• Bulletin of the Korean Chemical Society
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• v.14 no.4
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• pp.453-457
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• 1993

Cadmium(II) complexation by a well characterized soil fulvic acid (FA) from the Okchun Metamorphic Belt were studied at pH of 6.0 in 0.1 M $NaClO_4$ using the ultrafiltration technique. The conditional stability constants thus obtained were log K= 3.90${\pm}$0.15 and 3.99${\pm}$0.12 $L{\cdot}mol^{-1}$ at fulvic acid concentrations of 101 and 226 mg${\cdot}L^{-1}$ respectively. When free cadmium ion concentration was measured directly using an ion selective electrode, log K of 4.12${\pm}$0.03 $L{\cdot}mol^{-1}$ was obtained. These results show that fulvic acid forms predominately 1 : 1 complex with $Cd^{2+}$ ions. The maximum binding ability of this polyelectrolyte material was 0.886 mmol Cd/g FA. The average gram formula weight of fulvic acid was estimated to be 1130 daltons.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.26 no.3
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• pp.221-226
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• 2013

The water soluble quantum dots (QDs) are synthesized by the phase transfer and silica coating reaction. The photoluminescence intensity of silica-coated QDs are mainly affected by the amount of phase transfer agent, SDS (sodium dodecyl sulfate), and the maximum value is obtained at the cmc (critical micell concentration) concentration of SDS in the phase transfer reaction. Based on fluorescence spectra and field emission transmission electron microscope (FETEM), the energy transfer rate by forster resonance energy transfer (FRET) is increasing with the thickness of the silica shell coated on CdSe/ZnS QDs.

• 전자공학회논문지 IE
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• v.43 no.4
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• pp.1-7
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• 2006

In this paper, two types of blue organic light-emitting device were designed. We have analyzed the characteristics of Type I device without a hole blocking layer, and analyzed the characteristics of Type II device using a hole blocking layer of BCP or BAlq materials with 30 ${\AA}$ thickness. We obtained the ITO having the work function value of 5.02 eV using $N_2$ plasma treatment method with the plasma power 200 W. Type I device structure was ITO/2-TNATA/$\alpha$-NPD/DPVBi/$Alq_3$/LiF/Al:Li, and type II device structure was ITO/2-TNATA/$\alpha$-NPD/DPVBi/HBL/$Alq_3$/LiF/Al:Li. We have analyzed the characteristics of Type I and Type II device. The characteristics of the device were most efficiency on occasion of using a hole blocking layer of BAlq material with 30 ${\AA}$ thickness. Current density was 226.75 $mA/cm^2$, luminance was 10310 $cd/m^2$, Current efficiency was 4.55 cd/A, power efficiency was 1.43 lm/W at an applied voltage of 10V. The maximum EL wavelength of the fabricated blue organic light-emitting device was 456nm. The full-width at half-maximum (FWHM) for the EL spectra was 57nm. CIE color coordinates were x=0.1438 and y=0.1580, which was similar to NTSC deep-blue color with CIE color coordinates of x=0.14 and y=0.08.

• Korean Journal of Pharmacognosy
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• v.32 no.3 s.126
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• pp.226-232
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• 2001

To explore the possible cancer therapeutic application of "Bo-yang-hwan-oh-tang" (BH), a herbal medicinal recipe used for improvement of blood stasis, we have examined its direct cytotoxicity against tumor cell, and induction of cytotoxic activity of lymphocytes. Water extract of BH alone did not exhibit direct cytotoxicity to Yac-1 target cells even with high concentrations (10 mg/ml). By exposure for 3 days, BH did not induce any nonspecific cytotoxic activity of mouse spleen cells, either, when assessed in a 4 hr $^{51}Cr-release$ assay. However, when BH was added during CD3 stimulation of non-adherent spleen cells, non-specific CTL activity was markedly promoted in a dose dependent manner. In contrast, BH did not alter activated NK cell activity following IL-2 stimulation. These data suggest that BH does not induce but upregulates non-specific CTL effecter function and that activated NK cell does not respond to BH. For elucidation of the mechanism underlying this function of BH, time kinetic study for IL-2 production using ELISA was undertaken. IL-2 production following CD3 stimulation was significantly augmented and higher level of IL-2 is sustained over 3 days in the culture medium by BH treatment. Moreover, addition of exogenous IL-2 during CD3 stimulation resulted in a similar level of cytotoxicity between control and BH-treated culture. These data indicate that the BH-mediated upregulation of non-specific CTL activity is contributed by augmentation of IL-2 production. Our data imply the possible application of BH for combination therapy of cancer with non-specific activator.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.222-226
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• 2017

