• 제목/요약/키워드: CIN

검색결과 168건 처리시간 0.021초

Addition of Capsicum oleoresin, Carvacrol, Cinnamaldehyde and their mixtures to the broiler diet II: Effects on meat quality

  • Ipcak, Hasan Huseyin;Alcicek, Ahmet
    • Journal of Animal Science and Technology
    • /
    • 제60권4호
    • /
    • pp.9.1-9.11
    • /
    • 2018
  • Background: In recent years, with the prohibition of antibiotics used as growth stimulants in the nutrition of farm animals, researchers have searched for alternative natural and reliable products in order to be able to sustain the developments experienced during the use of antibiotics and to overcome the possible inconveniences. In this context, studies on evaluation of essential oils in poultry nutrition have been reported to improve the utilization of feed, stimulate the release of digestive enzymes, increase absorption in the stomach and intestines, antimicrobial and anti-parasitic effects and thus, can be an alternative to antibiotics and improve meat quality as well. Indeed, this study has been carried out to explore the effects of the addition of 150 mg/kg capsicum oleoresin (CAP), carvacrol (CAR), cinnamaldehyde (CIN) or their mixture (CAP+CAR+CIN) into the broilers' ration over sensory, physical and chemical properties in breast meat and leg meat. Methods: Experiments were conducted over 400 male and female broiler chicks (Ross-308) in 5 groups (1 control group and 4 treatment groups), each composed of 80 chicks. The control group was fed without feed additives while the second, third, fourth and the fifth groups were fed with 150 mg CAP/kg feed, 150 mg CAR/kg feed, 150 mg CIN/kg feed, and 150 mg CAP+CAR+CIN/kg feed, respectively. Results: Addition of CAP, CAR, CIN or CAP+CAR+CIN had effects on the sensory (of taste, tenderness, juiciness and overall acceptability); physical properties (of $L^*$ value and toughness), the chemical properties (of DM, CF, CP, linoleic, EPA, behenic, MUFA, PUFA and ${\Sigma}n-6$ of the leg meat), the physical characteristics (of toughness and firmness), and the chemical properties (of CF, CP, linoleic, ecosenic, EPA, lignoseric, MUFA and ${\Sigma}n-3$) of the breast meat in comparison to control group. Furthermore, while the treatments had positive impacts on thawing loss, cooking loss and water holding capacity in both breast and leg meat; no effect was observed on pH value and lipid oxidation on day 1, day 4 and day 8. Conclusion: The results strongly suggested that the addition of CAP, CAR, CIN or CAP+CAR+CIN to the rations of the broiler chicks changed the sensory, physical and chemical properties of breast and leg meat. It was also observed that these compounds were more effective when they were added to the ratio as a mixture rather than adding them individually.

Incidence and Risk Factors of Contrast-Induced Nephropathy after Bronchial Arteriography or Bronchial Artery Embolization

  • Song, June Seok;Kim, Sa Il;Kim, Woongjun;Park, Dong Won;Kwak, Hyun Jung;Moon, Ji-Yong;Kim, Sang-Heon;Kim, Tae Hyung;Sohn, Jang Won;Shin, Dong Ho;Park, Sung Soo;Yoon, Ho Joo
    • Tuberculosis and Respiratory Diseases
    • /
    • 제74권4호
    • /
    • pp.163-168
    • /
    • 2013
  • Background: In uncontrolled hemoptysis patient, bronchial arteriography and bronchial artery embolization (BAE) is a important procedure in diagnosis and treatment. The aim of this study is to assess the incidence of contrast-induced nephropathy and the risk factors of contrast-induced nephropathy (CIN) after bronchial arteriography and BAE. Methods: We retrospectively reviewed the medical records of the patients who underwent bronchial arteriography and BAE in two university hospitals from January 2003 to December 2011. CIN was defined as rise of serum creatinine more than 25% of baseline value or 0.5 mg/dL at between 48 hours and 96 hours after bronchial arteriography and BAE. We excluded patients who already had severe renal insufficiency (serum creatinine${\geq}4.0$) or had been receiving dialysis. Results: Of the total 100 screened patients, 88 patients met the enrollment criteria. CIN developed in 7 patients (8.0%). The mean duration between the exposure and development of CIN was $2.35{\pm}0.81$ days. By using multivariate analysis, serum albumin level was found to be significantly associated with the development of CIN (p=0.0219). Conclusion: These findings suggest that the incidence of CIN was higher than expected and patients with hypoalbuminemia should be monitored more carefully to prevent the development of CIN after bronchial arteriography and BAE.

