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The Effect of Cheonmagudeng-um gagam(CGG) on Spontaneous Hypertensive Rat(SHR)  

Song, Byoung-Yong (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Choi, Eun-Hee (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Jung, Tae-San (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Kang, Seong-Sun (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
An, Ga-Yong (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Kim, Oh-Young (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dong-Shin University)
Jeon, Sang-Yun (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Hong, Seok (Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University)
Publication Information
The Journal of Internal Korean Medicine / v.32, no.3, 2011 , pp. 345-360 More about this Journal
Abstract
Objectives : This study was examined to investigate the effects of Cheonmagudeng-um gagam (CGG) extract on spontaneous hypertension. Methods : For the study of CGG, we divided rats into three groups. The normal group was Wister Kyoto rats (WKY). The control group was spontaneously hypertensive rats (SHR). The treatment group was SHR which were administered CGG extract (SHR-CGG). SHR-CGG were orally administered CGG extract that was diluted in distilled water at the various concentrations for 4 weeks (234.5 mg/kg) and SHR were orally administered the same dosage of plain distilled water as SHR-CGG. Then we measured anti-oxygen effects, ACE inhibitory activity, weight of heart and kidney, blood pressure, heart rate, plasma aldosterone, electrolyte, creatinine, uric acid, BUN, and observed the cortex of the cardiac muscle, kidney, and adrenal gland. Results : CGG increased DPPH scavenging activity and SOD similar activity depending on the concentration. CGG significantly decreased ROS, TNF-${\alpha}$, IL-6, IL-$1{\beta}$, heart weight, blood pressure, heart rate, aldosterone, and BUN in SHR. CGG increased ACE inhibition activity depending on the concentration. CGG inhibited the heart, kidney and adrenal gland tissue injury that is caused by hypertension. Conclusions : These results suggest that CGG is effective in treatment and prevention of hypertension.
Keywords
spontaneously hypertensive rat; Cheonmagudeng-um gagam (ti$\bar{a}$nm$\acute{a}$g$\bar{o}$ut$\acute{e}$ng-y$\check{i}$n ji$\bar{a}$ji$\check{a}$n);
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Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 박경호, 최학주, 노성수, 구영선, 김동희. 淸熱導痰湯이 고혈압에 미치는 영향. 동의생리병리학회지 2007;21(3):626-33.
2 전국한의과대학 심계내과학교실. 심계내과학. 서울: 군자출판사; 2006, p. 154-9.
3 의학교육 연수원 편. 가정의학. 서울: 서울대학교 출판부; 2001, p. 414-25.
4 이영우, 오병희, 김철호. 고혈압. 서울: 고려의학; 2000, p. 2-5, 112-5, 167-95.
5 이영헌, 전상윤, 홍석, 조국령, 김남욱, 강성인, 등. 加味順氣活血湯이 DOCA-salt로 유발된 고혈압 흰 쥐에 미치는 작용기전. 대한동의생리학회지 2008;22(1):162-70.
6 유종삼, 김동희, 박종오, 남궁욱, 홍석. 加味豨簽湯이 고혈압 및 뇌손상에 미치는 효과. 대한한의학회지 2003;24(3):72-83.
7 진호준, 나기영, 정해일, 김연수, 김성권, 채동완. 혈중 요산 농도가 IgA 신병증의 진행에 미치는 연구. 대한신장학회지 2007;26:174-81.
8 보건복지부 질병관리본부. 2008 국민건강통계. 국민건강영양조사 제4기 2차년도 결과 보고서. 2008, p. 50-1.
9 Dostanic I, Paul RJ, Lorenz JN, Theriault S, Van Huysse JW, Lingrel JB. The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am J physiol Heart Circ Physiol 2005;288(2):H477-85.
10 김기환, 엄융의, 김전. 생리학. 서울: 의학문화사; 2004, p. 269, 281.
11 최소영, 이태원, 정경환, 임천규, 송세빈, 이설라. 신기능이 저하된 IgA 신증 환자의 관련 위험 인자. 대한신장학회지 2010;29(2):198-207.
12 전국한의과대학 본초학 공동교재편찬위원회. 본초학. 서울: 영림사; 2004, p. 233-4, 184-5, 638-9.
13 McFarlane SI, KuMar A, Sowers JR.. Mechanisms by which angiotensin-converting enzyme inhibitors prevent diabetes and cardiovascular disease. Am J Cardiol 2003;91(21A):30H-7H.