Background: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. Methods: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG ($3,947{\pm}4,943g$) for $86{\pm}63$ mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period. Results: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p < 0.0001) as well as between total amount of KRG and mean annual decrease in $CD4^+$ T-cell count in all 252 patients (r = -0.17, p < 0.01). The annual decrease in $CD4^+$ T-cell count (change in $cells/{\mu}L$) was significantly slower in KRG-treated patients than in patients receiving no KRG ($48{\pm}40$ vs. $106{\pm}162$; p < 0.001). The SD (in months) was also significantly longer in the KRG group than in the no-KRG group ($101{\pm}64$ vs. $59{\pm}40$, p < 0.01). Conclusion: KRG prolongs survival in HIV-1 patients, possibly by slowing the decrease in $CD4^+$ T-cell count.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.7 no.4
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• pp.226-234
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• 2002

A sediment exposure experiment was conducted to investigate the influence of acid volatile sulfides (AVS) and simultaneously extracted metals (SEM) in sediments on the bioavailability and toxicity of Cd, Ni and Zn to a marine polychaetes Neanthes arenaceodentata. The test animals were exposed to contaminated sediments spiked by metal mixtures of Cd, Ni, Zn (0.5～15 $\mu$mol/g of total SEM) in low (～1 $\mu$mol/g), medium (～5 $\mu$mol/g) and high AVS series (～10 $\mu$mol/g) to determine bioaccumulation, mortality and individual growth rate in each treatment after 20 days. Cd and Zn bioaccumulation in test animals increased with increasing of overlying water (OW) concentration controlled by AVS. In contrast, Ni bioaccumulation increased with increase of SEM concentration. Mortalities and growth inhibitions of N. arenaceodentata observed in only treatments with ［SEM-AVS］>0, due to a high level of OW-Zn. With regard to the mortality, the 20-d LC5O value fur OW-Zn was 9.3(8.0$\pm$11.0) $\mu$M. The LOEC (Lowest Observed Effect Concentration) for Tissue-Zn was 7.8 $\mu$mol/g and the NOEC (No Observed Effect Concentration) was 6.2 $\mu$mol/g. Regarding the inhibition of individual growth rate, the LOEC fer Tissue-Zn was 5.9 $\mu$mol/g, and NOEC was 5.1 $\mu$mol/g. In this study, the toxicity of dissolved metals, especially for Zn, was overemphasized due to the reduced distribution coefficients (K$\_$d/s) of metals in the experimental sediments.

• Progress in Medical Physics
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• v.28 no.4
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• pp.226-231
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• 2017

The aim is to investigate the spectra responsibilities of QD (Quantum Dot) for the innovation of new dosimetry application for therapeutic Megavoltage X-ray range. The unique electrical and optical properties of QD are expected to make it a good sensing material for dosimeter. This study shows the spectra responsibility of toluene based ZnCd QD and PPO (2.5-diphenyloxazol) mixed liquid scintillator. The QDs of 4 sizes corresponding to an emission wavelength (ZnCdSe/ZnS:$440{\pm}5nm$, ZnCdSeS:470, 500, $570{\pm}5nm$) were utilized. A liquid scintillator for control sample was made of toluene, PPO. The Composition of QD loaded scintillators are about 99 wt% Toluene as solvent, 1 wt% of PPO as primary scintillator and 0.05, 0.1, 0.2 and 0.4 wt% of QDs as solute. For the spectra responsibility of QD scintillation, they were irradiated for 30 second with 6 MV beam from a LINAC ($Infinity^{TM}$, Elekta). With the guidance of 1.0 mm core diameter optical fiber, scintillation spectrums were measured by a compact CCD spectrometer which could measure 200~1,000 nm wavelength range (CCS200, Thorlabs). We measured the spectra responsibilities of QD loaded organic liquid scintillators in two scintillation mechanisms. First was the direct transfer and second was using wave shifter. The emission peaks from the direct transfer were measured to be much smaller luminescent intensity than based on the wavelength shift from the PPO to QDs. The emission peak was shifted from PPO emission wavelength 380 nm to each emission wavelength of loaded QD. In both mechanisms, 500 nm QD loaded samples were observed to radiate in the highest luminescence intensity. We observed the spectra responsibility of QD doped toluene based liquid scintillator in order to innovate QD dosimetry applicator. The liquid scintillator loading 0.2 wt% of 500 nm emission wavelength QD has most superior responsibility at 6 MV photon beam. In this study we observed the spectra responsibilities for therapeutic X-ray range. It would be the first step of innovating new radiation dosimetric methods for radiation treatment.

