• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.244-244
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• 1994

Cortex Mori, the root bark of mulbery tree has been used as an antiphlogistic, diuretic, and expectorant in herbal medicine. The purpose of this study is to evaluate chicken gamma globulin (CGG)-specific IgE-induced morphologic and functional changes in rat peritoneal mast cells (RPMC), and to determine whether Cortex Mori could inhibit the CGG-specific IgE-depeildent mast cell degranulation and histamine release from RPMC. Results are 1) the degranuration and histamine release from RPMC were not induced within 1 hour after addition of Cortex Mori alone, 2) the CGG and CGG-specific IgE-Induced degranulation from RPMC was observed within 10 minutes, 3) the histamine release from RPMC sensitised with CGG-specific IgE was induced by tile addition of CGG, 4) CGG-specific IgE-dependent degranulation rate in RPMC pretreated with Cortex Mori was significantly Inhibited, compared to that of control group without Cortex Mori pretreatment, and 5) the CGG-specific IgE-dependent histamine release from RPMC was significantly inhibited by pretreatment with Cortex Mori. These data suggest that Cortex Mori contains some substances with capabilities to inhibit CGG-specific IgE-dependent degranulation and histamine release from RPMC.

• 지구물리와물리탐사
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• 제8권2호
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• pp.170-176
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• 2005

속도중합의 역산을 이용하면 탄성파 자료처리에 있어서 다양한 처리가 가능하므로 이 분야는 최근에 들어 매우 유용한 영역으로 주목을 받고 있다. 하지만 다양한 처리에 적용하기 위해서는 사용되는 역산 방법이 잡음에 강하면서도 고해상도의 속도중합 결과를 만들 수 있어야 한다. 이러한 특성을 갖는 대표적인 역산에는 ${L_1}-norm$을 최소화시키는 IRLS(Iteratively Reweighted Least-Squares)방법을 주로 사용하였다. 본 논문에서는 이러한 성질을 갖는 또 다른 역산 방법의 하나로서 CGG (Conjugate Guided Gradient) 방법을 소개한다. CGG 방법은 반복적 최소자승법의 하나인 Conjugate Gradient (CG)방법을 변형시킨 형태로 ${L_1}-norm$을 최소화 시키는 역산법으로 활용할 수 있다. 본 논문에서는 CGG방법을 소개하고 기존의 IRLS방법과의 차이점 및 결과들을 비교하였다. 모의자료와 현장자료에 대한 실험결과를 통해서 CGG 방법이 IRLS방법과 마찬가지로 다양한 잔여/모델 norm을 최소화시키는 역산방법으로 사용될 수 있음을 보여준다.

• 대한한방내과학회지
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• 제32권3호
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• pp.345-360
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• 2011

Objectives : This study was examined to investigate the effects of Cheonmagudeng-um gagam (CGG) extract on spontaneous hypertension. Methods : For the study of CGG, we divided rats into three groups. The normal group was Wister Kyoto rats (WKY). The control group was spontaneously hypertensive rats (SHR). The treatment group was SHR which were administered CGG extract (SHR-CGG). SHR-CGG were orally administered CGG extract that was diluted in distilled water at the various concentrations for 4 weeks (234.5 mg/kg) and SHR were orally administered the same dosage of plain distilled water as SHR-CGG. Then we measured anti-oxygen effects, ACE inhibitory activity, weight of heart and kidney, blood pressure, heart rate, plasma aldosterone, electrolyte, creatinine, uric acid, BUN, and observed the cortex of the cardiac muscle, kidney, and adrenal gland. Results : CGG increased DPPH scavenging activity and SOD similar activity depending on the concentration. CGG significantly decreased ROS, TNF-${\alpha}$, IL-6, IL-$1{\beta}$, heart weight, blood pressure, heart rate, aldosterone, and BUN in SHR. CGG increased ACE inhibition activity depending on the concentration. CGG inhibited the heart, kidney and adrenal gland tissue injury that is caused by hypertension. Conclusions : These results suggest that CGG is effective in treatment and prevention of hypertension.

