• Journal of Korean Neurosurgical Society
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• 제50권3호
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• pp.179-184
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• 2011

Objective : The aim of this study is to evaluate the therapeutic effects of gamma knife radiosurgery (GKRS) in patients with multiple brain metastases and to investigate prognostic factors related to treatment outcome. Methods : We retrospectively reviewed clinico-radiological and dosimetric data of 36 patients with 4-14 brain metastases who underwent GKRS for 264 lesions between August 2008 and April 2011. The most common primary tumor site was the lung (n=22), followed by breast (n=7). At GKRS, the median Karnofsky performance scale score was 90 and the mean tumor volume was 1.2 cc (0.002-12.6). The mean prescription dose of 17.8 Gy was delivered to the mean 61.1% isodose line. Among 264 metastases, 175 lesions were assessed for treatment response by at least one imaging follow-up. Results : The overall median survival after GKRS was $9.1{\pm}1.7$ months. Among various factors, primary tumor control was a significant prognostic factor ($11.1{\pm}$1.3 months vs. $3.3{\pm}2.4$ months, p=0.031). The calculated local tumor control rate at 6 and 9 months after GKRS were 87.9% and 84.2%, respectively. Paddick's conformity index (>0.75) was significantly related to local tumor control. The actuarial peritumoral edema reduction rate was 22.4% at 6 months. Conclusion : According to our results, GKRS can provide beneficial effect for the patients with multiple (4 or more) brain metastases, when systemic cancer is controlled. And, careful dosimetry is essential for local tumor control. Therefore, GKRS can be considered as one of the treatment modalities for multiple brain metastase.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8377-8382
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• 2016

Background: The aim of this study was to evaluate any association between a single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409, C>G) and the development and prognosis in patients with hepatocellular carcinoma (HCC). Materials and Methods: Two hundred heathy controls and 388 HCC cases were included: 211 with HBV, 98 patients with HCV, 29 with alcoholic steatohepatitis (ASH) and 52 with non-alcoholic steatohepatitis (NASH). The SNP was determined by real-time PCR based on TaqMan assays. Results: The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%). The GG genotype had significantly higher distribution in patients with ASH/NASH-related HCC compared with controls (OR=2.34, 95% CI=1.16-4.71, P=0.018), and viral-related HCC cases (OR=2.15, 95% CI=1.13-4.08, P=0.020). However, the frequency of the GG genotype was similar between controls and patients with viral-related HCC. At initial diagnosis, HBV-related HCC were larger and at more advanced BCLC stage than the other HCC groups. There were no significant differences between the GG and non-GG groups regarding clinical characteristics, tumor stage and overall survival. Conclusions: These data suggest an influence of the PNPLA3 polymorphism on the occurrence of HCC in patients with ASH/NASH but not among those with chronic viral hepatitis. However, the polymorphism was not associated with the prognosis of HCC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3073-3077
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• 2015

Background: TP53 mutations are the most common genetic alterations in human cancers. There are also several polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increase the risk of cancer development. Associations of the TP53 intron 6 G13964C polymorphism with increased risk of development of several cancers have been investigated in numerous studies, but the results were controversial and conflicting. In this study, we aimed to investigate the probable association of this polymorphism with risk of both thyroid and breast cancers among the Iranian-Azeri population. Materials and Methods: We performed two separate case control studies on associations of the intron 6 polymorphism with two different kinds of cancer. In one case-control study, a total of 75 patients with thyroid carcinoma and 180 controls were analyzed and the other study included 170 patients with breast cancer and 135 healthy women. The intron 6 genotype was determined by RFLP-PCR and the SPSS 16 program was applied for data analysis. Results: For thyroid cancer, the frequencies of GG genotype were 96.0% in patients and 93.3% in controls. The GC genotype had a frequency of 4.0 % in patients and 6.7% in controls. In the study on breast cancer, the frequency of GG and GC genotypes in patients were 95.3% and 4.7%, respectively. In breast related control group, the frequency of GG genotype was 93.3 % and the frequency of GC genotype was 6.7%. None of the cases and controls had the CC genotype. Conclusions: There was no significant association between the TP53 intron 6 G13964C polymorphism and risk of development of both thyroid and breast cancer in Iranian-Azeri patients.

• 한국융합학회논문지
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• 제8권11호
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• pp.63-69
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• 2017

IoT 시스템에서의 미들웨어는 인간과 사물, 사물과 사물 사이를 연결하여 데이터를 주고받을 수 있도록 중간 매개체 역할을 하는 소프트웨어이다. IoT 미들웨어는 그 형태와 목적이 서로 상이한 이기종간의 하드웨어, 프로토콜 및 통신 등을 전 영역에 걸쳐서 다양한 형태로 존재한다. 그러므로 시스템 각각의 역할별 종류를 달리 설계하더라도 공통적으로 보안을 강화할 수 있는 방안이 필요하다. 본 논문에서는 SOA(Service Oriented Architecture) 접근방법을 이용한 IoT 미들웨어 구조를 분석하고 이를 바탕으로 시스템 보안요구사항을 설계하였다. 기존 시스템 개발방법과는 달리 검증을 위하여 공통평가기준(Common Criteria) 기반으로 평가대상물(TOE: Target Of Evaluation)을 정의하였다. 향후 제시된 미들웨어 시스템은 보안문제정의 및 보안목적과 상관관계를 나타냄으로서 보안이 강화된 IoT 시스템 구현 근거가 될 것이다.

