• Journal of computational fluids engineering
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• v.9 no.3
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• pp.8-17
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• 2004

A Semi-Lagrangian method based on CIP(Cubic Interpolated Pseudoparticle)method is proposed and it is applied to solve the two dimensional advection equation. Especially the attentions are given to settle the pole problem and to enhance the accuracy in solving the advection equation on the spherical coordinate system. Tn this algorithm, the CU method is employed as the Semi-Lagrangian method and extended to the spherical coordinate system. To enhance the accuracy of the solution, the spatial discretization is made by CIP method. The mathematical formulation and numerical results are also described. To verify the efficiency, accuracy and capability of proposed algorithm, two dimensional rotating cosine bell problem and the frontogenesis problem are simulated by the present scheme. As results, it is confirmed that the present scheme gives an accurate solution and settles the pole problem in the advection equation on the sphere.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.326-334
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• 2010

In this study, we provide a comprehensive review of the CIP(Constrained Interpolation Pro file/Cubic Interpolated Propagation) method with a pressure-based algorithm that is known as a general numerical solver for soled liquid, gas and plasmas. And also we introduce a body-fitted grid system(Soroban grid) for computation of strongly nonlinear marine hydrodynamic problems such as slamming water on deck, wave impact by green water. This grid system can keep the third-order accuracy in time and space with the help of the CIP method. The grid system consists of the straight lines and grid points. In the 2-dimensional grid case, each grid points moving in these lines like abacus - Soroban in Japanese. The length of each line can be different and the number of grid points in each line can be different. Mesh generation and searching of upstream departure point are very simple and possible to mesh-free treatment. To optimize computation of free-surface and multi-fluid flows, We adopt the C-CUP method. In most of the earlier computations, the C-CUP method was used with a staggered-grid approach. Here, because of the mesh free nature of the Soroban grid, we use the C-CUP method with a collocated-grid approach.

• Journal of the Korea Computer Graphics Society
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• v.25 no.5
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• pp.21-30
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• 2019

We propose a physical simulation method based on the shallow water equation(SWE) to represent water surface effectively. In this paper, the water which can be represented has a much larger width compared to the depth does not have a large vertical direction flow. In order to calculate the water flow efficiently, we start with the shallow water equation as the governing equation, which is a simplified version of the Navier-Stokes equation. In order to numerically calculate the advection term of the SWE, we introduce a new conservtive USCIP(CUSCIP) method which improves the Constrained Interpolation Profile (CIP) method to preserve the physical quantity while increasing the numerical accuracy. The proposed method is based on Kim et. al.'s Unsplit Semi-lagrangian CIP[9], and calculates advection term with additional constraints on term that consider integral values. The experimental results show that the CUSCIP method is robust to the loss of physical quantity due to numerical dissipation, which improves wave detail and persistence.

• Journal of Life Science
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• v.28 no.11
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• pp.1316-1320
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• 2018

The effects of a green tea extract (GTE) were examined using the MCF-7 human breast cancer cell line. Cell viability assays using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays revealed that GTE had a significant cytotoxic effect on MCF-7 cells, depending on the concentration of GTE. Western blotting of p53 and its related proteins, p21/cip1 and CDK2, after GTE treatment revealed that a significant and concentration dependent increase in p53 protein in response to GTE. The levels of p21/cip1 proteins were also increased at low GTE concentrations were significantly increased even at the highest GTE concentrations. However, the level of CDK2 was significantly decreased by treatment with high concentrations of GTE. These results indicate that treatment with GTE increased the p53 level in MCF-7 cells, and this activation of p53 markedly elevated the levels of p21/cip1proteins, which, in turn, inhibited CDK2 expression in the MCF-7 cells. The inhibition of CDK2 expression might then affect cell cycle progression. Subsequent FACS analysis indicated that GTE treatment the gradually increased progression of the MCF-7 to the G1 phase. These results clearly demonstrate that the anti-tumor effect of GTE in MCF-7 cells is regulated by p53 arrest of the MCF-7 cells at the G1 stage of cell cycle.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.33 no.3
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• pp.93-100
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• 2021

Since the IB (Immersed Boundary) method, which can perform coupling analysis with objects and fluids having an impermeable boundary of arbitrary shape on a fixed grid system, has been developed, the IB method in various CFD models is increasing. The representative IB methods are the directing-forcing method and the ghost cell method. The directing-forcing type method numerically satisfies the boundary condition from the fluid force calculated at the boundary surface of the structure, and the ghost-cell type method is a computational method that satisfies the boundary condition through interpolation by placing a virtual cell inside the obstacle. These IB methods have a disadvantage in that the computational algorithm is complex. In this study, the simplified immersed boundary (SIB) method enables the analysis of temporary structures on a fixed grid system and is easy to expand to three proposed dimensions. The SIB method proposed in this study is based on a one-field model for immiscible two-phase fluid that assumes that the density function of each phase moves with the center of local mass. In addition, the volume-weighted average method using the density function of the solid was applied to handle moving solid structures, and the CIP method was applied to the advection calculation to prevent numerical diffusion. To examine the analysis performance of the proposed SIB method, a numerical simulation was performed on an object falling to the free water surface. The numerical analysis result reproduced the object falling to the free water surface well.

