• Wind and Structures
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• v.19 no.3
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• pp.249-270
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• 2014

Through comparing the mean wind profiles observed overland during the passages of four typhoons, and the gradient wind speeds calculated based on the sea level pressure data provided by a numerical model, the present paper discusses, (a) whether the gradient balance is a valid assumption to estimate the wind speed in the height range of 1250 m ~ 1750 m, which is defined as the upper-level mean wind speed, in a tropical cyclone over land, and (b) if the super-gradient feature is systematically observed below the height of 1500 m in the tropical cyclone wind field over land. It has been found that, (i) the gradient balance is a valid assumption to estimate the mean upper-level wind speed in tropical cyclones in the radial range from the radius to the maximum wind (RMW) to three times the RMW, (ii) the super-gradient flow dominates the wind field in the tropical cyclone boundary layer inside the RMW and is frequently observed in the radial range from the RMW to twice the RMW, (iii) the gradient wind speed calculated based on the post-landfall sea level pressure data underestimates the overall wind strength at an island site inside the RMW, and (iv) the unsynchronized decay of the pressure and wind fields in the tropical cyclone might be the reason for the underestimation.

• Journal of Microbiology and Biotechnology
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• v.16 no.5
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• pp.804-807
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• 2006

Bacterial serine proteases, especially those from Bacillus, have been extensively studied. Intracellular serine protease 1 (Isp1) is responsible for most of the proteolytic activity in B. subtilis. To identify Isp1 substrates and study its physiological functions, a mutant of Isp1, which has lost the enzymatic activity, was constructed. Through a GST affinity chromatographic method, several Bacillus proteins that specifically interacted with S246A mutant Isp1 protein were isolated and then identified by MALDI-TOF analysis. ClpC and elongation factor Tu (EF-Tu) were among those proteins specifically bound to mutant Isp1. In addition, several proteins involved in stationary phase adaptive response (such as RNA polymerase sigma factor, spoIIIE) were also identified. These findings led us to suggest that the major function of this serine protease, whose expression is greatly increased during the stationary phase, is to mediate transition of the cell into the stationary phase in a proper and timely manner.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.3C
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• pp.201-210
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• 2002

A number or MPLS ATM switching system have been proposed to increase the access speed or current routers, but they cannot satisfy the Internet users who use diverse applications. So they are required to support the so-called differential service, which discriminates service behaviors according to the service class. In this paper, to support this differential service we suggest an LSP control method, which uses the extended LDP message and establishes several different LSPs for each FEC according to the service class. Also, we propose an marking algorithm using the cell loss priority field or ATM cells in order to process the differential service according to application categories. In addition, we present a forwarding procedure based on the LSP control method and the marking algorithm. A forwarding model applied this forwarding procedure can be easily implemented with a minimum modification of existing MPLS ATM switching systems. Therefore, we can save cost and time needed to implement the proposed model. Finally, we estimate the performance behaviors of the proposed application-based forwarding model by the AweSim simulation package.

• BMB Reports
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• v.49 no.4
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• pp.214-219
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• 2016

A nucleosomal protein, high mobility group box 1 (HMGB1) is known to be a late mediator of sepsis. Dabrafenib is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. Inhibition of HMGB1 and renewal of vascular integrity is appearing as an engaging therapeutic strategy in the administration of severe sepsis or septic shock. Here, we examined the effects of dabrafenib (DAB) on the modulation of HMGB1-mediated septic responses. DAB inhibited the release of HMGB1 and downregulated HMGB1-dependent inflammatory responses by enhancing the expressions of cell adhesion molecules (CAMs) in human endothelial cells. In addition, treatment with DAB inhibited the HMGB1 secretion by CLP and sepsis-related mortality and pulmonary injury. This study demonstrated that DAB could be alternative therapeutic options for sepsis or septic shock via the inhibition of the HMGB1 signaling pathway.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.30 no.3
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• pp.280-291
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• 2020

