• 한국전자파학회논문지
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• 제18권9호
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• pp.1083-1089
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• 2007

본 논문에서는 무선 통신 기기의 주요 부품인 VCO(Voltage Controled Oscillator)의 고조파 특성을 개선시키기 위하여 CMRC(Compact Microstrip Resonant Cell) 구조를 이용한 여파기를 공진기 후단에 적용하였다. CMRC 여파기는 PBG, DGS 등 다른 여파기에 비하여 그 크기가 소형일 뿐 아니라 제작이 용이한 장점을 가지고 있다. 본 논문에서 제안한 CMRC를 이용한 VCO의 2차 고조파 특성은 -42.83 dBc, 위상 잡음 특성은 100 kHz offset에서 -95.83 dBc/Hz이었다. CMRC를 공진기 후단에 연결하는 것이 CMRC를 공진기로 이용하는 것보다 2차 고조파 특성은 약 15.73 dB, 위상 잡음은 약 31.13 dB 개선되었다.

• 한국전자파학회논문지
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• 제17권2호
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• pp.124-128
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• 2006

본 논문에서는 CMRC(Compact Microstrip Resonants Cell)를 이용한 직렬 구조의 3-Way 도허티 증폭기를 연구하였다. CMRC는 선형성과 효율의 개선뿐만 아니라 기존의 선형성 개선 방법보다 간단하며 크기가 작고 가격이 저렴하다는 장점이 있다. 또한 기존의 병렬 구조의 3-way 도허티 증폭기가 아닌 하나의 디바이더만을 사용하는 직렬 구조의 3-Way 도허티 증폭기를 통해 그 크기를 줄일 수 있었다. 그 결과 CMRC를 사용한 제안된 3-Way 도허티 증폭기는 IMD3를 약 4.5 dB, PAE는 약 $9.2\%$ 개선시킬 수 있었다.

• 한국전자파학회논문지
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• 제16권2호
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• pp.149-153
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• 2005

본 논문에서는 Compact Microstrip Resonant Cell을 이용하여 새로운 방법으로 선형성을 개선시킨 전력증폭기를 설계하였다. 전력증폭기의 입력단에 CMRC를 적용하였고, 입력단과 출력단에 각각 Tuning Line을 달아서 조정을 한 결과 기존의 전력증폭기보다 현저한 선형성을 보였다. 그 결과 CMRC를 적용한 전력증폭기는 기존의 전력증폭기보다 3차 IMD가 14.77 dB 만큼 개선되었다. CMRC의 크기는 $17.1\times5.22mm$이다.

• 대한전자공학회논문지TC
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• 제44권7호통권361호
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• pp.12-16
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• 2007

본 논문은 일반적으로 고효율 특성을 가지고 있는 class-F 전력 증폭기의 출력 단에서 기생되는 2차 고조파 성분을 제거함으로 3차 IMD (Intermodulation distortion) 특성을 개선하였다. class-F 전력 증폭기의 경우 과부동 특성으로 인해 고효율을 얻을 수 있으나 선형성 측면에서는 많은 단점을 가지고 있다. 따라서 본 논문은 특별한 선형화 기술을 적용하지 않고 CMRC 구조를 적용하여 2차 고조파를 제거하여 선형성을 나타내는 U 특성을 개선하였다. CMRC 구조의 경우 광대역 저지대역 특성을 가지고 있으며 PBG 구조 보다 작은 크기로 더 좋은 특성을 얻을 수 있다.

• 한국전자파학회:학술대회논문집
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• 한국전자파학회 2005년도 종합학술발표회 논문집 Vol.15 No.1
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• pp.77-78
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• 2005

In this paper, Compact Microstrip Resonants Cell(CMRC) have been employed to suppress IMD(Intermodulation Distortion) of the 3-Way Doherty amplifier. This method can not only improve the linearly and the efficiency but also is simpler, smaller and more inexpensive than existing linearly methods; (for example Harmonic feedback, Back off, Feed-forward, Predistortion and so on.) Also, the proposed 3-way Doherty amplifier using only one divider has been reduced size of existing 3-Way Doherty amplifier. As a result, the proposed Doherty amplifier using CMRC and only one divider has been improved for the IMD$_3$ by 4.474dBc, and the PAE by 9.199%, respectively.