• Membrane Journal
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• v.18 no.1
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• pp.94-102
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• 2008

For the treatment of the dye wastewater, a polyamide nano-composite membrane and reverse osmosis (RO) membranes were prepared using interfacial polymerization technique, in which piperazine, meta-phenylene diamine, and trimesoyl chloride were used as monomers, Their permselective properties were characterized with aqueous solutions of PEG 600, $Na_2SO_4$, and NaCl, and their performance was compared with that of Osmonics Co, They were found to be a typical nano-composite membrane and a low pressure RO membrane. Using them, a real dye wastewater supplied from the Kyungin Corporation, one of the domestic dye producer, was treated, studying the separation performances of the membranes, Also, during the wastewater treatment, cleaning in place (CIP) of the membranes was carried out regularly to recover the flux of the membranes. Three different chemical cleaners were employed for the CIP process and their performance were compared in this study.

• 한국지구물리탐사학회:학술대회논문집
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• 1999.08a
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• pp.202-216
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• 1999

The deep foundation is frequently used for the infrastructures. Since the quality control of the cast-in-place concrete foundations such as CIP piles and slurry walls is not so easy as that of the ready made PC(prestressed concrete) piles, it is necessary to get the information on the integrity of the concrete of the foundation. The depth estimation of foundations whose depths are unknown is also very important in repair and reinforcement works or in safety inspection and assessment to the big structures. The cross-hole sonic logging(CSL) system and the single channel reflection seismic measurement system were developed to test the integrity of pile. The former is well applied to CIP structures, while the later to all kinds of piles with less accurate result compared to that of CSL. To estimate the depth of the deep foundations, parallel seismics, borehole RADAR, and borehole magnetics can be used.

• Journal of the Korea Concrete Institute
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• v.26 no.2
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• pp.189-199
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• 2014

Currently, in the precast concrete construction, Precast Concrete (PC) and Cast-In-Place (CIP) concrete with different concrete strengths are frequently used. However, current design codes do not specifically provide shear design methods for PC-CIP hybrid members using dual concrete strengths. In the present study, simply supported composite beams with shear reinforcement were tested. The test variables were the area ratio of the two concretes, spacing of shear reinforcement, and shear span-to-depth ratio. The shear strengths of the test specimens were evaluated by current design codes on the basis of the test results. The results showed that the shear strength of the composite beams was affected by the concrete strength of the compressive zone and also proportional to the flexural rigidity of un-cracked sections. Furthermore, the contribution of shear reinforcements varied according to the concrete strength of the compressive zone.

• Korean Journal of Veterinary Service
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• v.30 no.1
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• pp.13-21
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• 2007

An atmospheric pressure chemical ionization (APcI) LC/MS/MS method was developed for the simultaneous analysis of fluoroquinolones (norfloxacin, ciprofloxacin, enrofloxacin, danofloxacin) residues in eggs. The spiked and blank samples were extracted from whole eggs using 50mM phosphate buffer (pH 7.4). The extract was cleaned up by passage though $Oasis^{(R)}$ MAX extraction cartridge for solid-phase extraction followed by elution with 4% formic acid in methanol. The extract of sample was separated on a Waters $Atlantis^{TM}$ $dC_{18}$ reversed-phase column ($4.6{\times}150mm,\;5{\mu}m$) and analyzed by APcI positive mode mass spectrometry. The mobile phase consists of aqueous 0.2% nonafluoropentanoic acid (NFPA) and methanol. Multiple reaction monitoring (MRM) using the precursor to product ion combinations of m/z $320\;{\dashrightarrow}\;302,\;332\;{\dashrightarrow}\;314,\;360\;{\dashrightarrow}\;342$ and m/z $358\;{\dashrightarrow}\;340$ were used to quantify norfloxacin (NOR), ciprofloxacin (CIP), enrofloxacin (ENR) and danofloxacin (DAN), respectively. The limits of quantification (LOQ) were 7.8ppb for NOR, 8.5ppb for CIP, 8.9ppb for ENR, and 4.8ppb for DAN. Average recoveries of fortified sample at levels of 0.025 to 0.1 ppm were estimated 71.29% for NOR, 75.27% for CIP, 85.51% for ENR and 81.22% for DAN. These results could be applied for the confirmation and quantification in eggs.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.15 no.3
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• pp.269-274
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• 2002

(Sm/Y)-Ba-Cu-O system high Tc composite superconductors with/without $CeO_2$ additive were directionally grown by zone-melting process, haying large temperature gradient, In air atmosphere. Cylindrical green rods of $({Sm/y})_{1.8}Ba_{2.4}Cu_{3.4}O_x$ [(Sm/Y)1.8] composite oxides by cold isostatic pressing(CIP) method using rubber mold were fabricated. The microstructure and superconducting properties were investigated by XRD, SEM, TEM and SQUID magnetometer. The size of nonsuperconducting $({Sm/y})_2BaCuO_5$ inclusions of the melt-textured (Sm/Y)1.8 sample with CeO$_2$ additive were remarkably reduced and uniformly distributed within the superconducting (Sm/Y)1.8 matrix. Both samples, with/without $CeO_2$ additive, showed an onset Tc $\geq$ 90 K and sharp superconducting transition. The critical current density Jc value of the $CeO_2$ addictive were $1{\times}10^5A/\textrm{cm}^2$ in 77 K, 0 Tesla.