• Biomolecules & Therapeutics
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• v.9 no.4
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• pp.285-290
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• 2001

Bioequivalence of two acetyl-1-carnitine tablets, test product (Carnitile tablet: Hanmi Pharm. Co., Ltd.) and reference product (Nicetil $e^{R}$ tablet: Dong-A Pharm. Co., Ltd.), was evaluated according to the guide- lines of Korea Food and Drug Administration (KFDA). Twenty-six healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 500 mg as acetyl-1-carnitine in a 2$\times$2 crossover study. Blood samples were taken at predetermined time intervals for 12 hours and the plasma concentration of acetyl-1-carnitine was determined using HPLC by derivatization with p-bromophenacyl bromide. The pearmacokinetic parameters (AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$) were calculated and ANOVA was utilized for the statistical analysis of parameters. The apparent differences of these parameters between two drugs were less than 20% (i.e., 1.26,-5.08 and 8.59% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The powers (1-$\beta$) for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, and Tmax were over 0.9. Minimal detectable difference ($\Delta$) at $\alpha$=0.05, 1-$\beta$=0.8 were less than 20% (i.e.,7.31, 14.88 and 11.77% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The confidence intervals ($\delta$) for these parameters were also within $\pm$ 20% (i.e.,-3.03$\leq$$\delta$$\leq$5.54, -13.80$\leq$$\delta$$\leq$3.64 and 1.69$\leq$$\delta$$\leq$15.48 for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating Carnitile bioequivalent to Nicetil $e^{R}$ .TEX>$^{R}$ .> R/ . R/ .

• Bulletin of the Korean Chemical Society
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• v.19 no.1
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• pp.63-67
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• 1998

The synthesis and characterization of the monomeric group 13 heterocyclic thiosemicarbazone complexes $Me_2M[SC_4H_3CHNNC(S)SCH_3]$ (M=Al (2), Ga (3)) are described. Compounds 2-3 were prepared using $MMe_3$ (M=Al, Ga) in toluene with 2-thiophenecarboxaldehyde-S-methyldithiocarbazat e under anaerobic conditions. These complexes have been characterized by $^1H\;NMR,\; ^{13}C\; NMR$, elemental analyses, and single-crystal X-ray diffraction. 2 crystallizes in the monoclinic space group $P2_1/c$ with unit cell parameters a=10.2930(5) Å, b=18.564 (1) Å, c=7.3812(6) Å, V=1347.9(2) Å3, $D_{calc}=1.342\; gcm^{-3}$ for Z=4, 9281 reflections with $I_o<3{\sigma}\;(I_o),$ R1=0.0500 and wR2=0.0526. 3 crystalizes in the orthorhombic space group $P_{bca}$ with unit cell parameters a=13.340(3) Å, b=19.9070(5) Å, c=11.3690(2) Å, $V=2673.88(9)\;{\AA}^3$, $D_{calc}=1.511\; gcm^{-3}$ for Z=8, 17004 reflections with $I_o>3{\sigma}\;(I_o),$, R1=0.0480 and wR2=0.0524. Compound 3 is a monomeric gallium compound with a weak interaction between the pendant thiophene and the gallium center.

• Journal of Veterinary Clinics
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• v.37 no.6
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• pp.311-316
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• 2020