• 한국통신학회:학술대회논문집
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• 한국통신학회 2004년도 하계종합학술발표회논문초록집
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• pp.303-303
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• 2004

• 응용통계연구
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• 제24권5호
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• pp.847-859
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• 2011

cDNA microarray-based comparative genomic hybridization(CGH) data includes low-intensity spots and thus a statistical strategy is needed to detect subtle differences between different cancer classes. In this study, genes displaying a high frequency of alteration in one of the different classes were selected among the pre-selected genes that show relatively large variations between genes compared to total variations. Utilizing copy-number changes of the selected genes, this study suggests a statistical approach to predict patients' classes with increased performance by pre-classifying patients with similar genetic alteration scores. Two-stage logistic regression model(TLRM) was suggested to pre-classify homogeneous patients and predict patients' classes for cancer prediction; a decision tree(DT) was combined with logistic regression on the set of informative genes. TLRM was constructed in cDNA microarray-based CGH data from the Cancer Metastasis Research Center(CMRC) at Yonsei University; it predicted the patients' clinical diagnoses with perfect matches (except for one patient among the high-risk and low-risk classified patients where the performance of predictions is critical due to the high sensitivity and specificity requirements for clinical treatments. Accuracy validated by leave-one-out cross-validation(LOOCV) was 83.3% while other classification methods of CART and DT performed as comparisons showed worse performances than TLRM.

• 약학회지
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• 제55권3호
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• pp.267-272
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• 2011

Human NK cells, identified 30 years ago based on their ability to spontaneously kill tumor cells, constitute a subset of lymphocytes, which play an important role in the first line of immune defense and the effective function of these cells are enhanced by cytokines. Lung carcinoma has been one of the most commonly diagonosed cancer as well as the leading cause of cancer death in male. Here we provide the evidence that human natural killer cells has inhibitory effects on tumor growth of human lung cancer cell NCI-H460 (non-small cell lung cancer). Enriched NK cell population was obtained by 2 weeks cultivation in interleukin-2(IL-2)-containing medium. The resulting population comprised 26% CD3$^+$ cells, 9% CD3$^+$CD4$^+$ cells, 16% CD3$^+$CD8$^+$ cells, 76% CD56$^+$ cells, 6% CD3$^+$CD56$^+$ cells and 70% CD3$^-$CD56$^+$ cells. Activated NK cells at doese of 2.5, 5, and 10 million cells per mouse inhibited 2%, 12% and 45% of NCI-H460-induced tumor growth in nude mouse xenograft assays, repectively. This result suggests that NK cell-based immunotherapy may be used as an adoptive immunotherapy for lung cancer patients.

• 약학회지
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• 제54권3호
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• pp.192-199
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• 2010

Colorectal cancer is one of the most common alimentary malignancies. In this study, the antitumor activity of activated human natural killer (NK) cells against human colorectal cancer was evaluated in vivo. Human NK cells are the key contributors of innate immune response and the effective functions of these cells are enhanced by cytokines. Human peripheral blood mononuclear cells (PBMC) were cultured with interleukin-2 (IL-2)-containing medium for 14 days and resulted in enriched NK cell population. The resulting populations of the cells comprised 7% $CD3^+CD4^+$ cells, 25% $CD3^+CD8^+$ cells, 13% $CD3^-CD8^+$ cells, 4% $CD3^+$CD16/$CD56^+$ cells, 39% $CD3^+$CD16/$CD56^-$ cells, and 52% $CD3^-$CD16/$CD56^+$ cells. Tumor necrosis factor alpha (TNF-$\alpha$), interferon gamma (IFN-$\gamma$), IL-2, IL-4, and IL-5 transcripts of the activated NK cells were confirmed by RT-PCR. In addition, activated NK cells at doses of 2.5, 5 and 10 million cells per mouse inhibited 10%, 34% and 47% of SW620-induced tumor growth in nude mouse xenograft assays, respectively. This study suggests that NK cell-based immunotherapy may be used as an adoptive immunotherapy for colorectal cancer patients.