• ETRI Journal
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• 제37권3호
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• pp.637-645
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• 2015

Common-mode noise (CMN) is an unresolved problem in wireless capsule endoscopy (WCE) systems. In a WCE system, CMN originates from various electric currents found within the human body or external interference sources and causes critical demodulation performance degradation. The differential operation, a typical method for the removal of CMN rejection, can remove CMN by subtracting two signals simultaneously received by two reception sensors attached to a human body. However, when there is impedance mismatching between the two reception sensors, the differential operation method cannot completely remove CMN. Therefore, to overcome this problem, we propose an enhanced CMN rejection method. The proposed method performs not only subtraction but also addition between two received signals. Then a CMN ratio can be estimated by sufficient accumulation of division operation outcomes between the subtraction and addition outputs during the guard period. Finally, we can reject the residual CMN by combining the subtraction and addition outputs.

• Advances in Traditional Medicine
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• 제9권3호
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• pp.259-267
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• 2009

Curcumin (CMN) is known to have beneficial role in anorexia, coryza, cough, diabetic wounds, and hepatic disorders apart from its inherent antioxidant effects. Therefore, the present study was aimed to evaluate antioxidant effect of CMN in prevention of nephrolithiasis in rats-induced by ethylene glycol (EG) and Vitamin D3 (Vit. D3). Male Wistar rats (175 - 200 g) were randomized in groups like control, EG + Vit. D3 induced nephrolithiatiatic rats, CMN treated rats, CMN + EG + Vit. D3 treated rats, Vit. E + EG + Vit. D3 treated rats. Urine was collected weekly throughout the experimental protocol and estimated for calcium oxalate (CaO) count. After completion of experimental protocol serum was estimated for blood urea nitrogen and creatinine. Both the kidneys were excised and used to evaluate levels of biomarkers of oxidative stress and calcium oxalate crystal deposition by histopathological studies. Administration of EG and Vit. D3 to rats resulted in increased oxidative stress, hyperoxaluria and renal deposition of CaO crystals. Supplementation with CMN improves kidney function, reduces elevated oxidative stress, urinary oxalate level and renal deposition of CaO which shows its protective action in nephrolithiasis. The increased deposition of stone in the kidney and stone forming constituents of nephrolithiatic rats were effectively lowered by treatment of CMN.

• Clinical and Experimental Reproductive Medicine
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• 제48권3호
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• pp.211-220
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• 2021

Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways. Methods: Eighteen male Wistar albino rats were randomly divided into three groups. The control group was given an intragastric administration of dimethyl sulfoxide (DMSO) daily for 14 days, the MTX group was given a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day, and the MTX+CMN group was given intragastric CMN (100 mg/kg/day, dissolved in DMSO) for 14 days and a single intraperitoneal dose of MTX (20 mg/kg) on the 11th day. At the end of the experiment, all animals were sacrificed and the testicular tissues were removed for morphometry, histology, and immunohistochemistry. Body and testicular weights were measured. Results: Body weights, seminiferous tubule diameter, and germinal epithelium height significantly decreased in the MTX group compared to the control group. Whereas, the number of histologically damaged seminiferous tubules and interstitial space width significantly increased in the MTX group. In addition, the number of p-p38 MAPK immunopositive cells and the immunoreactivity of NF-κB also increased in the MTX group compared to the control group. CMN improved loss of body weight, morphometric values, and histological damage due to MTX. CMN also reduced the number of p-p38 MAPK immunopositive cells and the NF-κB immunoreactivity. Conclusion: CMN may reduce MTX-induced testicular damage by suppressing the p38 MAPK and NF-κB signaling pathways.

• Applied Microscopy
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• 제40권4호
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• pp.229-235
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• 2010

암은 전 세계적으로 사망률이 높은 질병으로 현재 자궁암 치료는 cisplatin, 5-fluorouracil (5FU) 등의 항암화학요법과 방사선 요법 등을 복합적으로 병행하고 있다. 최근 항암효과를 가지고 있는 자연식품의 섭취에 관심이 커지면서 커리의 주성분인 curcumin (CMN), 녹차의 주성분인 카테킨, 토마토의 주성분인 리코펜 등의 약리효과에 대한 연구가 활성화되고 있다. CMN은 동물실험 결과 항염증의 활성이 있고, 피부, 대장, 유방, 전립선 등에서 암으로의 진행을 억제한다는 보고가 있으나 인체 자궁암에서는 그 효과가 밝혀져 있지않다. 본 연구는 항암제 5FU와 CMN이 인체 자궁암세포 HeLa에 미치는 영향을 apoptosis의 유도로 평가하고, p53유전자 발현율과의 상관관계로 확인하고자 시행하였다. CMN은 HeLa 세포의 성장을 억제하였으며, 5FU로 유도된 apoptosis의 발생률과 p53유전자의 발현률을 현저하게 증가시키는 것으로 나타났다(p<0.05). 이러한 연구결과는 CMN이 자궁암 치료제의 가능성이 있으며, 또한 5FU와 복합적으로 사용하면 항암제를 단독으로 투여하는 경우보다 자궁암 치료에 보다 효과적임을 강력히 시사하는 것이다.