들뢰즈 영화철학에서의 이미지론 (De l'image dans la philosophie cinémathographique chez G. Deleuze)

  • 진기행
    • 철학연구
    • /
    • 제117권
    • /
    • pp.355-372
    • /
    • 2011
  • 들뢰즈는 자신의 영화철학을 집대성한 대저(大著) "시네마"의 첫머리에서, 자신의 영화철학에 대한 연구는 영화사에 대한 연구가 아니라 하나의 분류학 taxinomie이며 이미지와 기호의 분류를 시도한 것이라고 규정하고 있다. 우리는 본 논문에서 들뢰즈가 이 규정에서 언급하고 있는 이미지의 분류란 무엇이며, 어떤 이미지들이 어떻게 분류되고 있는지를 규명해 보려고 한다. 특히 중점적으로 다루려고 하는 점은 "시네마"에서 가장 기본적인 분류인 '운동-이미지 image-mouvement'와 '시간-이미지 image-temps' 간의 구별이다. 그리고 들뢰즈가 운동-이미지로 이루어진 '고전적 classique' 영화라고 규정하고 있는 영화작품과, 다른 한편에서 시간-이미지로 이루어진 '현대적 moderne'이라고 규정하고 있는 영화작품 간에는, 그것을 감상하는 관객의 존재방식이 어떻게 변화하는가 하는 문제가 발생한다. 따라서 여기에는 관객의 문제가 개재될 수밖에 없고 우리는 이 점도 함께 논의할 것이다. 그리하여 우리는 "시네마"의 두 가지 이미지에 대한 이해를 통하여, 사유(思惟)를 현실에서 작동시키는 방법이라는 점에서 역시 영화가 가장 앞서 있는 예술이자 기술이라고 하는 점과, 나아가 세계와 이미지에 대한 우리의 능동적 해석의 자세가 항상 필요하다고 하는 점을 드러내려고 하였다.

대류가용잠재에너지와 대류억제도에 입각한 여름철 습윤 대류 예측성에 대한 연구 (A Study on the Predictability of Moist Convection during Summer based on CAPE and CIN)

  • 맹도열;강성락
    • 한국지구과학회지
    • /
    • 제44권6호
    • /
    • pp.540-556
    • /
    • 2023
  • 본 연구는 여름 및 초가을(6-9월)에 한반도에서 관측된 레윈존데 사운딩을 분석하여 대류가용잠재에너지와 대류억제도가 깊은 습윤 대류 및 강수 발생 예측에 유용성이 있는지를 확인해보았다. 레원존데 사운딩은 열역학적으로 깊은 습윤 대류가 발생할 가능성이 높은 고 대류가용잠재에너지 저 대류억제도 그룹과 대류 발생을 억제시킬 수 있는 저 대류가용잠재에너지 고 대류억제도 그룹으로 분류하였다. 이후, 두 그룹의 12시간 누적 강수량, 12시간 평균 최저운고, 12시간 평균 중하층운량의 분포 차이가 유의미한지 여부를 통계적 가설검정을 통해 확인하였다. 그 결과, 무강수인 경우 21:01-09:00 KST 시간대의 12시간 평균 최저운고를 제외하고 두 그룹은 통계적으로 유의미한 차이가 있음이 검증되었다. 이 결과는 고 대류가용잠재에너지 저 대류억제도 그룹이 저 대류가용잠재에너지 고 대류억제도 그룹보다 깊은 습윤 대류 및 강수 발생에 더 유리함을 시사한다.

'Drawing' a Molecular Portrait of CIN and Cervical Cancer: a Review of Genome-Wide Molecular Profiling Data

  • Kurmyshkina, Olga V;Kovchur, Pavel I;Volkova, Tatyana O
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제16권11호
    • /
    • pp.4477-4487
    • /
    • 2015
  • In this review we summarize the results of studies employing high-throughput methods of profiling of HPV-associated cervical intraepithelial neoplasia (CIN) and squamous cell cervical cancers at key intracellular regulatory levels to demonstrate the unique identity of the landscape of molecular changes underlying this oncopathology, and to show how these changes are related to the 'natural history' of cervical cancer progression and the formation of clinically significant properties of tumors. A step-wise character of cervical cancer progression is a morphologically well-described fact and, as evidenced by genome-wide screenings, it is indeed the consistent change of the molecular profiles of HPV-infected epithelial cells through which they progressively acquire the phenotypic hallmarks of cancerous cells. In this sense, CIN/cervical cancer is a unique model for studying the driving forces and mechanisms of carcinogenesis. Recent research has allowed definition of the whole-genome spectrum of both random and regular molecular alterations, as well as changes either common to processes of carcinogenesis or specific for cervical cancer. Despite the existence of questions that are still to be investigated, these findings are of great value for the future development of approaches for the diagnostics and treatment of cervical neoplasms.

Photopatternability of Poly(vinylcarbazole) Bearing Cinnamate Pendants and Its Blends with a Soluble Poly(p-phenylene vinylene) Derivative

  • Yu, Young-Jun;Lee, Seung-Hun;Choi, Dong-Hoon;Jin, Jung-Il;Tessler, Nir
    • Macromolecular Research
    • /
    • 제15권2호
    • /
    • pp.142-146
    • /
    • 2007
  • Poly[(1-(9-carbazoly1)ethylene)-co-(3-cinnamoyloxyoctyl-9-carbazolyl)] ethylene (PVK-Cin) was prepared by tethering cinnamate pendants to a carbazole group via an octylene spacer. The photopatternability of the new PVK based-polymer was investigated using a photocrosslinking reaction under UV light illumination $(\lambda=254nm)$. Blends of the PVK-Cin and a soluble poly(phenylene vinylene) (CzEh-PPV) were employed to study the photocrosslinking behavior. Well resolved lithographic patterns were observed in these polymer systems. PVK-Cin produced a blue light emitting pattern both before and after the photocrosslinking reaction. The blends of PVK-Cin and CzEh-PPV also showed corresponding emissions at 398 and 525 (560) nm in the film state.

