• 산업경영시스템학회지
• /
• 제28권4호
• /
• pp.14-19
• /
• 2005

In general, cell transmission delay is more sensitive for real time video service rather than cell losses in a wireless ATM network. Existing handoff schemes, which are emphasizing the prevention of cell losses, have limitations in cell transmission delay to satisfy QoS. In this paper, we propose a scheme to minimize transmission delay generated during the handoff and to maintain the sequence of cells. Transmission delay can be reduced by transmitting ATM cells with low CLP(i.e., CLP=0) prior to others and by discarding cells with high CLP(i.e., CLP= 1). The simulation results show that the proposed scheme is suitable for delay sensitive real time VBR service as well as fast handoff by giving high CLP to less meaningful MPEG frames.

• 산업공학
• /
• 제12권2호
• /
• pp.312-318
• /
• 1999

This paper considers the cell loss probability(CLP) in a multiplexer with the superposition of heterogeneous ON/OFF sources. The input traffic is composed of k classes. Traffic of class i is the superposition of M_(i) ON/OFF sources. Recently, the method based on the Markov modulated deterministic process(MMDP) is presented. Basically, it is the discretized model of stochastic fluid flow process(SFFP) and gives the CLP very fast, but under-estimates the CLP especially when the value of estimated CLP is very low. This paper develops the discretized model of Markov modulated Poisson process(MMPP). It is a special type of switched batch Bernoulli process(SBBP). Combining the transition probability matrix of MMDP and SBBP according to the state which is characterized by the arrival rate, this paper presents hybrid algorithm. The hybrid algorithm gives better estimate of CLP than that of MMDP and faster than SBBP.

• Journal of information and communication convergence engineering
• /
• 제17권3호
• /
• pp.213-220
• /
• 2019

This paper shows that novel engineering (NE) is a creative learning process (CLP) based on Seymour Papert's constructionism. First, the paper introduces NE, CLP, and constructionism. Next, a sample NE lesson is explored. NE is an innovative way of integrating literacy into an engineering discipline that was developed by the Center for Engineering Education and Outreach (CEEO) at Tufts University. NE consists of seven steps: picking a book, identifying problems, designing solutions, building, feedback, upgrading solutions, and reconstructing stories. Lifelong Kindergarten by Mitchel Resnick of the MIT Media Lab describes CLP, and the four elements necessary for a lesson to be creative. NE can be viewed as one of the most creative, comprehensive learning models ever developed. NE integrates several paradigms in Korea, following all the constructs of both CLP and constructionism. The aim of this paper is to show that NE is based on both CLP and constructionism.

• Bulletin of the Korean Chemical Society
• /
• 제31권4호
• /
• pp.887-890
• /
• 2010

The family of ClpB protein is a molecular chaperone which protects cellular proteins from being aggregated upon exposure to severe environmental stresses in association with DnaK/DanJ/GrpE in the ATP-dependent manner. In a psychrophilic bacterium which survives at a subzero temperature, any functional role of cold-active ClpB protein can be rather crucial. In order to identify a ClpB encoding gene from a cold-adapted bacterium whose genome sequence has not been fully discovered, we have employed a series of PCR technologies, including a gradient PCR with homologous primers, an inverse PCR and a cassette PCR. The full sequence of PaclpB gene was successfully identified and compared with those of other psychrophilic species. We have further cloned the gene in E.coli expression systems and were able to induce PaClpB protein expression by IPTG, which help us understand a molecular mechanism for survival against extremely cold environments.

• 한국인터넷방송통신학회논문지
• /
• 제21권5호
• /
• pp.189-195
• /
• 2021

본 논문은 금리가 다른 다중 은행의 다중 국가에서 어느 은행에서 얼마의 대출을 받아야 년 상환액을 최소로 할 수 있는지를 결정하는 대출선택 문제(CLP)를 다룬다. 이 문제에 대해 지금까지는 선형계획법과 같은 수학적 소프트웨어 패키지의 도움 없이는 해를 얻기가 사실상 불가능하였다. 본 논문에서는 수송문제에서 적용하고 있는 최소 금리부터 대출금을 결정하는 최소비용선택법(LCM)으로 초기 실현가능 해를 구하고, 교환 최적화 기법을 적용하여 초기 해를 개선하여 최적 해를 구하는 규칙을 가진 알고리즘을 CLP에 적용하였다. 제안된 알고리즘을 실험한 결과, LCM으로 얻은 초기 해에 대해 단지 최대 2회의 교환 최적화만으로도 최적 해를 얻을 수 있음을 보였다.

• 한국식품조리과학회지
• /
• 제25권2호
• /
• pp.199-205
• /
• 2009

울금가루를 새로운 식품소재로 활용하고자 하는 연구의 일환으로 울금가루 첨가량을 달리하여 국수를 제조하고 그 품질특성을 조사하였다. 밀가루와 울금가루 혼합분의 물결합력과 breakdown은 울금가루 8% 첨가구에서 가장 높았으나, setback은 울금가루 8% 첨가구에서 가장 낮았다. 울금가루 첨가 국수의 조리 특성에서 무게, 부피 및 인장강도는 울금가루 8% 첨가구에서 가장 낮았고, 대조구에서 가장 높았으나, 탁도는 울금가루 8% 첨가구에서 가장 높았으며, 울금가루 첨가량이 증가할수록 높았다. 국수의 조리 전과 조리 후의 색도 및 물성의 변화에서 L값은 조리 전 생국수가 조리된 국수보다 높았으나, 색도의 a값 및 b값과 물성에서는 조리 전 생국수보다 조리된 국수에서 높았다. 색도의 L값과 물성의 탄력성 및응집성은 울금가루 첨가량이 증가할수록 낮아졌고, 색도의 a값 및 b값과 물성의 경도, 점착성 및 씹힘성은 울금가루 첨가량이 증가할수록 높아졌다. 울금가루 첨가량에 따른 관능검사에서 울금가루 4% 첨가구의 기호도가 가장 높았고, 울금가루 2% 및 8% 첨가구는 대조구보다 낮은 기호도를 보였다.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
• /
• pp.77-77
• /
• 2003

