• Korean journal of aerospace and environmental medicine
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• v.31 no.3
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• pp.82-83
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• 2021

Chronic myeloid leukemia (CML) is myeloproliferative neoplasm associated with a characteristic chromosomal translocation (bcr-abl) called Philadelphia chromosome which plays a key role in the pathogenesis. Approximately 85% of patients with CML are in the chronic phase at the time of diagnosis. During this phase, patients are well tolerated and have few symptoms. But untreated, over the course of several years progresses to an accelerated phase and ultimately to a blast crisis, the terminal phase. CML is largely treated with targeted drug therapy called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since 2001. These drugs became standard treatment of this disease and allow most patients to have much better quality of life when compared to the former chemotherapy drugs and the bone marrow transplantation. Imatinib (Gleevec or Glivec, Norvatis) was the first of these TKIs and found to inhibit the progression of CML in the majority of patients (65%-75%) sufficiently to achieve remission. Since the advent of imatinib, CML has become the first neoplasm in which a medical treatment can give to the patient a normal life expectancy.

• Journal of Scientific & Technological Knowledge Infrastructure
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• s.6
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• pp.42-57
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• 2001

XML을 사용하여 수학식을 표현하는데 사용되는 MathML에 대해 설명하고, 화학식을 표현하는데 사용되는 CML, 염기서열등의 분자 생물학적 정보를 표현하는데 사용되는 BSML과 BIOML에 대해 설명하고자 한다.

• Proceedings of the CALSEC Conference
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• 2001.08a
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• pp.165-176
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• 2001

* Extension of EC(Electronic Commerce) * Standard of Message -EDI : UN/EDIFACT, ANSI X12, etc -XML : ebXML, CML, MathML, WIDL, etc * Various of Information -Business Transaction Data -Private Data : ID, Password, Personal Information -Charge Data : Accounts, Card, etc * Message Level Security(omitted)

• Clean Technology
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• v.27 no.2
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• pp.107-114
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• 2021

Material Life Cycle Assessment (MLCA) was performed to analyze the environmental impact characteristics of the Mg₂NiH_x-5 wt% CaO hydrogen storage composites' manufacturing process. The MLCA was carried out by Gabi software. It was based on Eco-Indicator 99' (EI99) and CML 2001 methodology. The Mg₂NiH_x-5 wt% CaO composites were synthesized by Hydrogen Induced Mechanical Alloying (HIMA). The metallurgical, thermochemical characteristics of the composites were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), specific surface area analysis (Bruner-Emmett-Teller, BET), and thermogravimetric analysis (TGA). As a result of the CML 2001 methodology, the environmental impact was 78% for Global Warming Potential (GWP) and 22% for Eutrophication Potential (ETP). In addition, as a result of applying the EI 99' methodology, the acidification was the highest at 43%, and the ecotoxicity was 31%. Accordingly, the amount of electricity used in the manufacturing process may have an absolute effect on environmental pollution. Also, it is judged that the leading cause of Mg₂NiH_x-5 wt% CaO is the addition of CaO. Ultimately, it is necessary to research environmental factors by optimizing the process, shortening the manufacturing process time, and exploring eco-friendly alternative materials.

• Clean Technology
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• v.24 no.1
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• pp.9-14
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• 2018

In this study, Material life cycle evaluation was performed to analyze the environmental impact characteristics of TiN-Zr membrane manufacturing process. The software of MLCA was Gabi. Through this, environmental impact assessment was performed for each process. Transition metal nitrides have been researched extensively because of their properties. Among these, TiN has the most attention. TiN is a ceramic materials which possess the good combination of physical and chemical properties, such as high melting point, high hardness, and relatively low specific gravity, high wear resistance and high corrosion resistance. With these properties, TiN plays an important role in functional materials for application in separation hydrogen from fossil fuel. Precursor TiN was synthesized by sol-gel method and zirconium was coated by ball mill method. The metallurgical, physical and thermodynamic characteristics of the membranes were analyzed by using Scanning Electron Microscope (SEM), Energy Dispersive X-ray (EDS), X-ray Diffraction (XRD), Thermo Gravimetry/Differential Thermal Analysis (TG/DTA), Brunauer, Emmett, Teller (BET) and Gas Chromatograph System (GP). As a result of characterization and normalization, environmental impacts were 94% in MAETP (Marine Aquatic Ecotoxicity), 2% FAETP (Freshwater Aquatic Ecotoxicity), 2% HTP (Human Toxicity Potential). TiN fabrication process appears to have a direct or indirect impact on the human body. It is believed that the greatest impact that HTP can have on human is the carcinogenic properties. This shows that electricity use has a great influence on ecosystem impact. TiN-Zr was analyzed in Eco-Indicator '99 (EI99) and CML 2001 methodology.

