• IMMUNE NETWORK
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• v.1 no.1
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• pp.61-69
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• 2001

Background: To determine the molecular structure of type II collagen-specific T-cell receptors associated with rheumatoid arthritis (RA). Methods: We generated CII-specific T-cell lines of 8 RA patients by prolonged in vitro culture with bovine CII (bCII) and the immunogenic peptide (256-270) of human CII. The proliferation response towards CII stimulation was measured from the uptake of 3H-thymidine. Changes in the secretion of Th 1 and Th2 cytokines in the culture supernatent were measured by ELISA. The TCR clonotypes of these T-cells were examined by RT-PCR/SSCP analyses of all 22 $V_{\beta}$ chains. Results: T-cells from patients' tissue exhibited strong proliferation index upon CII stimulation, which was maintained up to 6 months in the culture. The secretion of INF-$\gamma$from these T-cells increased along with the duration of culture time, while the amount of IL-4 production did not show significant changes. The SSCP band patterns of patients' T-cells appear as discrete bands unlike the smeary streak produced from normal samples. Some SSCP bands, each representing selected expansion of a TCR containing certain subtype of $V_{\beta}$ peptides, appeared to be identical in more than one patients. Among these, the expansion of SSCP band representing the $V_{\beta}$ 14 CDR3 region persisted after switching the antigen to the immunogenic human peptide (256-270). Conclusion: CII-reactive T-cells expressing distinct CDR3 motifs are selectively expanded in the peripheral blood and synovial fluid of RA patients, and their persistent proliferation upon CII stimulation, as well as the production Th 1-type cytokines, may play pivotal roles in RA pathogenesis.

• Korean Journal of Psychosomatic Medicine
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• v.22 no.2
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• pp.71-78
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• 2014

Objectives : Behavioral and psychological symptoms of dementia(BPSD) represent significant clinical problems, resulting in functional decline, caregiver distress, institutionalization and increased mortality. A recent study showed gender differences have important role in the development of BPSD, but relationship between BPSD and gender has never been studied in Korea. This study was designed to examine whether patients with Alzheimer's disease show gender differences in behavioral and psychological symptoms of dementia(BPSD). Methods : Ninety-eight subjects with Alzheimer's disease were included in this study. We carried out history taking and cognitive assessment for the diagnosis of Alzheimer's disease based on DSM-IV. Cognitive impairment and BPSD were measured using the Mini Mental State Examination(MMSE), Global Deterioration Scale (GDS), Clinical Dementia Rating(CDR) and the Korean Neuropsychiatric Inventory(K-NPI). Independent samples t-test was used to examine the differences across gender in BPSD. Correlation analysis between MMSE, CDR, GDS and NPI was performed using Pearson's correlation coefficient. Results : There were no significant gender differences between the gender in BPSD. We found statistically significant negative correlations between MMSE with NPI total score, and with scores of several sub-domains such as hallucination. Conclusions : This study showed that gender differences in BPSD are not significant. Further research is necessary to identify whether BPSD affect gender differences or individual differences.

• The Journal of the Korea Contents Association
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• v.10 no.2
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• pp.72-80
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• 2010

The 1Gbps clock and data recovery (CDR) circuit using the proposed multi-point phase detector (PD) is presented. The proposed phase detector generates up/down signals comparing 3-point that is data transition point and clock rising/falling edge. The conventional PD uses the pulse width modulation (PWM) that controls the voltage controlled oscillator (VCO) using the width of a pulse period's multiple. However, the proposed PD uses the pulse number modulation (PNM) that regulates the VCO with the number of half clock cycle pulse. Therefore the proposed PD can controls VCO preciously and reduces the jitter. The CDR circuit is tested using 1Gbps $2^{31}-1$ pseudo random bit sequence (PRBS) input data. The designed CDR circuit shows that is capable of recovering clock and data at rates of 1Gbps. The recovered clock jitter is 7.36ps at 1GHz and the total power consumption is about 12mW. The proposed circuit is implemented using a 0.18um CMOS process under 1.8V supply.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• v.61 no.11
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• pp.573-579
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• 2018

Background and Objectives Cochlear dead region (CDR) is a region in the cochlear where hearing loss has occurred due to damage to the inner hair cells and/or neurons. Recently, a subjective test involving a pure-tone test in the presence of threshold-equalizing noise (TEN) was introduced to identify CDR. However, for uncooperative patients, such a subjective method would be unsuitable and objective methods would be needed instead to detect CDR. The acoustic change complex (ACC) is an evoked potential elicited by changes in the ongoing sound. In this study, we developed an objective method of identifying CDR by combining ACC response with a TEN test, namely the TEN-ACC test, and investigated its feasibility in normal-hearing listeners. Subjects and Method Ten normal-hearing subjects participated in this study. All subjects underwent both behavioral TEN test and electrophysiological TEN-ACC test. The stimuli for the TEN-ACC test consisted of TEN and embedded pure tones with different frequencies/signals to noise ratios (SNRs). To identify the thresholds, the range SNR of stimulation was varied from 0 to 20 dB, in stages of 4 dB. Results The ACC responses of all subjects who participated in this study were well elicited by stimuli developed for the TEN-ACC test. We confirm that the pure-tones embedded in TEN elicited the objective ACC response. Conclusion The results of this study suggest that the novel TEN-ACC test can be applied to evoke ACC in normal-hearing listeners. Future research should incorporate hearing-impaired listeners to determine the feasibility of the TEN-ACC test as an objective method to identify CDR.