Sepsis remains common surgical problems with high morbidity and mortality despite improvement in the management for septic patient. Although hepatocellular dysfunction occurs during sepsis, the mechanism responsible for this remains unclear. In sepsis, a state of severe oxidative stress is encountered, with host endogenous antioxidant defenses overcome. Therefore, the aim of this study was to determine the effect of a-tocopherol (AT) vasoregulatory gene expression during polymicrobial sepsis. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP). AT (15 mg/kg) was intraperitonealy injected for 3 days prior to CLP. Blood samples were taken 24 h after CLP for measurement of the extent of hepatocellular damage. Liver samples were taken for RT-PCR analysis of mRNA for genes of interest: endothelin-l (ET-l), its receptors $ET_{A}$ and $ET_{B}$, nitric oxide synthases (iNOS and eNOS), cyclooxygenase-2 (COX -2), heme oxygenase-l (HO-l), and tumor necrosis factor-$\alpha$ (TNF-$\alpha$). The activities of serum alanine aminotransferase and lipid peroxidation level were significantly increased; an increase which was prevented by AT pretreatment. CLP significantly increased the mRNA levels of ET-1 and $ET_{B}$; an increase that was prevented by AT pretreatment. However, the level of $ET_{A}$ mRNA significantly decreased after CLP; a decrease that was not prevented by AT pretreatment. There were significant increases in the mRNA expression of iNOS, HO-l and COX -2 in CLP groups. This increase was prevented by AT pretreatment. The expression of eNOS and TNF-$\alpha$ mRNA significantly increased in CLP, which was not prevented by AT pretreatment. Our findings suggest that there was an imbalanced vasoregulatory gene expression in sepsis, and AT ameliorates this change through its free radical scavenging activity.

• 한국식품위생안전성학회지
• /
• 제25권1호
• /
• pp.6-9
• /
• 2010

본 연구는 황련, 금은화, 그리고 백작약 혼합분말(1:1:1)의 메탄올 추출물(CLP1000)과, 이에 dioctahedral smectite를 혼합한 합제 (CLPS1000)의 살모넬라에 대한 항균효과를 평가하기 위해 수행되었다. CLP1000와 CLPS1000는, 0. 5mg/ml 농도에서 S. typhimurium에 대한 항균효과를 보이지 않았으나, 1.0 mg/ml의 농도에서는 S. typhimurium에 대한 항균활성이 관찰되었다. BALB/c 마우스를 이용한 살모넬라 감염시험에서 Smectite, CLP1000 그리고 CLPS1000을 각각 10 mg/ml 농도로 12일 동안 투여한 결과, 사망률이 각각 90%, 90% 그리고 70%을 보여, CLPS1000이 마우스 살모넬라증에 강력한 효과를 갖고 있는 것으로 나타났다.

• Journal of Trauma and Injury
• /
• 제21권2호
• /
• pp.120-127
• /
• 2008

Purpose: Many studies on the time course of inducible nitric oxide synthase (iNOS) gene expression have been performed in the LPS (Lipopolysaccharide)-induced endotoxemic model, but there have been few experimental approaches to continuous peritonitis-induced sepsis model. We conducted this study to establish basic data for future sepsis-related research by investigating the time course of iNOS gene expression and the relationship with the production of inflammatory mediators in the early sepsis model induced by cecal ligation and puncture (CLP). Methods: Male Sprague-Dawley rats were operated on by sing the CLP method to induce of peritonitis; and then, they were sacrificed and samples of blood and lung tissues were obtained at various times (1,2,3,6,9 and 12 h after CLP). We observed the expression of iNOS mRNA from lung tissues and measured the synthesis of nitric oxide, $IL-1{\beta}$, and $TNF-{\alpha}$ from the blood. Results: iNOS mRNA began to be expressed at 3 h and was maintained untill 12 h after CLP. The nitric oxide concentration was increased significantly at 6 h, reached its peak level at 9 h, and maintained a plateau untill 12 h after CLP. $TNF-{\alpha}$ began to be detected at 3 h, increased gradually, and decreased steeply from 9 h after CLP. $IL-1{\beta}$ showed its peak level at 6 h after CLP, and tended to decrease without significance. Conclusion: We observed that the iNOS gene was expressed later in peritonitis-induced sepsis than in LPS-induced sepsis. Nitric oxide and key inflammatory mediators were also expressed later in peritonitis-induced sepsis than in LPS-induced sepsis.

• 한국미생물학회:학술대회논문집
• /
• 한국미생물학회 2005년도 International Meeting of the Microbiological Society of Korea
• /
• pp.49-52
• /
• 2005