• Journal of Electrical Engineering and Technology
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• 제6권2호
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• pp.161-166
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• 2011

This paper proposes an algorithm for determining critical generator lists using accelerating power and synchronizing power coefficient (SPC), and critical generator group (CGG) from CGG candidates, which is a combination of critical generators. The accurate determination of CGG provides a more accurate energy margin while providing system operator with information of possible unstable generator group. Classical transient energy function (TEF) method selects the critical generators with big corrected kinetic energy of each generator at the moment of fault removal. However, the generator with small acceleration after fault, that is, the generator with small corrected kinetic energy, is also likely to belong to CGG if the generator has small synchronizing power. The proposed algorithm has been verified to be effective compared with the classical TEF method. We utilized the power system of Korean Electric Power Corporation(KEPCO) as a test system.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제11권1호
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• pp.3-15
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• 2000

연구목적：자폐장애의 원인을 유전학적으로 규명하려는 연구가 시도되고 있으며, 그 중 fragile X 증후군과의 연관성에 대한 연구가 활발히 진행되고 있다. Fragile X 염색체(Xq27.3)는 세포유전학적 방법으로 증명할 수 있으나 검사에 많은 제약과 단점이 있으므로, 본 연구에서는 보다 신뢰성이 높은 분자생물학적 방법으로 FMR-1 유전자내 CGG 삼염기 반복부위를 분석하여 자폐장애와 fragile X 증후군의 연관성을 규명하고자 하였다. 방 법：자폐장애 환아(99명)와 정상대조군(8명)을 대상으로 FMR-1 유전자의 CGG 반복배열 부위를 sense와 antisense primer를 이용하여 PCR법으로 분석하였으며, 동시에 세포유전학적 검사도 시행하였다. PCR 분석에서 CGG 반복수가 50 이상인 경우에 대해서는 StB12.3 혹은 Pfxa3 probe를 이용한 Southern blot hybridization으로 확인하였다. 결 과：FMR-1 유전자의 CGG 반복배열에 대한 PCR 분석 결과 CGG 삼염기의 반복배열의 수는 자폐장애 환자군과 정상대조군 사이에 통계적으로 유의한 차이가 없었다(p=0.207). 자폐장애 환자에서 CGG반복수가 50회 이상인 조기변이(premutation) 환자가 2명 있었으나 Southern blot hybridization 결과 완전변이(full mutation)로 판정할 수 있는 경우는 없었다. 세포유전학적 검사에서 환자군 모두에서 정상 핵형을 나타내었으며 fragile X 염색체는 확인되지 않았다. 결 론：이상의 결과에서 자폐장애 환자가 FMR-1 유전자의 CGG 삼염기 반복부위 이상, 즉 fragile X 염색체 이상을 동반하지 않았음을 증명할 수 있었다. 이는 fragile X 증후군을 자폐장애의 직접적인 원인이라고 보기에는 어려움이 있음을 시사한다.

• Journal of Genetic Medicine
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• 제5권1호
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• pp.41-46
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• 2008

목 적 : 취약 X 증후군(fragile X syndrome)은 FMR1 유전자의 5' 비해독부위에 있는 CGG 3염기 반복의 확장에 의해 발생되는 유전성 질환이다. 방 법 : 본 연구에서는 임상 소견과 핵형분석에서 취약 X 증후군으로 진단 받은 여아 환자와 그 부모를 대상으로 Abbott Molecular Fragile X PCR Kit를 이용하여 CGG 3염기 영역을 PCR로 증폭하여 normal, premutation, full mutation의 CGG 반복의 유형을 확인하였으며, premutation과 normal allele의 경우에는 정확한 CGG 반복수를 분석하였다. 결 과 : 환자는 30회와 >200회의 CGG 3염기가 반복된 FMR1 대립유전자를 갖고 있는 것으로 확인되어 취약 X 증후군으로 진단되었다. 또한 환자의 어머니에서 30과 98회의 반복 allele을 확인함으로써, 이 환자의 full mutation allele은 모계의 premutation allele로부터 유래한 것임을 알 수 있었다. 결 론 : Abbott Molecular Fragile X PCR Kit를 사용한 진단방법은, 취약 X 증후군환자의 경우에서 통상적으로 시행되고 있는 PCR, MS-PCR, Southern blotting을 병행하는 방법에 비해 신속하고 정확한 분자유전학적 진단이 가능한 유용한 방법이라 생각된다.