• The Korean Journal of Nuclear Medicine
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• v.19 no.1
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• pp.57-58
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• 1985

• ETRI Journal
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• v.31 no.1
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• pp.92-94
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• 2009

We propose a system for mobile-phone fraud detection based on a bidirectional artificial neural network (bi-ANN). The key advantage of such a system is the ability to detect fraud not only by offline processing of call detail records (CDR), but also in real time. The core of the system is a bi-ANN that predicts the behavior of individual mobile-phone users. We determined that the bi-ANN is capable of predicting complex time series (Call_Duration parameter) that are stored in the CDR.

• Journal of Positioning, Navigation, and Timing
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• v.12 no.4
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• pp.391-398
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• 2023

In this paper, we propose a Correction Dead Reckoning (CDR) solution using correction information such as Map Matching FeedBack (MMFB) in an underground parking lot. In order to correct position errors in an underground parking lot, vehicle position and heading errors are corrected using MMFB information in road link properties. The proposed method was applied to an in-vehicle navigation system and tested. The experimental results show that the proposed robust dead reckoning solution corrects Dead Reckoning (DR) position errors that occur when driving for a long time in an underground parking lot.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.2
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• pp.55-63
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• 2018

This study analyzed the applications of near real-time drought monitoring using satellite rainfall for the Korean Peninsula and un-gaged basins. We used AWS data of Yongdam-Dam, Hoengseong-Dam in Korea area, the meteorological station of Nakhon Rachasima, Pak chong for test-bed to evaluate the validation and the opportunity for un-gaged basins. In addition, we calculated EDI (Effective doought index) using the stations and co-located PERSIANN-CDR, TRMM (Tropical Rainfall Measurement Mission) TMPA (The TRMM Multisatellite Precipitation Analysis), GPM IMERG (the integrated Multi-satellitE Retrievals for GPM) rainfall data and compared the EDI-based station data with satellite data for applications of drought monitoring. The results showed that the correlation coefficient and the determination coefficient were 0.830 and 0.914 in Yongdam-dam, and 0.689 and 0.835 in Hoengseng-Dam respectively. Also, the correlation coefficient were 0.830, 0.914 from TRMM TMPA datasets and compasion with 0.660, 0.660 based on PERSIANN-CDR and TRMM data in nakhon and pakchong station. Our results were confirmed possibility of near real-time drought monitoring using EDI with daily satellite rainfall for un-gaged basins.

• Journal of Korean Library and Information Science Society
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• v.47 no.4
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• pp.69-91
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• 2016

The purposes of this article are to raise the quality issues of Collaborative Digital Reference Services(CDRS) in Korean libraries and to suggest the feasible solutions to resolve the quality problems of CDRS. To the end, a thorough examination on the development process and present condition of main Korean CDRS such as 'Question포인트' and' '사서에게 물어보세요'. This article investigates the causes of 'low quality' in Korean CDRS with emphasizing both technical problems and managerial limitations. Finally suggested are the solutions to improve the low quality of CDRS with special concerns on Korean library situation. Discussions on this article are based on literature review, statistical analysis, and usability tests on the targeted Korean CDRS, '사서에게 물어보세요'(Ask a Librarian in Korean version).

• International Journal of Internet, Broadcasting and Communication
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• v.9 no.4
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• pp.8-13
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• 2017

Movement technique is comprised of the movement status of the circulation differentiation rate (CDR) and rotation differentiation rate (RDR) on the shiver movement form. Condition of the differentiation rate by the shiver movement form is to be modified the teetering movement system. As to fix the movement of signal on the material of body, we compared a shiver value of the circulation differentiation rate on the circulation state. The concept of rotation differentiation rate was identified the reference of rotation differentiation signal and rotation differentiation signal by the rotation state. For detecting a alteration of the CDR-RDR of the maximum and average in terms of the movement form, and shiver movement value that was a shiver value of the top alteration of the Top-ф$_{MAX-AVG}$ with $12.80{\pm}1.27units$, that was a shiver value of the peripheral alteration of the Per-ф$_{MAX-AVG}$ with $4.38{\pm}1.15units$, that was a shiver value of the limbus alteration of the Lim-ф$_{MAX-AVG}$ with $1.65{\pm}0.25units$, that was a shiver value of the center alteration of the Cen-ф$_{MAX-AVG}$ with $0.25{\pm}0.01units$. The teetering movement will be to assess at the ability of the movement form for the control degree of differentiation rate on the CDR-RDR that was shown the circulation and rotation form by the differentiation rate system. Teetering differentiation system was modified of a form by the special movement and was included a shiver data of teetering movement rate.