• 대한음성학회지:말소리
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• 제44호
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• pp.73-82
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• 2002

Channel distortion degrades the performance of speech recognizer in telephone environment. It mainly results from the bandwidth limitation and variation of transmission channel. Variation of channel characteristics is usually represented as baseline shift in the cepstrum domain. Thus undesirable effect of the channel variation can be removed by subtracting the mean from the cepstrum. In this paper, to improve the recognition performance of Korea connected digit telephone speech, channel compensation methods such as CMN (Cepstral Mean Normalization), RTCN (Real Time Cepatral Normalization), MCMN (Modified CMN) and MRTCN (Modified RTCN) are applied to the static MFCC. Both MCMN and MRTCN are obtained from the CMN and RTCN, respectively, using variance normalization in the cepstrum domain. Using HTK v3.1 system, recognition experiments are performed for Korean connected digit telephone speech database released by SITEC (Speech Information Technology & Industry Promotion Center). Experiments have shown that MRTCN gives the best result with recognition rate of 90.11% for connected digit. This corresponds to the performance improvement over MFCC alone by 1.72%, i.e, error reduction rate of 14.82%.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1349-1353
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• 2015

Background: Cervical cancer (CeCa) is the second most common cancer in women in developing countries, and human papilloma virus (HPV) is the primary etiological factor. Aberrant expression of HOX transcription factors has been observed in several types of cancer. To date, however, no reports exist on the expression of HOXB2 and HOXB13 proteins during neoplastic progression in CeCa and its correlation with HPV infection. Materials and Methods: Expression of HOXB2 and HOXB13 proteins was assessed in tissue microarrays from normal cervical epithelium, cervical intraepithelial neoplasias grade 1-3, and CeCa. HPV was detected by PCR and sequencing. Expression of HOX-positive cells was determined in each diagnostic group. Results: Percentage of HOXB2- and HOXB13-positive cells gradually increased from means of 10.9% and 16.7%, respectively, in samples from healthy women, to 75.2% and 88.6% in those from CeCa patients. Frequency of HPV infection also increased from 13% in healthy tissue samples to 92.3% in CeCa. Both HOXB2 and HOXB13 proteins were preferentially expressed in HPV+ samples. Conclusions: The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.

• 한국세라믹학회지
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• 제36권7호
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• pp.762-766
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• 1999

The crystal structure of A2+(Mg1/3Nb2/3)O3,(A2+=Sr2+ and Ca2+)ceramics was studied usig X-ray diffraction (XRD) and high resolution transmission electrion microscopy(HRTEM). Ba(Mg1/3Nb2/3)O3 (SMN) has the 1:2 ordered monoclinic structure which has the anti-phase tilt of octahedra. The type of tilting in SMN was considered to be a$^{\circ}$a$^{\circ}$c- or a­a­c$^{\circ}$ Ca(Mg1/3Nb2/3)O3 (CMN) also has the 1:2 ordered monoclinic structure which was distorted by the anti-phase tilt or in-phsae tilt of octahedra. A unit cell containing both the in-phase tilt axis and anti-phase tilt axis was not observed in the CMN. Therefore CMN has the mixed phase consisting of the 1:2 ordered monoclinic phase with anti-phase tilt of octahedra and the one with in -phase tilt of ocatahedra,. The anti-parallel shift of cation was also observed in the CMN.

• 대한음성학회지:말소리
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• 제43호
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• pp.179-188
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• 2002

Improving the recognition performance of connected digit telephone speech still remains a problem to be solved. As a basic study for it, this paper analyzes the variation of feature parameters of Korean digit telephone speech according to channel distortion. As a feature parameter for analysis and recognition MFCC is used. To analyze the effect of telephone channel distortion depending on each call, MFCCs are first obtained from the connected digit telephone speech for each phoneme included in the Korean digit. Then CMN, RTCN, and RASTA are applied to the MFCC as channel compensation techniques. Using the feature parameters of MFCC, MFCC+CMN, MFCC+RTCN, and MFCC+RASTA, variances of phonemes are analyzed and recognition experiments are done for each case. Experimental results are discussed with our findings and discussions

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 제14회 신호처리 합동 학술대회 논문집
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• pp.499-502
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• 2001

본 연구에서는 화자에 따라 서로 다른 성도의 길이에 의해 발생하는 음성인식 시스템의 성능 저하를 줄이기 위하여, VTN(Vocal Tract Normalization)을 음성인식 시스템에 적용하고, 주소 인식 실험을 통하여 인식 성능을 평가하였다. 또, VTN을 CMN과 동시에 적용하여 인식 실험을 하였다. 실험에서는 화자간 성도길이의 차이를 반영하기 위하여 13개의 Warping 계수에 대해 필터 뱅크를 이용한 선형 Warping 방법을 적용하였다. 실험결과, Baseline 인식 시스템에 비하여 VTN을 적용하면, WER(Word Error Rate)이 1.24% 감소하였고, CMN과 VTN을 동시에 적용한 실험에서는 Baseline 인식 시스템과 비교하여 WER이 0.33% 감소 하였지만 VTN을 적용한 실험결과와 비교하면 오히려 0.91% 증가하였다.

• 한국음향학회지
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• 제34권4호
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• pp.316-320
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• 2015

본 논문에서는 Cepstral Mean Normalization(CMN)과 Cepstral Mean and Variance Normalization(CMVN) 프레임워크에서 극점 필터링(pole filtering) 개념을 Mel-Frequency Cepstral Coefficient(MFCC) 특징 벡터에 적용한다. 또한 분산 정규화를 대신하여 스케일 정규화를 사용하는 Cepstral Mean and Scale Normalization(CMSN)의 성능을 잡음 환경 음성인식 실험을 통해 평가한다. CMN과 CMVN은 보통 발화 단위로 수행되기 때문에 짧은 발화의 경우 특징에 대한 평균과 분산의 추정 신뢰도가 보장되지 않는 문제점을 가지는데, 극점 필터링과 스케일 정규화 방식을 적용함으로 이러한 문제점을 보완할 수 있다. Aurora 2 데이터베이스를 이용한 실험 결과, 극점 필터링과 스케일 정규화를 결합한 특징 정규화 방식의 성능이 가장 높은 성능 향상을 보인다.