• Title/Summary/Keyword: C-14 concentration

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Pharmacokinetics And Gastric Adhesion Of Aceglutamide Aluminium On The Combination Of Antacid In Rats (흰쥐에서 제산제와 병용투여된 아세글루타미드 알루미늄의 약물동태 및 위장관 부착)

  • 조재열;남권호;유은숙;유영효;박명환;박정일
    • YAKHAK HOEJI
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    • v.39 no.6
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    • pp.577-584
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    • 1995
  • On the combination of antacid, the pharmacokinetics and gastric adhesion of [$^{14}c$]aceglutamide aluminium complex([$^{14}C$]AGA) were examined in rats. Specially, this study was focused on the drug interaction that the co-administration of antacid may affect the oral absorption and gastric adhesion of aceglutamide aluminium complex(AGA). In the study of the oral co-administration of [$^{14}C$] AGA and antacid(aluminium hydroxide and magnesium hydroxide(AM)), the radioactivity of plasma and urinary recovery was lower than that of [$^{14}C$]AGA alone administered group. However, the cumulative recovery of radioactivity in feces was increased significantly. The comparative bioavailability of [$^{14}C$] AGA from the plasma concentration-time curve and urinary recovery was about 60%. In vitro, the effect of antacid on the gastric adhesion of AGA was not significatly different between AGA and AGA/antacid treatment. And it accorded well with the result of in vivo experiment. In conclusion, on the combination of antacid, the oral absorption of AGA was decreased by the gastric adhesion was not affected in respect of drug interaction.

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Kinetic Studios of Milk Gelification (Part 1) (우유의 Gel화에 관한 동력학적 연구 (제1보))

  • LEE Keun-Tai
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.19 no.3
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    • pp.177-182
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    • 1986
  • The dynamic mechanical properties of milk gel were examined as function of temperature, concentrations of milk and enzyme. The real and imaginary parts of the complex rigdity G' and G' were measured at $2\%$ strain and 5 rad/s of frequency. The results showed that the rigidity of milk gel was dependent on the concentration of milk (C) in such a way that $\sqrt{G'}{\propto}C$. It was found that gel point ($t_g$) was dependent on the concentration of milk as $t_g{\propto}C$, and on the concentration of enzyme as $t_g{\propto}\;1/(E)$, The activation energy of enzymatic reaction stage and coagulation stage were $21.1{\pm}5.8\;kcal/mol$ and $26.4{\pm}1.14\;kcal/mol$, respectively.

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Antifertility Effect of Passive Immunization against Progesterone Monoclonal Antibody in Mice (Progesterone 단일클론항체의 수동면역이 Mouse 수정란의 착상저해에 미치는 효과)

  • 김정우;김종배;정길생;고대환
    • Korean Journal of Animal Reproduction
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    • v.14 no.3
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    • pp.157-164
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    • 1990
  • Anti-progesterone monoclonal antibody injected intraperitonially as a single dose(100$\mu\textrm{g}$) 48hours post coitum(p.c.) almostly blocked pregnancy in ICR mice. The blocking rate of pregnancy in mice treated with antibody were decreased proportionally according to dose of antibody injected ; the rate were 60%, 57% and 17% as the antibody of 10$\mu\textrm{g}$, 50$\mu\textrm{g}$ and 100$\mu\textrm{g}$ were injected respectively. Blood serum progesterone concentration was greatly increased(21 times) after treatment(100$\mu\textrm{g}$), by virtue of high-affinity binding by antibody in circulation of non-pregnant mice in coompared with that of control group at day 10 p.c.. The concentration was about 1.6 times higher in the pregnant mice than in the non-pregnant mice in antibody treated group. In control group, the progesterone concentration was over 7 times higher in the pregnant mice than in non-pregnant mice at day 5 p.c..

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Thermal Gelation Characteristics of Composite Surimi Sol as Affected by Rice Starch

  • Jung, Young-Hwa;Yoo, Byoung-Seung
    • Food Science and Biotechnology
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    • v.14 no.6
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    • pp.871-874
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    • 2005
  • The effect of rice starch at different concentrations (0, 4, 6, and 8%) on dynamic rheological properties of surimi sols was investigated by small-deformation oscillatory measurements at $10^{\circ}C$ and during heating from 10 to $95^{\circ}C$. Dynamic frequency sweeps at $10^{\circ}C$ showed that the magnitudes of storage modulus (G') decreased with increasing starch concentration while those of tan $\delta$ increased. G' values of surimi-rice starch sols during heating decreased with increasing starch concentration, indicating that the pattern of G' changes during heating was influenced by the concentration of the added rice starch. In general, the characteristic G' thermograms of all samples showed a similar sol-gel transition pattern.

