• Journal of Genetic Medicine
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• v.17 no.2
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• pp.73-78
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• 2020

Purpose: Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous group of disorders characterized by impaired neuromuscular transmission. This study aims to provide the clue for early diagnosis and improved therapeutic strategies in CMS. Materials and Methods: Through the targeted panel sequencing including twenty CMS causative genes, eleven patients were genetically confirmed and enrolled in this study. A retrospective medical record review was carried out for the clinical and laboratory data analysis. Results: The age of patients ranged from 5 to 23 years, with the median age of 16 years. The peak age at onset of symptoms was the neonatal period. Seven out of the eleven patients were symptomatic at birth. The most commonly reported initial finding was generalized hypotonia with poor sucking and crying. Mean time to accurate diagnosis was 9.3±5.0 years. Total fifteen different variants in seven genes associated with CMS (DOK7, AGRN, RAPSN, CHRNE, COLQ, SLC5A7, and GFPT1) were identified. Conclusion: We describe the clinical and genetic characteristics of CMS patients and treatment outcome in a single tertiary center. High clinical suspicion and timely molecular diagnosis is particularly important for the tailored therapy to maximize clinical improvement in CMS.

• Journal of Korea Society of Industrial Information Systems
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• v.14 no.5
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• pp.103-111
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• 2009

In this paper, we implement the web-based education system on CMS(Contents Management System). The goal of this paper is that Everyone who uses this system will use and maintain the web site easily. All procedures can be performed on the web and all content by the manager can be applied to users. This allows both user and administrator to use the web-based education system in a better environment. This system also will try to cover all user levels by providing web standards. So more user can use the standard web service without worrying about time and space. For this reason, this system will be developed with web standard guide so that all users won't experience any problems with the browsers of primary platforms complying with W3C. This paper can provide the possibility to overcome the limitations of current web-based education system.

• Journal of the Korean Magnetics Society
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• v.18 no.5
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• pp.163-167
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• 2008

The electronic structure and magnetism of superlattice systems consisted of Heusler compound $Co_2MnSi$ (CMS) and zinc-blende MnAs (MA) are investigated by means of the all-electron full potential linearized augmented plane wave method within the generalized gradient approximation. Four superlattice systems are considered, that is CMS(m)/MA(n), where m and n, being either 2 or 4, denote the number of alternatingly arrayed layers of the compounds in a superlattice along [001] direction. From the calculated total magnetic moments as well as the total density of states, it is found that neither of the four systems is half-metallic. It is also found that the Mn atoms are antiferromagnetically coupled in the systems of CMS2/MA2 and CMS2/MA4. The total and atom-resolved density of states of the four superlattices are compared with those of the bulk $Co_2MnSi$ and MnAs, and the influences of the change in the systems symmetry on the magnetism and half-metallicity are discussed.

• The Korea Journal of Herbology
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• v.29 no.2
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• pp.7-13
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• 2014

Objectives : Chronic mild stress (CMS) model is currently recognized as a better animal model of depression. The purpose of this study was to investigate the antidepressant-like effects of the Nelumbo nucifera leave extract using CMS model. Methods : The antidepressant-like effects of Nelumbo nucifera leaves extract was determined by using animal models of depression. Male ICR mice were divided into four groups: saline-treated normal, without CMS; saline-treated stress control; CMS+ Imipramine(20mg/kg); CMS+Nelumbo nucifera leaves extract(200mg/kg). All mice except the normal group exposed an unpredicted sequence of chronic mild stressors for 5 weeks. The behavior of mice were detected by sucrose preference test, forced swim test and tail suspension test. Then concentration of corticosterone in serum was detected by enzyme immunoassay. Results : Nelumbo nucifera leaves extract administration by daily gavage from the 3rd week exhibited an antidepressant-like effect on CMS-induced depression in mice. Nelumbo nucifera leaves extract administration at dose of 200 mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. Conclusions : Chronic mild stress can affect mouse behavior and corticosterone level and cause depression. The present experiments not only further confirm the antidepressant-like effects of Nelumbo nucifera leaves extract in the sucrose preference test, forced swimming test and tail suspension test, but also the improving effects of Nelumbo nucifera leaves extract on the depression-like symptoms in the CMS model. Nelumbo nucifera leaves extract has the antagonism on CMS and produce antidepressive effects.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.33 no.2
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• pp.138-145
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• 1988

The effect of directions (north to south vs east to west) of planting row, planting intensities (10/15, 15/15, 20/15, 25/15 cm/cm) and the number of rows consecutively (1,2, 3,4) for both the CMS and pollen parent in alternation, on the seed yield of CMS of rice was tested with a breeding line V20A/Iri342$\^$*8/. When the planting row was made in vertical direction to the wind direction during anthesis, the seed yield was higher than the other direction regardless the planting densities and number of rows consecutive. Seed yield increased as high as 46.9%. The higher planting intensities up to 10/15 cm/cm yielded the higher hybrid seeds. The highest yield was 81.2 kg/ha. The yield variation among plants within a plot and among the plants within a replication was relatively large. Increased pollen parent row numbers caused increased grain fertility per plant, but the seed yield was increased by reduced pollen parent row number. Reduced CMS parental row numbers caused increased grain fertility per plant, but the seed yield was increased by increased CMS parental row numbers. Considering the hybrid seed yield, parental seed yield and operational convenience, 4 rows of CMS and 1 row of pollen parent in alternate with 20/15 or 25/15 (cm/cm) planting densities seemed to be the rational layout.