• 대한간호학회지
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• 제24권3호
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• pp.345-363
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• 1994

This study attempted to identify important problems of the factors related to the indwelling catheter with closed drainage and to enhance recognization of Urinary Tract Infection management to protect patients with indwelling catheter from UTI. We selected the 58 patients with indwelling catheter with closed drainage from md-surg. intensive care units, and general neurological and neurosurgical ward, in one hospital in Pusan, Korea from May 30 to October 15, 1993. Patients were examined by urinary analysis before inserting catheter and then by urine cultures three times. The obtained data was analized using an SPSS /PC$^{+}$ The statistical analyses employed here was the frequency, percentage and x$^2$-tests. 1. Analyses for Indwelling Catheter induced UTI and infection rates were found to be presented in patients related to the factors of being on antibiotic drugs (x$^2$=14.105, p=.000) and the duration of the indwelling catheter(x$^2$=58.0, p=.000), both of which were found to affect the UTI. 2. UTI rates according to the duration of the in-dwelling catheter were high 8.6％ for the 2nd day, 27.6 for the 4th day, and 36.2% for the 7th day, and as the duration for the indwelling catheter was longer, UTI rates were higher. 3. The UTI rates according to the duration of the indwelling catheter related re factors, on the 7th day, were high-52.0% for women, 37.0% for more than 50 years in ages, 30.0% for patients under sur-gery, 33.3% for altered mental states outsides the alert, 76.7% for patients not given antibiotic drugs, 36.4% for less than 3500cc of fluids intakes, it was found that these affected to increase the UTI. 4. Causative organisms of UTI were found ; E.Coli appears the most than all other isolated organisms in women and Klebsiella and Pseudomonas in men. For antibiotic susceptibility of causative organisms, all causative organisms were found to be susceptible to Sul -cefoperazone, Trim-prim, and unasyn and Pseudomonas mostly net susceptible.e.

• 한국지반공학회논문집
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• 제19권6호
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• pp.371-378
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• 2003

한반도 서, 남해안 해성점토에 대하여 초기간극비와 자연함수비 및 액성한계의 물리적 특성과 압축지수와의 상관성을 규명하기 위해 비교적 신뢰성이 크다고 볼 수 있는 대형 항만 공사용 최근자료를 분석하였다. 시료교란의 정도를 분석하기 위하여 각 표본별 실내압밀시험을 실시하고 Schmertmann이 제안한 방법으로 보정하여 수정압축지수를 산정하였다. 또한 이들 자료를 토대로 실내압밀시험으로부터 얻어진 압축지수를 경험적 방법에 의하여 보정한 후 현장 처녀압축곡선과의 관계를 분석하고, 단순회귀분석, 다중회귀분석 및 비선형 회귀분석을 실시하여 최적의 회귀모델을 구한 후 해성점토에 적용할 수 있는 토질특성과 시료교란의 영향을 고려한 압축지수와의 상관 관계식을 제안하였다. 분석 결과, 시료교란의 영향을 경험적 방법으로 평가해 본 결과 현장 압축지수는 실험실 압축지수의 1.16배정도 크게 평가되었다. 해성점토의 물리적 특성과 압축지수의 상관성에 대한 최적의 회귀모형은 토질정수의 누승식 또는 지수승식 형태의 비선형회귀식이 가장 적합한 것으로 나타났다. 또한, 설계 및 실무에 보다 쉽게 적용할 수 있도록 하기 위하여 선형관계식을 사용하는 경우에는 압축지수의 상관식을 물성치의 구간에 따라 구분하여 사용하는 것이 바람직하다.