• International Journal of Contents
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• 제7권4호
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• pp.10-18
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• 2011

Cooperative Group Games (CGG) emphasize participation, challenges and fun by cooperation among group members rather than competition. CGGs have been proven to be an efficient education method that teaches the value of cultivating cooperation skills, discipline, and sense of public order for tackling problems together through various types of interactions. When integrated with computer game technology, the general classic CGG can be reborn with new educational and entertaining aspects. To combine the joy of physical movement of group games and the richness of computer game contents, a motion based arcade CGG has been developed in this study, based on the original ideas and structures of classic off-line CGGs. While implementing the classic game concepts in arcade environment, various design attributes have been considered and applied, which were supposed to promote cooperative game play. Overall, the process of the implementation and test results of our four CGGs suggest several design strategies for effective arcade CGGs.

• 기록학연구
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• 제3호
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• pp.115-137
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• 2001

The Museum of Chosen General Government(MCGG) was a supreme organ to take charge of business affairs of historical remains Japanese imperial rule. The MCGG was established in Kyongbok Palace in 1915. The MCGG was changed the reorganization of the Chosen General Government(CGG) setups, the MCGG was to maintain the cultural assets, to excavate the ruins and to put on display the remains. However, the Japanese colonist took advantage of the MCGG for political purposes. They didn't use the MCGG to promote the research of Korea culture. Therefore, the MCGG was an organization to belong to the Department of Education of the CGG. In this reason, the MCGG produced the amount of public document to business affairs. Now, This document left in the Museum of Korea. We have seen the document to study the cultural policies and the cultural assets of the CGG. This document includes the abundant information for the historical remains and ruins at that time. Accordingly, this document will help to survey the archaeological research and historical research. In addition, this document will help to manage the cultural assets. What then is the advantage of this document? The first is to see the cultural policies of the CGG through this document. The Japanese colonist took advantage of Korea history, which was low-grade culture, to justify rule of the colony. Therefore, they needed collect Korean assets to verity their theory. The second is to see the administration system of the MCGG. Indeed, this document includes information of organization of the MCGG, the policies and the process of the MCGG. In substance, we can see the systemic proceedings of the MCGG. The third is to provide historical materials to the historian. This document has the persons to plan the colonial culture policy of the MCGG, and events to rule the Korea culture. Moreover, the document of the MCGG would help to inquire into the truthfulness of history and to get the national identity.

• BMB Reports
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• 제39권6호
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• pp.766-773
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• 2006

Fragile-X-syndrome (FXS) is the most common type of inherited cognitive impairment. The underlying molecular alteration consists of a CGG-repeat amplification within the FMR-1 gene. The phenotype is only apparent once a threshold in the number of repeats has been exceeded (full mutation). The aim of this study was to characterize the FMR-1 CGG-repeat status in Argentine patients exhibiting mental retardation. A total of 330 blood samples from patients were analyzed by PCR and Southern blot analysis. Initially, DNA from 78 affected individuals were studied by PCR. Since this method is unable to detect high molecular weight alleles, however, we undertook a second approach using the Southern blotting technique to analyze the CGG repeat number and methylation status. Southern blot analysis showed an altered pattern in 14 out of 240 (6%) unrelated patients, with half of them presenting a mosaic pattern. Eight out of 17 families (47%) showed a (suggest deleting highlight). The characteristic FXS pattern was identified in 8/17 families (47%), and in 4 of these families 25% of the individuals presented with a mosaic model. The expansion from pre-mutation to full mutation was shown to occur both at the pre and post zygotic levels. The detection of FXS mutations has allowed us to offer more informed genetic counseling, prenatal diagnosis and reliable patient follow-up.

• Composites Research
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• 제35권6호
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• pp.402-411
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• 2022

In this study, the channels-contained hybrid membranes have been fabricated through the incorporation of glass fibers and GO sheets (GO/glass fibers, GG), or a mixture of chitosan/GO (CS/GO/glass fibers, CGG), as hybrid membranes using in organic dye removal. The material properties are well investigated the terms in the morphological, chemical, crystal, and thermal characterizations for verifying interactions in their formed structure. These hybrid membranes have been fitted well in pseudo-second order and Langmuir models that are associated with chemical adsorption and a monolayer approach, respectively. The highest adsorption ability of methylene blue and methyl orange reached 59.40 mg/g and 229.07 mg/g (GG); and 287.47 mg/g and 252.91 mg/g (CGG), which is more enhanced than that of previous GO-based other adsorbents. Moreover, the dye separation on these membranes could be favorable to superb sealing and trapping dye molecules from water instead of only the dye connection occurring on their surface, regarding the physically sieving effect. The membranes can also be reused within two and three adsorbing-desorbing cycles on the GG and CGG ones, respectively. These membranes can become future adsorbents to be applied for wastewater treatment due to their structural features.