The Effect of Temperature on the Critical Micelle Concentration of Cationic Surfactant for Chemical Dispersants (유처리제용 양이온 계면찰성제의 임계미셀농토에서 온도의 효과)

  • kim, Yeoung-Chan
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.14 no.2
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    • pp.145-148
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    • 2008
  • Cationic surfactant can be used as cosmetics and chemical dispersants. The variation of critical micelle concentration (CMC) with temperature over the range $40^{\circ}C$ to $60^{\circ}C$ for N-octadecyl pyridinium bromide was measured by drop methods. Thermodynamic quantities such as free energy, enthalpy, entropy and heat capacity for micellization of N-octadecyl pyridinium bromide in water were calculated by fourth-degree polynominal equation In the result, free energy change was decreased generally by the increment of temperature.

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Y-TZP Sintered with Spherical Fine Powders Prepared by Ultrasonic Spray Pyrolysis (초음파 분무 열분해 구형 미립자를 이용한 Y-TZP 소결체의 제조)

  • 김복희;이정형
    • Journal of the Korean Ceramic Society
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    • v.32 no.5
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    • pp.575-581
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    • 1995
  • Zr0.94Y0.06O1.97 powder was synthesized by the ultrasonic spray pyrolysis with various concentrations of starting solution and the influence of powder characteristics on sintering behavior was investigated. Powders prepared at 75$0^{\circ}C$ were characterized as narrowly distributed submicron spherical particles, which were crystalline, nonagglomerated, and compositionally homogeneous. The changes in concentration from 0.01 to 01. mol/ι increased mean particle size from 0.24 to 0.38${\mu}{\textrm}{m}$ and decreased the specific surface area from 14.2 to 2.9$m^2$/g. The relative density of the specimen from the powders, prepared with the solution concentration of 0.01 mol/ι, was 98% after sintering for 2 hr at 1,45$0^{\circ}C$ and the monoclinic phase was observed after sintering at 1,55$0^{\circ}C$. As the concentration of starting solution was increased, the formation temperature of monoclinic phase was lowered.

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Evaluation of some Ethanobotanical Plant Extracts for Fungitoxicity against Myrothecium roridum

  • Maji, Manas Dev;Chattopadhyay, Souman;Kumar, P. M. Pratheesh;Saratchandra, B.
    • International Journal of Industrial Entomology and Biomaterials
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    • v.14 no.2
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    • pp.75-80
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    • 2007
  • Ethanolic extracts of twenty-one plant species were tested in vitro for their fungitoxic properties against leaf spot causing pathogen of mulberry Myrothecium roridum by poisoned food technique. Ethanolic extracts of twenty-plant spp. reduced mycelial growth of M. roridum significantly except E. pulcherrima. Highest inhibition of M. roridum colony growth observed in 10% extracts of E. citriodora (49.45%) followed by D. metel (39.45%), Chromolaena odoratum (25.56%) and A. sativum (25.00%). Among the concentration tested, 10% concentration was found significantly higher effective on reducing colony growth followed by 5 and 2.5%. Aqueous extract fresh leaves/bulb of seven short-listed plant spp. (inhibition>15% in ethanolic extracts) revealed that D. metel inhibited (23.43%) followed by E. citriodora (14.66%), C. odoratum (13.53%). On dry leaf extracts D. metel was found more effective than E. citriodora. The results indicated that D. metel, E. citriodora, C. odoratum and A. sativum having high fungitoxicity against M. roridum and ethanolic extract found more effective than aqueous extract.