HPV Prevalence and Cervical Intraepithelial Neoplasia among HIV-infected Women in Yunnan Province, China: A Pilot Study

  • Zhang, Hong-Yun;Tiggelaar, Sarah M.;Sahasrabuddhe, Vikrant V.;Smith, Jennifer S.;Jiang, Cheng-Qin;Mei, Run-Bo;Wang, Xian-Guo;Li, Zu-An;Qiao, You-Lin
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제13권1호
    • /
    • pp.91-96
    • /
    • 2012
  • Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with $cells/{\mu}L$ had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

HC11 세포에서 인체 락토페리신의 발현 (Expression of Human Lactoferricin in HC11 Cells)

  • 남명수
    • 농업과학연구
    • /
    • 제28권2호
    • /
    • pp.92-98
    • /
    • 2001
  • 락토페리신은 다양한 생리활성을 나타내는 락토페린(약 80kD)에서 유래된 항균성펩타이드 분획물(5kD)이다. 마우스HC11유선상피세포에서 인체 락토페리신의 발현은 bovine beta-casein을 promotor로 하고 인체 락토페리신 cDNA를 삽입하여 제작한 pBL1-cin발현벡타를 이용하였다. 이 발현벡타를 이용하여 인체 락토페리신 발현여부를 RT-PCR, northern blot, dot blot분석을 통하여 확인하였다. pBL1-cin 발현백타를 HC11세포에 transfection 하여 얻은 RNA를 이용하여 RT-PCR를 한 결과 150bp의 크기로 확인되었고 Northern blot 분석결과는 약 2.3 kb의 크기로 확인되었다. 인체 락토페린 polyclonal항체를 이용하여 dot blot한 결과 인체 락토페리신이 분비됨을 확인하였다.

  • PDF

레이저 조사 전후 자궁경부조직의 상대적 전기물성 스펙트럼 변화를 이용한 자궁경부 이형성증 치료검증도구의 가능성 평가 (Feasibility Study of a Verification Tool for the Treatment of Cervical Intraepithelial Neoplasia Using Relative Electrical Property Change Before and After Laser Irradiation)

  • 허준범;;오동인;박동춘
    • 대한의용생체공학회:의공학회지
    • /
    • 제43권6호
    • /
    • pp.409-416
    • /
    • 2022
  • Since the detection of cervical intraepithelial neoplasia (CIN) is increasing due to regular cervical cancer screening, there is a high demand for simpler tools to diagnose and treat CIN in the clinic. In this study, we proposed an electric property of cervical tissue to verify treatment using a laser. At first, we observed the depth and width of ablated cervical tissues for 29 samples according to four different pulse energy of the fractional CO2 laser to find enough pulse energy to reach the basement layer for initiated CIN. And then, the relative frequency differences in impedance spectrum before and after laser irradiation for ten non-CIN samples were collected using bioimpedance spectroscopy with a multi-electrode probe. As a result, the laser ablated the cervical tissues with a depth of more than 300 ㎛ at 100 mJ pulse energy. Also, we confirmed that the relative changes of electrical property for cervical tissue increased as the pulse energy of laser output increased, and the variation between samples decreased. Since the relative change in electrical properties of cervical tissue can be easily and quickly measured, the proposed technique paves the way for further verification and follow-up study of laser treatment for CIN.

A Contrast Nephropathy in a Preterm Infant Following Preoperative Embolization of Giant Sacrococcygeal Teratoma

  • Lee, Byong Sop
    • Childhood Kidney Diseases
    • /
    • 제21권1호
    • /
    • pp.26-30
    • /
    • 2017
  • Newborn infants with huge and highly vascular sacrococcygeal teratoma (SCT) are frequently subjected to renal hypoperfusion secondary to high-output cardiac failure. Any underlying renal dysfunction is a significant risk factor for the development of contrast-induced nephropathy (CIN). However, reports on CIN in infants are rare. I report here a case of a premature infant born at 28 weeks and 3 days of gestation with a huge SCT who survived preoperative embolization and surgical resection but presented with persistent non-oliguric renal failure that was suggestive of CIN. During radiological intervention, a contrast medium had been administered at about 10 times the manufacturer-recommended dose for pediatric patients. Despite hemodynamic stabilization and normalization of urine output immediately following surgery, the patient's serum creatinine and cystatin-C levels did not return to baseline until 4 months after birth. No signs of reflux nephropathy were observed in follow-up imaging studies. Dosing guidelines for the use of a contrast medium in radiological interventions should be provided for infants or young patients.