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Evaluation of Antibacterial Effects of a Combination of Coptidis Rhizoma, Lonicerae Flos, Paeonia Japonica Extracts, and Dioctahedral Smectite Against Salmonella Typhimurium in Murine Salmonellosis  

Jung, Won-Chul (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
Lee, Yeon-Ok (Senong Co., Ltd.)
Cha, Chun-Nam (Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University)
Lee, Yeo-Eun (Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University)
Kim, Gon-Sup (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
Lee, Hu-Jang (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Journal of Food Hygiene and Safety / v.25, no.1, 2010 , pp. 6-9 More about this Journal
Abstract
The present study was undertaken to estimate the antibacterial effect of a combination of C. rhizoma, L. Flos, and P japonica (1:1:1) extracts (CLP1000) and a combination of the herbal extract mixture and dioctahedral smectite (CLPS1000) against murine salmonellosis. At the concentration of CLP1000 and CLPS1000 0.5 mg/ml, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, the antibacterial effect against S. typhimurium was observed at the concentration of CLP1000 and CLPS1000 1.0 mg/ml. Oral administration of Smectite, CLPl000, and CLPS1000 at the dose of 10 mg/ml showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of Smectite, CLP1000 and CLPS1000-treated mice was 90%, 90%, and 70% at 12 days, respectively, while that of untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that CLPS1000 has potential as an effective of salmonellosis.
Keywords
Coptidis rhizoma; Lonicerae Flos; Paeonia japonica; dioctahedral smectite; Salmonella typhimurium;
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1 Angulo, F.J., Johnson, K.R., Tauxe, R.V., Cohen, M.L.: Origins and consequences of antimicrobial-resistant nontyphoidal Salmonella: implications for the use of fluoroquinolones in food animals. Microb. Drug Resist. 6, 77-83 (2000).   DOI   ScienceOn
2 Zheng, W., Wang, S.Y.: Antioxidant activity and phenolic compounds in selected herbs. J. Agric. Food Chem. 49, 5165-5170 (2001).   DOI   ScienceOn
3 Jeong, I.Y., Lee, J.S., Oh, H., Jung, U.H., Park, H.R., Jo, S.K.: Inhibitory effect of hot-water extract of Paeonia japonica on oxidative stress and identification of its active components. J. Korean Soc. Food Sci. Nutr. 32, 739-744 (2003).   과학기술학회마을   DOI
4 Park, E., Kum, S., Wang, C., Park, S.Y., Kim, B.S., Schuller- Levis, G.: Anti-inflammatory activity of herbal medicines: inhibition of nitric oxide production and tumor necrosis factor- $\alpha$ secretion in an activated macrophage-like cell line. Am. J. Chin. Med. 33, 415-424 (2005).   DOI   ScienceOn
5 Cleaveland, S., Laurenson, M.K., Taylor, L.H.: Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence. B. Biol. Sci. 356, 991-999 (2001).
6 Kim, G.S., Kim, D.H., Lim, J.J., Lee, J.J., Han, D.Y., Lee, W.M., Jung, W.C., Min, W.G., Won, C.G., Rhee, M.H., Lee, H.J., Kim, S.: Biological and antibacterial activities of the natural herb Houttuynia cordata water extract against the intracellular bacterial pathogen Salmonella within the raw 64.7 macrophage. Biol. Pharm. Bull. 31, 2012-2017 (2009).
7 Haydel, S.E., Remenih, C.M., Williams, L.B.: Broad-spectrum in vitro antibacterial activities of clay minerals against antibiotic-susceptible and antibiotic-resistant bacterial pathogens. J. Antimicrob. Chemother. 61, 353-361 (2008).
8 Martirosian, G., Rouyan, G., Zalewski, T., Meisel-Mikolajczyk, F.: Dioctahedral smectite neutralization activity of Clostridium difficile and Bacteroides fragilis toxins in vitro. Acta Microbiol. Pol. 47, 177-183 (1998).
9 Kim, J.D.: The growth inhibition effect of E. coli KCTC 1039 by combination of natural products bearing antioxdative capacity. Korean J. Biotechnol. Bioeng. 17, 490-496 (2002).
