• Proceedings of the IEEK Conference
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• 2003.11a
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• pp.203-206
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• 2003

This study is focused on proposing a creative system that can display 3D hologram on the real-time basis. This method applies 3D display on volume hologram based on CGH. The process of implementing the system consists of two stages of fringe pattern recording for passive component that includes information on hologram, and irradiating object beam. Distinguished from an existing electronic holographic display system, this system is free from the process of a huge calculation that is necessary to compose CGH for a real-time 3D display.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2004.06a
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• pp.61-66
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• 2004

본 논문에서는 Tabu Search(TS) 알고리듬과 Simulated Anneal ing(SA) 알고리듬을 결합하여 향상된 성능을 갖는 컴퓨터 형성 홀로그램을 설계할 수 있는 방법을 제안하였다. 회절 효율의 향상을 위해 TS 알고리듬으로 이상적인 홀로그램에 근접한 패턴을 생성하고, 이를 SA 알고리듬에서 무작위로 구성된 초기 패턴과 대체하여 컴퓨터 형성 홀로그램을 설계하였다. 컴퓨터 모의 실험과 광 실험을 통하여 제안한 방법과 SA 알고리듬과의 성능을 비교한 결과 제안한 방법으로 재생한 영상이 SA 알고리듬을 이용하였을 때보다 향상된 회절 효율을 가지는 것을 확인 할 수 있었다.

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.242-243
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• 2003

A CGH is a hologram generated by computer. It is widely applied to wavefront manipulation, synthesis, optical information processing and interferometer. Some methods have been used to determine the optimum phase pattern to achieve high diffraction efficiency and uniform intensity such as DBS (Direct Binary Search), SA (Simulated Annealing), GA(Genetic Algorithm). These methods require long computation time to generate a hologram. (omitted)

• Proceedings of the Optical Society of Korea Conference
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• 2008.07a
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• pp.61-63
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• 2008

Parallel femtosecond laser processing using a computer-generated hologram (CGH) displayed on a liquid crystal spatial light modulator (LCSLM) is demonstrated. The use of the LCSLM enables to perform an arbitrary and variable patterning. This holographic femtosecond laser processing has advantages of high throughput and high light-use efficiency. A critical issue is to precisely control the intensities of the diffraction peaks of the CGH. We demonstrate some methods for the control of the diffraction peaks. We also demonstrate the laser processing with two-dimensional and three-dimensional parallelism.

• Proceedings of the Optical Society of Korea Conference
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• 2003.07a
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• pp.150-151
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• 2003

비구면은 점광원에서 출발한 광이 측정면에서 반사한 후 다시 한 점으로 모이지 않아 일반적인 간섭계로 측정하는데 어려움이 있다. 이 때 비구면이 만들어내는 파면과 반대되는 파면을 생성하는 null compensator를 설치하여 null test를 수행할 수 있다. CGH는 렌즈나 거울과 같은 기계적인 가공을 하지 않고, 이론상 수식적으로 표현이 가능한 모든 파면을 만들 수 있으므로 많이 사용되어 왔다. (중략)

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.1
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• pp.1-12
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• 2012

This paper is to propose a method to obtain a new digital hologram content, a high value-added digital content, by manipulating one or more existing digital hologram contents or depth informations. For the depth informations, we use both the ones converted from disparities by stereo matching and the ones taken by time-of-flight (TOF) depth cameras. For them, we analyze the properties and their differences for the two kinds of depth informations and propose a conversion method to homogenize them. By using them, we propose a method to convert and synthesize the depth informations to calculate a new CGH. Also, we propose a method to get a new digital hologram content by synthesizing the digital holograms themselves according to their linearity. The proposed methods are experimented with various depth informations and digital holograms to show that they are very effective as the manipulating methods for digital hologram contents.