• BMB Reports
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• 제36권2호
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• pp.237-242
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• 2003

Hepatic lipase is a key enzyme that is involved in HDL-C metabolism. The goal of this study was to find out the frequency of the hepatic lipase C514T polymorphism, and evaluate its relationship with plasma HDL-C levels and coronary artery disease (CAD) in Koreans. Two hundred and twenty four subjects with no previous history of lipid-lowering therapy, 118 patients with significant CAD, and 106 controls were examined with respect to their genotypes, lipid profiles, and other risk factors for CAD. The frequency of the -514T allele was 0.37 in men and 0.35 in women, which were higher than the frequency that was reported in Caucasians, but lower than the frequency that was reported in African-Americans. The -514T allele was associated with significantly higher HDL-C levels in women. After controlling for age, gender, BMI, DM, and smoking, the non-CC genotype was significantly associated with HDL-C levels, and explained 6% of the HDL-C variation in this study. When the genotypes-distribution was compared between the CAD and non-CAD patients, the hepatic lipase C-514T polymorphism was not associated with the presence of CAD. Koreans have a higher frequency of the hepatic lipase gene 514T allele than Caucasians, and the -514T allele is associated with higher plasma HDL-C levels in Korean women, and perhaps non-smoking men. However, our data does not suggest an association between the polymorphism and an increased risk of CAD.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6519-6522
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• 2013

Background: Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lung adenocarcinoma development in East Asian populations. This study aimed to investigate the relationship between common polymorphisms in the TP63 gene and the risk of lung adenocarcinoma, as well as interactions of the polymorphisms with environmental risk factors in Chinese non-smoking females. Methods: A case-control study of 260 cases and 318 controls was conducted. Data concerning demographic and risk factors were obtained for each subject. The genetic polymorphisms were determined by Taqman real-time PCR and statistical analyses were performed using SPSS software. Results: For 10937405, carriers of the CT genotype or at least one T allele (CT/TT) had lower risks of lung adenocarcinoma compared with the homozygous wild CC genotype in Chinese nonsmoking females (adjusted ORs were 0.68 and 0.69, 95%CIs were 0.48-0.97 and 0.50-0.97, P values were 0.033 and 0.030, respectively). Allele comparison showed that the T allele of rs10937405 was associated with a decreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). Our results showed that exposure to cooking oil fumes was associated with increased risk of lung adenocarcinoma in Chinese nonsmoking females (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, we did not observe a significant interaction of cooking oil fumes and TP63 polymorphisms. Conclusion: TP63 polymorphism might be a genetic susceptibility factor for lung adenocarcinoma in Chinese non-smoking females, but no significant interaction was found with cooking oil fume exposure.

• 천문학회보
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• 제35권1호
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• pp.30.2-30.2
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• 2010

Numerous operational anomalies and satellite failures have been reported since the beginnings of the "space age". Space weather effects on modern spacecraft systems have been emphasized more and more as increasing their complexity and capability. Energetic particles potentially can destroy and degrade electronic components in satellites. We analyzed the geostationary (GEO) satellite anomalies during 1997-2009 to search possible influences of space weather on the satellite anomalies like power problem, control processor problem, attitude control problem, etc. For this we use particle data from GOES and LANL satellites to investigate space weather effects on the GEO satellites' anomalies depending on Kp index, local time, seasonal variation, and high-energy electron contribution. As results, we obtained following results: (1) there is a good correlation between geomagnetic index(Kp) and anomaly occurrences of the GEO satellite; (2) especially during the solar minimum, occurrence of the satellite anomalies are related to electron flux increase due to high speed solar wind; (3) satellite anomalies occurred more preferentially in the midnight and dawn sector than noon and dusk sector; (4) and the anomalies occurred twice more in Spring and Fall than Summer and Winter; (5) the electron with the lowest energy channel (50-75keV) has the highest correlation (cc=0.758) with the anomalies. High association between the anomalies and the low energy electrons could be understand by the facts that electron fluxes in the spring and fall are stronger than those in the summer and winter, and low-energy electron flux is more concentrated in the dawn sector where the GEO satellite anomalies occurred more frequently than high-energy electron flux. While we could not identify what cause such local time dependences, our results shows that low-energy electrons (~100keV) could be main source of the satellite anomaly, which should be carefully taken into account of operating satellites.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5219-5223
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• 2015

Helicobacter pylori (H. pylori) infection as a serious problem in both adults and children can induce chronic gastritis, peptic ulcer disease (PUD), and possibly gastric cancer. The aim of the current study was to survey antibiotic resistance and also to determine influence of PPAR$\gamma$ polymorphism in patients with H. pylori infection. During an 11-month-period, 98 H. pylori isolates were collected from 104 biopsy specimens. In vitro susceptibility of H. pylori isolates to 4 antimicrobial agents metronidazole, clarithromycin, amoxicillin and tetracycline were assessed by quantitative method according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline. PPAR$\gamma$ polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism assay. The frequency of H. pylori infection in our study was 94.2%. In vitro susceptibility data showed that highest level of resistance was related to metronidazole (66.3%), and the majority of H. pylori isolates were highly susceptible to amoxicillin and tetracycline (94.9% and 96.9%, respectively). Genotypic frequencies were 25.5% for CC (Pro12Pro), 40.8% for GC (Pro12Ala) and 33.7% for GG (Ala12Ala). In our study, CG genotype had highest distributions among infected patients with H. pylori. The study suggests that the PPAR-$\gamma$ Pro12Ala polymorphism could be evaluated as a potential genetic marker for susceptibility to gastric cancer in the presence of H. pylori infection.