (CMS) classification. Furthermore, we compared groups clustered within our dataset to CMS groups and performed additional analysis of the methylation data between DEGs and CMS groups to provide comprehensive biological insights from various perspectives. Our study provides valuable insights into the molecular mechanisms underlying CRC in Korean patients and serves as a platform for identifying potential target genes for this disease. The raw data and processed results have been deposited in a public repository for further analysis and exploration.

• Journal of Positioning, Navigation, and Timing
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• v.10 no.2
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• pp.145-151
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• 2021

According to the Korea Augmentation Satellite System (KASS) system milestone, Site Acceptance Test (SAT) has three steps test until the end of the project. SAT#1 is the first time of SAT steps and verify the KASS Reference Station (KRS) and Sub System (S/S) for the monitoring and controllable. After the equipment and software were installed at the Mission Control Center (MCC) with Central Monitoring and Control Simulator (CMS) for the SAT#1, the 1:1 test was progressed when the KRS and S/S are ready to test. SAT#1 has a 10 steps test case and it was progressed each KRS sites. The test was finished throughout the real-time monitoring and the data collection including the data analysis all of the 7 KRS sites. Finally SAT#1 was completed on December 2020 with successfully.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.171-177
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• 2022

ROS1 (c-ros oncogene) is one of the gene with mutation in NSCLC (non-small cell lung cancer). The increased expression of ROS1 is leading to the increase proliferation of cell, cell migration and survival. Crizotinib and Entrectinib are the drugs that have been approved by FDA against ROS1 protein, but recently patients started to develop resistance against Crizotinib and there is a need of new drug that could act as an effective drug against ROS1 for NSCLC. In this study, we have performed virtual screening, where compounds are taken from Zinc 15 dataset and molecular docking was performed. The top compounds were taken based upon their binding affinity and their interactions with the residues. The compounds stability and chemical reactivity was also studied through Density Functional theory and their properties. Further study of these compounds could reveal the required information of ROS1-inhibitor complex and in the discovery of potent inhibitors.

• Journal of Korean Neurosurgical Society
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• v.61 no.1
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• pp.60-65
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• 2018

Objective : Choroidal metastases (CMs) are the most common intraocular tumor. Management is mainly radiation therapy with goals of pain control and visual improvement. However, many radiation-related complications are reported. Since gamma knife radiosurgery (GKS) for CM was first reported in 1995, few cases have been reported. We report 7 cases of CMs treated with GKS. Methods : From April 2011 to November 2014, 7 patients with CM underwent GKS. Their median age at treatment was 64 years (range, 51-71 years). Four males and three females were treated. Lung cancer was the most common primary pathology, followed by renal cell carcinoma and stomach cancer. Four patients had multiple cerebral lesions and were treated simultaneously for choroidal lesions. The median marginal dose of 20 Gy (range, 15-25 Gy) was administered at the 50% isodose line. Results : Median follow-up period after GKS was 8 months (range, 2-38.3 months). Four patients expired due to underlying malignancy progression. Except for two patients who were not followed with magnetic resonance image after GKS, all patients showed size reduction in the treated lesions, but a new choroidal lesion appeared in one patient and one recurred. Six of seven patients reported subjectively improved visual symptoms. Visual acuity improved in 2 patients, and 2 were stable upon objective examination. One patient showed no improvement in visual acuity, but ocular pain was relieved; another patient showed improved vision and tumor remission, but visual deterioration recurred. Conclusion : GKS was shown to be safe and effective and should be considered for CM treatment.

• The Journal of the Korea Contents Association
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• v.9 no.11
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• pp.231-239
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• 2009

The purpose of this study was to investigate changes in balance and upper extremity (UE) function associated with reaching training for children with quadriplegic cerebral palsy based on Biomechanical Frame of Reference. The baseline (phase A) lasted one week. The therapeutic protocol consisted of three reaching training (Phase B) for 40 minutes three times a week. Intervention phases lasted 4 weeks. The CMS-70P (Zebris Medizintechnik Gmbh, Germany) was used to evaluate the qualitative changes in UE function and Pediathc Berg Balance Scale was used to test the balance. The observed performance changes seem to be associated with the presence of intervention and suggest that biomechanical training can be a useful intervention to improve not only manual function but also balance.

• Journal of KIISE:Computer Systems and Theory
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• v.33 no.7
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• pp.390-398
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• 2006

The objective of the High Energy Physics(HEP) is to understand the basic properties of elementary particles and their interactions. The CMS(Compact Muon Solenoid) experiment at CERN which will produce a few PetaByte of data and the size of collaboration is around 2000 physicists. We cannot process the amount of data by current concept of computing. Therefore, an area of High Energy Physics uses a concept of Tier and Data Grid. We also apply Data Grid to current High Energy Physics experiments. In this paper, we report High Energy Physics Data Grid System as an application of Grid.

• Journal of Korean Society on Water Environment
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• v.28 no.6
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• pp.890-895
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• 2012

Duration curves describe the percentage of time that a certain water quality (total/fecal coliform (=TC/FC)) or discharge is exceeded. The curves methodology are usually based on daily records and are useful in estimating how many days per year and event will be exceeded. The technique was further applied to estimated TC/FC loading to the Geumho River, using the daily mean flow rate and TC/FC concentration data during January, 2001 and December, 2011 for the Geumhogang6 (=Seongseo water level station) where an automated monitoring station is located in Gangchang-bridge. Low flow of the Seongseo (=11.1 cms) was equivalent to 75.3% on an exceedance probability scale. Load Duration curve for TC/FC loading at the Seongseo was constructed. Standard load duration curve was constructed with the water quality criteria for class III (TC/FC concentration = 5000/1000 CFU/ 100 mL). By plotting TC/FC observed load duration curve with standard load duration curve, it could be revealed that water quality do not meet the desired water quality for 68.8/11.2% on an exceedance probability scale. IF linear correlation between flow rate and coliform concentration is assumed, it can be interpreted that water quality exceed desired criteria when daily average flow rate is over 11.9/109.9 cms.