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.3
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• pp.161-163
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• 2002

Apoptosis has been hypothesized to be involved in the pathogenesis in schizophrenia. A large number of genes are known to mediate the apoptotic process; Apo-1/Fas (CD95) is a well-known example of such genes. In the present study, MvaI restriction fragment length polymorphism, a polymorphic marker present within the Apo-1/Fas gene, was examined in a population consisting of 226 control subjects and 110 schizophrenia patients, all of them Korean in ethnicity. No statistically significant difference in the genotypic distribution and allelic frequencies was observed between the control and the schizophrenia patient group. To find out the precise effect of Apo-1/Fas gene polymorphisms on the susceptibility to schizophrenia, further studies are warranted to investigate possible involvement of other polymorphisms with a larger sample population.

• Economic and Environmental Geology
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• v.26 no.2
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• pp.217-226
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• 1993

Stream sediment samples were collected in the vicinity of the Sambo Pb-Zn-barite mine in order to investigate dispersion patterns and pollution levels of heavy metals, and to find out their mode of occurrences. Those samples were analyzed for Cd, Cu, Pb, Zn, Fe, and Mn by using partial extraction and sequential extraction methods. Stream sediments of this studied area has been contaminated severely by Pb, Zn, and Cd. Dispersion patterns of heavy metals in those sediments are different according to their pollution source and sampling distance from the mine. The stream sediment pH is generally neutral in control area, and is slightly acidic in the lower part of tailing dam. The main pollution source of stream sediments was confirmed as tailing and mine drainage. Their pollution level depends mainly on inflowed water and distance from the mine. The tolerance index ranges from -0.9 to 0.7. The mode of occurrances of heavy metals in polluted stream sediment are identified as Fe-Mn oxides, organic bounded and carbonate-bounded compound which show high potential of bioavailablity.

• Korean Journal of Soil Science and Fertilizer
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• v.38 no.3
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• pp.142-149
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• 2005

This investigation was conducted to observe and verify the distribution and their occurrence between heavy metals and natural isotopes in the soil collected at the 40 locations from the abandoned coal mine areas to the sediment of Chungra reservoir located at Chungra-Myon Boryung city, Chungnam. The results of the investigation showed that there were distinctive differences of the contents for the heavy metals and the natural isotopes between the area influenced by the coal mine tailing and the non-influenced area. The amounts of the heavy metals were Pb ($1.32-29.96mg\;kg^{-1}$), Cd ($0.15-0.76mg\;kg^{-1}$), Cu ($0.28-49.67mg\;kg^{-1}$), and Cr ($1.31-13.18mg\;kg^{-1}$) while the averages were Cu ($12.43mg\;kg^{-1}$), Pb ($10.44mg\;kg^{-1}$), Cr ($4.87mg\;kg^{-1}$), Cd ($0.51mg\;kg^{-1}$). The standard deviations of Pb and Cu were significantly higher compared to other heavy metals investigated in this experiment. And the amounts of the natural isotopes measured from the dried soil samples were Pb-210 ($4.87dpm\;g^{-1}$), Th-234 ($3.52dpm\;g^{-1}$), Ra-226 ($2.88dpm\;g^{-1}$), Ra-228 ($7.30dpm\;g^{-1}$), K-40 ($58.06dpm\;g^{-1}$) for all locations whereas Cs-137 which is fall-out by nuclear experiment from atmosphere was rarely found. From these results we found that the amounts of natural isotopes such as Pb-210 (4.41%), Th-234 (3.60%), and Ra-226 (2.09%) were less than those found in the coal-tailing while the proportion of Ra-228 (266%) and K-40 (308%) were significantly higher than those in the coal-tailing. Also occurrence of correlations between the amounts of the heavy metals and the natural isotopes was proportionally related.