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http://dx.doi.org/10.15204/jkobgy.2011.24.1.015

The anti-inflammatory effects of Cicadidae Periostracum  

Kim, Kyoung-Wan (Dept. of Oriental Obstetric and Gynecology, college of Oriental Medicine, Won-Kwang University)
Cho, Han-Baek (Dept. of Oriental Obstetric and Gynecology, college of Oriental Medicine, Won-Kwang University)
Kim, Song-Baeg (Dept. of Oriental Obstetric and Gynecology, college of Oriental Medicine, Won-Kwang University)
Choe, Chang-Min (Dept. of Oriental Obstetric and Gynecology, college of Oriental Medicine, Won-Kwang University)
Seo, Yun-Jung (Dept. of Oriental Obstetric and Gynecology, college of Oriental Medicine, Won-Kwang University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.24, no.1, 2011 , pp. 15-26 More about this Journal
Abstract
Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Cicadidae Periostracum(CP) on the RAW 264.7 cells. Method: We examined the cytokine productions including nitric oxide(NO), interleukin(IL)-1b, IL-6 and tumor necrosis factor-a(TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen -activated protein kinases(MAPKs) and nuclear factor kappa BNF-kB) using Western blot. Results: CP inhibited LPS-induced production of NO, IL-1b and TNF-a but not of IL-6 in RAW 264.7 cells. CP respectively inhibited the activation of MAPKs such as extracelluar signal-regulated kinase(ERK 1/2), c-Jun $NH_2$-terminal kinase(JNK), p38 and NF-kB in the LPS-stimulated RAW 264.7 cells. Also oral administration of CP inhibited CLP - induced endotoxin shock. Conclusion: our results showed that CP down-regulated LPS-induced NO, IL-1b and TNF-a productions mainly through ERK, JNK, p38 MAPK and NF-kB pathway, which suggest the anti-inflammatory effects of CP.
Keywords
Crytotympana pustulata(CP); lipopolysaccharide(LPS); Inflammation; Cytokine;
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Times Cited By KSCI : 4  (Citation Analysis)
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