• Transactions of the Korean hydrogen and new energy society
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• v.28 no.6
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• pp.627-634
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• 2017

In this study, Material life cycle evaluation was performed to analyze the environmental impact characteristics of TiN-ZrCo membrane manufacturting process. Gabi was used as software. The Eco-Indicator 99 methodology was used to evaluate the 11 impact categories and the 10 impact categories using the CML 2001 methodology. Precursor TiN was synthesized by sol-gel method and zirconium was coated by ball mill method. The metallurgical, physical and thermodynamic characteristics of the membranes were analyzed by using Scanning Electron Microscope (SEM), Energy Dispersive X-ray (EDS), X-ray Diffraction (XRD), Thermo Gravimetry/Differential Thermal Analysis (TG/DTA), Brunauer, Emmett, Teller (BET) and Gas Chromatograph System (GP). As a result of the characterization and normalization, the environmental impacts of each category of impacts were GWP 100 years with the highest environmental impact of 99.9%.

• Transactions of the Korean hydrogen and new energy society
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• v.33 no.1
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• pp.8-18
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• 2022

With rapid industrialization and population growth, fossil fuel use has increased, which has a significant impact on the environment. Hydrogen does not cause contamination in the energy production process, so it seems to be a solution, but it is essential to find an appropriate storage method due to its low efficiency. In this study, Mg-based alloys capable of ensuring safety and high volume and hydrogen storage density per weight was studied, and Mg₂NiH_x synthesized with Ni capable of improving hydrogenation kinetics. In addition, in order to improve thermal stability, a hydrogen storage composite material synthesized with CaO was synthesized to analyze the change in hydrogenation reaction. In order to analyze the changes in the metallurgical properties of the materials through the process, XRD, SEM, BET, etc. were conducted, and hydrogenation behavior was confirmed by TGA and hydrogenation kinetics analysis. In addition, in order to evaluate the impact of the process on the environment, the environmental impact was evaluated through "Material Life Cycle Assessments" based on CML 2001 and EI99' methodologies, and compared and analyzed with previous studies. As a result, the synthesis of CaO caused additional power consumption, which had a significant impact on global warming, and further research is required to improve this.

• Transactions of the Korean hydrogen and new energy society
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• v.33 no.2
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• pp.148-157
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• 2022

Research on hydrogen storage is active to properly deal with hydrogen, which is considered a next-generation energy medium. In particular, research on metal hydride with excellent safety and energy efficiency has attracted attention, and among them, magnesium-based hydrogen storage alloys have been studied for a long time due to their high storage density, low cost, and abundance. However, Mg-based alloys require high temperature conditions due to strong binding enthalpy, and have many difficulties due to slow hydrogenation kinetics and reduction in hydrogen storage capacity due to oxidation, and various strategies have been proposed for this. This research manufactured Mg₂Ni to improve hydrogenation kinetics and synthesize about 5, 10, 20 wt% of CaF₂ as a catalyst for controlling oxidation. Mg₂NiHx-CaF₂ produced by hydrogen induced mechanical alloying analyzed hydrogenation kinetics through an automatic PCT measurement system under conditions of 423 K, 523 K, and 623 K. In addition, material life cycle assessment was conducted through Gabi software and CML 2001 and Eco-Indicator 99' methodology, and the environmental impact characteristics of the manufacturing process of the composites were analyzed. In conclusion, it was found that the effects of resource depletion (ARD) and fossil fuels had a higher burden than other impact categories.