Objectives: Hazard classification is a controversial issue in the new MSDS system in which chemical companies have to prepare and submit MSDS for chemicals that they manufacture or import to the competent authorities according to the amended Occupational Safety and Health Act. The aim of this study is to suggest how to apply and manage harmonized hazard classification criteria and results by investigating current hazard classification systems and trends. Methods: The domestic issues about different hazard classification criteria and results were investigated by reviewing the literature and business outcomes regarding KOSHA. We also checked official and unofficial reports from the UN to understand international discussion about the topic. Chemical hazard classification results from agencies providing chemical information were analyzed to compare a harmonized rate between classifications. Furthermore, a field survey of a few chemical companies was conducted. Results: Under the related competent authorities, an integrated standard proposal was developed to harmonize the domestic hazard classification criteria. Although harmonized chemical information is strongly needed, we recognized the uncertainty and difficulty of harmonized hazard classification from the UN global list project review. In practice the harmonization rate of the classification was generally low between the classification in KOSHA, MoE, and EU CLP. Among hazard classes, health hazards largely led the disharmony. The field survey revealed a change of perception that the main body of chemical information production is manufacturers. Approaches and solutions about hazard classification issues differed depending on business size, types of chemical handling, and other factors. Conclusions: We proposed reasonable ways by time and step to apply hazard classification in the new MSDS system. Chemical manufacturers should make and offer chemical information including responsible hazard classifications. The government should primarily accept these classifications, evaluate them by priority, and support or supervise workplaces in order to communicate reliable chemical information.

• Korean Journal of Cleft Lip And Palate
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• v.15 no.2
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• pp.69-82
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• 2012

Our Team Approach consists of following five stages; (1) Peri-natal care until lip repair After ultrasound diagnosis, some obstetricians recommend the mother with CL/P fetus to undergo prenatal counseling in our CLP clinic. On the day the CL/P baby was born, our oral surgeon, nurse, and pedodontist visit the maternity clinic, and take counseling and take impression for a feeding plate. The cheiloplasty is performed in three months old. (2) From lip repair to palatal repair At one year of age, Otorhinolaryngologist checks middle-ear disease. Palatoplasty is carried out at 1.5 - 2 years old. (3) In deciduous and early mixed dentitions Speech is the most important issue in social life for the CL/P subjects, therefore the training of velopharyngeal function is essential. Orthodontist monitors dentofacial development from 5 years of age. In the case of severe maxillary under-growth or severe collapse, maxillary protractor or lateral expansion is indicative, respectively. In early mixed dentition, upper central incisor on the cleft area erupts with some torsion, and then the traumatic occlusion with tooth torsion must be corrected. (4) In mixed dentition Right before the eruption of upper canines, secondary bone grafting is performed. One year prior to the operation, maxillary fan-type expansion is carried out to correct the collapse of maxillary segments. Following the surgical operation, the erupted canine will be moved into the transplanted bone to avoid alveolar resorption. (5) In permanent dentition Final tooth alignment is carried out after eruption of second molars. Some cases may require orthognathic surgery after physical maturation. Prosthetic oral rehabilitation including the dental-implant is carried out after age eighteen.

• Journal of Ginseng Research
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• v.20 no.3
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• pp.325-330
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• 1996

Dynamic parameters of physiology including embryo ratio (ER), embryo length to endosperm length, dry weight ratio between embryo and endosperm (DWR) and respiration rate (RR) in American send (Panax quinquefolium L.) seed were investigated. According to the changes of ER during seed stratification, the duration of embryo afterripening could be divided into three stages as \circled1 embryo slow growth stage (ESGS), ER increased from 7.31% to 20.48% (0.16% day-1): \circled2 embryo rapid growth stage (ERGS), ER increased to 80.98% (0.61% day-1) (75G5+ ERGS=morphological afterripening stage (MP,5)) and \circled3pysiological afterripening stage (PAS), ER Increased to 88.50% (0.094 day-1) only. DWR Increased slowly from 0.20% to 2.76clp (0.016% day-1) in MAS and rapidly to 8.81% (0.061% day-1) in PAS. The RR correlated significantly with ER as well (r=0.8934 > rot, 0.6610). The steep increment of both DWR and RR in PAS indicated that the PAS was not a static stage although the ER was not changed too much. All of these may provide some information for understanding the dormancy mechanisms of American sting seed.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.1
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• pp.15-26
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• 2011

Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Cicadidae Periostracum(CP) on the RAW 264.7 cells. Method: We examined the cytokine productions including nitric oxide(NO), interleukin(IL)-1b, IL-6 and tumor necrosis factor-a(TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen -activated protein kinases(MAPKs) and nuclear factor kappa BNF-kB) using Western blot. Results: CP inhibited LPS-induced production of NO, IL-1b and TNF-a but not of IL-6 in RAW 264.7 cells. CP respectively inhibited the activation of MAPKs such as extracelluar signal-regulated kinase(ERK 1/2), c-Jun $NH_2$-terminal kinase(JNK), p38 and NF-kB in the LPS-stimulated RAW 264.7 cells. Also oral administration of CP inhibited CLP - induced endotoxin shock. Conclusion: our results showed that CP down-regulated LPS-induced NO, IL-1b and TNF-a productions mainly through ERK, JNK, p38 MAPK and NF-kB pathway, which suggest the anti-inflammatory effects of CP.

• Wind and Structures
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• v.29 no.5
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• pp.323-337
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• 2019

Wind tunnel testing technique has been established as a powerful experimental method for predicting wind-induced loads on high-rise buildings. Accurate assessment of the design wind load combinations for tall buildings on the basis of wind tunnel tests is an extremely important and complicated issue. The traditional design practice for determining wind load combinations relies partly on subjective judgments and lacks a systematic and reliable method of evaluating critical load cases. This paper presents a novel optimization-based framework for determining wind tunnel derived load cases for the structural design of wind sensitive tall buildings. The peak factor is used to predict the expected maximum resultant responses from the correlated three-dimensional wind loads measured at each wind angle. An optimized convex hull is further developed to serve as the design envelope in which the peak values of the resultant responses at any azimuth angle are enclosed to represent the critical wind load cases. Furthermore, the appropriate number of load cases used for design purposes can be predicted based on a set of Pareto solutions. One 30-story building example is used to illustrate the effectiveness and practical application of the proposed optimization-based technique for the evaluation of peak resultant wind-induced load cases.

• Wind and Structures
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• v.14 no.6
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• pp.517-536
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• 2011

The assessment of wind-induced motion plays an important role in the development and design of the majority of today's structures that push the limits of engineering knowledge. A vital part of the design is the prediction of wind-induced tall building motion and the assessment of its effects on occupant comfort. Little of the research that has led to the development of the various international standards for occupant comfort criteria have considered the effects of the low-frequency motion on task performance and interference with building occupants' daily activities. It has only recently become more widely recognized that it is no longer reasonable to assume that the level of motion that a tall building undergoes in a windstorm will fall below an occupants' level of perception and little is known about how this motion perception could also impact on task performance. Experimental research was conducted to evaluate the performance of individuals engaged in a manual tracking task while subjected to low level vibration in the frequency range of 0.125 Hz-0.50 Hz. The investigations were carried out under narrow-band random vibration with accelerations ranging from 2 milli-g to 30 milli-g (where 1 milli-g = 0.0098 $m/s^2$) and included a control condition. The frequencies and accelerations simulated are representative of the level of motion expected to occur in a tall building (heights in the range of 100 m -350 m) once every few months to once every few years. Performance of the test subjects with and without vibration was determined for 15 separate test conditions and evaluated in terms of time taken to complete a task and accuracy per trial. Overall, the performance under the vibration conditions did not vary significantly from that of the control condition, nor was there a statistically significant degradation or improvement trend in performance ability as a function of increasing frequency or acceleration.