Biomarkers used in dogs with heartworm disease include N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI), which are associated with damage to the myocardium. Pulmonary hypertension is one of the clinical signs of canine heartworm disease. The purpose of this study is to investigate the change in the concentration of each biomarker, severity of pulmonary hypertension and the correlation between biomarkers according to the severity of clinical signs. Five healthy dogs and 10 heartworm-infected dogs were recruited for the study. The heartworm-infected group was classified based on the history, clinical signs, and blood assay, thoracic radiography, and echocardiography after confirming the infection according to the results of the commercial ELISA kit (SNAP test, IDEXX Laboratories, Maine, USA). NT-proBNP was higher in the severely infected group than the control group (p < 0.05); cTnI was also higher in the severely infected group than the control group (p < 0.05). The pressure gradient of pulmonary hypertension was higher in the severe group than the mild group (p < 0.05). The severity of pulmonary hypertension was correlated with NT-proBNP (r = 0.818, p < 0.01), cTnI (r = 0.894, p < 0.01). When the correlation of the two serum values for each group was examined, a correlation was not found in the mild group (r = 0.707, p = 0.182), but a correlation was found in the severe group (r = 0.9, p < 0.05). NT-proBNP and cTnI were significantly increased and correlated with severe clinical signs. Pulmonary hypertension was significant higher in the severe group than in the mild group (p < 0.05). Evaluation of blood biomarker concentration and severity of pulmonary hypertension and referring to each correlation between these indicators may be helpful to assess the severity of the heartworm disease.

• Communications of the Korean Mathematical Society
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• v.39 no.3
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• pp.575-583
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• 2024

Let R be a commutative ring with 1 ≠ 0. Let Id(R) be the set of all ideals of R and let δ : Id(R) → Id(R) be a function. Then δ is called an expansion function of the ideals of R if whenever L, I, J are ideals of R with J ⊆ I, then L ⊆ δ (L) and δ (J) ⊆ δ (I). Let δ be an expansion function of the ideals of R and m ≥ n > 0 be positive integers. Then a proper ideal I of R is called an (m, n)-closed δ-primary ideal (resp., weakly (m, n)-closed δ-primary ideal ) if a^m ∈ I for some a ∈ R implies aⁿ ∈ δ(I) (resp., if 0 ≠ a^m ∈ I for some a ∈ R implies aⁿ ∈ δ(I)). Let f : A → B be a ring homomorphism and let J be an ideal of B. This paper investigates the concept of (m, n)-closed δ-primary ideals in the amalgamation of A with B along J with respect to f denoted by A ⋈^f J.

• Korean Journal of Agricultural and Forest Meteorology
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• v.21 no.3
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• pp.196-207
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• 2019

This study was carried out to investigate the effects of C. japonica, D. morbifera, D. macropodum, I. anisatum, Q. glauca and R. indica To investigate the photosynthetic ability, chlorophyll content, chlorophyll fluorescence analysis, and physiological environmental. The photosynthetic rate, cancer respiration rate, stomatal conductance, and rate of evaporation tended to decrease as a result of drying stress in the no-water condition for 28 days. I. anisatum, Q. glauca and R. indica showed a low rate of less than 40% until 28 days of no-treatment. The total chlorophyll contents were decreased in the order of D. macropodum> D. morbifera> C. japonica> Q. glauca> M. thunbergii> R. indica> I. anisatum. Chlorophyll fluorescence analysis showed that there was no change in the qP, but after 28 days no $Fv/F_m$, $F_o$, $R_{fd}$, $NPQ_{_-LSS}$ can be a useful indicator for quantitative estimation within a short period of time with a marked reduction rate of PSII quantum yield ${\Phi}PSII$ in the rectified state by continuous light during the nominal adaptation period. In the case of I. anisatum, Q. glauca and R. indica If water management can be carried out at intervals, it may be possible to plant trees in trees and landscape trees.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.42
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• pp.143-149
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• 1997

먼저 Cantor dust 의 성질 및 유사성, 축소인자, 불변집합, $\delta$ - covering, Box counting 차원 등에 대한 정의를 하였다, {f_i}{\;}{{\infty}\atop{i=1}}$ 를 $R^n$ 상에서 개집합 조건을 만족시키는 축소인 자 $C_i$에 대한 유사성 이라하자. F를｛{f_i}{\;}{{\infty}\atop {i=1}}$ 에 대한 $R^n$상의 불변집합, 즉, F = $\bigcup_{i=0}^\infty{\;}f_1(F)$를 만족시키는 집합이라 하자. 이때, $\sum\limits_{n=0}^\infty{\;}C^s_i{\;}=1,{\;}0{\;}<{\;}C_1{\;}<{\;}1$ 일 때, $dim{\;}_H{\;}F{\;}={\;}dim{\;}_B{\;}F{\;}={\;}s$ 임을 보임으로서, 자기동형집합의 후랙탈 차원에 대하여 논의 하고자 한다.