• Clinical and Experimental Pediatrics
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• v.60 no.9
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• pp.282-289
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• 2017

Purpose: Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay. Methods: We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had at least one or more physical or neurological problem other than global developmental delay; and patients in whom both array CGH and G-banded karyotyping tests were performed. Results: Fifteen male and 12 female patients with a mean age of $29.3{\pm}17.6months$ were included. The most common physical and neurological abnormalities were facial dysmorphism (n=16), epilepsy (n=7), and hypotonia (n=7). Pathogenic copy number variation results were observed in 4 patients (14.8%): 18.73 Mb dup(2)(p24.2p25.3) and 1.62 Mb del(20p13) (patient 1); 22.31 Mb dup(2) (p22.3p25.1) and 4.01 Mb dup(2)(p21p22.1) (patient 2); 12.08 Mb del(4)(q22.1q24) (patient 3); and 1.19 Mb del(1)(q21.1) (patient 4). One patient (3.7%) displayed a variant of uncertain significance. Four patients (14.8%) displayed discordance between G-banded karyotyping and array CGH results. Among patients with normal array CGH results, 4 (16%) revealed brain anomalies such as schizencephaly and hydranencephaly. One patient was diagnosed with Rett syndrome and one with $M{\ddot{o}}bius$ syndrome. Conclusion: As chromosomal microarray can elucidate the cause of previously unexplained developmental delay, it should be considered as a first-tier cytogenetic diagnostic test for children with unexplained developmental delay.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.246-252
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• 2008

Tumor tissue is usually contaminated by normal tissue components, which reduces the sensitivity of analysis for exploring genetic alterations. Although microdissection has been adopted to minimize the contamination of tumor DNA with normal cell components, there is a concern over the amount of microdissected DNA not enough to be applied to array-CGH reaction. To amplify the extracted DNA, several whole genome amplification (WGA) methods have been developed, but objective comparison of the array-CGH outputs using different types of WGA methods is still scarce. In this study, we compared the performance of non-amplified microdissected DNA and DNA amplified in 2 WGA methods such as degenerative oligonucleotide primed (DOP)-PCR, and multiple strand displacement amplification (MDA) using Phi 29 DNA polymerase. Genomic DNA was also used to make a comparison. We applied those 4 DNAs to whole genome BAC array to compare the false positive detection rate (FPDR) and sensitivity in detecting copy number alterations under the same hybridization condition. As a result microdissected DNA method showed the lowest FPDR and the highest sensitivity. Among WGA methods, DOP-PCR amplified DNA showed better sensitivity but similar FPDR to MDA-amplified method. These results demonstrate the advantage and applicability of microdissection for array-CGH analysis, and provide useful information for choosing amplification methods to study copy number alterations, especially based on precancerous and microscopically invaded lesions.

• Journal of Broadcast Engineering
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• v.28 no.1
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• pp.3-20
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• 2023

A computer-generated hologram (CGH) is a digitally calculated and recorded hologram in which the amplitude and phase information of an image is transmitted in free space. The CGH is in the form of a complex hologram, but it is converted into a phase-only hologram to display through a phase-only spatial light modulator (SLM). In this paper, in the process of including the amplitude information of an object in the phase information, when a technique that includes subsampling such as DPAC is used, we showed experimentally that the bandwidth of the phase-only hologram increases, and as a result, aliasing that was not present in the complex hologram can occur. In addition, it was experimentally shown that it is possible to generate a high-quality phase-only hologram by restricting the spatial frequency range even at a distance where the numerical reconstruction performance is degraded by aliasing.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.3
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• pp.285-293
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• 2017

Globally, 1.3 million people develop colon cancer every year, and 600,000 people die each year it. In Korea, colorectal carcinoma was associated with the highest death rate, accounting for 8,380 people, among solid cancers in 2015. Among the various methods for the diagnosis and study of colorectal carcinoma, the results obtained by cytogenetic and molecular genetic methods were compared. Detection rate was 47% in 18q, 40% in 17p, 27% in 22q, and 17% in 10q via CGH; detection rate was 57% in D18S59, 50% in D18S68, 50% in TP53CA, 47% in D18S6940% in D22S274, 37% in D22S283, 27% in D10S187, and 23% in D10S541 with LOH. Microsatellite marker matching rates were 100% in D22S274, 100% in D22S283, 100% in D10S186, 100% in D10S187, 100% in D10S541, 93% in D18S69, 93% in D18S68, 92% in TP53CA, and 89% in D18S59. The agreement rate between the two methods was 94.4% based on positive results using CGH. Based on the advantages of CGH, which was the ability to obtain information regarding the entire tumor genome at once, this experiment could identify the region with significant deletion using CGH and the more limited region LOH, with a completely different approach. LOH in the recurrent high-risk group, 18q21, was helpful in the selection of treatment modalities and in prognostic estimation as well as making the most appropriate decision for treatment. Therefore, it is suggested that LOH with surgical site tissues could be one of the treatment methods for recurrent high-risk group among patients with colorectal carcinoma.