14 Bakris GL. Angiotensin-converting enzyme inhibition to enhance vascular health-clinical and research models. Am J Hypertension 2001;14(8Pt 2) :264S-9S.
15 이귀녕, 권오헌. 임상병리파일. 서울: 의학문화사; 2003, p. 95-8, 102-5, 116-121, 122, 126-7,430, 609-12, 399-401.
16 이윤미, 이소은, 이재문, 김태영, 최승옥. 운동강도에 따른 MDA와 SOD의 변화. 운동영양학회지 2008;12(2):843-8.
17 Dhawan V, Jain S. Effect of garlic supplementation on oxidized low density lipoproteins and lipid peroxidation in patients of essential hypertension. Mol Cell Biochem 2004;266(1-2):109-15.
18 Sanchez-Moreno C. Methods used to evaluate the free radical scavenging activity in foods and biological systems. Food Sci Technol Int 2002;8:121-37.
19 Blois M.S. Antioxidant determination by the use of stable free radical. Nature 1958;181:1199-200.   DOI   ScienceOn
20 한의과대학방제학교수 공편저. 방제학. 서울: 영림사; 2006, p. 457-8.
21 Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 2006;5(14):1-8.
22 예방의학 편찬위원회, 예방의학, 서울: 계축문화사; 2004, p. 280-4.
23 대한병리학회, 병리학, 서울: 고문사; 2000, p.17-8, 995.
24 Badwey, JA. Karnovsky, ML. Active oxygen species and the fucntion of phagocytic leucocytes. Annu Rev Biochem 1980;49:695-726.   DOI   ScienceOn
25 Babior BM. Phagocytes and oxidative stress. Am J Med 2000;109(1):33-44.   DOI   ScienceOn
26 강익현, 조남수, 성강경, 문병순. 天麻鉤藤飮이 뇌조직의 생화학적 변화에 미치는 영향. 대한한방내과학회지 1998;19(2):107-24
27 Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension and the European Society of Cardiology. Eur Heart J 2007;28: 1462-536.
28 Kasper DL, Gauci AS, Braunwald E, Hause Sl, Longo DL, James JL, et al. 대한내과학회 해리슨내과 편집위원회 편. HARRISON'S 내과학 제 1권. 서울: 도서출판 MIP; 2003, p.215-7, 1456-72.
29 Cushman DW, Cheung HS, Sabo EF, Ondetti MA. Development and design of specific inhibitors of angiotensin-converting enzyme. Am J Cardiol 1982;49(6):1390-4.   DOI   ScienceOn
30 Chobanian A, Bakris G, Black H, et al. and the National High Blood Pressure Education Program Coordinating Committee. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003;42(6):1206-52.   DOI   ScienceOn
31 임동윤, 문석재, 배남규, 권오성. 마취흰쥐에서 天麻鉤藤飮의 심혈관작용에 대한 연구. 대한본초학회지 1997;12(2):157-82.
32 홍석. 加味天麻鉤藤飮의 혈전증 뇌허혈증 및 뇌손상에 대한 실험적 연구. 학위논문(박사). 대전대학교 대학원; 1999.
33 송병용, 홍석, 김동희, 전상윤. 加味天麻鉤藤飮이 고혈압 병태모델에 미치는 영향. 동의생리병리학회지 2007;21(2):504-10.
34 이윤미, 강대길, 김명규, 장지연, 이호섭. 蒼耳子로부터 안지오텐신 전환효소 억제 유효 성분의 분리. 동의생리학회지 2005;19(1):119-23.
35 진귀정, 양사수. 실용중서의결합 진단치료학. 서울: 의성당; 1993, p. 55-7.
36 정대영, 이인, 문병순. 天麻鉤藤飮의 항간질성 효과에 대한 실험적 연구. 대한한방내과학회지 1997;18(2):65-81.
37 송낙근, 최학주, 김동희, 노성수, 서영배. 黑蔘이 폐고혈압 유발 흰쥐에 미치는 영향. 대한본초학회지 2009;24(4):69-75.
38 문형권, 조현경, 유호룡, 설인찬, 김윤식. 加味除濕順氣湯이 고혈압에 미치는 영향. 동의생리병리학회지 2006;20(4):887-95.
39 서용원, 김호현, 고흥. 何首烏가 고혈압과 수축혈관에 미치는 영향. 대한동의생리병리학회지 2008; 22(3):593-9.