Studies on the Ecological Characteristics of Marine Bacteria Isolated from Deep Sea (심해 해양미생물의 분리 및 분리균의 생태적 특징에 관한 연구)

  • LEE Won-Jae;OHWADA Kouichi
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.28 no.4
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    • pp.401-411
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    • 1995
  • Flavobacterium spp., Pseudomonas spp., and Vibrio spp. were isolated from samples(sediments) of Sagami Bay and Suruga Bay(in Japan) at 810-4,000m in depth. Among isolated strains, Vibvio sp.-86 and sp.-87 strains were identified as barophilic and psychrophilic ones. They grew in 400 atm and showed best growth at 100 atm. Marine bacteria grown at 400 atm were long rod shape and 30 to 50times longer than those grown at 1 atm. which were short rod shape and formed flocks (aggregates). Vibrio sp,-86 strain grew at $5-37^{\circ}C\;and\;0,5-9.0\%\;NaCl\;(3.0\%\;of\;optimum\;concentration),$ while Vibrio sp.-87 strain grew at $1-7\%\;NaCl\;(2,0\%\;of\;optimum\;concentration).$ The fatty acid compositions of Vibrio sp.-86 strain grown at 1 atm were $C_{20}-C_{22:0},\;C_{l6:1},\;and\;C_{16:0}$ in the order of their abundance and at 400 atm the order were $C_{18:1},\;C_{18:0},\;and\;C_{20}-C_{22}$, whereas those of Vibrio sp.-87 strain at 1 atm were $C_{6:1},\;C_{14:1},\;and\;C_{20}-C_{22}$ and at 400 atm the order were $C_{14:1},\;C_{12:0},\;and\;C_{16:1}$ The amino acids compositon of Vibrio sp.-86 strain grown at 1 atm were abundant in the order of aspartic acid, methionine, and glutamic acid and those at 400 atm were abundant in the order of methionine, glutamic acid, and aspartic acid. The amino acids composition of Vibrio sp.-87 strain grwon at 1 atm were abundant in the order of methionine, glutamic acid, and aspartic acid and those at 400 atm were abundant in the order of methionine, glutamic acid, and isoleucine.

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Behavior of Chloride Binding in Hardened Cement Pastes (Forcused on $C_3A$ content) (시멘트 경화체내 염화물의 고정화 성상 ($C_3A$ 함유량을 중심으로))

  • 임순지;소형석;소승영;박홍신;소양섭
    • Proceedings of the Korea Concrete Institute Conference
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    • 1994.10a
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    • pp.87-92
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    • 1994
  • The main objective of this study is to determine the critical chloride ion concentrations in the pore solutions causing depassivation of steel reinforcement in concrete made with cements of different $C_3A$ contents. Cement pastes with water-ratio of 0.5 were prepared using four cements with $C_3A$ contents of 0.46, 5.97, 9.14, and 9.65 percent. The pastes were allowed to hydrate in sealed containers for 28days and then objected to pore solution expression. The expressed pore fluids were analyzed for chloride and hydroxyl ion concentrations. It was found that the free cholride concentration in the pore solution decreases significantly with an increase in the $C_3A$ content of the cement. With increasing level of chloride addition, although the alsolute amount of bound chloride increase, the ratio of bound to total chlorides decreases.

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Trophic Transfer of Disinfectant Chemical in Aquatic Ecosystem (소독살균제 기인 화학물질의 수생태계 내 생물 전이 특성 연구)

  • Ha-Eun Cho;Dokyun Kim;Eun-Ji Won;Hyeong-Wook Jo;Kwang-Guk An;Kyung-Hoon Shin
    • Korean Journal of Ecology and Environment
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    • v.55 no.4
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    • pp.376-389
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    • 2022
  • Despite the consumption of disinfectants have been increased by COVID-19 pandemic, the fate of the chemicals in aquatic food webs are still unclear. In order to understand the trophic transfer of the chemicals, the concentration of disinfectants including six benzalkonium chloride (BACs) and five didecyldimethylammonium chlorides(DDACs) were measured at the Geum (2020), Han (2021), and Yeongsan River (2021), before and after rainfall. The highest concentration of ∑BACs (mainly C12 and C14) and ∑DDACs (mainly C10 and C14) were observed in the Han River, followed by Yeongsan River, Geum River Estuary, and Gapcheon. After rainfalls, both concentration and detection frequency were decreased in all sites. Although the BAC and DDAC seems to be accumulated in organisms, they were bio-diluted rather than magnified in the aquatic food web with the biomagnification factor(BMF) of less than 1, trophic magnification slope (TMS) from -0.236 to 0.001, and trophic magnification factor(TMF) from 0.85 to 1.01.