• Kyungpook Mathematical Journal
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• v.56 no.1
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• pp.107-120
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• 2016

Let R be a commutative semiring. The purpose of this note is to investigate the concept of 2-absorbing (resp., weakly 2-absorbing) primary ideals generalizing of 2-absorbing (resp., weakly 2-absorbing) ideals of semirings. A proper ideal I of R said to be a 2-absorbing (resp., weakly 2-absorbing) primary ideal if whenever $a,b,c{\in}R$ such that $abc{\in}I$ (resp., $0{\neq}abc{\in}I$), then either $ab{\in}I$ or $bc{\in}\sqrt{I}$ or $ac{\in}\sqrt{I}$. Moreover, when I is a Q-ideal and P is a k-ideal of R/I with $I{\subseteq}P$, it is shown that if P is a 2-absorbing (resp., weakly 2-absorbing) primary ideal of R, then P/I is a 2-absorbing (resp., weakly 2-absorbing) primary ideal of R/I and it is also proved that if I and P/I are weakly 2-absorbing primary ideals, then P is a weakly 2-absorbing primary ideal of R.

• Journal of the Korean Chemical Society
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• v.37 no.1
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• pp.76-82
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• 1993

Two crystal structures of fully dehydrated Ca(II) and Tl(I) exchanged zeolite A, $Ca_{5.6}Tl_{0.8}-A (a = 12.242(2){\AA})\;and\;Ca_{1.4}Tl_{9.2}-A (a = 12.191(1){\AA})$, have been determined by single-crystal X-ray diffraction methods in the cubic space group Pm3m at 21(1)$^{\circ}C$. All crystals were ion exchanged in flowing streams of mixed $Ca(NO_3)_2\;and\;TINO_3$ aqueous solution with total concentration of 0.05M. All crystals were dehydrated at 360$^{\circ}C$ under $2{\times}10^{-6}\;torr$ for two days. The structures of the dehydrated $Ca_{5.6}Tl_{0.8}-A$ and $Ca_{1.4}Tl_{9.2}-A$ were refined to the final error indicies, $R_1$ = 0.072 and $R_2$ = 0.076 with 179 reflections for I > 3$\sigma$(I), and $R_1$ = 0.048 and $R_2$ = 0.043 with 226 reflections for I > 3$\sigma$(I), respectively. In each structure, Ca(II) ions are located on threefold axes associated with three 6-ring oxygens. $Ca^{2+}$ ions prefer to 6-ring sites and $Tl^+$ ions prefer to 8-ring sites when total number of exchanged cations per unit cell is more than 8.

• Journal of the Korean Statistical Society
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• v.13 no.2
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• pp.114-120
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• 1984

A parallel flats fraction for the $3^n$ design is defined as union of flats ${t}At=c_i(mod 3)}, i=1,2,\cdots, f$ and is symbolically written as At=C where A is rank r. The A matrix partitions the effects into n+1 alias sets where $u=(3^{n-r}-1)/2. For each alias set the f flats produce an ACPM from which a detection matrix is constructed. The set of all possible parallel flats fraction C can be partitioned into equivalence classes. In this paper, we develop some properties of a detection matrix and C.

• Korean Journal of Mathematics
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• v.12 no.1
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• pp.23-32
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• 2004

Let (B, $m_B$, ${\kappa}$) be a maximal commutative ${\kappa}$-subalgebra of a matrix algebra $M_n(\kappa)$. We will construct a maximal commutative ${\kappa}$-subalgebra (R, $m$, ${\kappa}$) of $M_n+3(\kappa)$ from the algebra B such that the algebra R has dimension greater than the dimension of B by 3. Moreover, we will show a $C_i$-construction doesn't imply a $C^3_2$-construction for $i=1,2$.