10 Aufreiter, S., Mahaney, W.C., Milner, M.W., Huffman, M.A., Hancock, R.G., Wink, M., Reich, M.: Mineralogical and chemical interactions of soils eaten by chimpanzees of the Mahale Mountains and Gombe Stream National Parks, Tanzania. J. Chem. Ecol. 27, 285-311 (2001).   DOI   ScienceOn
11 Chang, F.Y., Lu, C.L., Chen, C.Y., Luo, J.C.: Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome. J. Gastroenterol. Hepatol. 22, 2266-2272 (2007).   DOI   ScienceOn
12 Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., Wang, Y.: Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J. Ethnopharmacol. 126, 5-17 (2009).   DOI   ScienceOn
13 Szajewska, H., Dziechciarz, P., Mrukowicz, J.: Meta-analysis: Smectite in the treatment of acute infectious diarrhoea in children. Aliment. Pharmacol. Ther. 23, 217-227 (2006).   DOI   ScienceOn
14 Muragami, N., Saka, M., Shimada, H., Matsuda, H., Yamahara, J., Yoshikawa, M.: New bioactive monoterpene glycosides from Paeoniae radix. Chem. Pharm. Bull. 44, 1279- 1281 (1996).   DOI   ScienceOn
15 Son, D.H., Lee, S.I., Chung, Y.G.: Antioxidative of medicinal plants on pathogenic bacteria. J. Korean Soc. Hygiene Sci. 7, 103-108 (2001).
16 Abrahams, P.W.: Soils: their implications to human health. Sci. Total Environ. 291, 1-32 (2002).   DOI   ScienceOn
17 Kang, S.S., Kim, W.K., Park, K.K., Cho, Y.H., Park, H.S.: Platelet anti-aggregation of Paeony root. Kor. J. Pharmacogn. 22, 215-218 (1991).
18 Bang, M.H., Song, J.C., Lee, S.Y., Park, N.K., Baek, N.I.: Isolation and structure determination of antioxidants from the root of Paeonia lactiflora. J. Korean Soc. Agric. Chem. Biotechnol. 42, 170-175 (1991).
19 Kim, J., Kim, H.S.: The immunomodulating effects of the supplementation of Paeonia Japonica extracts in mice. Nutr. Sci. 5, 60-67 (2002).
20 Park, U.Y., Chang, D.S., Cho, H.R.: Screening of antimicrobial activity for medical herb extracts. J. Korean Soc. Food Nutr. 21, 91-96 (1992).
21 Iizuka, N., Miyamoto, K., Hazama, S., Yoshino, S., Yoshimura, K., Okita, K., Fukumoto, T., Yamamoto, S., Tangoku, A., Oka, M.: Anticachectic effects of Coptidis rhizoma, an antiinflammatory herb, on esophageal cancer cells that produce interleukin 6. Cancer Lett. 158, 35-41 (2000).   DOI   ScienceOn
22 Merken, H.M., Merken, C.D., Beecher, G.R.: Kinetics method for the quantitation of athocyanidins, flavonols, and flavones in foods. J. Agric. Food Chem. 49, 2727-2732 (2001).   DOI   ScienceOn
23 Tae, J., Han, S.W., Yoo, J.Y., Kim, J.A., Kang, O.H., Baek, O.S., Lim, J.P., Kim, D.K., Kim, Y.H., Bae, K.H., Lee, Y.M.: Anti-inflammatory effect of Lonicera japonica in proteinaseactivated receptor 2-mediated paw edema. Clin. Chim. Acta 330, 165-171 (2003).   DOI
24 Choi, H.Y.: Antimicrobial activity of Paeonia japonica extract and its quality characteristic effects in Sulgidduk. Korean J. Food Cookery Sci. 25, 435-444 (2009).   과학기술학회마을
25 Kwon, H.A., Kwon, Y.J., Kwon, D.Y., Lee, J.H.: Evaluation of antibacterial effects of a combination of Coptidis Rhizoma, Mume Fructus, and Schizandrae Fructus against Salmonella. Int. J. Food Microbiol. 127, 180-183 (2008).   DOI
26 Gross, U., Tschape, H., Bednarek, I., Frosch, M.: Antibiotic resistance in Salmonella enterica serotype Typhimurium. Eur. J. Clin. Microbiol. Infect. Dis. 17, 385-387 (1998).
27 O'Brien, T.F.: Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else. Clin. Infect. Dis. 34, S78-S84 (2002).   DOI
28 Kim, D.H., Lim, J.J., Lee, J.J., Jung, W.C., Shin, H.J., Lee, H.J., Kim, G.S., Kim, S.: Antibacterial and therapeutic effects of houttuynia cordata ethanol extract for murine salmonellosis. Kor. J. Environ. Agricul. 27, 156-162 (2008).   과학기술학회마을   DOI
29 Bae, J.H., Lee, SM.: Identification of antimicrobial substances from Prunus mume on the growth of food-borne pathogens. Food Sci. Biotechnol. 12, 128-132 (2003).
30 Yun, Y.G., Kim, G.M., Lee, S.J., Ryu, S.H., Jang, S.I.: Inhibitory effect of aqueous extract from Lonicera japonica flower on LPS-induced inflammatory mediators in RAW 264.7 macrophages. Kor. J. Herbology 22, 117-125 (2007).   과학기술학회마을
31 Valle, E., Guiney, D.G.: Characterization of salmonella-induced cell death in human macrophage-like THP-1 cells. Infection and. Immunity 73, 2835-2840 (2005).   DOI   ScienceOn