• Journal of the Korean Burn Society
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• v.22 no.1
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• pp.1-9
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• 2019

Purpose: The aim of this study was to investigate the characteristics of Acute Kidney Injury Network (AKIN)-defined nephrotoxicity in patients undergoing intravenous colistimethate sodium (CMS) therapy for major burns. Methods: This retrospective study included burn patients who received more than 48 h of intravenous CMS between September 2009 and December 2015. Data collection was performed using the institution's electronic medical record system. Patients assigned to the developed nephrotoxic group experienced aggravation of current AKIN stage during CMS treatment; those assigned to the non-nephrotoxic group experienced no change in current or exhibited improved AKIN stage during CMS therapy. Results: A total of 306 patients were included in this study. All patients were grouped according to AKIN stage: AKIN 0 (n=152); AKIN 1 (n=6); AKIN 2 (n=9); AKIN 3 (n=139). The baseline creatinine (Cr) level was 0.73 mg/dL. The incidence of nephrotoxicity was 50.3% according to AKIN stage; overall mortality was 45.8%. The non-nephrotoxic group consisted of 127 (74.7%) patients and 43 (25.3%) were in the developed nephrotoxic group. In patients requiring continuous renal replacement therapy (CRRT), baseline Cr level was 0.83 mg/dL, pre-CMS Cr level was 1.17 mg/dL, and post-CMS Cr level was 1.34 mg/dL. Conclusion: CMS can be administered without signs of nephrotoxicity for a certain period (approximately 1 week), it can be used relatively safely for 2 weeks. Application of CMS is a reasonable option for treating infections caused by multi-drug resistant gram-negative bacteria in patients with major burns. The caution should be exercised nevertheless.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.1076-1077
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• 2007

CMS(Condition Monitoring System) is a useful tool to predict the defect of machine condition, for example, Motor, Bearing, Gear, Fan, etc. And, recently CMS is very important on plant. In this paper, describe the bearing electric arcing with example.

• 프린팅코리아
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• s.13
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• pp.140-143
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• 2003

많은 디자이너들이 느끼는 문제 중에 하나는 모니터에서 보이는 대로 색상이 출력되지 않는다는 점이다. 그리고 같은 파일이라 하더라도 모니터마다 보이는 색상이 다르다는 것도 문제이다. 또한 같은 파일이라도 출력기마다 색상이 다르며, 같은 파일이라도 작업자마다 색상이 다르다는 것이다. 이러한 문제들을 해결하기 위해 도용되는 시스템이 CMS(Color Management System)이다. 구광모 트루컬러시스템 대표의 설명을 바탕으로 모니터와 인쇄 현장에서의 CMS를 자세히 알아본다.

• Digital Contents
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• no.8 s.99
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• pp.70-74
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• 2001

일반 웹 콘텐츠 뿐만 아니라 그룹웨어,ERP,CRM 등 기간 시스템에 이르기까지 모든 디지털 정보를 통합 관리해 주는 솔루션이 콘텐츠 관리시스템(CMS:Content Management System)이다. 최근 인터넷을 통한 다양한 서비스와 전자상거래가 발전함에 따라 웹사이트를 구성하는 콘텐츠의 양도 급속도로 증가하고 있다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.5
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• pp.436-446
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• 2006

The purpose of this study was to isolate and identify the bacteria in chronic maxillary sinusitis (CMS) lesions from 3 patients and to determine the antimicrobial susceptibility of them against 10 antibiotics. One of them was odontogenic origin and the others were non-odontogenic origin. Pus samples were collected by needle aspiration from the lesions and examined by culture method. Bacterial culture was performed in three culture systems (anaerobic, CO2, and aerobic incubator). Identification of the bacteria was performed by 16S rRNA gene (16S rDNA) nucleotide sequencing method. To test the sensitivity of the bacteria isolated from the maxillary sinusitis lesions against seven antibiotics, penicillin G, amoxicillin, tetracycline, ciprofloxacin, cefuroxime, erythromycin, clindamycin, and vancomycin, minimum inhibitory concentration (MIC) was performed using broth dilution assay. Our data showed that enterobacteria such as Enterobacter aerogenes (30%), Klebsiella pneumoniae (25%), and Serratia marcescens (15%) were predominately isolated from the lesion of non-odontogenic CMS of senile patient (70 year old). Streptococcus spp. (40.3%), Actinomyces spp. (27.4%), P. nigrescens, M. micros, and P. anaerobius strains were isolated in the lesion of odontogenic CMS. In the lesion of non-odontogenic CMS, Streptococcus spp. (68.4%), Rothia spp. (13.2%), and Actinomyces sp. (10.5%) were isolated. The susceptibility pattern of 10 antibiotics was determined according to the host of the bacteria strains ratter than the kinds of bacterial species. Even though the number of CMS was limited as three, these results indicate that antibiotic susceptibility test must be accompanied with treatment of CMS. The combined treatment of two or more antibiotics is better than single antibiotic treatment in the presence of multidrug-resistant bacteria in the CMS lesions.